EKS-XET-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	473.9	1.6E-142	685	949	265

Status

Unreviewed

Ensembl Protein

ENSXETP00000005353

UniProt Accession

F6VTG3;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000031142	ENSXETP00000005353	ENSXETT00000005353

Organism

Xenopus tropicalis

Functional Description

Protein Length

1157

Protein Sequence
(FASTA)

GNLSGLKMAL DGVFNCRNGM AIKLRQVCNF IPDCEEEEDE GDLCRNLPPG FYCMFEEGSC 60

GWALDHLNSR WQVGSVGKSP EFQSHSGSVL YLNVSNSKSA ARDVLSSVLF PAPLKNSSCE 120

LRMSFLLKGF LLGNISVLLV DNKTGKVRTR PLWSFENGEG LGVWQHIVLY LKDVMERFWL 180

EIHTSWAQES DSIIAFDNVS LSLGCYLTSN GELPLQTVSY LSSNLLMESS NQRLNDTEGD 240

EQHTEILLST GYWHFTTCGA TGPYGPSQKL CDDTYKNFSV VYGNGGLKGV QMWRVPETNT 300

YRISGYGAAG GNGGKTPTLA QGISLIGIFE LQKDEILYIL VGQKGEDACP RANSVLQMVC 360

IGENTEIEDE LRINGSVSEW AGGGGGGGGA TYVFKMESGK PVPLLIAAGG GGRAYRSKAS 420

VIPPERLESN YTIPGMNGKS GAAGGGGGWN DHTALPWAGK SLMEGAIGGE SCPQAVKKWG 480

WETRGGFGGG GGGCSSGGGG GGYIGGNAAE GNSAEMDGLE GVSFISPRGV VYTPPLKVIE 540

GHGEVEIKLH LNCSHCEMDE CLLDPESKRI VCLCERGTVL AEDGVSCIDE ALAPAQETHL 600

PLSLVLSIVT SALVAALILA FSGIMIVYRK KHQELQAIQM ELQSPDYKLS KVRTSTIMTD 660

YNPNYCFAGK VTSIGDLKEV PRKNISLIRG LGHGAFGEVY EGQVLGTPSD PNPLKVAVKT 720

LPEVCSEQDE LDFLMEALII SKFSHQNIVR CIGVSLQALP RFILLELMAG GDLKSFLRQT 780

RPRLNQPSSI TMLDLLNVSC DIAHGCKYLE ENHFIHRDIA ARNCLLTCQG SGRVAKIGDF 840

GMARDIYRAS YYRKGGCAML PVKWMPPEAF MEGIFTSKTD TWSFGVLLWE IFSLGYMPYP 900

SKSNQEVLEF VTSGGRMDPP KNCPGPVYNL IRGLLRKSNS DLLRFSSVVS LEPHKIHISS 960

LLRTSYGDLR FSSVVSLEPH TVISLLRTSY SDLRFSSVVS LEPHTVMTSY SDFLRTLSVV 1020

SLGTCLTKTY SVAVLKILIS FLRSFTGKTV VKTPGPPDKP TPEKENPPSS VTEGNCTAAN 1080

RVAGSRLPGS SLLLEPSTLT SNVQEVPLFR LRHFPCGTVN YGYQQQGLPI EPPMAPPPCP 1140

QKDSAPRSTS SSAQEKL 1157

Nucleotide Sequence
(FASTA)

