EKS-XET-00516

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00516

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	506.1	6.2E-152	529	859	331

Status

Unreviewed

Ensembl Protein

ENSXETP00000062710

UniProt Accession

F6Y4D9;

Protein Name

Protein Synonyms/Alias

Gene Name

FLT3

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000032628	ENSXETP00000062710	ENSXETT00000061895

Organism

Xenopus tropicalis

Functional Description

Protein Length

878

Protein Sequence
(FASTA)

VEVNVFDSVT LEVTQNVSGI VSCAWVLRDN SAPCRVLQNG NSSLVVSLEL VRMSEKDSGE 60

YKLLINNNNV SYSVHIELKV KDFQIFLSKP RKPFFTESQG TVSCISDGYP EPTVYWLMPS 120

SPHGRCKQAP PPTSMHTSYL PHHDRGREEE YIWCCATNAF GTECTQMYTL DLNSERDLPK 180

ISVTVGEPFI IRCRAIHESF KFGVKWSSNS TDKKELHTFE KTSYVRSPQE SRMVRVLFAT 240

SSQIKKANSG IYTCSSTHQQ SKSVQVILLD KGFIRLNTSR EEYTIDQSKE FCFHVTFEAY 300

PAARCTWLYQ SSHFPCENTT EGARNNSTSK YCNHKYMPGE YTFYIENEDV QLHKTFILHL 360

LSEVVSNDKE KLTYNDDLPV LETITHLVIS NKCHLLFQYK PTSAHSAVSS HRVFGCHPVL 420

CLHHPGTNYL LALVLVFTIA TIVELGAAKT EPKYYISQLP LGFPVGVSTC KPNILFLIAL 480

IYSKSQKKNL YQSQLQMIQY IGPSDNEYIY IDFSILEYDL KWEFPRENLE FGKVLGSGAF 540

GRVVTATAYG ITKPGVSLQV AVKMLKENAD GSEKDALMSE LKMMTQIGHH QNIVNMLGAC 600

TAAATTGPVY LIFEYCRHGD LLNYLRNERE TFHKTWTDVV KDHNFSFYHN FTQHQKPSYP 660

GFNQVPGRLE AEQVPGKWVE EVIKYENTRC YDEEDLHVLT FEDLLCFSYQ VAKGMEFLES 720

KLCIHRDLAA RNILITNGKV AKICDFGLAR DIENDLNYVV KGNARLPVKW MAPESIFEGI 780

YTIKSDVWSY GILLWEIFSL GINPYPGIQV NAQFYKLLQS GFKMEQPFYS TNEIYFLMQS 840

CWAFDSRKRP SFPQLVSFLG YQISNTEALV CQNAQGRI 878

Nucleotide Sequence
(FASTA)

