EKS-XET-00487

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XET-00487

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	364.4	3.0E-109	238	486	249

Status

Unreviewed

Ensembl Protein

ENSXETP00000059101

UniProt Accession

F7B4H0;

Protein Name

Protein Synonyms/Alias

Gene Name

LOC100491303

Gene Synonyms/Alias

LOC100491303;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXETG00000033189	ENSXETP00000059101	ENSXETT00000064719

Organism

Xenopus tropicalis

Functional Description

Protein Length

499

Protein Sequence
(FASTA)

QDLLQENFPH IMESFLREQL NCLNCLWDRI WSPLSSNGGV SVITPHRDFN STENIVTALY 60

NFDARCTEEL TIEQGEELYK IRDDGEYIFA RKLTGMESGL VPASYVAQSS LPGGHYTIQE 120

PWYMEVANRN EAERLLLSPP NAHGSFLVRP SDSTPGHYSL SDTVRNQDKV SHFRISVSAG 180

GEFYIQNERL FASIEELINF YKVNWKLIKS QLLQPCVWPY WVPRLQRDQW ERPRSEFVLV 240

KELGAGNFGE VWEGLWNNKD KVAIKTFKQD NINESDFKKE VDALKTLCHR NLIQLYAVCS 300

VGEPVYIVTE LMSKGSLQQF LRGNEGRYLT AANFMHIISQ VAEGMAYLEN NHVVHRDLAA 360

RNVLVGEELV CKVADFGLAR ILKDDLYLMH SSKNVPVKWT APEALTHGKY STKSDVWSYG 420

IVIYEVFILG QPPYQGMNNR QVLDKITSGY RLPKPDLCSP DIYNLMLECW QEKPNQRPSF 480

YDLVRKLTAI QSSLRIGTT 499

Nucleotide Sequence
(FASTA)

CAGGATCTCT TGCAGGAGAA CTTTCCTCAC ATCATGGAGT CCTTTCTAAG GGAACAGCTG 60

AATTGTCTGA ATTGTCTGTG GGACAGGATC TGGTCTCCTC TGAGCAGTAA TGGGGGGGTA 120

TCAGTTATCA CACCCCACAG GGATTTCAAC TCTACAGAAA ACATAGTCAC AGCCCTGTAC 180

AATTTTGATG CCCGGTGTAC AGAAGAGCTG ACAATTGAGC AGGGGGAAGA GCTGTACAAG 240

ATACGTGATG ATGGTGAATA CATCTTTGCC AGGAAACTAA CAGGCATGGA AAGTGGGTTG 300

GTTCCGGCAT CCTACGTGGC CCAGTCCAGT CTCCCAGGGG GTCACTACAC CATCCAGGAA 360

CCTTGGTACA TGGAAGTGGC CAATCGCAAT GAAGCTGAAA GGCTTCTCTT GAGCCCTCCG 420

AATGCCCATG GCTCGTTCCT TGTGCGCCCC AGTGATAGCA CCCCCGGGCA TTACTCACTA 480

TCTGACACAG TGCGCAACCA GGACAAAGTC TCCCATTTCC GCATCAGCGT CAGTGCCGGG 540

GGCGAGTTTT ACATTCAGAA TGAAAGATTA TTTGCCTCCA TTGAAGAACT CATCAACTTC 600

TATAAAGTAA ACTGGAAACT CATCAAAAGT CAGTTGTTGC AGCCTTGCGT GTGGCCTTAC 660

TGGGTCCCCA GACTGCAGAG AGACCAGTGG GAAAGGCCAC GCAGTGAGTT TGTATTGGTT 720

AAGGAACTGG GAGCAGGGAA TTTTGGAGAA GTATGGGAAG GCCTCTGGAA TAACAAAGAT 780

AAAGTGGCCA TAAAGACCTT CAAACAAGAC AACATCAACG AGAGTGATTT TAAGAAGGAG 840

GTAGATGCCC TCAAGACCTT GTGTCACAGG AACCTGATCC AACTTTATGC AGTTTGCTCA 900

GTAGGAGAAC CAGTCTATAT AGTCACTGAG CTCATGTCTA AAGGAAGCCT CCAGCAGTTC 960

CTGAGAGGTA ACGAAGGACG TTATTTAACA GCCGCTAATT TCATGCACAT CATCTCTCAG 1020

GTGGCAGAGG GGATGGCGTA TCTAGAGAAC AATCATGTAG TCCATCGAGA CTTGGCCGCC 1080

CGCAACGTGC TTGTGGGGGA GGAGCTGGTG TGCAAGGTGG CAGATTTTGG GTTGGCCAGA 1140

ATACTCAAGG ATGATTTATA CTTAATGCAC AGCAGTAAGA ACGTCCCAGT TAAATGGACT 1200

GCCCCTGAGG CCCTGACCCA CGGCAAATAC TCCACAAAGT CCGATGTCTG GTCGTATGGT 1260

ATTGTGATAT ATGAAGTCTT CATACTGGGA CAGCCGCCCT ACCAAGGAAT GAATAACCGT 1320

CAAGTGTTGG ATAAAATCAC ATCAGGATAC AGACTCCCCA AGCCGGATCT CTGTAGCCCC 1380

GATATTTACA ACTTGATGTT GGAATGTTGG CAGGAAAAAC CCAACCAAAG ACCGAGCTTC 1440

TATGACCTTG TGAGGAAACT GACTGCCATC CAGAGTAGCC TCCGGATTGG CACAACC 1497

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

          lvk+lG+G+fGevw+g+w+++ kva+kt+k++++++++f +e+++lk+l h++l++lya

Q: 238   VLVKELGAGNFGEVWEGLWNNKDKVAIKTFKQDNINESDFKKEVDALKTLCHRNLIQLYA  297

         589*********************************************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yivtelm+kGsl++fl+ +eg++l+  +++++ +qvaeGmayle+++++hrd

Q: 298   VCSVGEPVYIVTELMSKGSLQQFLRGNEGRYLTAANFMHIISQVAEGMAYLENNHVVHRD  357

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarnvlvge+lv+kvadfGlar+++dd y +++++++P+kWtaPea++ gk+++ksdvW

Q: 358   LAARNVLVGEELVCKVADFGLARILKDDLYLMHSSKNVPVKWTAPEALTHGKYSTKSDVW  417

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         s+Gi+++e++  G+ Py+Gm+n++vl++++ gyrlp+p+ c  ++y+l+lecw+++p++r

Q: 418   SYGIVIYEVFILGQPPYQGMNNRQVLDKITSGYRLPKPDLCSPDIYNLMLECWQEKPNQR  477

         ************************************************************

S: 242   Ptfetlqev  250

         P+f  l ++

Q: 478   PSFYDLVRK  486

         ***988766

Domain Sequence
(FASTA)

VLVKELGAGN FGEVWEGLWN NKDKVAIKTF KQDNINESDF KKEVDALKTL CHRNLIQLYA 60

VCSVGEPVYI VTELMSKGSL QQFLRGNEGR YLTAANFMHI ISQVAEGMAY LENNHVVHRD 120

LAARNVLVGE ELVCKVADFG LARILKDDLY LMHSSKNVPV KWTAPEALTH GKYSTKSDVW 180

SYGIVIYEVF ILGQPPYQGM NNRQVLDKIT SGYRLPKPDL CSPDIYNLML ECWQEKPNQR 240

PSFYDLVRK 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013