GGAAACCTGT CGGGACTGAA GATGGCGCTG GACGGGGTGT TTAACTGCAG GAACGGAATG 60

GCCATCAAAC TGCGCCAAGT GTGCAACTTC ATTCCCGACT GCGAAGAAGA GGAGGATGAA 120

GGAGACCTGT GCAGGAATCT GCCCCCTGGA TTTTACTGTA TGTTTGAGGA GGGCAGTTGC 180

GGATGGGCGC TGGATCACTT GAATTCTCGG TGGCAAGTCG GTTCTGTAGG GAAGTCGCCA 240

GAATTTCAGA GTCACAGTGG CTCGGTGCTG TACCTGAATG TCAGTAACTC CAAGTCTGCG 300

GCGAGGGACG TCCTGAGCAG TGTCCTGTTC CCTGCGCCCC TCAAGAACTC CTCGTGTGAG 360

CTACGGATGT CATTCCTGCT GAAGGGATTT CTGCTCGGGA ACATCTCCGT GCTGCTTGTT 420

GATAATAAAA CAGGGAAGGT GCGGACCCGG CCCCTCTGGA GCTTTGAGAA CGGGGAAGGT 480

TTGGGGGTTT GGCAGCACAT TGTGCTCTAT CTTAAGGATG TCATGGAGAG GTTCTGGCTG 540

GAGATCCACA CATCGTGGGC CCAGGAGTCG GATTCTATTA TTGCCTTTGA CAACGTGTCG 600

CTGAGCCTGG GCTGTTACCT AACAAGTAAT GGGGAGCTGC CCTTGCAAAC GGTCTCGTAC 660

CTTTCCAGCA ACCTCCTAAT GGAGAGCAGC AACCAGAGGC TCAACGACAC TGAGGGGGAT 720

GAGCAACATA CAGAGATATT GCTCAGTACA GGTTATTGGC ATTTCACTAC ATGTGGGGCC 780

ACAGGGCCCT ATGGACCAAG CCAGAAGCTC TGTGATGACA CCTACAAGAA CTTTAGTGTA 840

GTGTATGGGA ACGGAGGGCT TAAAGGTGTG CAGATGTGGC GAGTTCCAGA AACCAACACA 900

TACAGGATTT CAGGTTACGG AGCGGCGGGG GGGAATGGAG GGAAGACCCC CACATTGGCT 960

CAAGGCATCT CATTAATTGG GATCTTTGAG CTCCAGAAGG ACGAGATCCT GTATATTCTG 1020

GTTGGGCAGA AGGGAGAGGA CGCCTGCCCC CGGGCCAATT CTGTGCTGCA GATGGTTTGT 1080

ATTGGGGAAA ACACTGAGAT TGAGGATGAA TTGCGGATTA ACGGCAGTGT GAGCGAGTGG 1140

GCGGGAGGAG GAGGCGGCGG AGGCGGAGCA ACATACGTCT TCAAGATGGA GAGTGGAAAG 1200

CCTGTCCCAT TGCTGATAGC GGCAGGGGGG GGCGGAAGGG CGTATCGCTC CAAGGCCAGT 1260

GTAATCCCCC CCGAGAGACT GGAGAGCAAT TACACCATCC CGGGAATGAA TGGCAAATCA 1320

GGGGCAGCAG GTGGCGGTGG CGGATGGAAT GATCACACTG CGTTACCGTG GGCGGGCAAG 1380

TCCCTAATGG AAGGCGCCAT TGGTGGAGAA TCCTGCCCCC AGGCCGTTAA GAAGTGGGGC 1440

TGGGAGACTA GAGGTGGATT CGGAGGGGGC GGAGGGGGAT GTTCCTCAGG AGGCGGAGGA 1500

GGGGGATATA TTGGAGGAAA CGCTGCTGAG GGTAACAGTG CAGAAATGGA TGGGCTGGAA 1560

GGCGTGTCCT TTATCAGCCC CCGGGGGGTT GTCTACACCC CTCCCTTAAA AGTGATAGAG 1620

GGACACGGGG AGGTGGAGAT CAAACTGCAC CTGAACTGCA GTCACTGCGA GATGGACGAG 1680

TGTCTCCTGG ATCCCGAGAG CAAGAGAATC GTCTGTCTAT GTGAGCGCGG CACTGTCCTG 1740

GCTGAGGATG GGGTCTCCTG TATTGATGAG GCGTTGGCGC CGGCCCAGGA GACGCATCTG 1800

CCACTGTCGC TGGTTTTGTC CATTGTGACG TCGGCCCTGG TGGCGGCTCT CATATTGGCT 1860

TTCTCTGGGA TAATGATAGT GTACCGAAAG AAGCACCAGG AGCTACAGGC CATACAGATG 1920

GAGCTGCAGA GCCCGGACTA TAAGCTCAGC AAGGTCCGAA CCTCCACCAT CATGACGGAC 1980

TATAACCCCA ACTATTGTTT TGCCGGGAAG GTCACCTCTA TCGGCGACCT CAAGGAAGTA 2040

CCGCGCAAAA ATATCTCCCT TATTAGGGGT TTGGGGCACG GGGCATTCGG AGAAGTGTAT 2100

GAAGGGCAAG TGCTGGGTAC CCCAAGTGAC CCGAACCCTT TAAAGGTGGC AGTGAAGACT 2160

CTTCCAGAAG TTTGTTCCGA ACAAGACGAA CTGGACTTTC TGATGGAAGC TCTGATTATA 2220

AGTAAATTCA GCCACCAGAA CATAGTGCGG TGCATCGGTG TCAGCCTGCA GGCGCTGCCC 2280

CGGTTTATCC TCCTGGAACT CATGGCCGGA GGGGACCTGA AATCCTTCCT CAGGCAGACG 2340

