EKS-XET-00496

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00496

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	293.1	1.9E-87	463	719	257

Status

Unreviewed

Ensembl Protein

ENSXETP00000051997

UniProt Accession

F7EQZ5;

Protein Name

Protein Synonyms/Alias

Gene Name

tnni3k

Gene Synonyms/Alias

tnni3k;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000024099	ENSXETP00000051997	ENSXETT00000051997

Organism

Xenopus tropicalis

Functional Description

Protein Length

835

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYAIIVER LEDDLQIKDV EQSELNVVFS SDEAFNKVNL 60

NYRTENGLSL LHLCCICGGN KSHIRTLMLK GLRPSRLTKN GFTALHMAAY KDNAELLTAL 120

LHGGADIQQV GYGALTALHI ATIAGNHEAV DILLQHGAFV NVQDAVFFTP LHIAAYYGHE 180

QVTHLLLKFG ADVNMSGEVG DRPLHLASAK GYLNITKLLL EEGTKADVNA QDNEDHVPLH 240

FCSRFGHHEI VKYLLQSNSD VQPHVVNIYG DTPLHLACYN GKAEVVKELI QLSGTESLTK 300

ENIFSETAFH SACTYGKNME LVKFLLDQNV LNINHQGRDG HTGLHCACYH GHIRLVQFLL 360

DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL LKHYKRPQDE SPCNEYSQPG 420

GDGSYVSVPS PLGKIKSMTK EKADVLLLRA SLPSHFHLQM SEIEFHEIIG SGSFGKVYKG 480

RCRNKIVAIK RYRANTYCSK SDVDMFCREV SILCRLNHPC VIQFVGACLD DPSQFAIVTQ 540

YISGGSLFSL LHEQKRNLDL QSKLIIAVDV AKGMEYLHNL TYPIIHRDLN SHNILLYEDG 600

HAVVADFGES RFLLSLDEDN MTKQPGNLRW MAPEVFSQCT RYTIKADVFS YALCLWELLT 660

GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLMR GWNACPEGRP EFSEVVSKLE 720

ECLSNIELMS PASSNSSGSL SPSASSDCLL GRGSPGRSHV AALRTRFELE YALNSRAYSF 780

WSQRLDSESA RGLAFEEIRK SFQYPPIDKN GYVSDPMSTM RFHSCCRSSS FEDSN 835

Nucleotide Sequence
(FASTA)

