EKS-XET-00592

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00592

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	492.9	2.4E-148	76	342	267

Status

Unreviewed

Ensembl Protein

ENSXETP00000027888

UniProt Accession

F7A5W1;

Protein Name

Protein Synonyms/Alias

Gene Name

cdc42bpb

Gene Synonyms/Alias

cdc42bpb;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000025675	ENSXETP00000027888	ENSXETT00000027888

Organism

Xenopus tropicalis

Functional Description

Protein Length

1738

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGPQR NEAALSVETL LDVLLCLYTE CSHSTLRRDK YVSEFLEWAK 60

PFTDLLKGMQ LHRDDFEIIK VIGRGAFGEV AVVRLKSTER IYAMKILNKW EMLKRAETAC 120

FREERNVLVN GDCQWITSLH YAFQDENYLY LVMDYYVGGD LLTLLSKFED RLPEDMARFY 180

LAEMVLAIHS IHQLHYVHRD IKPDNVLLDM NGHIRLADFG SCLKMNADGT VQSSVAVGTP 240

DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300

QFPSHIGDVS ESAKDVIQRL ICSRERRLGQ NGIDDFKAHP FFEGIDWDNI RNLEAPYIPD 360

VSSPYDTSNF DVDDDVLRNP EVIPPSTHSG FSGFHLPFVG FTYTTDSCFS DRGSLKDTIH 420

SNAVTKDEDV QRGLQNSLQI DAYERRIRRL EQEKLELNRK LQESTQTVQS LQGGSRTTGT 480

LTREKEIRKL NEEIERLKNK ISDSNRIERQ LEDVVALRQQ YEDSTNKMKG LEKQHRALKQ 540

ERDDLQKQFS DAQERLKSQT KELKDANQHR KVTQQEFAEL TEKMAELRSQ KLKLSRQLRD 600

KEEELELVMQ KIDTMRQENR KSEKARKELE AQLDDATAEA SKERKLREHS EIFCKQLESE 660

VESLKLKQGV RTPGATLEHQ QELSKVKSEQ EKKNLYFEEE LLRRETAHSF EMKNIKKEIH 720

DSESQQLALK KETLMLKDKL EKAKRERQSE LEEAVGAVKE KYERERSILL DENKKLFSQT 780

ERLSSFVDKL TEQNRQLEDD LQDLTAKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAS 840

KMTEELESLR SSSLGSRALV SLPFKFKTFQ LLIGGRRQNC LFREDTNIKS KDVSMEKVWS 900

SVSGMNKGLM SKLKDAELKN KELLEEMENL KKKLEEKYKD DSGLKIPDFH ESIFEYFNTS 960

PLPHDLTLRS TSSLLAYWGP AQTSSSPLPH TAQLQEKKQP DFIGCPMKRK PKAHQLIIKS 1020

FVNPTQCSHC TSLMVGLVRQ GYACEVCPFA CHVSCKDSAP QVCPIPAEQA KRPLGVDVQR 1080

GIGTAYKGYV RIPKPTGVKK GWQRAFAVVC DCKLFLYDVP EGRSTQPGVV SSQVVDLRDE 1140

DFSVSSVLAS DVIHATRKDI PCIFRVTASL LGSPSKTTAS LLILTESEAE KRKWVGILEG 1200

LQAILQKNNL RNRAVHCPQE AYDSTLPLIK TIVAAAVVDH DRIAVGTEEG LYVIEVTRDV 1260

IVRAADCKKV YQIELVPKEK IVILVCGRNH HVHLFPWSSL DGSEGSFDIK LPESKGCQFI 1320

TTGSLKKSVS PCLFVAVKRQ IFCYEIHRTK PFHKKFNEIV APGNVQWMAV FKDKLCVGYQ 1380

SGFSLLTIHG EGQPINLVNP NDPSLAFLSQ QPVDALCAVE LSKDEYLLCF SQLGIYVDSQ 1440

GRRTRMQELM WPATPLACSC SSSYVTVYSE YGIDVFDVST MEWVQTIGLR RIKPLNAEGS 1500

LNLLNSEPAR LLYLKSIYSV EGPILTVPET SDNSKKQMVR TRSKRKFVFK VPEEERLQQR 1560

REMLRDPELR SKMISNPTNF NHVAHMGPGD GMQVLMDLPL ISPPANFEHV YHMSSVSANI 1620

FLQNEQCSLQ GLSLSSSSSC PSSTSLARSH QVTELSRHRQ RLKAEKIPRL SDGPGELSSR 1680

SIGDPDQEIE KEHLQPDSDS TKHSTPSNSS NPSGPPSPNS PHRNQLTLDG LDQSACDA 1738

Nucleotide Sequence
(FASTA)