CGGCCCCGGC TGAACCAGCC TTCCTCCATC ACCATGTTGG ACCTATTGAA CGTGTCTTGT 2400

GACATCGCCC ATGGCTGCAA GTATCTGGAG GAAAACCATT TCATTCACAG GGATATCGCT 2460

GCCAGGAATT GTCTCCTTAC CTGCCAGGGG TCGGGACGGG TGGCCAAGAT TGGAGATTTC 2520

GGGATGGCGC GGGACATATA CAGGGCCAGC TACTACAGGA AGGGAGGCTG CGCCATGTTG 2580

CCCGTCAAAT GGATGCCACC CGAGGCCTTT ATGGAGGGGA TCTTTACATC TAAGACCGAC 2640

ACGTGGTCCT TCGGAGTCCT GCTGTGGGAG ATCTTCTCTC TGGGATACAT GCCCTACCCC 2700

AGCAAGAGTA ACCAGGAGGT GCTGGAGTTT GTAACGAGCG GAGGAAGGAT GGATCCCCCC 2760

AAGAACTGTC CGGGGCCGGT GTATAACCTC ATCCGTGGCC TTCTTAGAAA ATCGAACAGT 2820

GATCTCCTTA GATTCTCATC AGTAGTCTCC TTAGAACCTC ATAAAATTCA CATCAGTAGT 2880

CTCCTTAGAA CCTCATACGG TGATCTTAGA TTCTCATCAG TAGTCTCCTT AGAACCTCAT 2940

ACAGTGATTA GTCTCCTTAG AACCTCATAC AGTGATCTTA GATTCTCATC AGTAGTCTCC 3000

TTAGAACCTC ATACAGTGAT GACCTCGTAC AGTGATTTCC TTAGAACATT ATCAGTAGTC 3060

TCTTTAGGAA CTTGTCTCAC TAAAACCTAT TCAGTCGCAG TCCTAAAGAT CCTCATCAGT 3120

TTCCTTAGAT CTTTTACCGG GAAAACAGTG GTGAAAACTC CCGGCCCTCC GGATAAACCG 3180

ACCCCCGAGA AGGAGAACCC CCCAAGCTCA GTCACCGAGG GGAACTGCAC GGCTGCCAAT 3240

CGGGTCGCGG GGAGTCGACT CCCAGGATCC TCTCTGCTAC TGGAACCATC AACACTGACT 3300

TCTAACGTTC AGGAAGTGCC TCTCTTCAGG CTCCGCCACT TCCCCTGCGG TACAGTCAAC 3360

TATGGCTACC AGCAGCAGGG CCTGCCCATA GAGCCGCCCA TGGCCCCGCC CCCATGCCCA 3420

CAGAAAGACT CCGCCCCCAG GAGTACGAGC AGCAGTGCCC AGGAGAAACT CTAA 3474

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i l+r+lG+GafGevyeg+v g p+d+ +l+vavktlpe++seqdeldfl+ealiiskf+

Q: 685   ISLIRGLGHGAFGEVYEGQVLGTPSDPNPLKVAVKTLPEVCSEQDELDFLMEALIISKFS  744

         679*********************************************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflr++rp+ +q+ss++m dll+v++d+a+

Q: 745   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRQTRPRLNQPSSITMLDLLNVSCDIAH  804

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gckyleen+fihrdiaarn+ll+++G++rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 805   GCKYLEENHFIHRDIAARNCLLTCQGSGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  864

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 865   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  924

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsil  265

         g+vy++++   +++  d  +f s++

Q: 925   GPVYNLIRGLLRKSNSDLLRFSSVV  949

         ********99999999999888886

Domain Sequence
(FASTA)

ISLIRGLGHG AFGEVYEGQV LGTPSDPNPL KVAVKTLPEV CSEQDELDFL MEALIISKFS 60

HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRQTRPRL NQPSSITMLD LLNVSCDIAH 120

GCKYLEENHF IHRDIAARNC LLTCQGSGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180

MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTSG GRMDPPKNCP 240

GPVYNLIRGL LRKSNSDLLR FSSVV 265

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013