EKS-XET-00513
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00513
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR565.16.9E-170596952357
StatusUnreviewed
Ensembl ProteinENSXETP00000062141
UniProt AccessionF6SUT8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000031823ENSXETP00000062141ENSXETT00000061965
OrganismXenopus tropicalis
Functional Description
Protein Length1085
Protein Sequence
(FASTA)
MKGVTGGAVV PTIFILQLQL WVPTVLLVAS RTSSFSITPP EGSEIVLDLY STYSLYCSSN 60
EELVWEHDGQ FIDSALEVKD GIFTRKLTLF DVTGLNTGQY SCYFNDSVHT TEPVKKSVYI 120
FVPDPSMVFL PVKESEEFIF IIHNVENIIP CRVTDPNMTV TLHERKGDTD IPMHYDNKKG 180
FIGVFSDINY YCKASVNEEE VYTEPFHVYS IQVSTIDMSI EAEKDLVKRG ENITVRCIVT 240
NNEILNFTWD YPAKKIGRTS TPDVIFLPNN SIGSVLTIHN ADLDDSGTYS CSAVEMTLDQ 300
LDSKNIDITV IEQGFVNIIT NESSISYTIQ HKSKLFRINI ESYPPPTIVW LKDNITLTGN 360
KTNQITIVDK ATSKNRYTSH LSLVRVKEQD AGLYTIRVFN EDTTQEKSFY LQINEDDLVL 420
SYTQLYPNQD NSLLACKLNQ IHKSLDLPTI TLSHLCSFLH AVQKCMQMLT TTNGKEGLAL 480
WYTEYTEYSS FLLGNYLYTS NPVFVNCMLQ ILTQYICTYY ILDLPFKIVL VSAILALVVL 540
VLLLLIILVV LWQKKPRYEI RWKVIESVSS DGHEYIYVDP LQLPYDSSWE LPRDKLVLGR 600
TLGSGAFGRV VEATAHGLGH AQSVTKVAVK MLKSTARSSE KQALMSELKI MSHLGPHLNI 660
VNLLAACTKG GPVYIITEYC RYGDLVDYLH RNKHTFLQCY ADKSRKDTGV YSNASIGEEL 720
HSQLTFSSES DGGYMDMTKD DMCYVPMLNQ KGEIKYADIE TSNYGTTYEL ENYSTAAPER 780
TNNVILINES ATLSYTDLIG FSYQVANGME FLASKNCVHR DLAARNVLIC EGKLVKICDF 840
GLARDIMKDS NYISKGSTFL PLKWMAPESI FNNLYTTLSD VWSFGILLWE IFTLGGTPYP 900
ELPMNEQFYN AIKRGYRMSK PSYASEEVYE IMKKCWDEKF ETRPPFSQLV TLTGNLLADT 960
YKQKYKEVDE EFFRSDHPAV VRVRPRINKI NSTMNTGETI ANNILYSVVQ PNDNNDYIIP 1020
LPDPKPEDSD NIFNESSASR PSSTLQEGNT SSTISCDSPL EQPDQDLEHD PCQECQQQDI 1080
EESFL 1085
Nucleotide Sequence
(FASTA)
ATGAAAGGTG TAACAGGCGG TGCTGTAGTA CCCACAATTT TCATTCTCCA ATTACAGTTG 60
TGGGTTCCAA CTGTGTTACT GGTTGCGAGC AGAACCTCTA GCTTTTCTAT CACACCGCCG 120
GAAGGCTCCG AGATTGTGCT CGATCTGTAT AGTACCTACT CCTTATATTG TTCCTCAAAT 180
GAAGAGCTTG TGTGGGAACA TGATGGACAG TTCATCGATT CAGCACTTGA GGTTAAAGAT 240
GGCATCTTCA CCCGAAAACT TACCCTTTTT GATGTGACGG GGCTGAACAC AGGGCAGTAC 300
TCATGCTACT TCAATGATTC CGTCCATACC ACTGAACCTG TGAAGAAATC GGTCTATATC 360
TTTGTACCAG ATCCATCTAT GGTTTTTCTG CCAGTGAAAG AGAGTGAAGA GTTTATTTTC 420
ATTATTCACA ATGTTGAAAA CATCATTCCG TGCCGAGTGA CGGACCCAAA CATGACTGTG 480
ACTCTCCATG AGAGAAAAGG GGATACTGAC ATCCCTATGC ACTACGACAA CAAGAAAGGA 540
TTCATAGGGG TTTTCAGTGA TATCAACTAC TATTGCAAAG CTTCAGTTAA TGAGGAGGAG 600
GTTTACACAG AACCATTTCA TGTCTATAGT ATACAAGTTT CCACAATCGA CATGTCAATT 660
GAAGCAGAGA AGGACTTGGT AAAGAGAGGT GAAAATATCA CTGTTAGATG CATAGTCACT 720
