EKS-XIM-00047

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XIM-00047

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	296.0	2.7E-88	867	1136	270

Status

Unreviewed

Ensembl Protein

ENSXMAP00000000241

Gene Name

TYK2

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXMAG00000000220	ENSXMAP00000000241	ENSXMAT00000000243

Organism

Xiphophorus maculatus

Protein Length

1155

Protein Sequence
(FASTA)

MPRKSGCFKP GKIPGPNEAP QSHGIHVYLF WTKGGEKYLS HTSGDVTAED LCISAAKAVG 60

ITPLCHVLFA LYNPKTKYWY NPNHVFSPDE NSSELVHYCM RFYFRNWHGL NEKEPSVSRH 120

TLKSGTDNNA GSPLLDITSL EYLFAQAKHE FVNNVEEPKS DVENNRFKNE SLGMAVLHLS 180

HLAMQKGLNL QEVAGKIGFQ NCIPRTFAEN ISRDNFLTKI RIRRVFTEFV QTFQQHTVDK 240

GQLGAHEIMY KYISTLENLV PSFGTETFSV TRLQLTEDGD ENVSYSNNES NGDSKKGFTA 300

PFTHEIMVSG TKGIQWRMLK TQKAEENSYH RGSYVNQKTP KQSTSNPPDK WTFFCDFREI 360

IHIAITEANV CITTQKSHCM EVQMNSSQEA RAFISLLDGY YRLTADAHHY LCHEVAPPRV 420

VLSEANMLHG PMHEDFVLHK LKREAGEEGA FLVRWSALDY HRIILAVLNR NENGSKPSHK 480

QFRIQQKGSV FSMEGWDKEF SSVKELTDNL KTYVLKSGSD NFTVRKCCLP RQAEISNLLV 540

KRQGIDQRSY SDCLPLNLTE LRFHQIKDKE IKQEHHLGRG TRTNIYSGQL MLRETDNGFN 600

NNFSQNKGIR VVLKILEESH KDIALAFFET ASLMSQVSHS HLVFVHGVSV KGSENILVEE 660

YLECGPLDVF LRREQHSITA QWKFVVSLQL ARALNYLETK RLVHGNVCAK NVLVARGGLE 720

PGTSPFVKLS DPGIALNVLS REERLDRIPW VAPECIDSGA PIESTVDQWS FGVTLLEIFN 780

NANLPMSSCT LPEKERFYQT KGRLANPSSE ELARFISMCL TYEPNERPTF QTILRELTKL 840

IQMNPDISPV DTLPPMDPSV FQKRYLRKMR DLGEGHFGKV TLYQYDPSSD GTGEFVAVKS 900

LKQENGNASQ SWMKEIEILK SLYHSNIVKY KGLCTEAGRQ EVQLIMEYVP LGSLREYLPK 960

NKTSSTQCLM FAQQICQGMD YLHSKRYVHR DLAARNVLVE NKNVVKIGDF GLTKYIPEGE 1020

IYYRVREDGD SPVYWYAIEC LKELKFSFAS DVWSFGVTLY EILTRCDHRQ SPPAKFIEMS 1080

EDKEEHMNVV KLIKLLERNQ RLPCPRDCPH EVKLLMDQCW DANPDNRPTF SNLSERFESA 1140

RKMLDWSFSP MSQIC 1155

Nucleotide Sequence
(FASTA)

