EKS-XET-00338

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00338

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	376.2	9.0E-113	12	265	254

Status

Unreviewed

Ensembl Protein

ENSXETP00000061249

UniProt Accession

F7AHQ9;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase PLK4;

Gene Name

plk4

Gene Synonyms/Alias

plk4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000022522	ENSXETP00000048746	ENSXETT00000048746
ENSXETG00000022522	ENSXETP00000061249	ENSXETT00000061872

Organism

Xenopus tropicalis

Functional Description

Protein Length

951

Protein Sequence
(FASTA)

MAGSIGERRE DFKVLNLLGK GSFACVYRAQ SINTGIDVAI KMIDKKAMQK VGMVQRVRNE 60

VEIHCQLKHP SILELYNYFE DSNYVYLILE MCHNGEMNRF LKNRKKPFSE DEARHFMHQI 120

VTGMLYLHSH GILHRDLTLS NLLLSSDMNI KIADFGLATQ LKMPNEKHFT MCGTPNYIAP 180

EIATRSAHGL ESDVWSLGCM LYTFLVGRPP FDTDTVKNTL NKIVLADYEM PDFVSREAKD 240

LIFQLLRKNP ADRLSLSSVL DHAFMTGFSN VQSKVMGAVE DSIDSGHATI STGFTGSSGV 300

SISGRFQEKR ILSGPSLPNK VNIFQFKDKH PAERSNGGSF HNTQRENNDF SEGNGRKTVA 360

CEDRPHSRYL RRAHSSDRSG TSQSQTYGKP SSFSERCHSV EMLAKPSNLK GYCTSSPPKS 420

YGDIPQMFTD ERSLERHTSP PVKEKTPSEF MCPAKQITPR SGDKCQAETV QQWFGAMQLN 480

GKFKNTPDTS SVSNMGGDFY SQQTMQNGAP QYAWNDVKRK KDTDSSVESV LRGISKLPSG 540

QHKAEKSQFG EQSKARVPQQ AFGSSTLRSI ISPLNAERLK PIRQKTKNAV VSILETGEVC 600

MEFLKEQNSQ ERVKEVLRIS CDGNLIYVYH PNEGKGFPLV ERPPSPPENM RSYTFDSLPE 660

KYWKKYQYAA KFIQLVRSKM PKVTYYTRYA KCMLMENGPN ADFEVCFYDG AKIHKTPDLI 720

RVIEKSGKSY TVEGSRLSTL SDQVRSYVNH ANESHCVCLS LESAINTEEK KGENISLFPI 780

TFGRFATSSS SPPYNQKTKQ KRRNRSVLNH YHIYINFGMH KLKNTQTAKE AKVLLISYEG 840

SVFSATTAQP SPPTSNTLKT HAPDRAQVLK SVFVENVGWA SQLNSGAVWV QFNDGSQLVV 900

QPGVSSIIYT APNGQITRHG ENDKLPEYIK SKLQCLSSIL ILFASSSNSF N 951

Nucleotide Sequence
(FASTA)

