EKS-XET-00091
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-XET-00091
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec431.97.3E-130372622251
StatusUnreviewed
Ensembl ProteinENSXETP00000009530
UniProt AccessionF7D3B3;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSXETG00000033235ENSXETP00000009530ENSXETT00000009530
OrganismXenopus tropicalis
Functional Description
Protein Length628
Protein Sequence
(FASTA)
MNNPVILQQQ LIKKSQQKRR TSPANYKSRI FILTHSSLNY YEHRQGKIRA LRGSIDLARI 60
KCVEIVTTDL SIACRNKYPF QVIHDYFLYV FAPDRESRQK WVLALKEETK DNDFLVAKYH 120
SNFWLEGRWR CCFQTEKMAT GCALYDRSKD VVLSNVPDTP QIQISKKPLP PTPNDNMANQ 180
GWEVALYDYK AQSSQELTLC RGEEYLPLDT SEPHWWKVLD KNGPSASGNV PQMSLNYNSH 240
HSLRGYVYYC IFNSIHSACS TYHRATGKEG AFMVRDSRQP GLYTVSIFTK ALGENNHAVK 300
HYHIRHTNDS PAKYYLAEKH VFNSIPELIN YHQHNGAGTE NKLTWAMFTQ HSFRALAHGG 360
PWRKWEIDPT HLTLKEEIGS GQFGVVQLAI WQGTTKVAVK MIREGMMSEE DFVEEAQVLM 420
KLSHPKLVQL LGVCTQQVPI FLVFEYMKYG CLFNYLRSHR GTLSKETALG MCQDVCEGMQ 480
YLERSNFIHR DLAARNCLVG ESLVVKVSDF GMTRFVLDDQ YTSSSGTKFP VKWSAPEVFR 540
FGLYSSRSDV WSFGVLVWEV FSEGKIPFEH LSNSEAVEKI SAGLRLFKPK MSSERVYKLM 600
NNCWQEKADL RPTFQQLLKE VMDIAECD 628
Nucleotide Sequence
(FASTA)
ATGAATAACC CTGTTATCCT GCAACAACAG CTTATTAAGA AGTCCCAGCA GAAGAGAAGG 60
ACGTCCCCAG CTAACTACAA GTCCAGGATC TTCATCCTGA CCCACTCTTC ACTCAACTAC 120
TACGAGCATC GGCAAGGGAA AATACGTGCT CTCCGTGGCT CCATTGACTT GGCTCGGATT 180
AAATGTGTCG AGATTGTTAC CACTGATCTC AGCATTGCTT GCAGGAACAA ATACCCATTT 240
CAGGTTATCC ATGATTATTT TCTGTACGTC TTTGCTCCTG ACAGAGAGAG TCGTCAAAAG 300
TGGGTGCTGG CACTGAAAGA AGAGACCAAA GACAATGACT TTCTTGTGGC TAAATATCAC 360
TCCAACTTCT GGTTGGAAGG GAGATGGAGA TGTTGCTTCC AGACAGAGAA AATGGCCACC 420
GGCTGTGCCT TGTACGACAG GAGCAAAGAT GTGGTTCTAT CCAATGTACC GGATACTCCT 480
CAGATTCAAA TCTCAAAGAA GCCTCTGCCC CCCACACCCA ATGACAACAT GGCGAACCAA 540
GGCTGGGAGG TGGCACTGTA TGATTACAAG GCACAAAGCA GCCAGGAGCT GACGCTTTGT 600
AGAGGGGAAG AATATCTGCC ACTGGACACA TCAGAACCTC ATTGGTGGAA AGTTCTGGAT 660
AAAAATGGGC CCTCTGCATC AGGGAATGTC CCCCAGATGT CCTTAAACTA TAACTCCCAC 720
CACTCCCTGA GAGGCTATGT ATATTATTGT ATTTTTAATT CCATTCATTC AGCATGCAGT 780
ACATATCACA GAGCCACAGG TAAAGAAGGA GCCTTTATGG TTCGAGACTC AAGGCAGCCG 840
GGGTTGTACA CTGTATCCAT CTTCACCAAA GCTCTTGGAG AGAACAATCA TGCAGTGAAA 900
CATTACCATA TCCGCCACAC AAATGACTCC CCAGCCAAAT ATTACCTGGC TGAGAAGCAC 960
GTCTTCAACT CCATCCCCGA GCTAATTAAC TACCACCAGC ATAACGGAGC AGGTACAGAG 1020
