EKS-XET-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	430.4	2.5E-129	393	653	261

Status

Unreviewed

Ensembl Protein

ENSXETP00000062002

UniProt Accession

F7A8E3;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

LOC100489041

Gene Synonyms/Alias

LOC100489041;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000030064	ENSXETP00000062002	ENSXETT00000060481

Organism

Xenopus tropicalis

Functional Description

Protein Length

765

Protein Sequence
(FASTA)

ANLTGHTEKV GLENFELLKV LGTGAYGKVF LVRKISGHDS GKLYAMKVLK KATIIQKAKT 60

AEHTRTERQV LEHIRQSPFL VTLHYAFQTD TKLHLILDYI NGGELFTHLS QREKFTENEV 120

LVYIGEIVLA LEHLHKLGII YRDIKLENIL LDSSGHVVLT DFGLSKEFLS DENERAYSFC 180

GTIEYMAPEI VKGGDSGHDK AVDWWSLGVL MYELLTGASP FTVDGEKNSQ AEISRRILKS 240

EPPYPQEMSE AVKDIIRCLL LKDPKKRLGC GPDGCDEIKK HPFFKSFNWD DLAAKKIPAP 300

FKPIIKDELD VGNFAEEFTE MDPTYSPAAL PMNADRIFQG YSFVAPSILF RPNAAIADPL 360

QYHLGIERPG TTSIARSAMM KDSPFYQHYE LDLKDKPLGE GSFSICRKCL HKKTNQEYAV 420

KIVSKRMESN TQREIAAMKL CQSHPNIVKL CDVFHDQLHT FLVMELLKGG ELFERIKKKK 480

LFSETEASHI MRRLVSAVSH MHDVGVVHRD LKPENFLFTD ESDNSEIKII DFGFARLKPP 540

DNQPLKTPCF TLHYAAPELL NENGYDESCD LWSLGVILYT MLSGQVPFQC HGKTLQCTSA 600

EDIMKKIKQG DFSCEGEAWT NVSQEAKDLI QGLLTVDPNK RIKMSTLRYN EWLQDGSQLS 660

SNPLMTPDIL GSAGASVHTH VKATFHAFNK YKREGFRLQN VDKAPLAKRR KMKKTSTSTE 720

TRSSSSESSH SSSSHSHGKT SPAKMLQPAN PSESNNPEAI FQFAD 765

Nucleotide Sequence
(FASTA)

