EKS-XET-00535

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00535

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	300.3	1.2E-89	217	487	271

Status

Unreviewed

Ensembl Protein

ENSXETP00000060361

UniProt Accession

F6W523;

Protein Name

Protein Synonyms/Alias

Wee1-like protein kinase 2;

Gene Name

wee2

Gene Synonyms/Alias

wee2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000031988	ENSXETP00000060361	ENSXETT00000063226

Organism

Xenopus tropicalis

Functional Description

Protein Length

563

Protein Sequence
(FASTA)

MRTAMSCGGG LAQRLDFSSS DEEDGMSPGL EEGSHSNQRG SPVNSWRANN CPFPITPQRN 60

ERGLSPSQEE LSPCSDYSPV PSDKGVGGEC PGTPLHYSTW KKLKLCDTPY TPKSLLYKTL 120

PSPGSRVQCR GQRLLRFVAG TGAELDDPAL VNVNPFTPES YRQANFHPNG KRKERPEDDC 180

SAEPQMKYAE KEHPAVFQSK RFVLRETNMV SRYKTEFLEI EKIGAGEFGS VFKCVKRLDG 240

CFYAIKRSKK PLAGSTDEQL ALREVYAHAV LGHHPHVVRY YSAWAEDDHM IIQNEYCNGG 300

SLQDLIMENK KEGRFVPEQE LKEILLQVSM GLKYIHSSGL VHMDIKPKRL GESQCEREWG 360

VEQKGGSLGY DLRSLPISIA GDLGHVTSIL NPQVEEGDSR FLANEILQED YRQLPKADIF 420

ALGLTITLAA GAGPLPCNED SWHHIRKGNL PHIPQPLTPA FLALLKLLVH PDPVMRPPAV 480

SLAKNSLLRR CVGKAAQLQK QLNVEKFKTA MLERELKAAK LAHGSGKDEC SDLPPMSDFS 540

CRGRKRLVGA KNARSLSFTC GGY 563

Nucleotide Sequence
(FASTA)

