EPS-XIM-00053

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-XIM-00053

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	193.3	6.3E-57	1041	1286	246

Status

Unreviewed

Ensembl Protein

ENSXMAP00000017006

Gene Name

PHLPP1 (1 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSXMAG00000016960	ENSXMAP00000017006	ENSXMAT00000017030

Organism

Xiphophorus maculatus

Protein Length

1571

Protein Sequence
(FASTA)

GSSSNSSSLL LRRRRLKRNL SAAAAATTTA ASSAVTAKMS SALSSASLHT RSLDRKTLLK 60

HRLNQQLQPA DREWVRADLH RGCIHVHDRL TSSYPRPVLC TMDNTAGEVA LRLSKLCSKS 120

SSVMRIFCKD TSKTDQNGNC NVKCEFNDDS FHAKDGSLRK CNQQTSLGSA EVSGHPGDRL 180

RLLLMENADD RQKQQEVDGK LFTPESDDDM ILGTEASILS PSFDSATEGH DMYGSSSDEL 240

ELDCPVSGSG IDHSNGISAI TASYTQCSMG HLNDMTKNVG PDSRLNSHSL GSLPPSSSAC 300

SLSRFCSTDI TPGNQDCGQD AVKQEPTTLQ NGDCSDTSPT LYVQLHGEAV RRLSPDERPL 360

QIQNDFLFKL GFKDPWRVQE EGLNTEIGSL LRFYAGKPQS IESSERVQLS GTYNVRKGKL 420

QLPVNRWTRR QVILCGTCLI VSSVKESQIG KMHILPLIGG KVEEVKKHNH CLAFSSAGPQ 480

SQTYYVSFDS FTEHLRWHRH AAKMVSQRIN SVDLSCCSLE LLPPNLFYSH DLTHLNLKHN 540

FLPADHRLQQ LQRFSRLRSL NLSNNHLGQF PLAICDIPTL TEVNLSCNYM DSVPSSVGAM 600

SNLQTFLLDG NSLSELPCEL GSLQRLSYLG LSFNQFSHVP QVLERLASME KLCMAGNNQE 660

TLTLQNFRLL HVKHIDLRLN KISVMVPDEP DLLRHVTQLD LRDNQLTELD ASIFPRLEVL 720

HCERNHITCL KVKGSLLKGI YASNNELRQL DVSPVPSNLT YMDISRNHME SLPDWLCEAK 780

KLEVLDVSHN LITELPARLF CSNSLRKLSA GHNQLQKLPE RVERPLLEVL DVQHNQLVEL 840

PCNLFLKSNS LRCVNASANK LEHLPPSSLS EESHSILQEL YLTNNWLTDK CVPMLTGHTH 900

LRVLHMAYNH LQTFPASKMA KLEELEEVDL SGNMLKTVPT TIMNCRRMHT LIAHSNSIEV 960

FPEVMQLMEM KCVDLSCNEL SEITLPENLP PKLQELDLTG NPRLNLDHKT LEQLNNIRCF 1020

RIDPPPTFSS NEASGGPAVW SHGYTEASGV KNKLCVAALS VNSFCGSREA LYGVFDGDRN 1080

VEVPYLLQCT MNDVLAEEIH KTKSEEDYMT NTFLVMQRKL GTAGQKLGGS AALCHIRHDP 1140

TDPSGCFILT AANVGKCQAI LCRDGKPMSL SLLHNVGLEE EYRRIRQHRA IVTEDNKVNG 1200

VTDSTRIMGY SFLYPSVIPC PYVQTVTLTP QDEFFILGSR GLWDAVSPTE AVEAVRNVPD 1260

GLAAAKKLCT LAQGYGCTDS LSAVVVQLSV SEDCCSCCCS DPPQPPPSPG LGAYPSSSSA 1320

IKDRPSDGSL PVPPSSCSEI SSEISTSEMS SEVGSTASSD EPPQSSCSEL ASARNCCALH 1380

PACLAGSFQR QLSSATFSSA LSDNGLDSED EEPIAGVFSN GSRVEVEADV HCLKAELSQL 1440

SSPQSLLPVS SSQDSIDLNL AEAENGLERD ESWPGVGAGA GDGGKFPGKR RVNGSVARQE 1500

KSHNLIEVAA DAPSKKSGGY FTAPAQPDPD DQFIIPPELE EEVKEIMKQH QQKQQKPAGT 1560

DQPTDYYDTP L 1571

Nucleotide Sequence
(FASTA)