AACAATGAAA TCCTGAACTT TACTTGGGAT TATCCTGCCA AGAAGATAGG AAGGACAAGC 780
ACCCCGGACG TGATATTTCT GCCCAATAAC AGCATAGGTT CTGTTTTGAC CATCCACAAT 840
GCTGATCTCG ATGACTCTGG AACGTACAGT TGCAGCGCTG TGGAGATGAC ATTGGATCAA 900
TTAGACTCAA AAAATATTGA TATAACTGTA ATAGAACAAG GATTTGTAAA TATAATTACG 960
AATGAAAGCA GCATATCCTA TACTATCCAG CATAAAAGCA AATTATTTAG AATCAACATT 1020
GAGTCCTACC CACCACCCAC CATTGTCTGG CTAAAAGACA ACATTACCCT AACAGGCAAT 1080
AAAACCAACC AAATCACTAT TGTGGACAAA GCTACATCTA AAAACAGGTA CACAAGTCAC 1140
TTATCCCTTG TGCGAGTGAA AGAACAGGAC GCAGGCCTCT ACACAATCAG GGTTTTTAAT 1200
GAAGATACAA CTCAAGAGAA GTCTTTCTAC CTCCAGATAA ATGAAGATGA CTTAGTTTTG 1260
TCTTATACTC AGCTTTATCC CAACCAAGAT AATAGTCTCT TAGCTTGCAA ATTGAACCAA 1320
ATTCATAAAA GTTTAGATCT ACCAACTATA ACATTATCAC ATCTCTGTTC ATTCTTGCAT 1380
GCTGTACAAA AGTGCATGCA AATGCTGACT ACTACAAATG GAAAAGAGGG CCTTGCTCTG 1440
TGGTACACTG AATATACTGA ATATAGTTCT TTCCTGTTGG GTAATTATCT ATACACTAGT 1500
AATCCTGTCT TTGTTAATTG CATGCTGCAG ATACTCACAC AATATATATG CACTTATTAT 1560
ATTTTAGATT TGCCCTTTAA GATTGTGCTT GTATCTGCCA TCCTGGCATT GGTAGTGCTG 1620
GTTCTGCTTC TTTTGATTAT CCTTGTCGTC TTGTGGCAAA AGAAACCTCG ATATGAAATC 1680
CGATGGAAGG TCATTGAATC GGTCAGCTCT GATGGCCATG AATACATATA TGTTGACCCT 1740
TTGCAGCTTC CGTACGATTC TAGCTGGGAG CTTCCCAGAG ATAAGTTAGT GCTAGGTCGA 1800
ACACTTGGTT CTGGGGCATT TGGCAGGGTG GTAGAGGCCA CAGCCCATGG ATTAGGCCAC 1860
GCCCAGTCGG TCACAAAAGT AGCTGTAAAA ATGCTAAAAT CAACCGCCAG AAGCAGCGAG 1920
AAACAGGCTC TCATGTCTGA GCTGAAGATT ATGAGCCATC TTGGGCCACA TCTCAATATT 1980
GTCAACCTGC TGGCAGCATG CACCAAAGGC GGACCTGTTT ATATCATAAC TGAGTATTGT 2040
CGTTACGGAG ACTTAGTTGA TTACCTGCAT CGTAACAAGC ACACGTTTCT TCAGTGCTAT 2100
GCTGATAAGA GCAGAAAGGA CACTGGAGTG TACAGTAACG CTTCTATTGG GGAAGAACTG 2160
CACAGTCAGT TGACATTTTC CTCTGAAAGC GATGGAGGCT ACATGGATAT GACCAAAGAT 2220
GACATGTGTT ATGTGCCGAT GCTAAACCAA AAAGGAGAAA TCAAATATGC TGATATTGAA 2280
ACTTCAAACT ATGGCACCAC ATATGAGCTG GAGAATTACT CAACAGCAGC TCCAGAGAGG 2340
ACAAACAACG TCATCCTCAT AAACGAGTCG GCGACTCTCA GTTATACTGA TCTGATTGGA 2400
TTCAGCTACC AAGTGGCCAA CGGAATGGAA TTCCTTGCCT CAAAAAATTG TGTTCATCGT 2460
GATTTGGCAG CAAGGAACGT GCTTATCTGC GAGGGAAAGC TGGTTAAGAT TTGTGACTTT 2520
GGGCTAGCCA GAGACATCAT GAAGGATTCC AACTACATCT CCAAAGGAAG CACATTCCTC 2580
CCTTTAAAAT GGATGGCGCC TGAGAGTATT TTCAACAATT TATACACAAC ATTAAGTGAC 2640
GTGTGGTCTT TCGGAATTCT CCTTTGGGAA ATTTTCACTT TGGGTGGAAC TCCATACCCC 2700
GAATTACCAA TGAATGAACA GTTCTACAAT GCCATAAAGC GAGGCTACCG AATGTCAAAG 2760
CCTTCCTATG CTTCAGAGGA AGTATATGAA ATCATGAAAA AATGCTGGGA TGAGAAGTTT 2820
GAGACAAGAC CACCATTTTC TCAGCTGGTG ACACTCACAG GGAATCTTCT GGCTGACACC 2880
TACAAACAGA AATACAAAGA AGTGGATGAG GAATTCTTTA GAAGCGATCA TCCTGCGGTT 2940
