EKS-XET-00154
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00154
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKG467.11.4E-140461719259
StatusUnreviewed
Ensembl ProteinENSXETP00000046551
UniProt AccessionF6S6L9;
Protein NamecGMP-dependent protein kinase
Protein Synonyms/Alias
Gene Nameprkg2
Gene Synonyms/Alias prkg2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000021539ENSXETP00000046551ENSXETT00000046551
OrganismXenopus tropicalis
Functional Description
Protein Length770
Protein Sequence
(FASTA)
MGNGSMKSKP LKQPDGQRVN FSISSCNKLR NADTVKNKVW ELEIELKKKD EKLKNKEQIF 60
QELQEQIKKQ NQVIEEMAEE LQNKCVQLNK LQVVVQTQNG ISTTPDGSPL KTFSGLFSNS 120
NKRKGAKEGV SAEPTSRYDG GDHPRFSFEK ARVRKICNLS EKILISDALN KNQFMKRMDH 180
HQIQDMVECM YERIYLQGEF IIRQGEPGSQ IFVLADGKAE VFQENKLLTS IPVWTTFGEL 240
AILYNCTRTA SVKEAITGVR TWALDREVFQ NIMRKTAQSK HEEYLSFLRV SVPLLKELPE 300
HKLMKIADCL ELEFYEMDDY IIREGEEGST FFIISKGKVK VTQSTEGYKE PQYIKFLEKG 360
DYFGEKALIS DDVRSANILA YGDRVECLVM DRETFNKTVG TYEELMKCLE GYVANLTLDD 420
ERRHANRSPV NERHLRAVSM ELNKMKQTLA RFPSASPFEN LEIVTTLGVG GFGRVELVKV 480
KNENLVFALK CIKKRHIVDN RQQEHIHSEK NILEEACSPF IVKLYCTFKD NKYVYMLLEA 540
CLGGELWSIL RDRGSFDEPT AKFCTGCVTE AFEYLHQKGV LYRDLKPENL LLDSEGYVKL 600
VDFGFAKKIF PGQKTWTFCG TPEYVAPEVI LNKGHSFSVD FWSLGILLYE LLTGSPPFTG 660
PDQMIIYNLI LQGIEKIEFY KNITKRPEDL IRRLCRENPA ERLGNMKNGI ADIKKHRWFN 720
GFNWEGLNTR SLPSPLKPEL EGPTDHSYFD SYPPDEEIPP DEVSGWDQDF 770
Nucleotide Sequence
(FASTA)
ATGGGAAATG GCTCTATGAA ATCCAAACCA CTTAAGCAGC CAGATGGACA ACGGGTGAAC 60
TTCTCCATCA GCTCCTGCAA CAAGCTCCGT AATGCAGACA CTGTAAAAAA TAAAGTCTGG 120
GAATTAGAGA TAGAACTTAA GAAAAAAGAT GAGAAGCTGA AGAACAAAGA ACAAATATTT 180
CAAGAGCTGC AGGAACAAAT TAAGAAGCAA AATCAGGTTA TTGAAGAGAT GGCAGAAGAA 240
CTTCAAAACA AATGTGTTCA ACTTAACAAA CTGCAAGTTG TTGTACAAAC TCAGAATGGT 300
ATCTCCACAA CTCCAGACGG ATCCCCACTT AAAACCTTTT CAGGCCTGTT CAGCAACAGC 360
AACAAGAGAA AAGGGGCAAA GGAAGGAGTT TCTGCAGAAC CTACCAGCAG ATATGATGGA 420
GGTGATCATC CAAGATTCTC ATTTGAAAAA GCACGTGTTA GGAAAATTTG TAATCTAAGT 480
GAGAAGATTC TTATATCAGA TGCTTTAAAC AAGAACCAGT TTATGAAGAG AATGGATCAT 540
CATCAAATTC AAGACATGGT AGAATGCATG TATGAAAGAA TATATCTTCA AGGTGAATTT 600
ATTATCAGAC AAGGGGAACC AGGAAGCCAG ATCTTTGTAT TAGCAGATGG AAAAGCAGAA 660
GTTTTTCAGG AGAACAAACT TCTGACATCC ATCCCAGTCT GGACAACATT TGGGGAGCTT 720
GCAATATTGT ACAACTGCAC AAGAACAGCC TCTGTGAAAG AAGCAATCAC CGGTGTCAGA 780
