EKS-XET-00358

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00358

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	304.5	7.9E-91	211	512	302

Status

Unreviewed

Ensembl Protein

ENSXETP00000047768

UniProt Accession

F6Q787;

Protein Name

Protein Synonyms/Alias

Gene Name

bmpr2

Gene Synonyms/Alias

bmpr2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000022074	ENSXETP00000047768	ENSXETT00000047768

Organism

Xenopus tropicalis

Functional Description

Protein Length

1043

Protein Sequence
(FASTA)

KCSRSERSVL VCWLEPWQFD LIAVHLATQS EERLCAYKDP NNQDQALSES QISLENGTVK 60

CTKGNICFGL WEKTRDGEIN LVRQGCWSHV SDSRDCYYEE CAVTTPPPVI QNGTYRFCCC 120

SKDMCNVNFT ENFTPSDPTS ASPYISFSPS GWLHREMTII IALASISVLA VLIVVFFFGY 180

RIFGGDRKQG LHSMNVLEAA TSEPSLDLDN LKLLELIGRG RYGSVYKGSL DERPVAVKVF 240

SFNNRQNFIN ERSIYRTPLL EHDNIAHFIA ADERITSDGR LEYLLVMEYY ANGSLSKYLS 300

VHSNDWLNSC RLAHSVTKGL AYLHTELLRG VCFGPRAFRI MELSTISMII HKMLHAMSIC 360

LSDLSLNANW SINAFLCPSF KCNGLSKVGT IRYMAPEVLE GAVNLRDCES ALKQVDMYAL 420

GLIYWEIFMR CTDLFPGESV PEYQMAFQTE AGNHPTFEDM QVLVSREKQR PKFPEAWKEN 480

SLAVRSLKET IDDCWDQDAE ARLTAQCAEE RMAELMMIWE RNKSVSPTIN PTSTAVQNER 540

NLSQNRRVPK IGPYPDYSSS SYIEDSVHNT DSIVKNISSE TSISSAPLTT GEKNRNSINY 600

ERQQAQARLP SPETSVTSLS TNTTTTNTTG LTPSTGMTTI SEVQYSDETM HGVQNIGPTP 660

VCLQLTEEDL ETNKLDPKEV DKNLKESSDE NLMEHSLKQF SGPDPLSSTS SNLFYPLIKL 720

AVESTGPQDF NQTGNGQACI VQDVHAAQLY PLPKQQNLPK RPTSLPLNTK NSGKESRLKF 780

SSKHKSNLKH VETGVAKMNT VTAAEPHVVT VTTASVSGRT GYVNSQGPAA QYSNTTAVLS 840

SNSMAHRAQE MLQNQFRGED SRLNINSSPD ENEPLLRREQ QAGQDESVLD RLVDRRERPA 900

ENSRVNSNNN NNSSQCVLQE TAPQSALVET RQRQTRRAQR PNSLDLSNSS IMDNCSTQCL 960

GETLSDSRSG SGEKIKKRVK TPYSLKRWRP STWAIPTERQ DCEVNNNGGS ETFSHSKSST 1020

AVYLIDGGTA TSTLSKEAKM SCL 1043

Nucleotide Sequence
(FASTA)

