EKS-XET-00059

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00059

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	374.2	4.3E-112	710	1003	294

Status

Unreviewed

Ensembl Protein

ENSXETP00000051128

UniProt Accession

F6ZH01;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 12;

Gene Name

cdk12

Gene Synonyms/Alias

cdk12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000023695	ENSXETP00000051128	ENSXETT00000051128
ENSXETG00000023695	ENSXETP00000043552	ENSXETT00000043552

Organism

Xenopus tropicalis

Functional Description

Protein Length

1234

Protein Sequence
(FASTA)

MPNPVRHGNK KDSGGSASTM PESSGSVNNK DRQRISSKHK RHKSKHLRES SVPEPQTLST 60

LKLVEYDDIS SDSDTFSDVP AKQERRENDE RRPSEKSDKM HKSRHRHQHK RLKEATRTKQ 120

VEKERKPEKT QEVMVNKVPS SKDKIISSAK RTADEQEEHG RTSKSSSKDS RSKMHKDKSR 180

REREMKSGHK ERSKSHRKRD SSKRYKTSDS PKRKGRSPRR KYGGSPKQDD SHSEGSCGQD 240

YDDSPSRVHA SGNFNETYRK NMDSPSYKEP AAYQSSARSP SPYSRKQRSV SPYRRRSSSY 300

ERGSGSYSGR SPSPYVRRRS SSPFVSRRSL SRSPAPRKSA KSRSRSPLYP RKSSSSSRSK 360

KQKSQSRSRH SSISPARLPL NSSLGAELSR KKKEIAAAAA AAGRESKGSP LILKKESGDS 420

RVASALDLKK ATKVLKLEKP VSEPEMVTAT SSETKTISAK KEESEKKPQV QAKDPKISGL 480

KDCKPAAIKE EVLTPKEGVT DRDKDVPPLP PILSPPPPLP TSPPSNIPPL PPLPPSPAVL 540

QQPPPPLPPP PTLTFLPLPT TVAASLTSSH YVRQSSLSTQ ANSQLPVPSP AKPQPPLIHM 600

VPHMKTSTLP PLPLPPLLLG EDDIESPKEI PPPKSVKKEK DKDRPRHLLT DLPLPPELPG 660

GDPSPPDSPE RKVVAPPQPP LKKRPKICCP RYGERKQTET DWGKRCVDKF DIIGIIGEGT 720

YGQVYKAKDK DTGELVALKK VRLDNEKEGF PITAIREIKI LRQLIHKSVV NMKEIVTDKQ 780

DALDFKKDKG AFYLVFEYMD HDLMGLLESG LVQFSEDHIK SFMKQLMEGL EYCHKKNFLH 840

RDIKCSNILL NNSGQIKLAD FGLARLYSSE ESRPYTNKVI TLWYRPPELL LGEERYTPAI 900

DVWSCGCILG ELFTKKPIFQ ANQELAQLEL ISRLCGSPCP AVWPDVIKLP YFNTMKPKKQ 960

YRRRLREEFS FVPTPALDLL DHMLTLDPSK RCTAEQTLQS DFLKDVDVCK MATPELGTVM 1020

VELSSGKEVR GKNVYMETSN AISPLASRLE GVNATYVIPA ANDPLMPWKS SSSLAFCSVL 1080

GDITQQLNQS ELAVLLNLLQ SQTDLSVSQI SQLLNVQANP DMQLQLEALN QSITALTGAA 1140

VPPQEVEPPK ETPTLDQVDP LGAGTQGEVQ NVLAVLLSQL LKPQEVVDAP GESNGEQSGS 1200

NPTAHITLEE EEEPDKHHEQ NEEEEEDAGN YWSP 1234

Nucleotide Sequence
(FASTA)