GTGGAAGTAA ATGTATTTGA CTCTGTAACA CTGGAAGTGA CCCAGAATGT AAGTGGGATT 60

GTATCTTGTG CCTGGGTTCT CCGAGACAAC AGCGCGCCAT GCAGAGTGTT ACAGAATGGG 120

AACAGCAGCC TCGTCGTTTC TTTGGAACTA GTAAGAATGT CAGAGAAAGA CTCCGGGGAA 180

TATAAACTCC TCATTAACAA TAACAATGTC AGCTACTCTG TGCATATTGA ATTAAAGGTT 240

AAAGATTTTC AGATTTTTTT AAGCAAACCA AGGAAACCAT TTTTCACAGA ATCTCAGGGA 300

ACTGTGAGCT GCATATCTGA TGGATACCCT GAACCCACTG TTTATTGGTT AATGCCCTCA 360

TCCCCCCACG GCAGATGTAA GCAAGCCCCC CCCCCCACAA GCATGCATAC CTCATACTTA 420

CCACACCATG ATCGGGGGAG GGAGGAAGAA TATATTTGGT GTTGTGCAAC TAATGCCTTT 480

GGCACAGAAT GTACCCAAAT GTATACATTA GACCTTAATT CTGAGAGAGA CCTACCCAAA 540

ATATCTGTTA CGGTTGGGGA GCCCTTTATT ATAAGGTGTC GTGCTATACA TGAATCCTTT 600

AAATTTGGTG TAAAATGGTC CTCTAACAGT ACAGATAAGA AGGAGCTGCA CACCTTTGAA 660

AAAACGTCAT ATGTTCGAAG CCCACAAGAG TCACGTATGG TCAGAGTCTT ATTCGCAACA 720

TCTTCACAGA TAAAGAAAGC AAACAGCGGC ATTTATACCT GTTCCTCAAC CCACCAACAA 780

AGCAAGTCAG TCCAGGTTAT CCTCTTAGAT AAAGGTTTCA TTCGCCTGAA TACTTCAAGG 840

GAAGAGTACA CTATTGACCA GAGCAAAGAG TTTTGTTTCC ATGTAACATT CGAAGCATAC 900

CCAGCAGCAC GGTGTACGTG GCTTTACCAG TCCAGCCATT TCCCATGTGA AAACACTACG 960

GAGGGAGCAA GGAACAACAG CACGTCCAAG TACTGCAACC ATAAATATAT GCCTGGAGAG 1020

TATACGTTCT ACATAGAAAA TGAAGATGTG CAGCTCCACA AAACATTCAT TTTACATCTA 1080

CTGAGTGAGG TGGTCAGTAA TGACAAGGAA AAGCTGACAT ATAATGATGA TTTGCCTGTA 1140

TTAGAAACAA TAACCCACTT GGTGATATCA AATAAGTGTC ACCTTCTTTT TCAATATAAG 1200

CCTACATCTG CGCACTCCGC AGTCAGCTCA CACAGAGTTT TTGGGTGTCA CCCTGTTTTG 1260

TGCCTCCACC ACCCAGGCAC CAATTACCTG CTTGCACTTG TATTAGTATT TACAATTGCC 1320

ACAATAGTGG AACTGGGTGC TGCCAAGACA GAACCTAAAT ATTACATTTC ACAGTTGCCA 1380

CTTGGCTTTC CTGTTGGTGT CAGTACCTGT AAGCCCAACA TCCTTTTCTT AATTGCACTG 1440

ATTTATAGCA AATCCCAAAA GAAGAACCTC TATCAAAGCC AGTTACAAAT GATTCAGTAC 1500

ATTGGCCCAT CAGACAATGA ATACATATAC ATTGATTTCA GTATCTTGGA GTATGATCTA 1560

AAATGGGAGT TCCCTAGGGA AAATCTGGAA TTTGGGAAAG TATTAGGTTC TGGGGCGTTT 1620

GGAAGGGTGG TGACCGCAAC CGCATATGGT ATTACCAAGC CAGGGGTCTC ACTTCAAGTT 1680

GCTGTAAAAA TGCTCAAAGA GAATGCTGAT GGTTCGGAAA AAGATGCGCT TATGTCAGAA 1740

CTAAAGATGA TGACTCAAAT TGGGCACCAT CAAAACATAG TCAATATGCT GGGAGCGTGC 1800

ACAGCGGCAG CAACAACAGG ACCTGTTTAC CTAATTTTTG AATACTGTCG TCATGGAGAT 1860

CTTCTAAATT ATTTGAGAAA TGAACGAGAA ACATTTCACA AAACATGGAC AGATGTTGTC 1920

AAGGACCATA ACTTTAGTTT CTACCATAAT TTTACTCAGC ACCAAAAACC CAGTTATCCT 1980

GGCTTTAATC AAGTTCCTGG GAGACTGGAA GCAGAGCAGG TCCCTGGTAA GTGGGTGGAG 2040

GAGGTAATCA AATATGAAAA CACAAGATGT TATGATGAAG AAGACCTGCA TGTTCTGACA 2100

TTTGAAGACC TGCTGTGCTT TTCATATCAA GTTGCCAAGG GGATGGAGTT CCTTGAGTCA 2160

AAACTTTGTA TCCACAGGGA TCTCGCAGCA AGAAATATCC TGATAACCAA TGGGAAAGTG 2220

