EKS-XET-00341

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00341

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	461.2	2.1E-138	192	505	314

Status

Unreviewed

Ensembl Protein

ENSXETP00000044526

UniProt Accession

F7CZ52;

Protein Name

Protein Synonyms/Alias

Gene Name

dyrk3

Gene Synonyms/Alias

dyrk3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000023677	ENSXETP00000044526	ENSXETT00000044526
ENSXETG00000023677	ENSXETP00000051090	ENSXETT00000051090

Organism

Xenopus tropicalis

Functional Description

Protein Length

570

Protein Sequence
(FASTA)

MLLTRKPEGP IAAVRYGDGL YDSYMRLDQM AAQDAAEDKE SPSTLPSFGR LTGCTISGNK 60

LAMKDQQQVK VQQLFEDSGN RRVGAGVTST ESAFPLLTKE KSSDSSGTSK SSDSSAKSSK 120

ATYLTPDQAV KQYKHQLSAY ELQEISSFSE IYFVGPNAKK RQGVVGGPNN GGYDDDQGGY 180

NLVPHDHVAY RYEVLKVIGK GSFGQVAKVY DHKLHQHLAL KMVRNEKRFH RQAAEEIRIL 240

EHLKKQDKTG SMNVIHMLES FTFRNHICMT FELLSMNLYE LIKRNKFQGF SLQLVRKFAH 300

SILQCLEALY RNKIIHCDLK PENILLKQQG RSGIKVIDFG SSCFDHQRVY TYIQSRFYRA 360

PEVILGSRYG MPIDMWSFGC ILVELLTGYP LFPGEDEGDQ LACMMELLGA PPPKLLEQAK 420

RAKNFINSKG YPRYCTVTTL PNGTTVLNGS RSRRGKMRGA PGSKDWVAAL KGCEDSLFID 480

FLKGCLTWDP VARMTPSQAL RHQWISKRLP KPSVTEKASG KRISSQTSSF PGIGSKLPPV 540

VGVANKLRAN LMNDSNGSIP LRTVLPKLVS 570

Nucleotide Sequence
(FASTA)