ATGTCGGCCA AAGTGAGGCT GAAGAAGCTG GAGCAGCTGC TCCTGGATGG GCCCCAGAGG 60

AACGAGGCGG CCCTGAGTGT GGAGACCTTG CTGGATGTGC TTCTCTGCCT GTATACCGAG 120

TGCAGCCATT CCACCCTCCG CAGGGACAAG TATGTCAGCG AGTTCCTGGA ATGGGCAAAA 180

CCCTTTACAG ATCTGCTCAA GGGAATGCAG CTTCATCGGG ACGACTTTGA AATTATCAAA 240

GTAATTGGAA GAGGAGCTTT TGGAGAGGTT GCGGTTGTTA GATTGAAAAG TACTGAACGC 300

ATTTATGCGA TGAAAATCCT GAACAAATGG GAGATGCTTA AAAGAGCAGA GACTGCTTGT 360

TTCCGAGAAG AGCGAAATGT GTTGGTAAAC GGTGACTGTC AGTGGATCAC TAGCTTACAT 420

TATGCCTTTC AGGATGAGAA CTATTTGTAT TTAGTGATGG ATTACTATGT AGGTGGGGAC 480

CTACTGACTC TTCTCAGCAA ATTTGAAGAC AGGCTTCCTG AAGACATGGC CAGATTTTAT 540

CTTGCTGAAA TGGTGCTTGC TATTCACTCT ATTCATCAGC TGCATTATGT ACACAGGGAT 600

ATCAAACCCG ATAATGTTCT CTTGGATATG AATGGCCACA TTCGCCTAGC AGATTTTGGA 660

TCTTGTCTAA AAATGAACGC TGATGGAACT GTTCAGTCTT CAGTGGCCGT AGGAACACCT 720

GACTATATCT CCCCTGAGAT CTTACAAGCC ATGGAAGATG GAATGGGAAA ATATGGACCT 780

GAATGCGATT GGTGGTCCCT TGGGGTGTGC ATGTATGAAA TGCTTTATGG GGAAACTCCT 840

TTCTATGCAG AGTCACTCGT GGAAACCTAT GGAAAGATCA TGAATCATGA AGAAAGATTT 900

CAGTTCCCAT CTCATATTGG GGATGTGTCT GAATCAGCCA AAGATGTTAT CCAGAGGCTA 960

ATCTGCAGCA GGGAGAGGCG ACTCGGTCAA AATGGAATTG ATGATTTTAA GGCTCATCCG 1020

TTTTTTGAAG GAATCGACTG GGATAACATT AGAAACTTGG AAGCCCCCTA CATTCCTGAT 1080

GTCAGCAGTC CCTATGACAC ATCAAACTTT GACGTGGACG ATGATGTTCT AAGGAACCCT 1140

GAAGTTATTC CTCCAAGTAC CCACAGTGGC TTTTCAGGCT TCCATCTGCC ATTTGTAGGA 1200

TTTACATACA CAACAGACAG CTGTTTTTCT GACCGTGGCT CCTTAAAAGA CACCATTCAC 1260

TCGAATGCTG TGACCAAAGA TGAGGATGTG CAGCGAGGCC TTCAAAATAG CTTACAGATT 1320

GATGCCTATG AGAGAAGAAT CAGGCGACTC GAGCAGGAAA AACTGGAGCT AAACAGGAAA 1380

TTACAAGAGT CAACTCAGAC AGTCCAGTCT CTGCAAGGTG GTTCTAGAAC AACAGGAACA 1440

TTAACCAGAG AGAAAGAAAT CCGAAAGCTA AATGAAGAAA TCGAACGGCT GAAGAATAAA 1500

ATATCAGATT CAAATCGAAT AGAGCGGCAG CTGGAGGATG TTGTTGCTCT GAGGCAGCAA 1560

TATGAGGATT CCACAAACAA GATGAAAGGC CTGGAGAAGC AACACCGTGC TCTGAAACAG 1620

GAACGTGATG ATCTACAAAA GCAATTTAGT GATGCTCAGG AGAGGTTAAA ATCCCAGACC 1680

AAGGAGCTGA AGGATGCCAA TCAACACAGA AAGGTGACTC AGCAAGAGTT TGCTGAACTT 1740

ACTGAGAAAA TGGCGGAATT GAGATCACAG AAGCTAAAGC TGTCCCGCCA GCTACGAGAT 1800

AAAGAGGAAG AATTGGAGTT GGTTATGCAG AAAATTGACA CCATGCGCCA GGAAAACCGC 1860

AAATCTGAGA AAGCTAGAAA AGAGTTGGAA GCACAACTTG ATGATGCCAC TGCTGAGGCA 1920

TCAAAGGAAC GCAAATTGCG TGAACACAGT GAGATATTCT GCAAACAGTT AGAAAGTGAA 1980

GTGGAATCTC TTAAGTTAAA ACAGGGAGTT CGAACTCCTG GTGCAACATT AGAGCATCAG 2040

CAGGAGCTCT CAAAAGTCAA ATCTGAGCAG GAAAAGAAGA ACTTGTATTT TGAAGAAGAG 2100

