EKS-XIM-00044

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-XIM-00044

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	322.9	1.8E-96	536	796	261

Status

Unreviewed

Ensembl Protein

ENSXMAP00000003031

Gene Name

JAK2 (2 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXMAG00000003004	ENSXMAP00000003031	ENSXMAT00000003036

Organism

Xiphophorus maculatus

Protein Length

1122

Protein Sequence
(FASTA)

MLLMASPPAM DTVTDSRPTV HQNGTAHRES SDTRPASPVL RLHFYHSSQG AADSGTLSYP 60

PGDYVAEELC IDAAKACCIS PLYYNLFSLY RERDNLWFSP NHVFRLDDSA SEDLFFRIRY 120

YFPGWYSSGA SRAYRYGVKK GSESPVLDDY VMTYLFSQWR NDFVNGVVMI SDSHESQEEC 180

LGMAVLDMTR TAKERQMSPL DIYHNTSYKS FLPKDMRNQI QDCSFLTRKR IRFRFKRFIQ 240

QFSQCRTTVR DLKLKYLISI ESLEKAFYTE TFQVREPASG QLIILVAADT GIQWCREKFK 300

DSDEELQTLC DFHDVTDISI KQACKEGATE SRLVTINKQD GKNLELEFPS LFEAMSFASL 360

VDGYYRLTTD AHHYLCKEVA PPRLVEAISC HCYGPISMEF AVSRLQKCGD KRGLYILRCS 420

PKDFNKYFLT FPVEVFDTVD YKHCQITRSA AGEFNLSGTK RNFSSLQELL NCYQKETVRS 480

DGIVFQFSKC CPPQSKEKSC LLICRSNKGS EVPLSPSLQR HNVSQMVFHK IRKEDLEFVE 540

SLGLGTFTKI FKGVRKELGD YGQMHETEVV MKVLDQAHRN YAESFFEAAS MMSQLSHKHL 600

ILNYGVCVCG EENIMVQEYV KLGSLDTYLK KNKNSINIQW KLEVAKQLAW AMNFLEEKHL 660

VHGNVCAKNV LLIREEDRRA GNPPFIKLSD PGIGITVLPK EILIERIPWV PPEYINEPMT 720

LSLAADKWSF GTTLWEICSG GEKPLAMLDN TKKVLFYNDR QQLPAPKWTE IANLITSCMD 780

YEPTFRPTFR AVIRDLHSLF TPDYELIMDD ILPNRTTGAS GTAGGFENQE PALFQERHLI 840

FLQLLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTAE HMRDFEREIE ILKSLQHENI 900

VKYKGVCYSA GRRNLRLIME YLPFGSLRDY LIKNMERIDH KKLVHYASQI CKGMEYLSSK 960

RYIHRDLATR NILVESELRV KIGDFGLTKV LPQDKEYYMV QEPGESPIFW YSPESLTESK 1020

FSVASDVWSF GVVLYELFTH SYKNCSPPAV FMSMMGNDKQ GQLIVYHLIE LLKSGSRLPQ 1080

PLGCPSEIYQ IMEECWDNDP TLRPSFNELA LRIDLIRDSE EF 1122

Nucleotide Sequence
(FASTA)

