EKS-XET-00348

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00348

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	465.6	6.3E-140	201	489	289

Status

Unreviewed

Ensembl Protein

ENSXETP00000050561

UniProt Accession

F6V2S7;

Protein Name

Protein Synonyms/Alias

Gene Name

tgfbr1

Gene Synonyms/Alias

tgfbr1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000023394	ENSXETP00000050561	ENSXETT00000050561

Organism

Xenopus tropicalis

Functional Description

Protein Length

500

Protein Sequence
(FASTA)

MSISSPCLRL PRLIVLLLIA LARWAEALIC HCEQCANRTC MTDGLCLVNV LIQDGKVTHN 60

SLCIADSERV PRDRPFMCFS TSTNGIYHNV ECCQTDFCNK KLPAPSTSPS PRPPTNLGPV 120

ELAAVIAGPV CLVCILLMLV LYICHNRTVI HHRVPNDEDP SLDRPFISEG TTLKDLIYDM 180

TTSGSGSGLP LLVQRTIART IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR 240

EAEIYQTVML RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMLK 300

LSLSTASGLA HLHMEIVGTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT 360

IDIAPNHRVG TKRYMAPEVL DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGVGIHED 420

YQLPYYDLVP SDPSVEEMKK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL 480

TALRIKKTLS QLSQQEGLKM 500

Nucleotide Sequence
(FASTA)

ATGTCTATAT CGTCTCCTTG TCTAAGGCTG CCAAGGCTTA TCGTGCTCTT GTTGATTGCA 60

CTGGCACGCT GGGCTGAGGC ACTAATATGT CATTGCGAAC AGTGTGCAAA CCGTACCTGT 120

ATGACCGATG GATTGTGCTT AGTTAATGTC CTAATTCAAG ATGGCAAAGT AACCCACAAC 180

AGCTTATGCA TTGCTGACTC TGAGCGTGTA CCTCGAGACA GACCATTTAT GTGTTTTTCT 240

ACTTCTACAA ATGGAATATA CCATAATGTT GAGTGCTGTC AAACGGACTT CTGCAATAAG 300

AAATTACCAG CTCCCTCAAC TTCACCATCA CCTAGGCCTC CTACAAACTT AGGGCCTGTG 360

GAGCTGGCAG CTGTTATTGC TGGCCCAGTT TGCCTTGTTT GCATCCTGCT GATGTTGGTC 420

CTTTACATAT GCCATAACCG CACAGTCATT CATCATCGAG TTCCTAATGA TGAAGATCCT 480

TCATTAGATC GGCCTTTTAT ATCTGAGGGC ACAACACTAA AAGATCTCAT TTATGATATG 540

ACAACTTCAG GTTCTGGTTC AGGTCTGCCT TTACTTGTGC AGAGAACAAT TGCAAGAACA 600

ATTGTTTTGC AAGAAAGCAT TGGAAAAGGT CGATTTGGTG AAGTATGGCG TGGAAAGTGG 660

AGGGGAGAGG AAGTGGCAGT GAAAATTTTC TCCTCAAGGG AAGAGCGTTC CTGGTTCCGT 720

GAGGCAGAAA TATATCAGAC AGTTATGTTG CGCCATGAGA ACATACTTGG CTTCATTGCA 780

GCAGACAACA AAGATAATGG CACATGGACT CAGCTATGGT TGGTTTCTGA TTACCATGAA 840

CATGGATCAC TATTTGATTA CCTAAATCGT TATACAGTGA CTGTAGAAGG AATGTTGAAG 900

CTTTCTTTAT CCACTGCTAG TGGTTTAGCT CATCTTCATA TGGAGATAGT TGGAACACAA 960

GGGAAACCAG CTATTGCCCA CCGAGATTTG AAGTCCAAAA ATATACTGGT TAAGAAAAAT 1020

GGAACTTGCT GTATTGCTGA CCTGGGTCTG GCTGTCAGGC ATGATTCTGC TACAGATACA 1080

ATAGATATTG CACCAAATCA CAGAGTTGGG ACAAAAAGAT ATATGGCACC AGAGGTTTTG 1140

GATGACTCTA TTAATATGAA ACATTTTGAA TCGTTTAAGC GTGCTGATAT CTATGCAATG 1200

GGCCTGGTTT TCTGGGAAAT TGCGCGACGA TGTTCTATAG GTGTAGGAAT CCATGAAGAT 1260

TATCAGTTAC CTTATTATGA CCTTGTACCT TCTGACCCAT CTGTTGAAGA AATGAAAAAA 1320

GTGGTTTGTG AACAGAAATT GAGACCAAAC ATTCCAAACA GGTGGCAGAG CTGTGAAGCA 1380

CTTCGCGTGA TGGCCAAAAT AATGCGTGAA TGTTGGTATG CCAATGGAGC AGCACGTCTA 1440

ACTGCTTTAC GGATCAAGAA AACGTTGTCA CAACTAAGCC AACAGGAAGG CCTTAAAATG 1500

TAA 1503

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e igkGr+geVw++k+rgeevAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 201   IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  260

         57899*******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t++ve +l+l ls+asGlahLH+eivgt+

Q: 261   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMLKLSLSTASGLAHLHMEIVGTQ  320

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRDlkskNilvkk++tcciaDlGLa++++++++++d+a n++vGtkRYmaPE

Q: 321   G--KPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPE  378

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl++++n+k+fe+fkraD+Y++gLv+WE+a+Rc+   +++e+y+lp+++ v+sdPs+eem

Q: 379   VLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGVGIHEDYQLPYYDLVPSDPSVEEM  438

         ************************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         k+vv+e+klrP+ip++w+++eal++++k+++ecW+a+++aRltalr+kk+l

Q: 439   KKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL  489

         *************************************************97

Domain Sequence
(FASTA)

IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMLK LSLSTASGLA HLHMEIVGTQ 120

GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT IDIAPNHRVG TKRYMAPEVL 180

DDSINMKHFE SFKRADIYAM GLVFWEIARR CSIGVGIHED YQLPYYDLVP SDPSVEEMKK 240

VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL TALRIKKTL 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013