GCCAAAATAT GCGACTTTGG ACTTGCTAGA GATATTGAGA ATGACTTAAA CTATGTGGTC 2280

AAAGGCAATG CTCGTCTGCC AGTCAAATGG ATGGCACCAG AAAGCATATT TGAAGGCATA 2340

TATACCATAA AAAGTGATGT GTGGTCATAT GGCATATTAC TGTGGGAGAT CTTTTCTCTT 2400

GGAATTAATC CCTATCCTGG CATTCAGGTT AATGCCCAGT TCTACAAGCT CCTGCAAAGC 2460

GGATTTAAAA TGGAACAGCC ATTCTACTCC ACTAATGAGA TATATTTCCT GATGCAATCC 2520

TGCTGGGCGT TTGATTCTAG GAAAAGACCA TCTTTCCCAC AGCTTGTTTC CTTTTTGGGA 2580

TATCAGATTT CAAATACGGA AGCTTTGGTA TGTCAAAATG CACAGGGAAG GATA 2634

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         le+GkvlGsGafG+vv atayG++k +++l+vavkmlk++a+ sek+almselk+++++G

Q: 529   LEFGKVLGSGAFGRVVTATAYGITKPGVSLQVAVKMLKENADGSEKDALMSELKMMTQIG  588

         79**********************************************************

S: 61    ehenivnllGactk...gGpiyviteyccyGdllnylrrkresflkkslekkkekeeeld  117

         +h+nivn+lGact    +Gp+y+i+eyc++Gdllnylr++re+f+k++++  k+++++++

Q: 589   HHQNIVNMLGACTAaatTGPVYLIFEYCRHGDLLNYLRNERETFHKTWTDVVKDHNFSFY  648

         ************963336****************************************99

S: 118   skalladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaale  177

         ++       + ++++ s ++ ++ v  + + ++v  +         ++++++ e +   +

Q: 649   HN-------FTQHQKPSYPGFNQ-VPGRLEAEQVPGK--------WVEEVIKYENTRCYD  692

         98.......55666666666555.3333333333333........333344444555679

S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237

         eed +vl++edll+fsyqvakGmefl+sk c+hrdlaarn+l+t+Gkv+kicdfGlardi

Q: 693   EEDLHVLTFEDLLCFSYQVAKGMEFLESKLCIHRDLAARNILITNGKVAKICDFGLARDI  752

         99**********************************************************

S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297

          +d nyvvkGnarlpvkwmapesif+++yt+ksdvwsyGillweifslG +pypg+ v++

Q: 753   ENDLNYVVKGNARLPVKWMAPESIFEGIYTIKSDVWSYGILLWEIFSLGINPYPGIQVNA  812

         ************************************************************

S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         +fykl+++G++m+qp+y+t+eiy +mq+cw+++++krpsf qlv++l

Q: 813   QFYKLLQSGFKMEQPFYSTNEIYFLMQSCWAFDSRKRPSFPQLVSFL  859

         ********************************************986

Domain Sequence
(FASTA)

LEFGKVLGSG AFGRVVTATA YGITKPGVSL QVAVKMLKEN ADGSEKDALM SELKMMTQIG 60

HHQNIVNMLG ACTAAATTGP VYLIFEYCRH GDLLNYLRNE RETFHKTWTD VVKDHNFSFY 120

HNFTQHQKPS YPGFNQVPGR LEAEQVPGKW VEEVIKYENT RCYDEEDLHV LTFEDLLCFS 180

YQVAKGMEFL ESKLCIHRDL AARNILITNG KVAKICDFGL ARDIENDLNY VVKGNARLPV 240

KWMAPESIFE GIYTIKSDVW SYGILLWEIF SLGINPYPGI QVNAQFYKLL QSGFKMEQPF 300

YSTNEIYFLM QSCWAFDSRK RPSFPQLVSF L 331

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013