ATGTTGCTGA TGGCTTCCCC GCCAGCTATG GACACTGTGA CGGACTCGCG GCCCACGGTG 60

CACCAGAACG GGACCGCCCA TCGTGAATCT TCAGACACAC GACCAGCTTC TCCTGTTCTG 120

AGGCTTCATT TCTACCACAG CAGCCAGGGA GCAGCCGACA GCGGCACTCT CAGCTACCCA 180

CCCGGGGACT ACGTGGCTGA GGAGTTGTGT ATAGATGCAG CCAAGGCGTG CTGTATATCA 240

CCCCTGTACT ACAACCTTTT TAGCCTTTAT CGAGAGAGAG ACAACTTGTG GTTTTCTCCC 300

AATCACGTCT TTCGGCTTGA TGACTCGGCC TCTGAAGATC TGTTTTTCAG AATACGGTAC 360

TACTTTCCTG GCTGGTACAG TAGTGGTGCA TCGCGGGCAT ATCGATATGG GGTCAAAAAA 420

GGGTCAGAAA GTCCCGTCCT TGATGATTAT GTAATGACCT ATCTCTTCTC TCAGTGGAGG 480

AATGATTTTG TGAACGGCGT GGTGATGATT TCCGACTCCC ATGAGTCACA GGAGGAGTGC 540

CTTGGTATGG CTGTGCTTGA CATGACCAGG ACAGCTAAGG AGAGACAGAT GTCCCCTCTG 600

GACATCTATC ACAATACAAG TTACAAGTCC TTCCTACCGA AGGATATGAG AAATCAGATC 660

CAGGATTGTA GTTTTTTAAC TCGTAAGAGG ATTCGCTTCC GCTTCAAGCG CTTCATCCAG 720

CAGTTCAGTC AGTGTCGAAC CACGGTGCGC GACCTGAAGC TAAAGTACCT CATCAGCATC 780

GAGTCGCTGG AGAAAGCCTT CTACACGGAG ACCTTTCAGG TCAGAGAACC AGCTAGCGGA 840

CAGCTCATCA TCCTGGTGGC AGCGGACACG GGAATACAGT GGTGTCGAGA GAAATTTAAA 900

GATTCTGATG AGGAGTTGCA GACATTGTGC GACTTCCATG ATGTCACTGA CATCAGCATC 960

AAACAGGCCT GCAAAGAAGG CGCCACAGAG AGCCGGTTGG TCACCATCAA TAAGCAGGAT 1020

GGGAAGAACC TGGAGCTGGA GTTTCCGAGT CTGTTTGAAG CCATGTCATT CGCGTCCCTT 1080

GTTGACGGCT ACTATCGACT GACCACAGAT GCACATCACT ACCTTTGTAA GGAGGTGGCC 1140

CCTCCCAGGC TTGTTGAGGC CATATCTTGT CATTGCTACG GCCCCATTTC AATGGAATTT 1200

GCTGTCAGCC GGCTTCAGAA GTGTGGAGAC AAGCGAGGGT TGTACATTTT GAGATGCAGC 1260

CCAAAAGACT TCAATAAGTA TTTTCTAACT TTCCCAGTAG AGGTGTTTGA TACGGTGGAT 1320

TACAAGCACT GTCAGATCAC CAGGTCCGCT GCTGGCGAGT TTAACCTCAG TGGAACCAAG 1380

AGGAACTTCA GCTCACTGCA GGAGTTGCTC AACTGCTACC AAAAAGAAAC GGTTCGCTCG 1440

GACGGCATCG TGTTCCAGTT CAGCAAGTGC TGTCCTCCTC AGTCCAAAGA AAAGTCCTGC 1500

CTCCTCATCT GCAGGAGCAA CAAAGGTTCA GAAGTGCCTC TGTCTCCGTC GCTACAACGA 1560

CACAACGTCA GTCAGATGGT GTTTCACAAG ATCAGGAAAG AAGACTTGGA GTTTGTGGAG 1620

AGTCTTGGTC TTGGCACATT TACAAAGATC TTTAAAGGAG TTCGTAAGGA GCTCGGCGAC 1680

TATGGGCAAA TGCACGAAAC TGAAGTTGTG ATGAAAGTTC TGGACCAGGC CCACAGAAAT 1740

TACGCCGAGT CTTTCTTTGA AGCAGCCAGC ATGATGAGCC AGTTATCCCA TAAACACCTG 1800

ATCCTCAACT ATGGAGTTTG TGTCTGTGGA GAAGAGAACA TCATGGTGCA GGAATATGTG 1860

AAGTTGGGTT CGCTGGACAC CTACCTGAAG AAAAACAAGA ACTCTATAAA CATTCAGTGG 1920

AAGCTCGAAG TGGCAAAACA GCTGGCCTGG GCCATGAACT TCCTGGAGGA AAAGCATCTT 1980

GTCCATGGGA ATGTTTGTGC CAAAAATGTT CTGCTGATCA GGGAGGAGGA TCGGAGGGCT 2040

GGGAATCCCC CGTTCATCAA GCTTAGCGAC CCCGGCATCG GCATCACTGT CCTGCCTAAA 2100

GAAATCCTGA TTGAAAGGAT CCCCTGGGTG CCACCGGAAT ACATAAACGA GCCGATGACT 2160

CTGAGTCTGG CTGCAGACAA GTGGAGCTTC GGCACCACGC TTTGGGAAAT CTGCAGCGGC 2220

GGAGAGAAAC CACTGGCAAT GCTGGACAAC ACAAAGAAAG TCCTGTTCTA CAACGATCGC 2280

CAGCAGCTTC CGGCACCAAA GTGGACAGAA ATCGCTAACC TGATCACCAG TTGCATGGAC 2340

TACGAGCCGA CATTCAGGCC CACATTCCGG GCGGTGATCC GCGACCTTCA CAGCCTCTTC 2400