ACATGGGCTC TAGACCGCGA AGTGTTTCAG AATATAATGA GAAAGACAGC CCAAAGTAAA 840
CATGAAGAAT ACCTAAGTTT CTTAAGAGTA AGTGTGCCCT TGTTGAAGGA ACTTCCTGAA 900
CATAAGCTAA TGAAGATTGC AGATTGCTTG GAACTGGAAT TCTATGAAAT GGATGATTAC 960
ATTATTCGTG AAGGAGAAGA AGGGAGCACA TTCTTCATAA TTTCTAAAGG AAAGGTGAAA 1020
GTGACCCAGA GCACAGAGGG TTATAAAGAA CCTCAGTATA TAAAATTTTT GGAAAAAGGA 1080
GATTACTTTG GTGAAAAAGC TCTTATCAGT GATGATGTCA GATCAGCAAA TATACTAGCA 1140
TATGGAGATA GAGTGGAGTG TCTTGTCATG GATCGAGAGA CATTTAATAA GACAGTTGGA 1200
ACGTACGAAG AACTTATGAA ATGTCTTGAG GGATATGTAG CAAATTTGAC CCTTGATGAT 1260
GAAAGAAGGC ATGCCAATAG GAGCCCAGTG AATGAACGAC ATCTAAGAGC CGTGTCAATG 1320
GAACTGAATA AAATGAAACA AACTCTTGCA AGATTTCCAT CTGCATCCCC TTTTGAGAAT 1380
CTAGAGATTG TCACAACACT GGGTGTCGGT GGGTTCGGGA GAGTGGAACT TGTCAAGGTA 1440
AAGAATGAGA ATCTGGTTTT TGCACTAAAA TGCATTAAGA AGAGGCACAT TGTGGACAAC 1500
AGGCAACAAG AGCATATACA TTCTGAAAAA AACATTTTAG AAGAAGCATG CTCTCCTTTT 1560
ATTGTGAAAC TCTACTGCAC TTTCAAGGAT AATAAGTATG TGTATATGCT TCTTGAAGCA 1620
TGCCTTGGAG GGGAGCTTTG GAGCATTTTA AGAGATAGGG GCAGTTTTGA TGAGCCTACT 1680
GCAAAATTCT GCACTGGGTG TGTAACAGAG GCTTTTGAGT ATTTGCATCA AAAAGGGGTT 1740
CTATATCGGG ATTTGAAGCC AGAAAACTTA CTTCTGGATT CAGAAGGCTA TGTCAAACTG 1800
GTTGATTTTG GATTTGCTAA GAAAATTTTC CCTGGGCAAA AAACATGGAC ATTTTGTGGC 1860
ACGCCAGAAT ATGTTGCTCC AGAAGTTATT TTAAACAAAG GACATAGCTT CAGTGTGGAT 1920
TTCTGGTCAC TAGGAATATT ATTGTATGAA CTCCTGACAG GAAGCCCTCC TTTTACTGGA 1980
CCTGACCAGA TGATCATCTA CAATTTAATT CTTCAAGGAA TTGAAAAAAT AGAATTTTAC 2040
AAAAATATAA CAAAACGCCC TGAAGATTTG ATTCGCCGCC TCTGTAGGGA GAATCCAGCA 2100
GAACGACTTG GAAATATGAA GAATGGCATA GCTGATATTA AAAAGCACAG GTGGTTTAAT 2160
GGCTTTAACT GGGAAGGATT AAATACTAGG AGTCTGCCTT CTCCTTTAAA ACCTGAGCTA 2220
GAAGGCCCCA CAGATCATAG TTATTTTGAC AGCTACCCAC CAGATGAAGA AATCCCTCCA 2280
GATGAGGTGT CAGGATGGGA TCAAGACTTC TGA 2313
Domain Profile
S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60
         l++++tlgvggfgrvelvkvk+ e+ +falk++kk+hivd++qqeh+ sek+ileea+s+
Q: 461   LEIVTTLGVGGFGRVELVKVKN-ENLVFALKCIKKRHIVDNRQQEHIHSEKNILEEACSP  519
         689******************9.899**********************************
S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120
         fivkly tfkd+kyvy+lleaclggelw+ilrdrgsfd+ takf+++cv+ea+eylh+k+
Q: 520   FIVKLYCTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTAKFCTGCVTEAFEYLHQKG  579
         ************************************************************
