EKS-XIM-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XIM-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	305.9	2.6E-91	889	1162	274

Status

Unreviewed

Ensembl Protein

ENSXMAP00000002236

Gene Name

JAK1

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXMAG00000002212	ENSXMAP00000002236	ENSXMAT00000002241

Organism

Xiphophorus maculatus

Protein Length

1174

Protein Sequence
(FASTA)

MTASFVMELS RQLCMKMRKN KKTQFSSLPA STLGLEIHFY IPEIRHLEYI KGTYTAEELC 60

VTAAKKCTIS PLCHNLFALY NDSTGTWYSP SHEFNIKEDS GIKLHYRMRF YFKNWHGTTE 120

GESPVWRHCL NKLRGQSPQK TPEGTPLLDV GSLEYLYFQC QHDFQTGKAP LRAAQSEAEQ 180

HEIENECLGM AVLAITHYAK NFDIPFSAAS REMSYKRFIP ESLNSNIKQR NILTRIRISN 240

VFKKFLAEFN TQTVGESNIT CYDLKIKYLA TMEGLTSRMG SELFEPVSLA ITQEKELSTG 300

GYYGYCNQSQ LQTKCQNQNL EPSSDMQVLV TGTTGISWRQ KPAAVPVMPK DKSKSKKSKQ 360

DEKQKNNRNK ETGDGWVLFC DFHMITHTVI KETTVTIMRQ DNKKMELQLL SRAEALSFVA 420

LVDGYFRLIV DAHHYLCKEV APSLVVQNTE TGCHGPICTE YAVQKLRQEG NEEGTYILRW 480

SCTEYNFIII TVVCHESDHF NIQYKNFQIE VDSDGYRLYG TDTSRPSLKE LLDHLERQCL 540

HTDNLQFQLR RCCPPQPREI SNLLVVTKER ASICQPTKHE RELCIFHRIP KEDIEQEEHL 600

GVGTKTNIYL GTLRVKNEED EDAGYTSFQE VKVVLKVLGS GHRDISLAFF ETANMMRQVS 660

HKHIVLLYGV CVRHQENIMV EEYAQLGPLD VFIRRQQSPL STRWKFQVAK QLASALSYLE 720

DKKLVHGFVC AKNILLARDG LDEEEGEPFI KLSDPGIPIT VLSREECVHR IPWIAPECVK 780

NPSELSVAAD KWGFGTTLWE ICYDGEVPLK EKKLTEKERF YEAEFQLAIP DYKELAELMT 840

RCMNYDPKKR PFFRAIVRDL DVLEEKSPFI KPCPIQPVDP TVFETRFLRK IRELGEGHFG 900

KVELCRYDPR GDRTGEMVAV KSLKPENGEE QSNNLLKEIE ILKALYHENI VKYKGISQEE 960

GGKTIKLIME YLPLGSLKEY LPRYKSQTSL GTLLSYCIQI CRGMDYLGSR NYIHRDLAAR 1020

NVLVEKEGMV KIGDFGLTKS LKENNGYYTV KDENDSPVFW YAPECLTQCK FYLASDVWSF 1080

GVTMYEIITY CDSSKSPMTC FLDMIGRAQG QMTIVRLVNV LQDGRRLACP ESCPRRVYEL 1140

MRKCWEHTPE RRITFKRLIE ELSILQQHHQ QNSL 1174

Nucleotide Sequence
(FASTA)