ACACCGGACT ACGAGTTGAT CATGGATGAC ATCCTGCCAA ACCGAACAAC AGGTGCTAGT 2460

GGCACAGCTG GCGGCTTTGA GAATCAGGAG CCAGCTCTGT TTCAAGAACG ACATCTCATA 2520

TTTTTACAGT TACTTGGCAA GGGAAACTTT GGCAGTGTGG AGATGTGCCG CTATGACCCA 2580

CTCCAGGACA ACACCGGAGA GGTTGTTGCT GTGAAGAAAC TCCAGCACAG CACAGCGGAG 2640

CACATGCGAG ACTTTGAGAG GGAGATTGAG ATTCTGAAAT CTCTCCAGCA TGAGAACATC 2700

GTCAAGTATA AGGGTGTCTG TTACAGCGCA GGTCGACGTA ATCTTCGCCT CATCATGGAG 2760

TATCTTCCCT TTGGAAGTCT TCGTGATTAT CTCATAAAAA ACATGGAGCG GATCGATCAT 2820

AAAAAGCTAG TCCACTATGC CTCTCAGATC TGCAAGGGAA TGGAGTACCT GTCGAGTAAA 2880

CGGTACATCC ACAGAGACCT GGCGACACGG AACATCCTAG TTGAGAGTGA GCTAAGAGTG 2940

AAAATTGGAG ACTTCGGCCT CACCAAAGTT CTGCCTCAGG ACAAAGAGTA TTATATGGTC 3000

CAAGAGCCGG GAGAGAGTCC CATTTTCTGG TATTCCCCTG AGTCACTGAC TGAGAGCAAG 3060

TTCTCTGTGG CTTCAGACGT CTGGAGCTTT GGAGTGGTGT TGTATGAGCT CTTCACACAC 3120

AGTTACAAGA ACTGCAGCCC TCCTGCAGTA TTTATGTCAA TGATGGGTAA CGATAAGCAG 3180

GGGCAGCTGA TCGTCTATCA CCTCATTGAG CTCCTCAAAT CAGGCAGCAG GCTGCCTCAG 3240

CCCCTGGGTT GTCCTTCAGA GATCTACCAG ATCATGGAGG AGTGTTGGGA TAACGACCCA 3300

ACCTTACGTC CGTCTTTTAA TGAGCTGGCT CTGCGCATCG ACCTGATCAG GGACAGTGAG 3360

GAGTTTTAA 3369

Domain Profile

S: 1     lkqiesLgkgtftkvfevred...aegdsteeevalkvLkesgedisrdfkreaeilsql  57

         l++ esLg gtftk+f++ ++   ++g+ +e+ev++kvL++++++++++f+++a+++sql

Q: 536   LEFVESLGLGTFTKIFKGVRKelgDYGQMHETEVVMKVLDQAHRNYAESFFEAASMMSQL  595

         57889*************997677999*********************************

S: 58    shehivklkgvcvaegenrlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         sh+h++ ++gvcv+++en++V+eyv+ GsLd+yL+k+k++++++++l+vakqla+am++L

Q: 596   SHKHLILNYGVCVCGEENIMVQEYVKLGSLDTYLKKNKNSINIQWKLEVAKQLAWAMNFL  655

         ************************************************************

S: 118   edkklvhrdvaarnvLveresn..egtppfvklsdpglakavnqdeYylvreerdsripw  175

         e+k+lvh++v+a+nvL+ re++   g+ppf+klsdpg+  +v      l++e   +ripw

Q: 656   EEKHLVHGNVCAKNVLLIREEDrrAGNPPFIKLSDPGIGITV------LPKEILIERIPW  709

         *******************9998899****************......************

S: 176   lapeclseaknlstasdvWsFgvtlyelltcskgesplrseslerklelleekerlpkpk  235

         ++pe+++e  +ls+a+d+WsFg+tl+e+  cs ge+pl + ++++k+ +++++++lp+pk

Q: 710   VPPEYINEPMTLSLAADKWSFGTTLWEI--CSGGEKPLAMLDNTKKVLFYNDRQQLPAPK  767

         ****************************..******************************

S: 236   cpaelaelmtnclsyepsqrpsFrailedl  265

         ++ e+a+l+t c++yep++rp+Fra+++dl

Q: 768   WT-EIANLITSCMDYEPTFRPTFRAVIRDL  796

         **.*************************98

Domain Sequence
(FASTA)

LEFVESLGLG TFTKIFKGVR KELGDYGQMH ETEVVMKVLD QAHRNYAESF FEAASMMSQL 60

SHKHLILNYG VCVCGEENIM VQEYVKLGSL DTYLKKNKNS INIQWKLEVA KQLAWAMNFL 120

EEKHLVHGNV CAKNVLLIRE EDRRAGNPPF IKLSDPGIGI TVLPKEILIE RIPWVPPEYI 180

NEPMTLSLAA DKWSFGTTLW EICSGGEKPL AMLDNTKKVL FYNDRQQLPA PKWTEIANLI 240

TSCMDYEPTF RPTFRAVIRD L 261

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>