ATGCCAAACC CAGTGCGGCA TGGGAACAAG AAGGACAGCG GTGGGTCAGC TTCTACCATG 60

CCGGAGAGCA GTGGAAGTGT CAACAATAAA GACCGTCAAC GGATCAGCTC GAAACACAAA 120

AGGCATAAGT CGAAACACCT CAGAGAATCT TCTGTCCCGG AGCCTCAGAC CTTGAGCACC 180

TTGAAGCTGG TGGAATATGA CGACATCAGC TCCGACTCTG ACACTTTCTC CGATGTCCCA 240

GCCAAGCAAG AGAGGAGGGA AAATGACGAG CGGCGCCCTT CTGAGAAAAG TGATAAAATG 300

CACAAATCTC GCCATCGCCA CCAACACAAA CGGCTCAAAG AAGCTACCAG GACCAAGCAA 360

GTAGAGAAGG AGAGGAAGCC GGAAAAAACT CAAGAGGTAA TGGTTAACAA GGTGCCCAGT 420

AGTAAAGACA AGATCATTAG CTCAGCTAAA AGGACTGCAG ATGAGCAAGA GGAGCACGGG 480

CGAACGTCTA AGAGCAGTAG TAAAGACTCA CGGTCTAAGA TGCACAAGGA CAAATCGAGA 540

AGGGAAAGGG AGATGAAATC CGGACATAAG GAGAGGAGCA AAAGTCACAG GAAAAGGGAT 600

TCTTCCAAAC GCTATAAAAC CTCGGATAGC CCTAAGCGGA AAGGTCGGAG CCCTCGCAGG 660

AAGTATGGCG GCAGCCCGAA ACAGGACGAC AGCCACTCTG AGGGATCTTG TGGCCAAGAC 720

TATGATGACA GCCCTTCACG CGTGCACGCT TCTGGTAACT TCAATGAGAC TTATAGGAAA 780

AACATGGACA GTCCCAGTTA CAAGGAGCCC GCGGCTTACC AAAGCAGCGC GCGCTCTCCA 840

AGTCCTTACA GCCGAAAGCA GCGTTCTGTT AGCCCCTACA GAAGGAGGTC ATCTAGTTAT 900

GAAAGAGGTA GTGGATCTTA CAGTGGGAGG TCTCCAAGCC CTTATGTGCG AAGGAGGTCC 960

AGCAGTCCGT TTGTGTCTAG GCGCTCACTG AGTCGGAGCC CGGCGCCCAG GAAGTCTGCC 1020

AAGTCTAGAA GCAGGAGTCC CTTGTATCCC AGAAAGTCAT CTTCATCATC TCGCAGTAAG 1080

AAGCAAAAAT CCCAGTCAAG AAGTCGCCAT TCCAGTATTT CGCCTGCCAG GCTACCGTTA 1140

AACTCCAGCC TTGGAGCCGA GCTCAGTCGC AAGAAGAAGG AGATAGCAGC TGCAGCGGCG 1200

GCAGCTGGTA GAGAATCAAA GGGCAGCCCT TTGATTTTGA AAAAAGAGAG TGGAGATTCT 1260

AGAGTTGCCT CTGCATTGGA CCTCAAAAAG GCAACCAAAG TTCTCAAGTT GGAAAAACCT 1320

GTTTCTGAGC CGGAAATGGT GACTGCAACC AGTTCAGAAA CCAAGACTAT TTCTGCCAAA 1380

AAAGAGGAGA GTGAAAAGAA GCCCCAGGTA CAGGCTAAAG ATCCTAAAAT TTCAGGATTA 1440

AAGGACTGCA AACCAGCAGC AATCAAGGAG GAAGTATTGA CGCCGAAAGA AGGAGTGACA 1500

GACAGAGATA AAGATGTACC TCCTCTTCCT CCTATACTGT CACCTCCTCC ACCTTTACCA 1560

ACATCCCCTC CTTCAAATAT TCCCCCACTG CCTCCTCTTC CGCCATCCCC AGCTGTCCTG 1620

CAACAGCCGC CTCCACCCCT ACCACCTCCA CCTACACTAA CATTCCTGCC CCTTCCTACT 1680

ACAGTGGCTG CCTCTTTGAC ATCCTCTCAT TATGTACGGC AGTCATCTTT GTCCACTCAG 1740

GCAAATTCCC AGCTCCCAGT TCCTTCACCT GCCAAGCCAC AACCACCTCT AATTCATATG 1800

GTCCCTCACA TGAAGACATC AACGCTGCCT CCGTTGCCGC TTCCACCGCT GCTGCTAGGA 1860

GAGGATGACA TTGAAAGCCC TAAGGAGATC CCTCCTCCCA AAAGTGTTAA GAAGGAAAAA 1920

GATAAGGATA GACCACGACA TCTCTTAACT GACCTTCCTC TGCCTCCTGA GCTTCCAGGA 1980

GGTGATCCAT CACCTCCAGA TTCACCAGAA AGGAAAGTGG TCGCACCTCC TCAACCGCCT 2040

TTAAAGAAGA GACCAAAAAT CTGTTGCCCC CGTTACGGCG AGAGAAAGCA GACAGAAACT 2100

GACTGGGGAA AGAGATGTGT GGACAAGTTT GACATTATCG GGATAATTGG AGAAGGAACC 2160

TATGGGCAGG TTTACAAAGC CAAGGACAAG GATACAGGAG AACTTGTGGC CTTAAAGAAA 2220

GTTCGTCTAG ATAATGAAAA AGAAGGCTTC CCCATAACTG CCATCCGGGA AATAAAAATC 2280

CTGCGGCAGC TCATTCACAA GAGTGTGGTC AACATGAAGG AGATTGTAAC GGATAAACAG 2340