CTATTAAGAC GTGAAACAGC TCATTCATTT GAGATGAAAA ACATAAAGAA AGAAATACAT 2160

GATTCTGAGA GTCAGCAGCT TGCCCTAAAG AAAGAGACCC TCATGCTGAA AGATAAGCTT 2220

GAAAAAGCAA AACGTGAGCG GCAATCTGAG CTGGAAGAAG CTGTTGGAGC CGTAAAGGAA 2280

AAATATGAGC GAGAGAGGAG CATCCTTTTA GATGAAAATA AAAAACTTTT TTCTCAAACA 2340

GAAAGGCTCT CTTCCTTTGT GGATAAATTG ACTGAGCAGA ATCGGCAGCT GGAAGATGAC 2400

CTGCAGGACC TTACAGCTAA AAAGGAATCT GTAGCTCACT GGGAAGCTCA GATTGCTGAA 2460

ATCATTCAGT GGGTAAGTGA TGAAAAAGAT GCCCGTGGTT ATCTTCAAGC TTTAGCGTCA 2520

AAGATGACCG AAGAACTTGA GTCATTAAGG AGTTCAAGTC TTGGATCCCG AGCCCTGGTA 2580

TCCTTGCCCT TTAAGTTTAA AACATTTCAG TTGCTGATAG GGGGGAGGAG GCAGAATTGT 2640

TTGTTTAGGG AGGATACCAA TATAAAGAGT AAAGATGTAA GTATGGAAAA AGTGTGGTCT 2700

TCTGTGTCAG GGATGAATAA AGGTTTGATG AGTAAACTGA AGGATGCAGA ATTGAAAAAT 2760

AAAGAACTTT TAGAGGAGAT GGAGAATCTT AAAAAGAAGC TGGAGGAAAA ATACAAAGAC 2820

GACAGTGGAC TCAAAATTCC TGACTTTCAT GAGTCCATCT TTGAGTATTT TAACACCTCT 2880

CCGCTGCCAC ATGACCTAAC CTTAAGATCT ACCTCCTCAC TACTAGCCTA CTGGGGTCCA 2940

GCACAAACTT CTAGCAGTCC TCTTCCCCAT ACAGCTCAAT TGCAAGAAAA GAAGCAGCCG 3000

GATTTTATAG GGTGTCCAAT GAAACGGAAA CCCAAAGCAC ACCAGCTTAT TATAAAGTCC 3060

TTTGTGAATC CCACACAGTG TTCCCACTGC ACATCACTCA TGGTTGGGTT GGTGAGGCAA 3120

GGATATGCAT GTGAAGTGTG TCCTTTTGCG TGCCATGTAT CATGCAAGGA CAGTGCACCA 3180

CAGGTTTGTC CTATTCCAGC AGAGCAGGCC AAGAGACCAC TTGGAGTAGA TGTACAAAGG 3240

GGTATTGGAA CTGCTTACAA GGGATATGTG AGGATTCCAA AACCTACCGG AGTGAAAAAA 3300

GGCTGGCAGA GAGCATTTGC TGTAGTTTGC GACTGTAAGC TGTTTCTGTA TGATGTCCCA 3360

GAAGGACGTT CTACTCAGCC TGGAGTTGTT TCCAGCCAGG TTGTAGATCT TAGGGATGAA 3420

GACTTTTCTG TGAGCTCTGT TTTGGCATCT GATGTCATAC ATGCCACACG CAAGGACATT 3480

CCCTGCATAT TTAGGGTGAC AGCTTCTCTT CTAGGTTCTC CCTCCAAAAC CACAGCATCT 3540

CTTCTAATAC TAACAGAGAG TGAAGCAGAG AAGAGGAAGT GGGTTGGAAT TCTGGAAGGG 3600

CTGCAAGCGA TTTTACAGAA AAACAACCTG AGGAACCGGG CAGTGCATTG TCCACAGGAA 3660

GCCTATGACA GCACTTTGCC TCTTATTAAA ACTATTGTAG CTGCTGCTGT TGTAGATCAT 3720

GATCGAATAG CTGTTGGCAC TGAAGAAGGA CTGTATGTAA TAGAGGTTAC AAGAGATGTG 3780

ATTGTTCGTG CTGCTGACTG TAAAAAAGTC TACCAGATAG AACTGGTTCC CAAAGAGAAG 3840

ATTGTTATTC TTGTGTGTGG GCGTAATCAC CATGTTCACC TGTTTCCTTG GTCCTCCCTT 3900

GATGGCTCAG AGGGCAGCTT TGACATCAAA TTGCCAGAGT CCAAAGGTTG CCAATTCATT 3960

ACAACTGGAT CACTGAAAAA ATCCGTTTCT CCCTGCTTGT TTGTGGCGGT CAAACGGCAG 4020

ATCTTTTGCT ATGAAATCCA TAGAACTAAA CCATTCCATA AGAAGTTCAA TGAGATTGTG 4080

GCTCCAGGAA ATGTACAGTG GATGGCTGTG TTTAAAGACA AACTCTGTGT TGGTTACCAG 4140