GCAAACTTAA CAGGACACAC AGAAAAAGTT GGCCTTGAAA ACTTTGAACT ATTGAAAGTC 60

CTTGGAACCG GAGCATATGG CAAAGTATTT CTGGTGCGAA AAATCAGCGG CCATGACTCT 120

GGGAAGCTTT ATGCAATGAA AGTATTAAAA AAGGCAACTA TCATCCAAAA AGCAAAGACG 180

GCAGAACACA CAAGAACAGA ACGACAAGTG TTGGAACATA TAAGGCAATC GCCTTTCCTT 240

GTTACACTTC ATTATGCTTT TCAGACAGAC ACAAAACTTC ATCTCATTTT GGATTATATT 300

AATGGTGGAG AGCTCTTCAC TCATTTATCC CAGAGAGAGA AGTTCACTGA AAATGAGGTG 360

CTGGTATATA TTGGTGAAAT TGTTCTGGCA CTTGAACATT TACATAAGCT TGGAATAATC 420

TACCGGGATA TAAAACTTGA GAACATACTT CTAGACTCCA GTGGACACGT GGTGTTAACA 480

GATTTTGGAC TTAGTAAAGA GTTTCTGTCT GATGAAAATG AAAGGGCATA TTCTTTTTGC 540

GGGACTATAG AGTATATGGC ACCAGAGATT GTCAAAGGAG GTGATTCAGG ACATGACAAG 600

GCGGTAGACT GGTGGAGTTT AGGTGTCCTA ATGTATGAGT TATTGACTGG AGCATCCCCT 660

TTTACTGTTG ATGGAGAGAA AAATTCTCAG GCTGAAATTT CTAGGAGGAT ATTAAAAAGT 720

GAACCCCCTT ATCCTCAAGA AATGAGTGAA GCTGTGAAAG ATATAATTCG GTGCCTTTTA 780

TTAAAGGATC CCAAGAAGCG ATTGGGATGT GGACCAGATG GATGCGATGA AATAAAAAAG 840

CATCCCTTCT TTAAGAGTTT TAATTGGGAT GACTTGGCTG CTAAAAAAAT ACCTGCACCA 900

TTTAAACCCA TAATTAAAGA TGAATTGGAT GTTGGAAATT TTGCAGAGGA ATTTACAGAG 960

ATGGATCCCA CATACTCCCC TGCTGCTTTG CCTATGAACG CAGACAGGAT ATTTCAGGGC 1020

TATTCTTTTG TAGCACCTTC TATCCTGTTT AGGCCCAATG CTGCTATAGC AGATCCCTTG 1080

CAGTACCATT TGGGGATTGA ACGTCCTGGC ACTACATCTA TAGCAAGAAG TGCAATGATG 1140

AAGGACTCTC CTTTTTATCA GCATTATGAA CTGGATCTCA AAGACAAACC ACTGGGTGAG 1200

GGAAGTTTTT CCATATGCCG CAAATGCTTG CATAAAAAAA CAAACCAAGA GTATGCAGTG 1260

AAAATCGTCA GCAAACGTAT GGAAAGCAAC ACTCAGAGAG AAATTGCAGC CATGAAGCTA 1320

TGTCAGAGTC ACCCAAATAT AGTCAAATTG TGTGATGTTT TCCACGATCA GCTTCACACA 1380

TTCTTAGTAA TGGAGTTACT GAAAGGAGGC GAATTGTTTG AACGCATCAA GAAAAAGAAA 1440

TTATTTAGTG AGACAGAAGC AAGCCATATC ATGCGCAGAC TTGTCTCAGC TGTCAGTCAT 1500

ATGCACGATG TTGGAGTAGT CCATAGAGAT CTGAAACCTG AGAATTTTCT ATTCACCGAT 1560

GAAAGTGATA ACTCTGAGAT AAAAATTATA GATTTTGGGT TTGCCCGATT AAAGCCACCT 1620

GACAATCAGC CACTGAAAAC GCCATGTTTT ACTCTTCATT ATGCTGCACC TGAACTTTTA 1680

AATGAAAACG GCTATGATGA ATCATGTGAT TTGTGGAGCC TGGGAGTCAT TCTGTATACC 1740

ATGCTGTCAG GTCAAGTGCC CTTCCAGTGT CACGGAAAGA CCCTGCAATG TACAAGTGCT 1800

GAAGATATAA TGAAGAAAAT AAAACAAGGT GATTTCTCAT GTGAGGGTGA AGCTTGGACA 1860

AATGTGTCCC AGGAGGCCAA AGACTTGATA CAAGGGCTTC TCACTGTGGA TCCTAATAAA 1920

CGAATTAAGA TGTCAACGTT AAGATACAAT GAGTGGCTCC AAGATGGCAG CCAGCTTTCT 1980

TCCAACCCAC TTATGACACC AGATATTCTG GGTTCAGCAG GGGCTTCTGT ACACACACAT 2040

GTGAAAGCTA CATTTCATGC ATTTAACAAG TACAAGCGAG AAGGATTTCG TCTCCAGAAT 2100

GTAGACAAAG CACCACTGGC AAAGCGCAGG AAGATGAAGA AGACAAGCAC AAGTACAGAA 2160

ACACGAAGCA GCTCTAGTGA GAGTTCACAC TCCTCCTCCT CCCACTCGCA TGGCAAAACT 2220

TCACCTGCAA AAATGTTGCA GCCAGCTAAT CCTTCTGAGA GCAATAACCC AGAGGCCATC 2280

TTCCAGTTTG CAGACTAG 2298

Domain Profile

S: 2     evkedlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkd  60

         +++++lG+Gs+s+c++c+hk+tnqe+avki++k+ + +t++ei++++++++hpniv+l d

Q: 393   LKDKPLGEGSFSICRKCLHKKTNQEYAVKIVSKRmESNTQREIAAMKLCQSHPNIVKLCD  452

         5789******************************9*************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         v++d+++++lv+ellkGGel++rikkkk fse+eas+i+r lv+av+++h++Gvvhrdlk

Q: 453   VFHDQLHTFLVMELLKGGELFERIKKKKLFSETEASHIMRRLVSAVSHMHDVGVVHRDLK  512

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         pen l++desdn+e ikiidfGfa+lk+++n++lktpc+tl+++ape+l+++Gyde+cdl

Q: 513   PENFLFTDESDNSE-IKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNENGYDESCDL  571

         **************.*********************************************

S: 181   wslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvs  236

         wslGv+lytml+G+vpf    + +++++ae+i++kik+G+fs +Geaw +vs+eakdl++

Q: 572   WSLGVILYTMLSGQVPFqchgKTLQCTSAEDIMKKIKQGDFSCEGEAWTNVSQEAKDLIQ  631

         *****************9887788999*********************************

S: 237   klltvdpakrlkleqllkhswl  258

         +lltvdp+kr+k+++l++++wl

Q: 632   GLLTVDPNKRIKMSTLRYNEWL  653

         *********************7

Domain Sequence
(FASTA)

LKDKPLGEGS FSICRKCLHK KTNQEYAVKI VSKRMESNTQ REIAAMKLCQ SHPNIVKLCD 60

VFHDQLHTFL VMELLKGGEL FERIKKKKLF SETEASHIMR RLVSAVSHMH DVGVVHRDLK 120

PENFLFTDES DNSEIKIIDF GFARLKPPDN QPLKTPCFTL HYAAPELLNE NGYDESCDLW 180

SLGVILYTML SGQVPFQCHG KTLQCTSAED IMKKIKQGDF SCEGEAWTNV SQEAKDLIQG 240

LLTVDPNKRI KMSTLRYNEW L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013