AAGTGTTCTA GATCAGAACG ATCTGTTTTG GTTTGTTGGT TAGAACCATG GCAATTTGAC 60

CTTATAGCAG TCCATTTAGC TACTCAAAGT GAGGAACGCC TGTGTGCCTA TAAGGATCCT 120

AATAACCAGG ACCAGGCACT CAGCGAAAGT CAGATATCGC TGGAGAATGG CACTGTTAAG 180

TGTACCAAGG GCAATATCTG TTTTGGATTA TGGGAGAAAA CAAGAGATGG CGAAATCAAT 240

CTCGTCAGAC AAGGTTGCTG GTCCCATGTA AGTGACTCCC GTGATTGTTA CTATGAAGAA 300

TGTGCCGTTA CCACCCCACC ACCAGTCATC CAGAATGGAA CATACCGTTT CTGTTGCTGC 360

AGCAAGGACA TGTGCAATGT CAACTTTACG GAGAATTTCA CCCCTTCAGA TCCTACTAGT 420

GCTTCACCAT ACATAAGTTT TAGTCCCAGT GGCTGGCTCC ATCGAGAGAT GACGATAATC 480

ATTGCCCTGG CATCTATCTC TGTGTTGGCA GTTTTAATAG TTGTCTTCTT CTTTGGATAC 540

AGGATATTTG GAGGAGACCG TAAGCAAGGT CTTCACAGTA TGAATGTGCT GGAGGCTGCC 600

ACATCAGAAC CATCCCTGGA CCTAGACAAC CTGAAGTTAT TAGAGCTTAT AGGAAGGGGT 660

CGCTATGGCT CAGTGTACAA AGGGTCCCTG GATGAACGCC CTGTGGCTGT GAAAGTCTTT 720

TCCTTTAACA ACCGTCAGAA TTTCATCAAC GAAAGGAGCA TTTACCGCAC CCCACTGCTG 780

GAGCACGATA ACATAGCTCA CTTTATTGCG GCAGATGAGC GGATAACATC AGATGGGCGT 840

CTGGAATACC TCTTGGTTAT GGAGTACTAC GCAAATGGAT CTCTGAGCAA ATATTTAAGT 900

GTTCACAGCA ATGACTGGCT TAACTCCTGT CGCTTGGCAC ATTCCGTAAC TAAAGGATTG 960

GCATATCTGC ACACTGAATT ACTGCGGGGA GTATGCTTCG GACCTAGGGC TTTTCGGATC 1020

ATGGAACTTT CAACAATTTC TATGATCATA CATAAAATGT TGCATGCAAT GTCAATATGT 1080

TTATCAGATC TATCGCTAAA TGCAAATTGG AGCATAAATG CTTTTCTGTG CCCCAGCTTT 1140

AAATGCAATG GTTTGAGTAA GGTTGGTACG ATCCGATACA TGGCCCCTGA AGTTTTGGAA 1200

GGAGCTGTTA ATCTGAGGGA CTGTGAGTCT GCTTTAAAGC AAGTGGACAT GTACGCACTG 1260

GGTCTCATCT ACTGGGAAAT ATTTATGAGA TGCACTGACC TCTTTCCAGG GGAATCTGTG 1320

CCAGAATACC AGATGGCATT TCAGACAGAG GCTGGCAACC ACCCTACATT TGAAGATATG 1380

CAGGTATTGG TGTCCAGAGA GAAGCAAAGG CCCAAATTCC CAGAGGCTTG GAAGGAGAAC 1440

AGTCTGGCTG TGAGGTCATT GAAAGAGACA ATTGATGATT GCTGGGATCA GGATGCAGAA 1500

GCCAGACTAA CTGCACAGTG CGCAGAAGAG AGGATGGCTG AACTCATGAT GATTTGGGAA 1560

CGGAACAAAT CTGTGAGCCC AACTATCAAC CCAACCTCTA CAGCAGTGCA AAATGAACGT 1620

AACTTGTCAC AAAATAGGCG AGTCCCAAAG ATTGGGCCAT ACCCAGATTA TTCCTCTTCA 1680

TCCTACATAG AAGATTCTGT GCACAACACT GACAGCATTG TGAAAAACAT CTCATCTGAG 1740

ACCTCAATAT CTAGTGCCCC CCTTACAACT GGTGAGAAGA ACCGAAACTC CATCAACTAC 1800

GAGAGGCAGC AAGCTCAGGC TCGCCTACCC AGTCCTGAAA CTAGCGTCAC AAGCTTGTCA 1860

ACAAACACTA CCACTACCAA CACCACTGGG CTCACACCAA GCACTGGAAT GACCACCATA 1920

TCAGAAGTCC AGTACTCAGA TGAAACCATG CACGGTGTGC AAAATATTGG CCCCACTCCT 1980

GTGTGTTTGC AGCTGACAGA GGAAGACCTA GAGACTAATA AGCTTGATCC AAAGGAAGTA 2040

GATAAGAACC TAAAAGAGAG CTCAGATGAA AATCTTATGG AGCATTCCCT CAAACAGTTT 2100

AGTGGACCTG ATCCCTTAAG CAGCACAAGC TCCAACCTCT TTTATCCACT TATAAAACTA 2160

GCAGTTGAGT CCACGGGGCC ACAGGACTTT AATCAAACAG GGAATGGACA AGCTTGCATT 2220

GTCCAGGATG TTCATGCTGC ACAGCTGTAT CCTCTTCCCA AGCAGCAGAA CCTTCCCAAA 2280

AGACCTACCA GCCTCCCACT GAACACTAAA AACTCTGGCA AAGAATCCAG GCTGAAATTT 2340