GGCTCGTCCA GTAACTCCAG CTCCCTCCTG TTGAGACGGC GGCGCTTGAA GAGGAACCTC 60

TCCGCCGCAG CTGCAGCAAC AACTACCGCC GCCAGCTCAG CTGTCACTGC GAAGATGAGC 120

TCGGCCCTGT CCTCCGCGTC CCTTCACACC CGGAGCCTGG ACAGGAAGAC TCTGCTGAAG 180

CACCGCTTGA ACCAGCAGCT GCAGCCAGCG GATCGCGAGT GGGTGAGAGC GGATTTGCAC 240

CGGGGCTGCA TTCACGTACA CGATAGGCTG ACGTCCTCAT ATCCCAGGCC AGTCCTTTGC 300

ACTATGGACA ACACAGCCGG CGAGGTGGCG CTCCGTTTGA GTAAACTCTG CAGCAAGTCG 360

AGCTCGGTGA TGCGCATATT TTGTAAAGAT ACCTCCAAGA CTGACCAAAA TGGCAACTGC 420

AATGTGAAGT GTGAATTTAA TGACGATTCC TTTCATGCGA AAGACGGGTC ACTAAGAAAG 480

TGCAACCAGC AGACTTCCTT AGGATCTGCA GAAGTGAGTG GGCACCCCGG TGACAGATTG 540

AGGCTGCTGC TTATGGAGAA TGCAGATGAC AGGCAAAAGC AACAGGAAGT TGATGGGAAA 600

CTTTTCACCC CCGAATCAGA TGATGACATG ATCCTGGGAA CAGAAGCATC CATCCTCAGC 660

CCCTCATTTG ACAGTGCCAC AGAGGGCCAC GACATGTATG GAAGTTCCTC AGACGAGCTG 720

GAGCTCGACT GTCCAGTGTC TGGCTCAGGC ATTGACCACA GTAATGGCAT CTCAGCAATC 780

ACTGCGAGCT ACACGCAGTG CAGCATGGGA CATTTAAATG ACATGACGAA AAACGTGGGC 840

CCTGACAGCA GACTGAACTC ACACAGTTTG GGCAGCCTGC CACCCAGCAG TAGTGCCTGC 900

TCATTGTCAA GATTCTGCTC CACAGATATT ACACCTGGCA ATCAAGATTG TGGTCAAGAT 960

GCTGTGAAAC AGGAGCCAAC AACACTCCAA AATGGAGATT GTAGTGATAC CAGCCCCACA 1020

CTGTATGTTC AGCTGCATGG TGAAGCTGTG AGGAGGCTTA GTCCAGATGA GAGGCCTCTG 1080

CAGATCCAGA ATGATTTTCT GTTTAAGCTT GGATTTAAGG ACCCTTGGAG AGTTCAAGAG 1140

GAAGGACTCA ACACAGAAAT TGGCTCCCTG TTACGTTTTT ATGCAGGGAA GCCCCAAAGT 1200

ATTGAGAGCT CCGAGCGGGT CCAGCTTTCA GGGACCTACA ACGTCCGGAA AGGGAAGCTC 1260

CAGCTGCCTG TCAACCGATG GACCAGACGG CAGGTCATTC TATGCGGCAC CTGTCTCATT 1320

GTCTCCTCTG TCAAGGAGAG CCAGATTGGG AAGATGCACA TCCTGCCGCT CATCGGCGGG 1380

AAGGTGGAGG AGGTGAAGAA GCACAATCAC TGTTTGGCCT TCAGCTCGGC AGGGCCTCAA 1440

AGTCAAACCT ACTATGTCAG CTTTGACAGC TTCACAGAGC ACCTGCGCTG GCACAGACAC 1500

GCTGCCAAGA TGGTGTCCCA GAGAATCAAC TCAGTTGATT TGTCCTGCTG CAGTCTGGAA 1560

CTTCTTCCCC CCAACCTCTT TTATAGCCAC GATCTCACCC ACCTCAACCT AAAACACAAC 1620

TTCCTCCCTG CAGACCATCG CCTTCAGCAA CTGCAAAGGT TCTCTCGTCT CCGCAGCCTC 1680

AACCTCTCCA ATAACCACCT TGGTCAGTTC CCGTTGGCCA TTTGTGACAT CCCCACCCTG 1740

ACAGAGGTCA ACCTCAGCTG TAACTACATG GACTCTGTCC CCAGCTCTGT GGGGGCCATG 1800

AGCAATTTGC AGACGTTCCT GTTGGACGGA AACAGTTTAA GTGAGCTGCC GTGTGAGCTG 1860

GGGTCCCTGC AGAGGCTGAG CTACTTAGGC CTTTCCTTCA ACCAGTTCAG CCACGTGCCC 1920

CAGGTGCTCG AGCGCTTGGC CTCCATGGAG AAGCTTTGCA TGGCTGGAAA CAACCAGGAA 1980

ACGCTTACCC TGCAGAATTT CAGACTGCTC CATGTCAAAC ACATCGATCT AAGGTTGAAT 2040

