EKS-XET-00620

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00620

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	332.0	3.0E-99	22	312	291

Status

Unreviewed

Ensembl Protein

ENSXETP00000048442

UniProt Accession

F6XC08;

Protein Name

Protein Synonyms/Alias

Gene Name

mapk4

Gene Synonyms/Alias

mapk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000022383	ENSXETP00000048442	ENSXETT00000048442

Organism

Xenopus tropicalis

Functional Description

Protein Length

577

Protein Sequence
(FASTA)

MAEKCEYIAN MYGYDLGCHF VDFKPLGFGA NGLVLSAVDS KNSRRVAVKK IAISDGRSMK 60

HALREIKIIR RLNHDNIVKV HAVLGPRGAD LQGDILKYNL VYIVQEHMET DLAQLLEQGP 120

LTEDHAKLFM YQLLRGLKYI HSTNVLHRDL KPANIFISTE ELLLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GSHELEQMQL 240

ILDTIPVIHE EDKEELLKVM PSFINASWEV RKPLRKLLPE MNSEAIDFLE KILTFNPMDR 300

LTAEAALQHP YMSPYSCPED EPISQHPFRI EDEIDDILLM EASQSQLSNW DRYQVSLSSD 360

MDWRSDLSRG MSDVQRDPRA GSELQVEEAQ VDPRKYSQSS SERFLEQSHS SMDRVFEGES 420

FEYKVGSPSY LDKLLWRDNK PHHYSEPKLI MDLSNWKRTT IPPAEDLSLQ EEPSNLFLEI 480

AQWVKSTQVG LECPSNPPSE TQQHDPPCSP RHELPPSSIS KDAESQFDLD VFITRALKLC 540

TSPEDIADNK MADLNGACIS EHPNDIVPKE TFHKDRW 577

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTGTGAGTA TATTGCCAAC ATGTATGGCT ACGATTTGGG CTGCCATTTT 60

GTGGATTTTA AGCCGTTGGG GTTTGGGGCC AATGGTTTAG TTCTGTCAGC TGTCGACAGC 120

AAGAACTCGA GAAGGGTGGC TGTGAAAAAG ATTGCCATCA GCGATGGGCG AAGCATGAAG 180

CACGCCTTGA GGGAAATTAA GATTATCCGG CGTCTGAACC ATGACAACAT TGTAAAAGTC 240

CATGCAGTCC TGGGTCCGAG AGGAGCTGAC TTACAAGGAG ATATATTAAA GTACAACTTG 300

GTGTATATTG TGCAGGAGCA TATGGAGACC GACCTCGCCC AGCTGCTGGA ACAAGGTCCC 360

CTTACTGAAG ACCACGCTAA GCTGTTCATG TACCAGCTCC TCCGAGGGCT CAAGTACATT 420

CACTCAACCA ACGTGCTTCA CAGGGATTTA AAGCCGGCCA ATATATTCAT CAGTACTGAG 480

GAACTGCTGC TCAAGATTGG GGATTTTGGA TTGGCCAGGA TTGTGGACCA ACATTACTCA 540

CATAAGGGCT ATCTCTCTGA AGGGCTGGTA ACGAAATGGT ATCGATCCCC ACGGCTTCTG 600

CTGTCCCCTA ACAACTATAC TAAGGCTATT GATATGTGGG CGGCAGGGTG CATACTGGCA 660

GAGATGCTCA CAGGGAGAAT GCTGTTTGCA GGGAGCCATG AATTGGAGCA GATGCAGCTG 720

ATATTGGACA CCATCCCTGT GATTCATGAG GAGGATAAGG AGGAGCTGCT CAAGGTCATG 780

CCATCCTTCA TAAACGCCTC CTGGGAGGTC CGGAAACCCC TGCGAAAGCT GCTCCCTGAG 840

ATGAACTCGG AGGCGATCGA TTTCTTGGAA AAGATACTAA CCTTCAACCC GATGGACCGG 900

TTAACCGCCG AAGCTGCTCT ACAGCATCCC TACATGAGCC CCTACTCCTG CCCCGAGGAT 960

GAGCCCATAT CCCAACATCC GTTCCGGATT GAGGATGAAA TTGATGACAT TTTGCTCATG 1020

GAAGCCAGTC AGAGCCAACT CTCTAACTGG GACAGGTATC AAGTCAGCCT GTCTTCTGAC 1080

ATGGACTGGA GGTCTGACCT GAGCCGCGGG ATGAGCGACG TCCAACGAGA CCCCCGAGCC 1140

GGATCTGAAC TGCAAGTAGA AGAAGCCCAA GTGGACCCGC GCAAGTATTC CCAGAGCAGC 1200

TCCGAGAGGT TCCTGGAACA ATCCCACTCG TCCATGGATC GGGTTTTCGA GGGAGAGTCC 1260

TTTGAATACA AAGTGGGGTC CCCTTCCTAC CTGGACAAGC TGCTCTGGAG AGACAACAAG 1320

CCCCACCACT ACTCGGAACC CAAGCTAATT ATGGATCTCT CCAACTGGAA AAGAACCACA 1380

ATCCCACCCG CTGAGGACTT ATCGCTGCAG GAGGAGCCAT CCAACCTGTT TCTGGAGATC 1440

GCTCAGTGGG TGAAGAGCAC CCAGGTTGGC CTTGAGTGTC CGTCCAACCC ACCCTCAGAG 1500

ACACAACAAC ACGACCCACC TTGCTCCCCT AGACACGAGT TGCCGCCGAG TAGTATCAGC 1560

AAAGACGCCG AGTCTCAGTT TGACCTCGAT GTTTTTATTA CCCGGGCGTT AAAGTTATGT 1620

ACAAGCCCAG AAGACATAGC GGACAATAAA ATGGCTGATC TCAATGGCGC TTGTATCTCA 1680

GAGCACCCGA ATGACATTGT GCCAAAGGAA ACATTTCACA AAGACCGATG GTAG 1734

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + kplg Ga+g+v+savd+++++rva+kk++  +++  s+k++lRE+k++++l+h+Ni+k

Q: 22    DFKPLGFGANGLVLSAVDSKNSRRVAVKKIA--ISDGRSMKHALREIKIIRRLNHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +  v+ p+      ++ +++ vY+v+e metdL++++++  l+++h+kl++yq+lrglky

Q: 80    VHAVLGPRGadlqgDILKYNLVYIVQEHMETDLAQLLEQGPLTEDHAKLFMYQLLRGLKY  139

         ******99888888999*******************************************

S: 118   lHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hs+nv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSTNVLHRDLKPANIFISTEELlLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765439**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++il++++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGSHELEQMQLILDTIPVIHEEDKEELLKV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++i+  ++ +k ++++l+p+ ++ea+d+lek+L+++p++R+++e aL+hpY+

Q: 260   -MPSFINASWEVRK-PLRKLLPEMNSEAIDFLEKILTFNPMDRLTAEAALQHPYM  312

         .9999998887766.***************************************7

Domain Sequence
(FASTA)

DFKPLGFGAN GLVLSAVDSK NSRRVAVKKI AISDGRSMKH ALREIKIIRR LNHDNIVKVH 60

AVLGPRGADL QGDILKYNLV YIVQEHMETD LAQLLEQGPL TEDHAKLFMY QLLRGLKYIH 120

STNVLHRDLK PANIFISTEE LLLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG SHELEQMQLI LDTIPVIHEE DKEELLKVMP 240

SFINASWEVR KPLRKLLPEM NSEAIDFLEK ILTFNPMDRL TAEAALQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

xtr:100498202

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013