AACAAACTGA CCTGGGCCAT GTTTACTCAG CACAGTTTTA GGGCTCTGGC ACACGGGGGG 1080
CCGTGGCGTA AGTGGGAAAT TGACCCCACA CACCTGACAC TCAAGGAAGA GATTGGCAGT 1140
GGCCAGTTTG GGGTTGTACA GCTGGCAATA TGGCAGGGCA CTACCAAAGT GGCAGTAAAG 1200
ATGATTCGGG AAGGGATGAT GTCTGAGGAG GACTTTGTGG AGGAAGCCCA GGTCCTTATG 1260
AAACTTTCTC ACCCTAAATT GGTGCAGCTT CTGGGAGTTT GCACCCAACA GGTGCCCATT 1320
TTTCTAGTGT TTGAGTACAT GAAATATGGC TGCCTGTTTA ACTACCTGCG CAGTCATCGA 1380
GGGACGCTCT CCAAGGAAAC AGCTTTGGGG ATGTGCCAGG ATGTATGTGA GGGGATGCAG 1440
TACTTGGAAA GGTCCAATTT TATTCACAGG GACTTGGCTG CACGCAACTG CCTGGTGGGG 1500
GAATCATTGG TAGTCAAGGT TTCAGATTTT GGGATGACCA GGTTTGTTCT GGATGATCAG 1560
TACACCAGCT CCTCTGGCAC CAAATTTCCT GTTAAATGGT CGGCTCCAGA AGTTTTCCGT 1620
TTTGGCCTTT ACAGCAGCAG ATCCGATGTG TGGTCCTTTG GAGTGTTGGT GTGGGAGGTG 1680
TTTAGTGAAG GCAAGATCCC ATTTGAACAC CTTTCCAACT CTGAAGCTGT TGAAAAAATC 1740
TCAGCTGGAC TGAGGCTTTT CAAACCAAAG ATGTCTTCTG AAAGAGTGTA CAAGCTGATG 1800
AACAACTGCT GGCAAGAGAA AGCAGATTTA CGTCCAACAT TCCAACAACT ACTGAAAGAG 1860
GTCATGGACA TTGCAGAATG TGAC 1884
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         ltl +e+gsgqfgvv+l  w++ ++va+k+i+eg mseedf+eea+v+mklshpklvql 
Q: 372   LTLKEEIGSGQFGVVQLAIWQGTTKVAVKMIREGMMSEEDFVEEAQVLMKLSHPKLVQLL  431
         68889*******************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++q pi++v+ey++ gcl nylr+++++l+ke+ l mc+dvcegm+yler++fihrd
Q: 432   GVCTQQVPIFLVFEYMKYGCLFNYLRSHRGTLSKETALGMCQDVCEGMQYLERSNFIHRD  491
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e+lvvkvsdfg++r+vlddqy+ss+g+kfpvkws+pev+++  yss+sdvw
Q: 492   LAARNCLVGESLVVKVSDFGMTRFVLDDQYTSSSGTKFPVKWSAPEVFRFGLYSSRSDVW  551
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvl+wevfsegk+p+e+ snse vek+s glrl++pk++s++vy++m++cw+ek++ r
Q: 552   SFGVLVWEVFSEGKIPFEHLSNSEAVEKISAGLRLFKPKMSSERVYKLMNNCWQEKADLR  611
         ************************************************************
S: 241   ptfkellsale  251
         ptf++ll++++
Q: 612   PTFQQLLKEVM  622
         *******9986
Domain Sequence
(FASTA)
LTLKEEIGSG QFGVVQLAIW QGTTKVAVKM IREGMMSEED FVEEAQVLMK LSHPKLVQLL 60
GVCTQQVPIF LVFEYMKYGC LFNYLRSHRG TLSKETALGM CQDVCEGMQY LERSNFIHRD 120
LAARNCLVGE SLVVKVSDFG MTRFVLDDQY TSSSGTKFPV KWSAPEVFRF GLYSSRSDVW 180
SFGVLVWEVF SEGKIPFEHL SNSEAVEKIS AGLRLFKPKM SSERVYKLMN NCWQEKADLR 240
PTFQQLLKEV M 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MIM-00047
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013