AAGATCTCCG TCATGGTGCC AGACGAGCCG GACCTGCTGA GGCACGTGAC CCAGCTGGAC 2100

CTGAGGGATA ACCAGCTGAC GGAGCTTGAC GCCTCCATCT TCCCCAGGCT GGAGGTCCTC 2160

CACTGCGAGA GGAACCACAT AACGTGTCTT AAGGTCAAAG GTTCCCTGCT CAAAGGCATC 2220

TACGCCTCAA ACAATGAATT ACGACAGCTA GATGTAAGTC CTGTGCCCTC CAATCTCACT 2280

TACATGGATA TCTCGAGGAA CCACATGGAG TCCTTGCCAG ACTGGCTGTG TGAAGCGAAG 2340

AAACTGGAAG TCCTGGACGT GAGCCACAAC CTCATCACCG AGCTCCCGGC GAGGTTGTTC 2400

TGCAGCAACA GCCTAAGGAA GCTGAGTGCT GGACATAACC AGCTGCAGAA GCTGCCTGAA 2460

AGAGTGGAGC GCCCTCTGCT GGAGGTTTTG GATGTTCAGC ATAATCAACT GGTGGAACTT 2520

CCCTGCAACC TGTTCCTCAA ATCCAACAGT TTACGATGCG TAAATGCATC AGCCAACAAG 2580

CTGGAGCACC TGCCACCCTC CAGTCTGTCA GAGGAAAGCC ACAGCATCCT GCAGGAGCTC 2640

TACCTGACCA ATAACTGGCT GACGGACAAG TGTGTGCCGA TGCTCACAGG TCACACACAC 2700

CTGCGGGTTT TGCACATGGC ATACAATCAC CTCCAAACCT TCCCAGCGAG TAAAATGGCC 2760

AAGTTGGAGG AGCTGGAGGA GGTGGACCTG AGTGGAAACA TGCTGAAGAC TGTTCCCACC 2820

ACCATCATGA ACTGTAGACG GATGCACACG CTTATTGCCC ATTCCAACTC CATCGAGGTC 2880

TTCCCTGAGG TCATGCAGCT GATGGAGATG AAGTGTGTGG ACCTGAGCTG TAATGAGCTG 2940

AGTGAGATCA CTCTCCCAGA GAATCTGCCT CCAAAACTTC AGGAGCTGGA CCTCACTGGC 3000

AACCCTCGCC TCAACCTGGA CCATAAAACC CTCGAGCAGC TTAATAACAT TCGCTGTTTC 3060

CGTATTGATC CACCACCAAC CTTTTCATCG AATGAGGCAT CTGGGGGGCC CGCTGTGTGG 3120

AGTCATGGTT ACACAGAGGC CTCAGGCGTA AAGAACAAAC TCTGCGTTGC CGCCCTTTCA 3180

GTAAACAGTT TCTGTGGGAG TCGGGAAGCT CTGTACGGCG TGTTTGACGG AGACAGGAAC 3240

GTGGAAGTGC CCTACCTGCT GCAGTGCACG ATGAACGACG TCCTGGCCGA GGAAATCCAC 3300

AAGACAAAAA GCGAAGAGGA TTACATGACC AACACCTTCC TCGTCATGCA AAGGAAATTG 3360

GGAACAGCCG GACAGAAACT TGGCGGCTCT GCAGCCCTGT GTCACATCCG CCACGACCCC 3420

ACCGACCCCA GTGGCTGCTT CATCCTCACA GCAGCTAATG TGGGAAAGTG CCAGGCCATC 3480

CTGTGCCGGG ACGGGAAGCC CATGTCCCTG TCGCTGCTTC ACAACGTGGG CCTTGAGGAG 3540

GAATACCGTA GGATCAGGCA GCACAGAGCC ATCGTGACTG AGGACAACAA GGTGAACGGG 3600

GTGACTGACT CCACAAGGAT TATGGGCTAC TCCTTCCTTT ACCCTTCAGT CATTCCTTGC 3660

CCCTATGTGC AGACGGTGAC TCTCACCCCT CAGGATGAGT TCTTCATCCT GGGCAGCCGC 3720

GGGCTGTGGG ACGCTGTGTC TCCTACAGAA GCAGTGGAGG CGGTTCGGAA TGTCCCGGAC 3780

GGTCTCGCTG CGGCTAAGAA GCTCTGCACC TTGGCTCAAG GCTACGGCTG TACCGACAGC 3840

CTGAGTGCAG TCGTGGTGCA GCTCAGCGTG AGTGAAGACT GCTGCTCCTG CTGCTGCTCC 3900

GACCCGCCCC AGCCTCCACC TAGCCCCGGC CTGGGCGCCT ACCCATCGTC GTCTTCTGCC 3960

ATTAAGGATC GACCCTCGGA CGGCTCCCTG CCCGTTCCGC CGTCTTCCTG CAGCGAAATC 4020