AGTAGCAAGC ACAAATCAAA TTTAAAGCAT GTTGAGACAG GAGTAGCCAA AATGAACACA 2400

GTGACTGCTG CAGAACCACA TGTGGTGACA GTGACCACTG CCTCAGTGAG TGGTAGGACA 2460

GGTTATGTAA ACTCTCAGGG CCCTGCAGCC CAGTATTCTA ACACAACTGC TGTGTTGAGC 2520

AGTAATTCAA TGGCTCACAG GGCACAGGAG ATGCTACAGA ACCAGTTTAG AGGGGAAGAC 2580

AGTCGACTAA ATATTAACTC TAGCCCAGAT GAAAATGAGC CTCTACTAAG GAGAGAGCAA 2640

CAAGCTGGCC AGGATGAATC AGTCTTAGAT CGGCTAGTGG ATAGGAGGGA ACGTCCTGCA 2700

GAAAATAGTC GCGTGAACTC CAATAACAAC AACAATAGCA GCCAATGTGT CCTTCAAGAG 2760

ACAGCTCCGC AAAGTGCTCT TGTAGAGACA AGGCAACGTC AGACAAGGAG AGCTCAGAGA 2820

CCAAACTCCC TGGATTTATC CAACTCCAGT ATTATGGATA ACTGCAGCAC ACAGTGTTTA 2880

GGTGAAACAC TGTCAGACAG TCGATCTGGC TCAGGAGAGA AGATTAAGAA GAGAGTGAAG 2940

ACACCATACT CCCTTAAACG GTGGCGCCCT TCAACTTGGG CTATTCCAAC TGAACGCCAA 3000

GACTGTGAGG TCAACAATAA TGGAGGCAGT GAAACCTTCA GTCACTCAAA GTCCAGCACG 3060

GCCGTTTACC TTATAGATGG GGGTACTGCC ACCTCTACTC TTTCTAAAGA AGCCAAGATG 3120

AGCTGCTTGT AA 3132

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +E+ iy+t+ll+h+ni +fia

Q: 211   LKLLELIGRGRYGSVYKGSLDERPVAVKVFSFNNRQNFINERSIYRTPLLEHDNIAHFIA  270

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

         ad+  ++d + e+llv+ey+ +gsLs+yL+ +  d+ +++rla+s+++Gla+LH+e+

Q: 271   ADErITSDGRLEYLLVMEYYANGSLSKYLSVHSNDWLNSCRLAHSVTKGLAYLHTELLRG  330

         ***9999*************************************************9655

S: 120   kgkkKpaiaHRDlkskNilvkk...dltcciaDlGLalkleeekee...ldlaansqvGt  173

           +   a    +l++  ++++k    ++ c++Dl L  + + ++      + +  s+vGt

Q: 331   VCFGPRAFRIMELSTISMIIHKmlhAMSICLSDLSLNANWSINAFLcpsFKCNGLSKVGT  390

         44556666667899999999872224678*******99887776544447778899****

S: 174   kRYmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeev  230

          RYmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++

Q: 391   IRYMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTE  450

         *******************99***************************************

S: 231   vgsdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkk  289

          g++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++++cWd+d+eaRlta++ ++

Q: 451   AGNHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIDDCWDQDAEARLTAQCAEE  510

         *****************************9999*************************99

S: 290   rl  291

r+

Q: 511   RM  512

Domain Sequence
(FASTA)

LKLLELIGRG RYGSVYKGSL DERPVAVKVF SFNNRQNFIN ERSIYRTPLL EHDNIAHFIA 60

ADERITSDGR LEYLLVMEYY ANGSLSKYLS VHSNDWLNSC RLAHSVTKGL AYLHTELLRG 120

VCFGPRAFRI MELSTISMII HKMLHAMSIC LSDLSLNANW SINAFLCPSF KCNGLSKVGT 180

IRYMAPEVLE GAVNLRDCES ALKQVDMYAL GLIYWEIFMR CTDLFPGESV PEYQMAFQTE 240

AGNHPTFEDM QVLVSREKQR PKFPEAWKEN SLAVRSLKET IDDCWDQDAE ARLTAQCAEE 300

RM 302

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013