ATGACAGCTT CATTCGTGAT GGAGTTGAGC AGGCAACTCT GTATGAAGAT GAGGAAAAAT 60

AAGAAGACCC AATTTTCCTC TCTTCCTGCT TCTACTTTGG GCCTGGAAAT CCACTTTTAC 120

ATCCCAGAAA TACGCCACCT GGAGTACATC AAAGGAACTT ACACAGCTGA GGAGCTGTGC 180

GTCACTGCTG CCAAGAAGTG CACTATTTCT CCATTGTGCC ATAATTTGTT TGCCCTTTAC 240

AATGATTCAA CTGGCACCTG GTACTCTCCA AGCCACGAGT TCAACATCAA AGAGGACAGC 300

GGTATCAAGT TGCACTATCG CATGAGATTC TATTTTAAGA ACTGGCATGG GACCACAGAA 360

GGAGAGTCTC CAGTTTGGAG ACACTGCCTC AATAAACTCA GAGGACAGAG CCCACAGAAA 420

ACACCAGAGG GAACACCGCT GCTTGATGTC GGTTCCCTTG AATACCTTTA TTTCCAGTGC 480

CAGCATGATT TTCAGACAGG CAAGGCTCCC CTGAGGGCAG CCCAGTCAGA AGCCGAGCAA 540

CATGAGATAG AAAACGAATG TTTGGGCATG GCTGTGCTTG CTATTACTCA CTATGCCAAG 600

AACTTTGATA TACCCTTTTC AGCAGCTTCC CGTGAGATGA GTTACAAGCG TTTCATCCCG 660

GAGTCACTGA ACTCTAACAT TAAGCAGCGG AACATCCTGA CCCGCATCCG CATCAGCAAC 720

GTGTTCAAGA AATTCCTCGC TGAATTCAAC ACCCAAACAG TTGGGGAGAG CAACATCACC 780

TGCTATGATC TGAAGATCAA ATACCTGGCC ACGATGGAGG GGCTGACCAG CAGAATGGGC 840

AGCGAGCTCT TTGAACCCGT CTCCCTGGCT ATAACACAAG AAAAGGAGCT CTCCACTGGA 900

GGTTACTATG GGTACTGTAA CCAGAGCCAG TTGCAGACGA AATGTCAGAA TCAGAACTTG 960

GAGCCAAGCA GTGACATGCA AGTTCTTGTC ACTGGCACCA CCGGCATTTC CTGGAGGCAA 1020

AAACCAGCAG CTGTGCCAGT GATGCCCAAA GACAAAAGCA AGTCGAAGAA GAGTAAGCAG 1080

GATGAAAAAC AGAAGAACAA CAGGAATAAG GAGACGGGTG ATGGCTGGGT GCTGTTCTGT 1140

GATTTCCATA TGATCACACA CACAGTCATC AAAGAGACAA CAGTCACAAT CATGAGACAA 1200

GACAACAAGA AGATGGAACT CCAACTGCTG TCAAGGGCTG AAGCCCTGTC CTTTGTGGCC 1260

CTTGTTGATG GGTATTTCAG GTTAATTGTG GATGCCCACC ATTACCTGTG CAAGGAGGTG 1320

GCACCTTCCC TGGTGGTGCA GAACACAGAA ACTGGTTGCC ATGGACCCAT CTGTACTGAA 1380

TATGCTGTCC AAAAGCTGCG ACAGGAGGGT AATGAGGAAG GAACCTACAT ACTGCGCTGG 1440

AGCTGTACTG AGTACAACTT CATCATCATC ACTGTGGTCT GTCATGAGAG TGACCACTTC 1500

AATATCCAGT ATAAGAACTT CCAGATTGAG GTGGACTCTG ATGGCTACCG CCTGTATGGA 1560

ACGGACACAT CGCGGCCCAG CTTGAAGGAG CTGCTGGATC ACCTGGAGCG CCAGTGTCTC 1620

CACACCGACA ACTTGCAGTT CCAGCTCAGG CGCTGCTGCC CTCCACAGCC AAGAGAAATT 1680

TCTAACCTTC TTGTGGTTAC CAAGGAGAGA GCTTCCATCT GTCAGCCAAC AAAGCATGAG 1740

AGGGAGCTCT GCATCTTCCA CCGCATTCCC AAGGAGGACA TTGAGCAGGA GGAGCACCTT 1800

GGCGTTGGTA CAAAAACCAA CATATACCTG GGCACTCTGA GGGTCAAGAA TGAGGAAGAT 1860

GAAGATGCAG GTTACACATC TTTCCAGGAG GTTAAGGTCG TCCTGAAGGT GCTTGGTTCT 1920

GGACACAGGG ACATTTCTCT GGCCTTCTTT GAAACAGCCA ACATGATGCG CCAAGTGTCT 1980

CACAAACACA TCGTGCTGCT CTATGGCGTG TGTGTCCGTC ATCAGGAGAA TATCATGGTG 2040

GAAGAATATG CCCAGCTAGG ACCGCTAGAT GTGTTTATCA GGAGACAACA GAGTCCACTG 2100

AGCACCAGGT GGAAATTCCA GGTGGCCAAA CAGCTGGCCT CTGCTCTTAG CTACCTGGAA 2160

GACAAAAAGC TGGTCCATGG CTTTGTTTGT GCCAAGAACA TTCTGCTTGC CAGAGATGGA 2220

CTGGATGAAG AGGAGGGAGA GCCCTTCATC AAGCTCAGCG ACCCAGGAAT ACCAATAACG 2280

GTGCTCTCCA GGGAGGAATG TGTGCATCGC ATCCCATGGA TTGCTCCTGA ATGTGTGAAG 2340

AACCCATCAG AATTGAGCGT GGCGGCTGAT AAGTGGGGGT TCGGTACCAC CCTGTGGGAG 2400

ATCTGTTATG ATGGAGAGGT ACCTCTCAAA GAGAAGAAGT TGACGGAGAA GGAGAGGTTT 2460

TATGAAGCTG AATTCCAGTT GGCCATCCCA GACTACAAGG AGCTTGCTGA ACTCATGACC 2520

