| Tag | Content |
|---|
| EKPD ID | EKS-XET-00058 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 374.5 | 3.4E-112 | 19 | 319 | 301 |
|
| Status | Reviewed |
| Ensembl Protein | ENSXETP00000031527 |
| UniProt Accession | Q6GLD8; Q28F30; |
| Protein Name | Cyclin-dependent kinase 9 |
| Protein Synonyms/Alias | Cell division protein kinase 9; |
| Gene Name | cdk9 |
| Gene Synonyms/Alias | cdk9; TGas123e01.1; |
| Ensembl Information | |
| Organism | Xenopus tropicalis |
| Functional Description | Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H (By similarity). |
| Protein Length | 376 |
Protein Sequence
(FASTA) | | MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 60 | | ITALREIKIL QLLKHENVVN LIEICRTKIS PTANQYNRCK GTIFLVFDFC EHDLAGLLSN 120 | | AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL 180 | | AKNSQPNKYT NRVVTLWYRP PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH 240 | | QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDL YALDLIDKLL 300 | | VLDPAQRIDS DDALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG GHMPQQPANQ 360 | | ARNPAATNQS EFDRVF 376 |
|
Nucleotide Sequence
(FASTA) | | ATGGCCAAGA ACTACGACTC GGTGGAATTC CCTTACTGTG ATGAGGTCTC CAAGTACGAG 60 | | CGGCTCGCCA AGATCGGCCA GGGCACCTTC GGGGAAGTGT TCAAGGCCAA ACATCGACAG 120 | | ACGGGGAAGA AAGTGGCACT TAAAAAAGTT CTGATGGAAA ACGAGAAGGA AGGGTTTCCT 180 | | ATCACGGCTC TGCGAGAGAT AAAAATCCTG CAGCTGCTGA AACACGAGAA CGTAGTTAAC 240 | | CTCATAGAGA TCTGTCGGAC AAAAATTTCT CCCACAGCCA ACCAGTACAA TAGATGCAAA 300 | | GGAACTATTT TCCTGGTGTT CGACTTTTGT GAGCATGATC TAGCAGGCTT GCTGAGCAAT 360 | | GCTCATGTCA AGTTCACGCT CTCCGAGATC AAGAAGGTAA TGCAAATGCT GCTCAACGGC 420 | | CTCTACTACA TTCACCGGAA CAAGATCCTG CACAGAGACA TGAAGGCAGC AAACGTACTG 480 | | ATCACCAGGG ACGGAGTGTT GAAACTTGCA GACTTTGGGC TTGCCAGAGC ATTCAGCCTT 540 | | GCCAAGAACA GCCAGCCAAA CAAGTACACC AATCGCGTGG TTACGCTCTG GTATCGGCCC 600 | | CCTGAGCTAC TCCTAGGAGA GCGTGATTAT GGTCCTCCCA TTGATTTGTG GGGAGCAGGG 660 | | TGCATCATGG CTGAGATGTG GACCAGAAGC CCCATTATGC AGGGGAATAC GGAGCAGCAT 720 | | CAGCTAACAC TCATCAGCCA ATTATGCGGT TCCATCACAC CAGAGGTCTG GCCAAATGTG 780 | | GACAAATATG AGTTGTACCA GAAGCTGGAA CTGCCCAAAG GCCAGAAAAG AAAGGTGAAG 840 | | GAAAGGTTAA AGGCTTATGT GAAAGATCTC TATGCACTGG ACCTTATAGA CAAGCTGTTG 900 | | GTTTTGGACC CGGCTCAGAG AATCGACAGT GATGACGCCC TGAATCATGA TTTCTTCTGG 960 | | TCTGACCCGA TGCCTTCTGA TCTGAAGAAC ATGCTCTCTA CTCACAATCA GTCCATGTTT 1020 | | GAATACTTGG CACCTCCTAG GAGAAGAGGC GGGCACATGC CCCAACAGCC AGCCAATCAG 1080 | | GCACGGAATC CTGCTGCCAC AAACCAATCA GAATTTGACA GAGTCTTTTA A 1131 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni 60 | ye+l+kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+ | Q: 19 YERLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 | 899********************************************************* |
| S: 61 vkLlevva...........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllql 109 | v+L+e++ + k +++Lvf+f+e+dL+ ll++ + k++l+e+k+++++l | Q: 79 VNLIEICRtkisptanqynRCKGTIFLVFDFCEHDLAGLLSNAHV-KFTLSEIKKVMQML 137 | ***************99988889********************99.************** |
| S: 110 leglaylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlw 165 | l+gl y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf +s+ ++yt++vvTlw | Q: 138 LNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNKYTNRVVTLW 197 | *****************************************7776566668********* |
| S: 166 YraPelLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvw 225 | Yr+PelLlg+++Y+ +D+W++gci+ae++tr+p++qg++e++ql+ i++l+g+++ +vw | Q: 198 YRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVW 257 | ************************************************************ |
| S: 226 pevsklpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhk 282 | p+v k++ y+ ++pk +k+k+ke++k++ ++ aldl++kll ldp++Ri++++al+h+ | Q: 258 PNVDKYELYQkLELPKGQKRKVKERLKAYVKDlyALDLIDKLLVLDPAQRIDSDDALNHD 317 | **********8899999999******998877679************************* |
| S: 283 yf 284 | +f | Q: 318 FF 319 | 98 |
|
Domain Sequence
(FASTA) | | YERLAKIGQG TFGEVFKAKH RQTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60 | | VNLIEICRTK ISPTANQYNR CKGTIFLVFD FCEHDLAGLL SNAHVKFTLS EIKKVMQMLL 120 | | NGLYYIHRNK ILHRDMKAAN VLITRDGVLK LADFGLARAF SLAKNSQPNK YTNRVVTLWY 180 | | RPPELLLGER DYGPPIDLWG AGCIMAEMWT RSPIMQGNTE QHQLTLISQL CGSITPEVWP 240 | | NVDKYELYQK LELPKGQKRK VKERLKAYVK DLYALDLIDK LLVLDPAQRI DSDDALNHDF 300 | | F 301 |
|
| Keyword | ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |