EKS-XET-00641

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00641

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	372.2	1.2E-111	18	273	256

Status

Unreviewed

Ensembl Protein

ENSXETP00000057925

UniProt Accession

F6SGF6;

Protein Name

Protein Synonyms/Alias

Gene Name

tbck

Gene Synonyms/Alias

tbck;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000027870	ENSXETP00000057925	ENSXETT00000057925

Organism

Xenopus tropicalis

Functional Description

Protein Length

682

Protein Sequence
(FASTA)

MPPLKDAELG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTIVH PRLCQYVDIS 60

RGKHERLVVV AEHYPKSFED LLREGTPVSS SKIFRLAYEV LQGLEYMNRH RMVHRALAPH 120

NILLDGEGHA KLAKFGLYHI TDHGADVDFP IGYPSYLAPE VIAQGIVKPT DPTQCERPLP 180

SGPKSDVWSL GLILFELCMG RKLFQSLDIS EKLKLILTLG CVDDIITVLS EEHGCEDILK 240

SVPENTLALL RKCLTFHPTK RPTSAELLAD SVFSEVSPLY LPFRKPVGLF SSALRCANLI 300

LPEDISLLCK DEDSDFLAER SIEEVYHLWC LAGGDLEKEL ISKGIIRSKP PICTLPNLLL 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVPGEAY YPLLGEDQSN IPHSGSSNEL 420

STSATLPLII RERDTEYQLN RIVLFDRLLN AYPYKKNMIW KEARVDIPPL LRGLTWAALL 480

GVEGAIQEKY DMIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

NLVYWQVVNI TCLSYFFLTA LAYACMSAFI PKYLYNFFLK DNSHVIQEYL KVFSQMIAFH 600

DPELSNHLNE IGFIPDLYAI PWFLTMFTHV FPLHKIFHLW DTLLLGNASF PFCIGVAILQ 660

QLRVRLLANG FNECILLFSD LP 682

Nucleotide Sequence
(FASTA)