CGCTGCATGA ACTATGACCC CAAGAAGAGA CCCTTCTTCA GGGCTATTGT CAGAGACTTG 2580

GATGTACTAG AAGAAAAAAG TCCATTCATC AAACCATGTC CAATACAGCC GGTGGACCCG 2640

ACTGTATTTG AAACCAGATT CCTGAGGAAG ATCAGAGAAC TTGGAGAGGG TCACTTCGGT 2700

AAGGTGGAGT TGTGTCGCTA CGACCCTCGG GGAGACCGAA CGGGTGAAAT GGTGGCGGTG 2760

AAGTCCCTGA AGCCCGAGAA CGGCGAGGAG CAGAGCAACA ACCTCCTGAA AGAGATTGAG 2820

ATCCTAAAGG CACTTTATCA TGAAAACATC GTCAAATACA AAGGCATCAG CCAGGAAGAA 2880

GGTGGAAAGA CCATCAAGCT GATAATGGAG TATCTTCCGC TGGGCAGTTT GAAGGAATAT 2940

CTTCCCAGAT ACAAGAGCCA GACCAGCCTT GGCACCCTGC TAAGCTACTG TATCCAGATA 3000

TGTCGGGGCA TGGATTATTT GGGATCTCGG AACTACATCC ACCGCGACCT GGCAGCCCGG 3060

AACGTGCTGG TGGAAAAAGA AGGCATGGTG AAGATCGGAG ATTTTGGCCT CACAAAAAGC 3120

CTCAAGGAAA ACAACGGTTA TTACACGGTC AAAGACGAAA ACGACAGCCC CGTCTTCTGG 3180

TATGCTCCTG AGTGTCTGAC TCAGTGCAAG TTTTACCTTG CTTCAGATGT GTGGTCCTTC 3240

GGAGTGACCA TGTATGAAAT CATCACCTAC TGCGATTCCT CCAAAAGCCC AATGACGTGC 3300

TTCCTAGATA TGATCGGGAG AGCTCAAGGC CAGATGACCA TCGTCCGCTT GGTGAATGTT 3360

CTGCAGGATG GAAGAAGATT GGCTTGTCCT GAATCTTGCC CTCGCCGTGT GTATGAGCTG 3420

ATGCGGAAGT GCTGGGAGCA CACTCCAGAG CGGAGAATCA CCTTCAAGCG TCTGATTGAG 3480

GAGCTGTCCA TCCTGCAGCA GCACCACCAG CAGAACAGCC TGTAA 3525

Domain Profile

S: 2     kqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlshe  60

         ++i++Lg+g+f+kv+++r+d++gd t+e+va+k Lk e ge++s+++ +e+eil++l+he

Q: 889   RKIRELGEGHFGKVELCRYDPRGDRTGEMVAVKSLKpENGEEQSNNLLKEIEILKALYHE  948

         6789********************************************************

S: 61    hivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYLe  118

         +ivk+kg++ +eg +  +l+mey++ GsL++yL++ k + sl  ll++  q++++m+YL+

Q: 949   NIVKYKGISQEEGGKtiKLIMEYLPLGSLKEYLPRYKSQTSLGTLLSYCIQICRGMDYLG  1008

         *********9999999********************************************

S: 119   dkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwla  177

         +++++hrd+aarnvLve+e+       vk++d+gl+k ++++  Yy+v++e ds+++w+a

Q: 1009  SRNYIHRDLAARNVLVEKEGM------VKIGDFGLTKSLKENnGYYTVKDENDSPVFWYA  1062

         *********************......*********************************

S: 178   peclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklell  225

         pecl+++k +++asdvWsFgvt+ye++t c++++sp    l +++ +       r++++l

Q: 1063  PECLTQCK-FYLASDVWSFGVTMYEIITyCDSSKSPmtcfLDMIGRAqgqmtivRLVNVL  1121

         ********.***************************999977777767778889******

S: 226   eekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265

         ++++rl +p+ cp  ++elm++c++++p++r++F+ ++e+l

Q: 1122  QDGRRLACPEsCPRRVYELMRKCWEHTPERRITFKRLIEEL  1162

         *************************************9986

Domain Sequence
(FASTA)

RKIRELGEGH FGKVELCRYD PRGDRTGEMV AVKSLKPENG EEQSNNLLKE IEILKALYHE 60

NIVKYKGISQ EEGGKTIKLI MEYLPLGSLK EYLPRYKSQT SLGTLLSYCI QICRGMDYLG 120

SRNYIHRDLA ARNVLVEKEG MVKIGDFGLT KSLKENNGYY TVKDENDSPV FWYAPECLTQ 180

CKFYLASDVW SFGVTMYEII TYCDSSKSPM TCFLDMIGRA QGQMTIVRLV NVLQDGRRLA 240

CPESCPRRVY ELMRKCWEHT PERRITFKRL IEEL 274

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>