S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180
         ++yrdlkpenllld+egy+klvdfgfakk+  g+ktwtfcgtpeyvape+ilnkgh +sv
Q: 580   VLYRDLKPENLLLDSEGYVKLVDFGFAKKIFPGQKTWTFCGTPEYVAPEVILNKGHSFSV  639
         ************************************************************
S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240
         d+w+lgil+yelltg+ppf+g+d++ +ynlil+gi+k+e+ ++itk++edli++lcr+np
Q: 640   DFWSLGILLYELLTGSPPFTGPDQMIIYNLILQGIEKIEFYKNITKRPEDLIRRLCRENP  699
         ************************************************************
S: 241   aerlgylkggikdikkhkwf  260
         aerlg++k+gi+dikkh+wf
Q: 700   AERLGNMKNGIADIKKHRWF  719
         *******************9
Domain Sequence
(FASTA)
LEIVTTLGVG GFGRVELVKV KNENLVFALK CIKKRHIVDN RQQEHIHSEK NILEEACSPF 60
IVKLYCTFKD NKYVYMLLEA CLGGELWSIL RDRGSFDEPT AKFCTGCVTE AFEYLHQKGV 120
LYRDLKPENL LLDSEGYVKL VDFGFAKKIF PGQKTWTFCG TPEYVAPEVI LNKGHSFSVD 180
FWSLGILLYE LLTGSPPFTG PDQMIIYNLI LQGIEKIEFY KNITKRPEDL IRRLCRENPA 240
ERLGNMKNGI ADIKKHRWF 259
KeywordATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00158
EKS-ANC-00160
EKS-BOT-00166
EKS-CAE-00128
EKS-CAJ-00169
EKS-CAF-00173
EKS-CAP-00165
EKS-DAR-00456
EKS-DRM-00080
EKS-EQC-00165
EKS-FEC-00155
EKS-GAM-00085
EKS-GAG-00142
EKS-GAA-00197
EKS-GOG-00165
EKS-ICT-00161
EKS-LOA-00165
EKS-MAM-00164
EKS-MEG-00131
EKS-MOD-00165
EKS-MUM-00171
EKS-MUP-00170
EKS-MYL-00174
EKS-NOL-00159
EKS-ORN-00207
EKS-ORC-00153
EKS-ORL-00192
EKS-OTG-00172
EKS-PAT-00157
EKS-PES-00146
EKS-POA-00162
EKS-PTV-00148
EKS-RAN-00162
EKS-SAH-00159
EKS-SUS-00145
EKS-TAG-00195
EKS-TAR-00214
EKS-VIP-00079
EKS-XIM-00202
Gene Ontology
GO:0005524; F:ATP binding
GO:0030553; F:cGMP binding
GO:0004692; F:cGMP-dependent protein kinase activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR016232; cGMP-dependent_protein_kinase.
IPR002374; cGMP_dep_kinase.
IPR018490; cNMP-bd-like.
IPR018488; cNMP-bd_CS.
IPR000595; cNMP-bd_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014710; RmlC-like_jellyroll.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00027; cNMP_binding; 2.
PF00069; Pkinase; 1.
SMARTs
SM00100; cNMP; 2.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00888; CNMP_BINDING_1; 2.
PS00889; CNMP_BINDING_2; 1.
PS50042; CNMP_BINDING_3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR00104; CGMPKINASE.
Created Date20-Feb-2013