ATGCCACCTT TAAAAGATGC AGAGCTTGGA GCCTTCACAT TCTTTGCATC TGCTCTCCCA 60

CATGACGTTT GTGGAAGCAA TGGCCTTCCC CTCACACCGA ATTCAATAAA AATCTTGGGG 120

CGATTCCAAA TCTTAAAAAC CATTGTGCAT CCCAGACTTT GCCAGTATGT TGACATATCT 180

CGTGGTAAAC ATGAAAGGCT GGTGGTGGTA GCAGAACACT ATCCAAAAAG TTTTGAAGAC 240

TTGCTACGGG AGGGAACTCC TGTGAGCTCT TCAAAGATCT TTCGTCTAGC TTATGAAGTT 300

TTACAAGGCC TGGAGTATAT GAATCGCCAC CGAATGGTCC ATAGGGCACT TGCTCCTCAC 360

AATATTCTTC TAGATGGAGA GGGACATGCC AAACTGGCCA AGTTTGGGCT TTATCATATC 420

ACAGATCATG GGGCTGATGT TGATTTCCCA ATAGGATACC CTTCTTACCT GGCACCAGAA 480

GTGATTGCTC AGGGGATTGT AAAGCCGACA GACCCCACAC AGTGCGAGAG GCCTCTGCCT 540

TCAGGTCCAA AATCCGATGT CTGGTCTCTG GGTCTTATAT TGTTTGAACT GTGCATGGGT 600

AGAAAATTAT TTCAGAGTCT GGATATCTCT GAGAAATTAA AACTAATACT TACATTAGGT 660

TGTGTTGACG ACATTATAAC CGTACTTAGT GAAGAACATG GGTGTGAAGA TATTTTAAAG 720

AGTGTCCCTG AAAATACCTT AGCCTTGTTG CGAAAGTGCC TCACGTTTCA TCCTACAAAA 780

AGGCCTACCT CTGCGGAATT GCTTGCTGAC AGCGTGTTCA GTGAAGTGTC CCCTTTGTAC 840

CTCCCTTTTC GCAAACCTGT TGGTCTCTTT TCTTCTGCTT TGCGATGTGC TAATCTAATA 900

CTGCCTGAAG ATATTAGTCT CTTATGCAAA GATGAGGACA GTGACTTCCT TGCAGAAAGA 960

TCTATTGAAG AAGTATATCA CTTGTGGTGC TTGGCAGGCG GAGACCTAGA GAAAGAGCTT 1020

ATAAGCAAGG GCATAATTCG ATCAAAGCCA CCTATCTGCA CTTTACCCAA CCTTCTCCTT 1080

GAAGATGGTG AAAGCTTTGG TCAAGGAAGG GACAGGAGCT CCCTGCTGGA TGACACCACT 1140

GTGACTCTTT CCTTGTGCCA ACTCAGAAAT AGATTAAAAG ATGTCCCTGG TGAAGCATAT 1200

TATCCATTAC TAGGTGAAGA CCAATCCAAC ATACCACATT CTGGCAGCAG CAATGAGTTG 1260

TCCACCTCAG CCACTCTTCC TCTGATTATT CGTGAGAGAG ACACAGAGTA TCAGCTAAAC 1320

AGAATTGTTT TATTTGACCG GTTGCTAAAT GCATATCCAT ACAAGAAAAA TATGATTTGG 1380

AAAGAGGCCA GAGTGGATAT TCCTCCTCTT TTGAGAGGAT TAACTTGGGC TGCTCTTCTT 1440

GGTGTAGAGG GGGCCATTCA AGAAAAATAT GATATGATAG ATAAGGACAC TCCAATACCT 1500

ACAGACCGTC AGATTGAAGT AGATATCCCA CGTTGCCATC AGTATGATGA GCTCCTTTCT 1560

TCTCCTGAAG GCCATGCAAA ATTTCGAAGG GTACTGAAAG CTTGGGTGGT TTCACATCCT 1620

AACCTGGTAT ATTGGCAAGT TGTAAATATA ACTTGTTTAA GCTATTTTTT CCTGACAGCG 1680

CTGGCATATG CCTGTATGTC TGCCTTCATA CCCAAGTACC TGTATAATTT CTTTTTGAAG 1740

GACAATTCCC ATGTAATACA AGAGTACCTC AAAGTGTTCT CCCAAATGAT TGCCTTTCAT 1800

GACCCGGAAC TAAGCAACCA TCTCAATGAA ATTGGCTTTA TTCCAGATCT CTACGCAATT 1860

CCTTGGTTTC TTACAATGTT CACGCATGTT TTTCCTTTGC ACAAGATATT CCATCTCTGG 1920

GACACATTGC TGCTGGGGAA TGCTTCCTTC CCATTTTGCA TTGGAGTGGC CATTTTGCAA 1980

CAGCTACGAG TCAGGCTTCT TGCGAATGGT TTTAATGAAT GCATTCTTCT GTTTTCCGAT 2040

TTGCCA 2046

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk++ h+rLcqY+disrgkher++vvaeh+ +s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTIVHPRLCQYVDISRGKHERLVVVAEHYPKS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

          eDll+e+ pvs s++ r+ayevl+gl+y+n+h +vhral p++illd +g+  kLak+G

Q: 78    FEDLLREGTPVSSSKIFRLAYEVLQGLEYMNRHRMVHRALAPHNILLDGEGH-AKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+t++G+dvdfpigy+sylaPe+i+q+          +++l++++ksDvWsLglil+e

Q: 137   LYHITDHGADVDFPIGYPSYLAPEVIAQGivkptdptqCERPLPSGPKSDVWSLGLILFE  196

         *************************************999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf++ld+se+lk++l+l++vd+ + +l ee++c di k ++e+  all+kCLt+

Q: 197   LCMGRKLFQSLDISEKLKLILTLGCVDDIITVLSEEHGCEDILKSVPENTLALLRKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekvf  248

         +p kRp+  ell++ vf

Q: 257   HPTKRPTSAELLADSVF  273

         **************997

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT IVHPRLCQYV DISRGKHERL VVVAEHYPKS 60

FEDLLREGTP VSSSKIFRLA YEVLQGLEYM NRHRMVHRAL APHNILLDGE GHAKLAKFGL 120

YHITDHGADV DFPIGYPSYL APEVIAQGIV KPTDPTQCER PLPSGPKSDV WSLGLILFEL 180

CMGRKLFQSL DISEKLKLIL TLGCVDDIIT VLSEEHGCED ILKSVPENTL ALLRKCLTFH 240

PTKRPTSAEL LADSVF 256

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013