ATGCCTAGAA AATCGGGTTG TTTCAAGCCG GGAAAGATCC CAGGTCCAAA TGAGGCCCCT 60

CAGTCTCATG GCATTCACGT CTACCTTTTC TGGACTAAAG GTGGGGAGAA GTATCTGTCT 120

CATACCAGTG GAGATGTCAC AGCAGAGGAC CTGTGCATCT CAGCTGCAAA AGCTGTAGGG 180

ATAACACCAC TGTGCCATGT CTTATTTGCG TTGTACAACC CAAAAACAAA ATACTGGTAC 240

AATCCAAACC ATGTTTTCAG TCCAGATGAG AACTCCAGTG AATTGGTTCA CTACTGTATG 300

AGGTTTTACT TTCGCAATTG GCACGGACTC AATGAAAAGG AGCCAAGTGT GTCGCGCCAC 360

ACCCTCAAAT CTGGGACAGA TAACAATGCA GGTTCCCCTC TTCTTGACAT TACATCTTTG 420

GAGTATCTGT TTGCCCAGGC CAAGCATGAA TTTGTGAATA ATGTGGAAGA GCCAAAGTCT 480

GATGTGGAAA ACAATCGTTT CAAAAACGAG AGCTTGGGCA TGGCTGTACT CCACCTGTCA 540

CACCTCGCAA TGCAAAAGGG GTTGAACTTG CAGGAAGTTG CTGGAAAAAT TGGCTTCCAG 600

AACTGCATTC CAAGAACATT TGCGGAGAAC ATTTCCAGAG ACAACTTTCT GACTAAAATC 660

AGGATCCGCC GTGTGTTTAC TGAATTTGTG CAGACCTTCC AGCAGCACAC TGTAGATAAG 720

GGGCAGCTGG GAGCCCATGA AATCATGTAT AAGTACATCT CCACCCTTGA AAACCTGGTT 780

CCAAGTTTCG GAACAGAGAC TTTCTCTGTA ACTCGCCTGC AGCTGACGGA GGACGGGGAT 840

GAAAACGTCT CCTACTCCAA CAACGAAAGC AATGGCGATT CAAAGAAGGG CTTCACAGCG 900

CCGTTCACCC ATGAAATTAT GGTGTCTGGC ACTAAGGGGA TTCAGTGGAG AATGTTGAAA 960

ACTCAAAAGG CAGAGGAAAA CTCTTACCAC AGGGGCAGCT ATGTGAATCA GAAAACACCA 1020

AAACAGTCCA CGTCAAATCC TCCTGATAAA TGGACCTTCT TCTGTGATTT CCGCGAAATA 1080

ATTCACATCG CCATTACAGA AGCTAATGTG TGCATTACCA CTCAGAAAAG TCACTGCATG 1140

GAGGTACAGA TGAACTCCAG CCAGGAGGCC CGTGCCTTCA TCTCCCTGCT AGATGGATAC 1200

TATCGGCTGA CTGCAGACGC CCACCACTAT CTTTGTCATG AAGTGGCTCC CCCCAGGGTG 1260

GTGTTGAGTG AAGCAAATAT GTTGCACGGA CCTATGCATG AGGACTTTGT GTTACACAAG 1320

CTGAAAAGGG AGGCAGGAGA GGAGGGAGCC TTCCTTGTCC GCTGGAGTGC CCTCGACTAT 1380

CATCGCATCA TCCTTGCTGT ACTAAACAGA AATGAGAATG GTTCAAAACC AAGCCACAAG 1440

CAATTTCGCA TCCAGCAGAA GGGCTCGGTG TTCAGCATGG AAGGCTGGGA TAAAGAGTTC 1500

TCCAGTGTGA AGGAGCTCAC AGATAACCTC AAAACCTATG TGCTCAAGTC CGGGTCGGAC 1560

AACTTTACTG TCAGGAAATG CTGCTTACCG AGACAAGCAG AAATATCCAA TCTGCTGGTG 1620

AAGAGGCAAG GAATTGACCA ACGCAGCTAT TCTGACTGCT TGCCCCTGAA CCTGACAGAG 1680

CTTCGCTTTC ACCAGATCAA AGACAAAGAG ATTAAACAGG AACATCATTT GGGCCGCGGC 1740

ACAAGAACTA ACATTTACTC AGGACAGTTA ATGTTGCGAG AAACAGACAA TGGGTTTAAC 1800

AACAACTTCT CCCAAAACAA AGGCATCAGA GTGGTCCTCA AAATCTTAGA GGAAAGCCAT 1860

AAAGATATTG CTCTAGCCTT TTTTGAAACA GCAAGCCTCA TGAGCCAGGT ATCTCACAGT 1920

CACCTGGTGT TTGTGCACGG TGTGTCTGTC AAAGGATCTG AAAACATCCT GGTGGAGGAA 1980

TACCTGGAGT GCGGCCCACT TGATGTTTTT CTCCGCAGAG AACAACATTC CATCACAGCT 2040

CAGTGGAAAT TCGTTGTATC CCTGCAGCTT GCAAGGGCTC TCAATTATCT CGAGACAAAA 2100

CGACTTGTTC ATGGAAATGT TTGTGCCAAG AATGTTCTGG TTGCACGGGG AGGTTTGGAA 2160

CCTGGAACTT CTCCTTTCGT CAAGCTGAGT GATCCTGGAA TTGCGCTGAA TGTCCTCTCA 2220

CGAGAAGAAC GTTTGGATCG GATACCCTGG GTCGCTCCAG AGTGCATTGA CAGTGGCGCT 2280

CCTATTGAGA GTACTGTAGA TCAGTGGAGT TTTGGCGTCA CGCTGCTTGA AATCTTCAAC 2340

AACGCTAATC TTCCAATGAG CAGCTGCACA TTGCCTGAGA AAGAGCGTTT TTACCAGACG 2400

AAGGGCCGTC TGGCAAACCC ATCCTCCGAG GAACTGGCCA GGTTCATCAG CATGTGTTTG 2460