GATGCATTGG ACTTCAAGAA AGACAAAGGT GCCTTTTATT TGGTGTTTGA ATATATGGAC 2400

CATGACCTGA TGGGACTGCT GGAGTCAGGA CTGGTGCAGT TTTCAGAAGA CCACATCAAA 2460

TCTTTTATGA AACAGCTGAT GGAAGGGCTG GAATATTGCC ACAAAAAGAA CTTCCTTCAC 2520

AGAGATATCA AATGCTCTAA CATTTTGTTA AACAATAGTG GTCAGATCAA GCTAGCTGAT 2580

TTTGGATTGG CACGCCTTTA TAGCTCAGAG GAGAGCCGTC CATACACCAA TAAAGTGATT 2640

ACACTGTGGT ACAGACCTCC AGAGCTGCTT TTAGGAGAAG AGCGCTACAC TCCTGCTATA 2700

GATGTGTGGA GCTGTGGGTG CATCCTCGGG GAACTTTTTA CTAAAAAGCC CATCTTCCAA 2760

GCCAATCAGG AGTTGGCTCA GCTGGAACTG ATTAGCCGAC TGTGTGGCAG CCCCTGTCCA 2820

GCCGTTTGGC CGGATGTTAT CAAACTACCA TACTTCAATA CTATGAAACC GAAGAAGCAG 2880

TACAGACGGA GGTTACGGGA AGAGTTTTCC TTTGTTCCTA CACCTGCTTT GGATCTGTTG 2940

GACCATATGC TTACACTGGA CCCCAGCAAA CGTTGCACTG CTGAGCAGAC TCTACAGAGT 3000

GATTTCTTGA AGGATGTAGA TGTCTGCAAG ATGGCTACTC CAGAATTGGG TACTGTAATG 3060

GTTGAACTGA GCTCAGGAAA GGAAGTTAGG GGAAAAAATG TTTATATGGA AACCAGCAAT 3120

GCCATCTCTC CATTGGCTTC TAGACTGGAG GGTGTCAATG CTACGTACGT AATTCCAGCA 3180

GCTAATGACC CGTTAATGCC GTGGAAAAGT TCCAGCTCTC TTGCTTTTTG CTCGGTTTTA 3240

GGGGATATCA CCCAGCAGCT GAATCAGAGT GAGCTGGCCG TCCTGCTGAA TCTTCTTCAG 3300

AGCCAGACAG ACCTCAGTGT TTCCCAGATA TCTCAACTGT TAAATGTCCA GGCCAATCCA 3360

GACATGCAGC TGCAGCTGGA GGCCCTCAAC CAGTCTATCA CAGCCTTGAC TGGTGCTGCC 3420

GTTCCTCCCC AAGAGGTGGA GCCACCCAAA GAGACCCCTA CCCTGGACCA AGTGGACCCT 3480

CTGGGGGCAG GAACTCAGGG AGAGGTGCAG AATGTTCTAG CCGTCCTACT GAGCCAACTC 3540

CTCAAGCCCC AGGAAGTCGT GGATGCACCT GGAGAAAGCA ATGGAGAGCA GAGTGGAAGC 3600

AACCCCACAG CACACATCAC TCTTGAGGAG GAGGAGGAAC CAGATAAACA CCACGAGCAA 3660

AACGAAGAGG AGGAGGAAGA CGCAGGTAAT TACTGGTCAC CCTGA 3705

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l hk +

Q: 710   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSV  769

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e

Q: 770   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-QFSEDHIKSFMKQLME  828

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe

Q: 829   GLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  888

         ***************************************7665527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++l+g+p  +vwp+v k

Q: 889   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIK  948

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         lp +++  pkk+++ +l+e+++ + + aldll+++l+ldp+kR++a+++lq++++

Q: 949   LPYFNTMKPKKQYRrRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFL  1003

         *****7777777777******999999************************9985

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHKSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVQFSEDHI KSFMKQLMEG 120

LEYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRLCGSPC PAVWPDVIKL 240

PYFNTMKPKK QYRRRLREEF SFVPTPALDL LDHMLTLDPS KRCTAEQTLQ SDFL 294

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013