EKS-XET-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	428.6	8.9E-129	41	302	262

Status

Unreviewed

Ensembl Protein

ENSXETP00000059820

UniProt Accession

Q28FG8;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase-activated protein kinase 2;

Gene Name

mapkapk2

Gene Synonyms/Alias

mapkapk2; TEgg058i15.1-001;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000023673	ENSXETP00000059820	ENSXETT00000065503
ENSXETG00000023673	ENSXETP00000051087	ENSXETT00000051087

Organism

Xenopus tropicalis

Functional Description

Protein Length

374

Protein Sequence
(FASTA)

LDLGSKMMNP GIPFPNLPAL NQTSLKSTLQ IKKNAITDDY KVTNQVLGLG INGKVLEIFS 60

KKSGEKFAMK MLQDCAKARR EVELHWRASQ CSHIVKIIDV YENLYQSRKC LLIIMECLDG 120

GELFSRIQDR GDQAFTEREA SEIMRSIGEA IQYLHSINIA HRDVKPENLL YTSKRPNSVL 180

KLTDFGFAKE TTSHNSLATP CYTPYYVAPE VLGPEKYDKS CDMWSLGVIM YILLCGYPPF 240

YSNHGFAISP GMKKRIRMGQ YEFPNPEWSE VSDEVKQLIR NLLKTEPTQR MTITEFMNHP 300

WITQSMQIPP TPLHTSRVLK EEKDLWEDVK EEMTSALATM RVDYEQIKIK KIEDASNPLL 360

QKRRKKITPH VATH 374

Nucleotide Sequence
(FASTA)

TTGGATTTAG GATCTAAGAT GATGAACCCT GGCATTCCAT TTCCCAACCT TCCAGCCCTA 60

AACCAGACCT CACTTAAGTC TACTCTTCAA ATAAAAAAGA ATGCCATAAC TGATGACTAC 120

AAAGTCACTA ATCAGGTCTT GGGACTGGGG ATCAACGGGA AGGTGCTAGA GATCTTCAGT 180

AAGAAGTCTG GAGAGAAGTT CGCTATGAAG ATGTTACAGG ACTGTGCAAA GGCACGCAGG 240

GAGGTAGAAC TGCACTGGCG GGCTTCCCAG TGTTCTCATA TCGTGAAGAT TATTGATGTG 300

TACGAAAATC TATACCAGTC TAGAAAGTGT CTTCTTATTA TTATGGAATG TCTGGATGGA 360

GGAGAACTCT TCAGCAGAAT CCAGGATAGA GGGGACCAAG CTTTCACGGA GAGGGAGGCA 420

TCTGAGATCA TGAGAAGCAT TGGAGAAGCA ATCCAGTACT TACACTCTAT CAATATTGCC 480

CATAGAGATG TAAAGCCAGA AAATCTCCTA TATACATCGA AACGGCCAAA CTCAGTGTTA 540

AAGCTGACTG ATTTTGGTTT TGCTAAGGAA ACCACATCAC ACAATTCACT AGCAACACCT 600

TGTTACACAC CTTATTATGT TGCTCCTGAA GTTCTCGGGC CAGAAAAATA TGACAAGTCG 660

TGTGATATGT GGTCTCTAGG TGTTATCATG TACATTCTAC TATGTGGCTA TCCACCATTT 720

TACTCCAACC ATGGTTTTGC CATTTCCCCT GGAATGAAAA AACGAATCCG CATGGGCCAG 780

TATGAATTTC CAAACCCAGA GTGGTCTGAA GTTTCAGATG AAGTAAAACA GTTGATCAGA 840

AATCTTTTGA AGACTGAGCC AACTCAGAGG ATGACGATCA CAGAATTTAT GAACCATCCT 900

TGGATAACGC AGTCTATGCA GATTCCACCA ACACCTCTTC ATACTAGCAG GGTCTTGAAA 960

GAAGAGAAGG ATTTGTGGGA AGATGTTAAG GAAGAGATGA CAAGTGCCCT TGCCACCATG 1020

AGAGTTGACT ATGAGCAGAT AAAGATAAAG AAGATTGAAG ATGCCTCTAA TCCTCTCCTC 1080

CAGAAGAGAC GAAAGAAAAT TACTCCCCAT GTAGCAACTC ACTGA 1125

Domain Profile

S: 1     klteevlGeGisgkvlecvkkktgekyalkilkdrkkvrrevelhvqasghknivelidv  60

         k+t++vlG Gi+gkvle+++kk+gek+a+k+l+d++k+rrevelh++as++++iv++idv

Q: 41    KVTNQVLGLGINGKVLEIFSKKSGEKFAMKMLQDCAKARREVELHWRASQCSHIVKIIDV  100

         5799********************************************************

S: 61    fensfedekrlllvlekleGGellsriqer..kaftekeasevvkdiasalkflhsknia  118

         +en ++ +k+ll+++e+l+GGel+sriq+r  +afte+ease++++i++a+++lhs nia

Q: 101   YENLYQSRKCLLIIMECLDGGELFSRIQDRgdQAFTEREASEIMRSIGEAIQYLHSINIA  160

         *******************************9****************************

S: 119   hrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevleaekeeal  178

         hrD+kpenlLy+sk+ n+++kl+Dfg+aket+++++l+tpc+t++yvaPevl++ek

Q: 161   HRDVKPENLLYTSKRPNSVLKLTDFGFAKETTSHNSLATPCYTPYYVAPEVLGPEK----  216

         ********************************************************....

S: 179   lydksCDlWslGvilyillcGypPfyskkgraiskklkeriqegkyefPeeeWsevseea  238

          ydksCD+WslGvi+yillcGypPfys++g ais+++k+ri++g+yefP++eWsevs+e+

Q: 217   -YDKSCDMWSLGVIMYILLCGYPPFYSNHGFAISPGMKKRIRMGQYEFPNPEWSEVSDEV  275

         .***********************************************************

S: 239   kdlirklLkrdpkerltieevlnhpwv  265

         k+lir+lLk++p++r+ti+e++nhpw+

Q: 276   KQLIRNLLKTEPTQRMTITEFMNHPWI  302

         **************************8

Domain Sequence
(FASTA)

KVTNQVLGLG INGKVLEIFS KKSGEKFAMK MLQDCAKARR EVELHWRASQ CSHIVKIIDV 60

YENLYQSRKC LLIIMECLDG GELFSRIQDR GDQAFTEREA SEIMRSIGEA IQYLHSINIA 120

HRDVKPENLL YTSKRPNSVL KLTDFGFAKE TTSHNSLATP CYTPYYVAPE VLGPEKYDKS 180

CDMWSLGVIM YILLCGYPPF YSNHGFAISP GMKKRIRMGQ YEFPNPEWSE VSDEVKQLIR 240

NLLKTEPTQR MTITEFMNHP WI 262

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

xtr:550101

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013