ATGGCTGGCA GCATAGGGGA GAGGAGAGAG GACTTCAAAG TTCTCAATCT CCTTGGCAAA 60

GGCTCGTTTG CCTGTGTGTA CAGGGCCCAG TCTATCAACA CTGGCATCGA TGTAGCCATC 120

AAAATGATAG ACAAAAAAGC CATGCAGAAG GTTGGAATGG TGCAGAGAGT CCGAAATGAA 180

GTTGAGATCC ATTGTCAGTT AAAACACCCT TCTATCCTGG AGCTGTATAA TTATTTTGAA 240

GACAGCAATT ATGTGTATCT GATTCTTGAG ATGTGCCACA ATGGGGAGAT GAACAGGTTT 300

TTAAAGAACA GGAAAAAACC TTTCTCTGAA GATGAAGCCC GTCATTTTAT GCACCAAATT 360

GTTACCGGAA TGCTGTATCT TCATTCACAT GGTATATTAC ATCGGGATCT TACCCTTTCC 420

AATCTACTGC TGTCTAGTGA CATGAATATC AAAATTGCAG ATTTTGGCTT AGCAACTCAG 480

TTGAAAATGC CAAATGAGAA GCATTTTACT ATGTGTGGCA CACCAAACTA CATTGCTCCT 540

GAAATTGCTA CACGGAGTGC TCATGGCCTT GAGTCAGATG TCTGGTCCTT GGGATGTATG 600

CTGTATACTT TTCTTGTTGG AAGACCACCT TTTGACACAG ACACTGTAAA GAATACGCTG 660

AATAAAATTG TACTGGCAGA CTATGAAATG CCTGACTTTG TGTCAAGGGA GGCCAAAGAC 720

TTAATATTTC AGTTGCTAAG AAAAAACCCA GCAGATCGGT TAAGCCTTTC ATCAGTTTTA 780

GACCATGCAT TTATGACTGG TTTCTCTAAT GTCCAAAGTA AAGTTATGGG AGCTGTTGAG 840

GACTCCATTG ATAGTGGGCA TGCTACAATC TCCACTGGTT TCACTGGCTC TTCTGGAGTT 900

AGTATAAGTG GGCGTTTTCA GGAGAAAAGG ATCTTGTCTG GCCCTTCCCT CCCTAACAAA 960

GTCAATATAT TCCAATTTAA GGATAAGCAT CCTGCTGAAA GATCAAATGG TGGAAGCTTT 1020

CATAATACAC AGAGGGAAAA TAATGACTTT TCTGAGGGCA ATGGAAGGAA AACTGTTGCC 1080

TGTGAGGACA GACCACATTC TCGTTACCTG CGAAGGGCTC ATTCCTCTGA CAGGTCAGGA 1140

ACTTCTCAAA GCCAAACTTA TGGTAAACCA AGCAGCTTTT CAGAGAGGTG CCATTCAGTG 1200

GAGATGCTTG CTAAACCAAG TAATTTAAAG GGCTATTGTA CTTCTTCGCC ACCTAAAAGC 1260

TATGGAGATA TTCCACAGAT GTTTACAGAT GAACGTTCTT TGGAGAGACA CACTTCTCCC 1320

CCAGTAAAAG AAAAAACCCC TTCTGAGTTC ATGTGCCCAG CAAAGCAAAT TACTCCAAGA 1380

TCTGGCGATA AGTGCCAAGC TGAAACTGTT CAACAGTGGT TTGGAGCAAT GCAACTAAAT 1440

GGTAAATTTA AAAATACGCC AGATACAAGC AGTGTTAGTA ACATGGGTGG AGATTTCTAC 1500

AGCCAACAGA CCATGCAAAA TGGAGCTCCA CAATATGCCT GGAATGATGT AAAGAGGAAA 1560

AAAGATACAG ACTCCTCCGT TGAGAGTGTC TTGCGAGGAA TAAGTAAACT CCCTTCTGGA 1620

CAGCACAAGG CTGAAAAAAG TCAGTTTGGG GAGCAGAGCA AAGCCAGGGT ACCACAGCAG 1680

GCATTTGGAT CCAGTACCCT GCGATCCATT ATTTCTCCAT TAAATGCGGA AAGATTGAAA 1740

CCAATCAGAC AAAAAACAAA GAATGCAGTG GTTAGTATCC TTGAGACCGG AGAAGTCTGT 1800

ATGGAATTCC TAAAAGAGCA AAATTCTCAA GAACGTGTAA AAGAGGTGTT AAGGATATCT 1860

TGTGATGGAA ATTTGATTTA TGTGTATCAT CCAAATGAAG GGAAAGGTTT TCCTTTAGTT 1920

GAGAGACCTC CATCTCCTCC AGAAAACATG CGCAGTTACA CTTTTGACAG TTTACCAGAA 1980

AAATATTGGA AAAAATATCA GTATGCTGCA AAGTTCATAC AACTCGTACG ATCTAAAATG 2040

CCAAAGGTTA CCTACTACAC AAGATACGCA AAGTGTATGT TAATGGAAAA TGGTCCCAAT 2100

GCTGATTTTG AAGTCTGCTT CTATGATGGA GCAAAGATCC ATAAGACCCC TGATTTGATA 2160

AGAGTCATAG AGAAATCTGG AAAATCATAC ACTGTGGAAG GGAGTAGATT GAGCACCTTG 2220

TCTGATCAAG TTCGATCGTA TGTGAATCAT GCCAATGAGA GCCATTGCGT TTGCCTTTCT 2280

TTGGAATCTG CAATCAACAC AGAGGAGAAA AAGGGTGAAA ATATTTCTTT GTTTCCAATA 2340

ACGTTTGGCA GATTTGCTAC CTCCTCCTCT TCCCCCCCCT ATAATCAGAA AACAAAACAA 2400

AAGAGAAGAA ATAGAAGTGT GCTGAATCAT TATCATATAT ACATAAATTT CGGCATGCAC 2460

AAGCTGAAAA ATACTCAAAC AGCAAAAGAA GCAAAGGTTT TGCTTATTTC CTATGAGGGT 2520

TCTGTATTCT CTGCTACCAC CGCCCAACCT TCACCACCTA CTTCAAATAC TCTCAAGACT 2580

CATGCTCCAG ATCGTGCTCA GGTCCTAAAA TCTGTTTTTG TTGAAAATGT AGGCTGGGCA 2640

TCTCAGTTAA ACAGTGGAGC AGTATGGGTC CAGTTCAATG ATGGATCACA ACTTGTTGTT 2700

CAACCAGGGG TCTCCTCCAT AATTTATACC GCACCGAATG GACAGATAAC AAGACATGGG 2760

GAGAATGACA AACTTCCAGA GTACATCAAA AGCAAGTTGC AGTGTCTCTC CTCCATTCTA 2820

ATACTCTTTG CAAGTTCATC AAATTCCTTT AAT 2853

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++ +llGkG+fa +y++++++t+  +a+k+++k++++k  + ++v++e+eih++lkh++

Q: 12    FKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPS  71

         56789*******************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vyl+le+c++++++++lk+r k+++e e+r++++qiv+g++ylh++

Q: 72    ILELYNYFEDSNYVYLILEMCHNGEMNRFLKNRkKPFSEDEARHFMHQIVTGMLYLHSHG  131

         *******************************99899************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l++++e++ t+cGtPnyiaPe++++++h+le

Q: 132   ILHRDLTLSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc+lyt+lvG+PPf+t+++k+t++ki+ a+y++P  +s+eak+li +ll+k+P+

Q: 192   SDVWSLGCMLYTFLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl++ f+

Q: 252   DRLSLSSVLDHAFM  265

         ************97

Domain Sequence
(FASTA)

FKVLNLLGKG SFACVYRAQS INTGIDVAIK MIDKKAMQKV GMVQRVRNEV EIHCQLKHPS 60

ILELYNYFED SNYVYLILEM CHNGEMNRFL KNRKKPFSED EARHFMHQIV TGMLYLHSHG 120

ILHRDLTLSN LLLSSDMNIK IADFGLATQL KMPNEKHFTM CGTPNYIAPE IATRSAHGLE 180

SDVWSLGCML YTFLVGRPPF DTDTVKNTLN KIVLADYEMP DFVSREAKDL IFQLLRKNPA 240

DRLSLSSVLD HAFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013