ATGGGAAATT ACAAATCCAG ACCAACGCAA ACTTGTACTG ATGAGTGGAA GAAAAAAGTA 60

AGTGAATCAT ATGCAATTAT TGTTGAGAGA TTGGAGGATG ACCTTCAGAT TAAAGACGTG 120

GAGCAGAGTG AGCTTAATGT TGTTTTCAGC TCAGATGAAG CTTTTAACAA AGTCAATTTG 180

AACTATCGGA CAGAAAATGG CCTATCTTTG CTTCATTTGT GTTGCATCTG TGGTGGTAAC 240

AAGTCACACA TAAGAACTCT CATGCTAAAA GGATTACGAC CATCCAGGCT AACAAAAAAT 300

GGATTTACTG CTCTCCACAT GGCAGCCTAT AAGGATAATG CGGAACTACT GACTGCTCTC 360

TTGCATGGAG GAGCTGATAT TCAGCAGGTT GGTTACGGTG CTCTTACTGC CCTTCATATA 420

GCCACCATTG CAGGAAACCA TGAGGCTGTG GATATTCTGT TGCAGCATGG AGCATTTGTC 480

AATGTCCAAG ATGCTGTGTT CTTCACTCCA CTTCACATTG CAGCTTACTA TGGGCATGAA 540

CAGGTGACAC ATCTTCTACT GAAATTTGGT GCAGATGTTA ATATGAGTGG AGAGGTTGGT 600

GACAGGCCCC TGCATCTGGC CTCTGCAAAA GGGTATCTGA ATATTACAAA ATTATTGTTG 660

GAAGAGGGAA CTAAAGCAGA TGTAAATGCT CAGGATAATG AAGACCATGT TCCACTTCAT 720

TTCTGCTCAC GATTTGGACA CCATGAAATA GTGAAGTATC TCCTGCAAAG CAATTCTGAT 780

GTGCAGCCAC ATGTTGTAAA CATTTATGGG GATACTCCTT TACATCTTGC TTGTTACAAT 840

GGAAAAGCTG AAGTTGTGAA AGAACTCATC CAATTATCAG GCACTGAAAG TCTAACTAAG 900

GAAAATATTT TCAGCGAAAC CGCATTTCAC AGTGCATGCA CTTATGGAAA AAATATGGAG 960

CTTGTAAAAT TTCTTCTTGA TCAAAATGTT TTAAACATAA ATCACCAAGG ACGAGATGGT 1020

CATACAGGAT TGCACTGTGC CTGCTATCAT GGACACATAC GCCTAGTTCA GTTTTTATTG 1080

GACAATGGAG CTGACATGAA TCTAGTTGCC TGTGATCCCA GTAGATCTAG TGGTGAAAAA 1140

GATGAACAGA CATGCCTGAT GTGGGCTTAT GAAAAAGGTC ATGATGCAAT TGTTACACTG 1200

CTGAAACATT ATAAGCGGCC CCAGGATGAA TCTCCATGCA ATGAGTACTC TCAGCCTGGT 1260

GGAGATGGCT CATATGTATC AGTTCCATCA CCTCTTGGGA AAATAAAAAG CATGACTAAA 1320

GAAAAGGCAG ATGTGCTCCT GTTACGTGCT AGCTTGCCTT CTCACTTTCA TCTTCAGATG 1380

TCCGAAATTG AATTTCATGA AATAATAGGT TCAGGTTCGT TTGGAAAAGT GTATAAAGGA 1440

AGATGTAGAA ATAAAATAGT TGCAATCAAA AGATACAGAG CAAACACCTA TTGTTCAAAG 1500

TCTGATGTGG ACATGTTTTG TCGTGAAGTT TCCATTCTTT GTCGACTCAA CCACCCCTGT 1560

GTGATTCAGT TTGTGGGTGC TTGCCTTGAT GATCCAAGTC AGTTTGCCAT TGTGACTCAA 1620

TATATCTCTG GAGGTTCACT CTTCTCTTTG CTGCATGAAC AAAAAAGAAA CCTCGACCTG 1680

CAGTCAAAAT TAATAATTGC AGTTGATGTT GCCAAAGGAA TGGAATACTT ACATAACCTA 1740

ACCTACCCTA TTATACATCG TGACTTGAAT AGTCACAACA TATTACTGTA TGAAGATGGC 1800

CATGCAGTTG TTGCAGATTT TGGAGAATCG AGATTTCTCC TGTCACTGGA TGAGGACAAC 1860

ATGACTAAAC AGCCTGGGAA TCTACGCTGG ATGGCTCCAG AAGTATTCAG TCAGTGCACT 1920

CGATATACCA TTAAAGCGGA TGTCTTTAGT TATGCTTTGT GTCTTTGGGA ACTGTTAACA 1980

GGAGAAATCC CATTTGCTCA CTTAAAGCCA GCGGCAGCGG CAGCTGACAT GGCTTATCAC 2040

CATATAAGAC CGCCAATCGG ATACTCCATT CCAAAGCCCA TATCTTCGTT ATTAATGAGA 2100

GGATGGAATG CCTGCCCTGA AGGACGGCCT GAATTTTCTG AGGTTGTGTC AAAGCTAGAA 2160

GAGTGTCTCA GCAACATAGA GCTGATGTCG CCAGCATCTA GTAACAGCAG TGGTTCTCTG 2220

TCCCCATCTG CCTCTTCAGA TTGCCTATTA GGCCGTGGCA GTCCTGGTCG AAGCCATGTT 2280

GCTGCACTTC GTACTCGCTT TGAATTAGAG TATGCTTTAA ATTCAAGAGC ATACTCATTC 2340

TGGTCTCAAA GACTAGACTC TGAGTCTGCA CGTGGCTTGG CCTTTGAAGA AATAAGGAAA 2400

AGTTTCCAGT ACCCACCAAT AGACAAAAAT GGGTACGTGT CTGATCCCAT GAGCACAATG 2460

CGTTTCCATT CCTGCTGTCG GAGCAGCAGC TTTGAAGATA GTAACTGA 2508

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 463   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCRLNHPCVI  522

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr++dl+  + +a+++A+Gm+YLh+ +

Q: 523   QFVGACLDDPSqFAIVTQYISGGSLFSLLHE-QKRNLDLQSKLIIAVDVAKGMEYLHNLT  581

         ***********99******************.9**************************5

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

           +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l +  +++m+++ g+l+wmaPEv+ ++

Q: 582   -YPIIHRDLNSHNILL-YEDGHAVVADFGESRFLLSldEDNMTKQpGNLRWMAPEVFsQC  639

         .59*************.9***************9988877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a++++r+pi+ s+p+++++L+

Q: 640   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLM  699

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 700   RGWNACPEGRPEFSEVVSKL  719

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCRLNHPCVI 60

QFVGACLDDP SQFAIVTQYI SGGSLFSLLH EQKRNLDLQS KLIIAVDVAK GMEYLHNLTY 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LLSLDEDNMT KQPGNLRWMA PEVFSQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PISSLLMRGW 240

NACPEGRPEF SEVVSKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013