GTGCGAGTGA GGCCTAGAAT CAATAAAATC AACAGCACCA TGAATACTGG GGAAACTATA 3000
GCAAACAATA TTCTGTATTC AGTGGTGCAA CCAAATGACA ATAATGATTA CATTATTCCA 3060
CTGCCGGATC CCAAGCCCGA GGATTCTGAT AACATATTTA ATGAGAGTTC CGCCAGTCGT 3120
CCGAGCTCTA CACTACAGGA AGGCAATACT TCATCTACGA TTTCCTGTGA CAGCCCCTTG 3180
GAGCAGCCAG ATCAGGATTT AGAACATGAC CCATGTCAAG AGTGTCAACA GCAGGACATA 3240
GAGGAGAGTT TTCTGTAG 3258
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gl+++++v kvavkmlkstarssek+almselki+shlG
Q: 596   LVLGRTLGSGAFGRVVEATAHGLGHAQSVTKVAVKMLKSTARSSEKQALMSELKIMSHLG  655
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnll actkgGp+y+iteyc+yGdl++yl+r++++fl+ +++k+++++  ++s+ 
Q: 656   PHLNIVNLLAACTKGGPVYIITEYCRYGDLVDYLHRNKHTFLQCYADKSRKDTG-VYSN-  713
         ********************************************9999665444.4443.
S: 121   lladkslrsksslssesseeyvdlkkd...............vsdvssskadklasekkk  165
            +++l+s+ ++sses++ y+d+ kd               ++d+++s++ ++++ ++ 
Q: 714   ASIGEELHSQLTFSSESDGGYMDMTKDdmcyvpmlnqkgeikYADIETSNYGTTYELENY  773
         457999*********************************************998876655
S: 166   s..alerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteG  223
         s  a er+ +  l++e s +l+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eG
Q: 774   StaAPERTNNVILINE-SATLSYTDLIGFSYQVANGMEFLASKNCVHRDLAARNVLICEG  832
         5115566666666666.99*****************************************
S: 224   kvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweif  283
         k+vkicdfGlardimkdsny++kG+++lp+kwmapesif++lyt+ sdvws+Gillweif
Q: 833   KLVKICDFGLARDIMKDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEIF  892
         ************************************************************
S: 284   slGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         +lG+tpyp+l+++++fy++ik+Gyrm++p+ya+ee+yeim+kcw++++e+rp+f+qlv+l
Q: 893   TLGGTPYPELPMNEQFYNAIKRGYRMSKPSYASEEVYEIMKKCWDEKFETRPPFSQLVTL  952
         *********************************************************987
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA HGLGHAQSVT KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLA ACTKGGPVYI ITEYCRYGDL VDYLHRNKHT FLQCYADKSR KDTGVYSNAS 120
IGEELHSQLT FSSESDGGYM DMTKDDMCYV PMLNQKGEIK YADIETSNYG TTYELENYST 180
AAPERTNNVI LINESATLSY TDLIGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 240
KICDFGLARD IMKDSNYISK GSTFLPLKWM APESIFNNLY TTLSDVWSFG ILLWEIFTLG 300
GTPYPELPMN EQFYNAIKRG YRMSKPSYAS EEVYEIMKKC WDEKFETRPP FSQLVTL 357
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DRM-00197
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013