ATGAGGACGG CCATGTCGTG CGGAGGAGGG TTGGCGCAGC GTCTAGACTT TTCCAGCAGT 60

GATGAAGAGG ATGGAATGAG CCCTGGACTG GAGGAAGGCT CCCATAGCAA CCAGAGGGGT 120

AGTCCTGTGA ATTCATGGAG GGCAAATAAT TGCCCCTTCC CAATCACCCC TCAGAGGAAT 180

GAGAGGGGGC TTTCTCCTTC TCAGGAGGAG CTGAGCCCGT GTAGCGACTA CTCGCCTGTC 240

CCAAGTGACA AGGGTGTGGG GGGCGAATGC CCTGGTACCC CCCTGCACTA CAGCACGTGG 300

AAGAAGCTCA AGCTGTGTGA TACCCCTTAT ACCCCAAAGA GCCTTTTGTA CAAAACTCTC 360

CCCTCCCCGG GGTCCCGAGT GCAGTGTCGG GGTCAAAGGC TCCTCCGTTT TGTGGCTGGA 420

ACCGGGGCGG AATTGGATGA TCCGGCTCTG GTCAATGTTA ACCCCTTCAC CCCAGAATCC 480

TACAGGCAAG CGAATTTCCA CCCCAACGGG AAGAGGAAGG AGAGGCCAGA AGACGACTGC 540

AGCGCTGAGC CCCAGATGAA ATACGCAGAG AAGGAGCACC CAGCAGTTTT CCAGTCGAAA 600

AGATTCGTGT TACGGGAGAC CAACATGGTG TCTCGCTACA AGACGGAATT CCTGGAGATC 660

GAGAAGATCG GCGCCGGGGA GTTCGGATCT GTGTTCAAGT GCGTAAAGCG CCTGGACGGT 720

TGTTTCTATG CCATCAAACG CTCCAAAAAG CCATTGGCTG GCTCCACAGA TGAGCAGCTG 780

GCACTGAGAG AAGTGTACGC CCACGCGGTT CTGGGTCACC ACCCCCATGT TGTGCGCTAT 840

TACTCCGCGT GGGCGGAGGA TGATCACATG ATCATTCAGA ATGAGTACTG CAATGGTGGC 900

AGCCTGCAGG ATCTGATCAT GGAGAATAAA AAGGAGGGAC GGTTTGTGCC GGAGCAGGAG 960

CTGAAGGAGA TTCTTCTACA AGTGTCAATG GGCCTGAAAT ACATCCACAG CTCCGGCCTC 1020

GTGCATATGG ACATCAAGCC AAAGAGATTG GGAGAAAGTC AGTGTGAGAG GGAATGGGGA 1080

GTAGAACAGA AAGGGGGTTC CCTGGGGTAT GATCTAAGAT CTCTACCAAT TTCTATTGCA 1140

GGAGACCTTG GGCATGTGAC TTCTATACTT AACCCCCAGG TGGAAGAAGG AGACAGCAGG 1200

TTCCTGGCCA ATGAGATCCT GCAGGAGGAT TACAGGCAGC TGCCAAAGGC GGACATCTTT 1260

GCACTTGGTC TCACCATCAC CTTGGCAGCC GGAGCCGGAC CTCTTCCTTG CAACGAAGAC 1320

AGCTGGCACC ATATCCGAAA GGGCAACTTG CCCCACATTC CCCAGCCGCT GACTCCTGCC 1380

TTCCTGGCTC TGCTCAAGCT GCTGGTTCAT CCCGACCCGG TTATGAGACC CCCGGCTGTA 1440

TCTCTGGCTA AGAATTCTCT GCTGAGGCGC TGTGTTGGCA AGGCGGCCCA GCTACAGAAA 1500

CAACTCAATG TGGAGAAGTT CAAGACTGCC ATGCTTGAGA GGGAGCTGAA AGCTGCTAAA 1560

TTAGCCCACG GTTCTGGGAA GGACGAGTGT TCGGACCTGC CCCCCATGTC GGACTTCTCC 1620

TGCCGCGGAA GGAAACGCCT TGTTGGGGCA AAAAACGCTC GTTCTCTGAG CTTCACCTGC 1680

GGGGGCTACT AG 1692

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+ekiG Gefg+vfk+vkr+dg+ yAik+skkpl+g+++e+ alrEv+ahavlg+h++

Q: 217   FLEIEKIGAGEFGSVFKCVKRLDGCFYAIKRSKKPLAGSTDEQLALREVYAHAVLGHHPH  276

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+ggsL++ + e+++  + ++e+elk+ill+++ gl+y+H

Q: 277   VVRYYSAWAEDDHMIIQNEYCNGGSLQDLIMENKKEGRFVPEQELKEILLQVSMGLKYIH  336

         ************************************************************

S: 121   ssslvHlDikpenifi....................tkevtlklgDlGlvtelnsedksk  160

         ss lvH+Dikp+ +                       +  +   gDlG+vt++    +++

Q: 337   SSGLVHMDIKPKRLGEsqcerewgveqkggslgydlRSLPISIAGDLGHVTSI---LNPQ  393

         ************998899***************987666666779********...89**

S: 161   veEGDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpde  219

         veEGDsr+la+Eilqe+y++l kaDiF+lglti  +a++ +lP n ++Wh++Rkg+lp +

Q: 394   VEEGDSRFLANEILQEDYRQLpKADIFALGLTITLAAGAGPLPCNEDSWHHIRKGNLP-H  452

         **********************************************************.*

S: 220   ilkelsedlrellklmlepdperRptaeellkhev  254

         i + l+  +  llkl+++pdp  Rp a +l+k++

Q: 453   IPQPLTPAFLALLKLLVHPDPVMRPPAVSLAKNSL  487

         ******************************99875

Domain Sequence
(FASTA)

FLEIEKIGAG EFGSVFKCVK RLDGCFYAIK RSKKPLAGST DEQLALREVY AHAVLGHHPH 60

VVRYYSAWAE DDHMIIQNEY CNGGSLQDLI MENKKEGRFV PEQELKEILL QVSMGLKYIH 120

SSGLVHMDIK PKRLGESQCE REWGVEQKGG SLGYDLRSLP ISIAGDLGHV TSILNPQVEE 180

GDSRFLANEI LQEDYRQLPK ADIFALGLTI TLAAGAGPLP CNEDSWHHIR KGNLPHIPQP 240

LTPAFLALLK LLVHPDPVMR PPAVSLAKNS L 271

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013