TCTGGGTTCT CATTGTTGAC CATACATGGA GAGGGACAGC CCATAAATTT GGTGAACCCC 4200

AATGATCCTT CCCTAGCATT TTTGTCACAG CAGCCAGTGG ATGCCCTGTG TGCAGTAGAG 4260

CTCAGTAAGG ATGAATACTT GCTTTGCTTC AGCCAGTTAG GAATATATGT GGATTCTCAA 4320

GGACGAAGGA CACGAATGCA GGAGCTGATG TGGCCAGCAA CTCCTCTCGC TTGCAGTTGC 4380

AGCTCTTCAT ATGTTACAGT TTACAGTGAG TATGGCATTG ATGTTTTTGA TGTCTCCACC 4440

ATGGAATGGG TTCAGACCAT CGGTTTAAGA CGGATAAAGC CTCTAAATGC AGAGGGTTCC 4500

CTGAATTTAC TGAATTCTGA GCCTGCGCGT CTCTTGTATT TGAAGAGCAT ATATTCAGTA 4560

GAGGGACCTA TCCTGACAGT GCCAGAAACA TCTGACAACA GCAAAAAGCA AATGGTCCGG 4620

ACCAGGAGCA AAAGAAAGTT TGTGTTCAAG GTTCCAGAAG AGGAGAGATT GCAGCAAAGA 4680

AGGGAGATGC TTCGAGATCC TGAACTAAGA TCAAAAATGA TCTCCAACCC CACCAATTTC 4740

AACCACGTGG CACACATGGG ACCAGGGGAT GGAATGCAAG TGCTCATGGA CCTGCCTCTG 4800

ATATCACCTC CAGCAAACTT TGAACACGTC TATCATATGA GCTCTGTTTC AGCCAACATC 4860

TTTCTTCAGA ACGAGCAATG CTCCCTGCAA GGCCTCTCTC TGTCTTCTTC CTCTTCCTGC 4920

CCCTCTTCTA CTTCCTTAGC AAGGTCACAC CAAGTGACAG AACTGAGCAG ACATAGACAA 4980

AGACTTAAAG CTGAGAAAAT ACCAAGATTA AGTGATGGAC CTGGAGAGTT ATCCTCACGA 5040

AGTATAGGGG ACCCTGACCA AGAAATAGAA AAAGAGCATT TACAGCCAGA TTCAGATTCC 5100

ACAAAACATT CCACTCCTTC AAACAGCTCC AATCCCAGCG GCCCCCCGAG CCCTAATTCT 5160

CCACATAGGA ATCAGCTGAC GTTGGATGGC TTGGATCAAT CCGCATGCGA TGCGTAA 5217

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavvr k+te++yamkil+k+e+lkrae+a+freer+vlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVRLKSTERIYAMKILNKWEMLKRAETACFREERNVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+ed+lpe++arfylae+vla++s+h+l+

Q: 136   ITSLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVLAIHSIHQLH  195

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 196   YVHRDIKPDNVLLDMNGHIRLADFGSCLKMNADGTVQSSVAVGTPDYISPEILQAMEDGM  255

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp++  +vse+akd

Q: 256   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHIgDVSESAKD  315

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         +i++l++sre+rlg++gi+d+k+hpff

Q: 316   VIQRLICSRERRLGQNGIDDFKAHPFF  342

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVRL KSTERIYAMK ILNKWEMLKR AETACFREER NVLVNGDCQW 60

ITSLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV LAIHSIHQLH 120

YVHRDIKPDN VLLDMNGHIR LADFGSCLKM NADGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH IGDVSESAKD 240

VIQRLICSRE RRLGQNGIDD FKAHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 2.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013