ATGCTCCTGA CAAGGAAGCC TGAGGGCCCC ATAGCAGCAG TGCGATATGG TGATGGCTTG 60

TATGATTCAT ATATGAGGCT TGATCAGATG GCAGCACAAG ATGCGGCAGA GGATAAAGAA 120

AGCCCCTCCA CTCTACCTTC ATTTGGGAGA CTAACTGGAT GCACAATAAG TGGAAATAAA 180

CTTGCAATGA AGGATCAACA ACAAGTTAAA GTGCAACAGT TATTTGAAGA CTCCGGTAAC 240

CGAAGGGTTG GTGCAGGTGT TACAAGTACT GAAAGTGCAT TTCCCTTGCT GACAAAAGAA 300

AAAAGTTCAG ACAGCTCAGG AACTTCAAAA TCTAGTGATA GCTCTGCCAA GTCATCAAAG 360

GCCACATACC TGACTCCTGA CCAAGCAGTG AAGCAATACA AGCACCAGCT CTCTGCTTAT 420

GAGCTACAAG AAATTAGTAG TTTTTCTGAG ATATATTTTG TGGGTCCAAA TGCAAAGAAG 480

AGGCAAGGAG TTGTAGGGGG TCCTAATAAT GGAGGCTATG ATGATGATCA AGGAGGCTAC 540

AATTTAGTGC CACATGACCA CGTGGCATAC CGATATGAAG TTCTTAAGGT TATTGGGAAA 600

GGCAGTTTTG GTCAGGTTGC AAAAGTTTAT GACCACAAGC TTCACCAGCA TTTGGCACTA 660

AAGATGGTCC GCAATGAAAA GAGATTTCAC CGGCAGGCTG CAGAAGAGAT CCGCATCCTG 720

GAACACCTCA AGAAACAGGA CAAGACTGGT AGTATGAATG TGATACACAT GCTGGAGAGT 780

TTCACTTTCC GAAACCACAT TTGTATGACA TTTGAGCTTC TCAGCATGAA TTTATATGAG 840

CTAATTAAAC GAAATAAGTT TCAAGGTTTT AGTCTGCAAC TTGTTCGCAA ATTTGCCCAT 900

TCAATCCTTC AGTGCTTGGA AGCTTTATAC AGGAATAAGA TCATCCACTG TGACTTGAAA 960

CCTGAAAATA TTCTCCTCAA ACAGCAAGGG CGTAGTGGTA TTAAAGTGAT AGATTTTGGG 1020

TCCAGTTGCT TCGATCACCA AAGAGTCTAC ACATACATAC AGTCCCGTTT CTACAGAGCA 1080

CCCGAGGTCA TTCTGGGAAG CCGTTATGGT ATGCCCATTG ATATGTGGAG TTTTGGCTGC 1140

ATATTGGTTG AGCTCCTAAC AGGTTATCCA TTGTTCCCAG GTGAGGATGA GGGAGACCAA 1200

CTAGCATGTA TGATGGAGCT TCTTGGTGCA CCACCTCCAA AGCTTCTAGA ACAAGCCAAA 1260

AGAGCAAAGA ACTTTATTAA CTCCAAGGGA TACCCACGAT ACTGTACTGT CACCACTCTT 1320

CCTAATGGGA CAACAGTTCT CAATGGCAGC AGGTCGCGCA GAGGTAAAAT GCGTGGTGCA 1380

CCTGGCAGCA AAGACTGGGT GGCAGCTTTG AAGGGTTGTG AAGACTCCCT TTTCATTGAT 1440

TTTTTAAAGG GTTGTCTCAC CTGGGACCCA GTTGCACGTA TGACCCCTAG CCAGGCCCTG 1500

CGGCATCAGT GGATTTCCAA GAGACTGCCT AAGCCTTCAG TAACCGAGAA GGCTTCAGGT 1560

AAAAGAATTT CCAGCCAAAC CAGCTCTTTT CCAGGCATTG GCTCCAAACT GCCTCCAGTC 1620

GTAGGTGTGG CTAACAAATT ACGGGCCAAT TTAATGAATG ACTCCAATGG AAGCATACCA 1680

CTTCGAACTG TTTTACCTAA GCTAGTCAGC TGA 1713

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl+vigkGsfgqV+k++d+k ++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+ +

Q: 192   YEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS  251

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c++fells+nLyel+k+nkf+g+sl+lvrk+a++il++L++L++

Q: 252   MNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYR  311

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs +kviDFGss++ +q+ +ytyiqsrfYraPE+ilg +y

Q: 312   NKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQR-VYTYIQSRFYRAPEVILGSRYG  370

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWS+Gc+l+El+tG+pLfpGe+e dqla+++e+lg pp+klle+ak+ak+f+++k+

Q: 371   MPIDMWSFGCILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKG  430

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++t+  + +++l+ ++++++k r ap+sk+++ alk +ed+lf+d+lk +l++dp

Q: 431   YPRYCTVTTLPNGTTVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDP  490

         ************************************************************

S: 301   akRitpkealkhpfv  315

          +R+tp++al+h+++

Q: 491   VARMTPSQALRHQWI  505

         **************7

Domain Sequence
(FASTA)

YEVLKVIGKG SFGQVAKVYD HKLHQHLALK MVRNEKRFHR QAAEEIRILE HLKKQDKTGS 60

MNVIHMLESF TFRNHICMTF ELLSMNLYEL IKRNKFQGFS LQLVRKFAHS ILQCLEALYR 120

NKIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFDHQRVYT YIQSRFYRAP EVILGSRYGM 180

PIDMWSFGCI LVELLTGYPL FPGEDEGDQL ACMMELLGAP PPKLLEQAKR AKNFINSKGY 240

PRYCTVTTLP NGTTVLNGSR SRRGKMRGAP GSKDWVAALK GCEDSLFIDF LKGCLTWDPV 300

ARMTPSQALR HQWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013