AGCAGCGAGA TCAGCACCAG CGAGATGAGC AGCGAGGTGG GCTCCACGGC CTCGTCCGAC 4080

GAGCCCCCGC AGAGCTCCTG TTCAGAGCTG GCTTCCGCTC GGAACTGCTG TGCGCTCCAC 4140

CCGGCCTGCC TGGCCGGCTC CTTTCAGAGG CAGCTGTCCA GCGCCACCTT CTCCAGCGCC 4200

TTGTCCGACA ACGGGCTGGA CAGCGAGGAC GAGGAGCCCA TCGCCGGCGT CTTCTCCAAC 4260

GGGAGCCGAG TGGAAGTGGA GGCAGACGTT CACTGCCTGA AAGCGGAGCT GTCGCAGTTA 4320

TCATCGCCCC AAAGCCTCCT ACCCGTATCG TCCAGCCAGG ACAGTATCGA CCTGAACCTG 4380

GCAGAGGCCG AGAACGGCCT GGAGAGAGAC GAGTCGTGGC CAGGTGTGGG AGCAGGAGCT 4440

GGGGATGGTG GGAAGTTTCC GGGGAAGAGG AGGGTTAACG GTTCGGTGGC GCGTCAAGAG 4500

AAGAGTCACA ACCTCATCGA GGTGGCAGCC GACGCCCCGT CCAAGAAATC AGGGGGTTAC 4560

TTCACAGCTC CAGCTCAGCC CGACCCGGAC GACCAGTTCA TCATCCCCCC TGAGCTGGAG 4620

GAAGAGGTGA AGGAGATCAT GAAGCAGCAT CAGCAGAAAC AGCAGAAGCC AGCCGGGACG 4680

GATCAGCCCA CTGATTACTA CGACACCCCT CTCTAG 4716

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g+++ +g +n+++ a+ s+++f+ s+e+     ++gv+DG+++ ev + +++++ ++l

Q: 1041  SHGYTEASGVKNKLCVAALSVNSFCGSREA-----LYGVFDGDRNVEVPYLLQCTMNDVL  1095

         689***********************9885.....9************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

         aee+     +++  +++++++Fl ++++l       ++ +k G +a +++i+++

Q: 1096  AEEIH----KTKSEEDYMTNTFLVMQRKL------GTAGQKLGGSAALCHIRHDptdpsg  1145

         ***99....8999999*************......99****************99*****

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

            l+ anvG+++a+Lcr+gk+++ls  H++  e+E++Ri+++ + v++++  +v+Gv+

Q: 1146  cfILTAANVGKCQAILCRDGKPMSLSLLHNVGLEEEYRRIRQHRAIVTEDN--KVNGVTD  1203

         988888********************************************9..*******

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +R +G  +l+p v+p P v+ ++lt++def+iL+s Glwd vs+ eav++vr+v +

Q: 1204  STRIMGYSFLYPSVIPCPYVQTVTLTPQDEFFILGSRGLWDAVSPTEAVEAVRNVPD---  1260

         *********************************************************...

S: 234   aeqeaakkLvklalargskdnvsaivv  260

            +aakkL++la+ +g++d++sa+vv

Q: 1261  -GLAAAKKLCTLAQGYGCTDSLSAVVV  1286

         .************************97

Domain Sequence
(FASTA)

SHGYTEASGV KNKLCVAALS VNSFCGSREA LYGVFDGDRN VEVPYLLQCT MNDVLAEEIH 60

KTKSEEDYMT NTFLVMQRKL GTAGQKLGGS AALCHIRHDP TDPSGCFILT AANVGKCQAI 120

LCRDGKPMSL SLLHNVGLEE EYRRIRQHRA IVTEDNKVNG VTDSTRIMGY SFLYPSVIPC 180

PYVQTVTLTP QDEFFILGSR GLWDAVSPTE AVEAVRNVPD GLAAAKKLCT LAQGYGCTDS 240

LSAVVV 246

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>