EKS-XET-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.4	7.8E-126	192	479	288

Status

Unreviewed

Ensembl Protein

ENSXETP00000046976

UniProt Accession

F6R871;

Protein Name

Protein Synonyms/Alias

Gene Name

acvr2a

Gene Synonyms/Alias

acvr2a;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000021720	ENSXETP00000046976	ENSXETT00000046976

Organism

Xenopus tropicalis

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

MGAATKLAFA VFLISCSSGA ILGRSETKEC VYYNANWEKD KTNPNGTEIC YGDNDKRRHC 60

FATWKNISGS IEIVKQGCWL DDMNCYDKSD CTERKESPDV FFCCCEGNTC NERFYHSPEM 120

EVTQPTSNPV PTKPPLFNTL LYSLVPIMVV AVIVLFSFWM YRHHKLAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNETVAVKI FPIQDKLSWQ NEYEIYNLPG 240

MKHENILQFI GAEKRGTNLD TDLWLITAFH EKGSLTDYLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAVAH RDIKSKNILL KNSLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAF GLVLWELASR CTASDGPVDE YMLPFEEEVG 420

QHPSLEDMQE VVVHKKKRPI LRECWQKHAG MAMLCETIEE CWDHDAEARL SAGCVEERII 480

QMQKLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

ATGGGAGCTG CTACCAAGCT GGCCTTTGCA GTCTTTCTTA TCTCCTGTTC CTCAGGAGCC 60

ATCTTGGGAA GGTCAGAAAC CAAAGAATGC GTCTACTACA ATGCCAACTG GGAGAAGGAC 120

AAGACCAACC CCAACGGCAC GGAGATCTGC TACGGGGACA ACGACAAAAG GCGGCACTGC 180

TTTGCCACAT GGAAGAACAT TTCGGGCTCC ATAGAGATCG TTAAGCAAGG CTGCTGGTTG 240

GACGATATGA ACTGCTACGA CAAGAGCGAC TGCACAGAGA GGAAGGAGAG TCCGGATGTG 300

TTCTTCTGTT GCTGCGAAGG CAACACCTGC AATGAGAGGT TCTACCATTC GCCAGAGATG 360

GAGGTCACAC AGCCCACCTC GAATCCTGTC CCAACCAAGC CGCCTTTATT CAACACTCTG 420

CTGTACTCGC TGGTGCCTAT CATGGTGGTG GCGGTCATTG TTCTCTTCTC GTTCTGGATG 480

TACCGGCACC ACAAGCTCGC CTACCCCCCA GTGCTGGTTC CAACACAGGA TCCAGGCCCC 540

CCTCCTCCGT CTCCTCTGCT GGGATTAAAG CCATTGCAGC TGCTGGAGGT AAAAGCCAGA 600

GGGAGGTTCG GCTGCGTGTG GAAAGCCCAG TTATTAAATG AAACCGTAGC TGTCAAGATA 660

TTCCCAATAC AGGATAAACT GTCTTGGCAA AATGAGTATG AAATCTACAA CCTCCCTGGG 720

ATGAAGCACG AGAATATCCT GCAGTTCATC GGCGCCGAAA AGCGCGGCAC CAACCTCGAC 780

ACGGATCTGT GGTTAATTAC TGCTTTCCAT GAAAAGGGCT CCCTCACTGA CTATCTGAAA 840

GCCAACGTGG TGTCTTGGAA TGAGCTGTGC CACATCGCTG AGACAATGGC CAGGGGCTTA 900

GCTTACCTCC ACGAAGATAT CCCGGGGCTG AAGGATGGAC ACAAGCCTGC GGTGGCGCAT 960

AGGGATATCA AAAGCAAAAA CATTCTCCTA AAAAACAGCC TGACAGCCTG TATAGCAGAT 1020

TTCGGCCTCG CCTTAAAGTT CGAAGCTGGG AAATCTGCAG GGGACACTCA CGGCCAGGTC 1080

GGAACCCGCA GGTACATGGC CCCCGAGGTG TTAGAAGGTG CTATCAATTT CCAGAGAGAT 1140

GCCTTTTTAA GGATAGACAT GTATGCCTTT GGCTTAGTAC TCTGGGAGCT GGCGTCGAGG 1200

TGCACTGCCT CGGATGGTCC AGTCGATGAG TACATGTTAC CTTTTGAAGA AGAAGTTGGG 1260

CAGCACCCAT CTCTGGAAGA CATGCAGGAA GTGGTAGTGC ACAAAAAGAA AAGACCCATC 1320

TTAAGGGAGT GCTGGCAGAA ACATGCTGGA ATGGCGATGC TCTGCGAAAC CATAGAGGAG 1380

TGCTGGGATC ACGACGCGGA AGCCCGGTTG TCGGCCGGCT GCGTCGAAGA GCGAATCATT 1440

CAAATGCAAA AACTCACAAA CATTATCACA ACCGAGGACA TTGTCACAGT GGTCACGATG 1500

GTGACAAACG TGGACTTTCC GCCCAAGGAA TCGAGCCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d+ sw++E eiy+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNETVAVKIFPIQDKLSWQNEYEIYNLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ t+l+l+t++hekgsL+dyLk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpa+aHRD+kskNil+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee+vg++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAFGLVLWELASRCTASDGPVDEYMLPFEEEVGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+

Q: 429   QEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSAGCVEERI  479

         ************************************************985

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNETVAVKIF PIQDKLSWQN EYEIYNLPGM KHENILQFIG 60

AEKRGTNLDT DLWLITAFHE KGSLTDYLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAVAHR DIKSKNILLK NSLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAFG LVLWELASRC TASDGPVDEY MLPFEEEVGQ HPSLEDMQEV 240

VVHKKKRPIL RECWQKHAGM AMLCETIEEC WDHDAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013