ACATATGAGC CAAATGAGAG GCCTACATTT CAAACTATCC TCAGAGAACT CACAAAACTC 2520

ATCCAGATGA ATCCTGATAT ATCCCCGGTT GACACTCTCC CACCCATGGA CCCCAGCGTG 2580

TTTCAAAAGC GCTACCTGAG GAAGATGAGA GACTTAGGAG AGGGACATTT TGGAAAAGTC 2640

ACTCTGTACC AGTATGATCC GTCCAGCGAT GGGACAGGAG AGTTTGTGGC AGTAAAATCG 2700

TTGAAGCAAG AGAACGGAAA TGCATCTCAG AGCTGGATGA AGGAAATTGA AATCCTGAAG 2760

TCTCTCTATC ATTCCAACAT CGTGAAGTAC AAGGGCTTAT GCACTGAAGC AGGACGACAA 2820

GAGGTCCAGC TCATAATGGA ATATGTTCCT CTGGGGAGTC TGCGAGAGTA TCTTCCTAAA 2880

AATAAAACCA GTTCAACCCA GTGCCTCATG TTTGCTCAGC AGATCTGTCA GGGGATGGAC 2940

TACTTGCATT CAAAGCGCTA TGTGCATCGA GATCTTGCTG CTCGAAATGT TTTGGTGGAA 3000

AACAAAAATG TTGTAAAGAT CGGAGACTTC GGCCTAACAA AGTACATCCC AGAAGGAGAA 3060

ATCTACTATC GCGTTCGTGA GGACGGAGAC AGTCCTGTCT ACTGGTATGC CATCGAGTGC 3120

TTGAAGGAGC TCAAATTCTC ATTTGCCTCT GACGTCTGGT CGTTTGGAGT TACACTGTAT 3180

GAGATCCTGA CGCGCTGTGA CCATCGCCAG AGTCCTCCAG CTAAGTTCAT TGAAATGTCA 3240

GAAGATAAGG AAGAACACAT GAATGTGGTG AAACTGATAA AGCTGCTGGA GAGAAATCAA 3300

AGGTTGCCTT GTCCCAGGGA TTGCCCACAT GAGGTGAAGT TGTTGATGGA TCAGTGTTGG 3360

GATGCAAATC CTGATAATCG GCCTACGTTC AGTAACCTCA GCGAAAGGTT CGAGTCAGCA 3420

CGAAAAATGC TTGACTGGTC GTTCAGTCCC ATGTCTCAGA TTTGCTGA 3468

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlsheh  61

         +++++Lg+g+f+kv ++++d+ +d t+e va+k Lk+   + s+++ +e+eil++l+h +

Q: 867   RKMRDLGEGHFGKVTLYQYDPSSDGTGEFVAVKSLKQENGNASQSWMKEIEILKSLYHSN  926

         57899*******************************************************

S: 62    ivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLed  119

         ivk+kg+c++ g++  +l+meyv+ GsL++yL+k+  + s ++ l +a+q++++m+YL++

Q: 927   IVKYKGLCTEAGRQevQLIMEYVPLGSLREYLPKN--KTSSTQCLMFAQQICQGMDYLHS  984

         *************99*******************9..678889999**************

S: 120   kklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwlap  178

         k++vhrd+aarnvLve+++       vk++d+gl+k ++++  Yy vre++ds+++w+a

Q: 985   KRYVHRDLAARNVLVENKNV------VKIGDFGLTKYIPEGeIYYRVREDGDSPVYWYAI  1038

         ******************99......***************99*****************

S: 179   eclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklelle  226

         ecl+e k +s asdvWsFgvtlye+lt c++ +sp    +++++ +       ++++lle

Q: 1039  ECLKELK-FSFASDVWSFGVTLYEILTrCDHRQSPpakfIEMSEDKeehmnvvKLIKLLE  1097

         *******.****************************99955555446699999*******

S: 227   ekerlpkpk.cpaelaelmtnclsyepsqrpsFrailed  264

         +++rlp+p  cp e+  lm +c++++p++rp+F+++ e+

Q: 1098  RNQRLPCPRdCPHEVKLLMDQCWDANPDNRPTFSNLSER  1136

         **********************************99876

Domain Sequence
(FASTA)

RKMRDLGEGH FGKVTLYQYD PSSDGTGEFV AVKSLKQENG NASQSWMKEI EILKSLYHSN 60

IVKYKGLCTE AGRQEVQLIM EYVPLGSLRE YLPKNKTSST QCLMFAQQIC QGMDYLHSKR 120

YVHRDLAARN VLVENKNVVK IGDFGLTKYI PEGEIYYRVR EDGDSPVYWY AIECLKELKF 180

SFASDVWSFG VTLYEILTRC DHRQSPPAKF IEMSEDKEEH MNVVKLIKLL ERNQRLPCPR 240

DCPHEVKLLM DQCWDANPDN RPTFSNLSER 270

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>