EKS-CAE-00261

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00261

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	338.5	4.1E-101	35	286	252

Status

Reviewed

Ensembl Protein

F14H12.4b

UniProt Accession

Q9NB31; Q2AAC7;

Protein Name

Serine/threonine-protein kinase cst-1 18kDa subunit

Protein Synonyms/Alias

STE20-like kinase 1; STE20-like kinase MST; cMST;

Gene Name

cst-1

Gene Synonyms/Alias

cst-1; F14H12.4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F14H12.4	F14H12.4a	F14H12.4a
F14H12.4	F14H12.4b	F14H12.4b

Organism

Caenorhabditis elegans

Functional Description

Serine/threonine-protein kinase which extends lifespanand delays tissue aging, probably by activating daf-16.

Protein Length

497

Protein Sequence
(FASTA)

MPPSTDSSRR NSEEGSSDGF KLDSSALNKP PEEVFDIVGK LGEGSYGSVH KAIHRESGHV 60

LAIKKVPVDT DLQEIIKEIS IMQQCKSKYV VKYYGSYFKH SDLWIVMEYC GAGSISDIMR 120

ARRKPLSEQE ISAVLRDTLK GLQYLHDLKK IHRDIKAGNI LLNTDGIAKL ADFGVAGQLT 180

DTMAKRNTVI GTPFWMAPEV IEEIGYDTKA DIWSLGITAI EMAEGRPPYS DIHPMRAIFM 240

IPTKPPPTFK KPEEWSSEFN DFIRSCLIKK PEERKTALRL CEHTFIKNAP GCDIMQLMIQ 300

DAQEKAILGQ APMAASSGND ATLLSEGMST MIDGGESTLV QHKDNYVTAQ SLRSQMESLR 360

IGGEIPKSAY IPGSSKNGNS PRVQPPGHTA SASDPSKNQP FAQDGTGPNF QLGTSESSYK 420

DASYNMMNTE AEYENRFQRA VVDGDFEFLR NITLDELIRR KESLDSEMEE EIRELQRRYK 480

TKRQPILDVI EIKKRLQ 497

Nucleotide Sequence
(FASTA)

ATGCCACCGT CTACAGACAG CTCGCGGCGG AATTCGGAAG AGGGCTCAAG CGATGGATTT 60

AAATTGGATT CGTCGGCGCT TAACAAACCA CCAGAAGAAG TTTTCGACAT TGTTGGAAAG 120

CTGGGCGAAG GATCATATGG AAGCGTACAT AAGGCAATTC ACAGAGAGTC AGGTCATGTG 180

TTAGCCATCA AAAAAGTGCC AGTGGATACT GATCTTCAAG AAATTATCAA GGAAATCAGT 240

ATAATGCAAC AATGTAAAAG TAAATATGTT GTCAAATACT ATGGATCGTA TTTCAAACAT 300

TCGGATCTAT GGATTGTGAT GGAATACTGT GGAGCTGGGT CGATCTCCGA TATAATGCGT 360

GCCAGGCGGA AACCGTTATC CGAACAAGAA ATCAGTGCAG TTTTGCGCGA TACTCTCAAG 420

GGATTGCAAT ATTTGCATGA CTTGAAGAAG ATTCATAGAG ATATAAAGGC TGGAAACATT 480

CTACTCAATA CCGATGGAAT TGCAAAGCTT GCGGATTTCG GTGTCGCTGG ACAGTTGACT 540

GATACAATGG CAAAAAGAAA TACAGTCATT GGAACGCCAT TCTGGATGGC CCCTGAAGTT 600

ATCGAAGAAA TCGGATATGA CACAAAAGCT GATATATGGT CACTGGGAAT AACAGCTATC 660

GAAATGGCAG AGGGACGGCC TCCTTATTCA GATATTCATC CGATGCGAGC AATCTTCATG 720

ATTCCAACTA AACCACCACC TACGTTTAAA AAACCTGAAG AATGGTCGTC CGAGTTCAAT 780

GATTTCATAA GAAGCTGTTT AATTAAAAAG CCAGAAGAAA GAAAAACGGC ACTCCGATTG 840

TGTGAGCACA CATTCATCAA AAATGCACCA GGTTGCGATA TTATGCAGTT GATGATCCAG 900

GATGCTCAAG AAAAAGCTAT ACTAGGACAA GCACCAATGG CAGCAAGCAG CGGAAATGAT 960

GCAACGTTGC TAAGCGAGGG AATGTCCACT ATGATTGACG GTGGAGAGTC TACGTTAGTT 1020

CAACACAAAG ACAACTATGT CACTGCTCAA AGTCTTCGAA GTCAAATGGA AAGCTTGAGA 1080

ATTGGTGGAG AAATTCCTAA ATCGGCATAT ATTCCAGGCT CGTCGAAAAA TGGCAACTCA 1140

CCGCGCGTTC AACCACCGGG TCACACCGCA AGCGCTTCAG ACCCTTCAAA AAACCAACCG 1200

TTTGCTCAAG ATGGAACCGG TCCAAACTTT CAATTGGGCA CCAGCGAGAG CAGTTACAAA 1260

GATGCTAGTT ATAATATGAT GAACACGGAA GCCGAATACG AAAATAGATT TCAACGGGCA 1320

GTGGTCGATG GAGATTTCGA ATTTTTACGA AACATCACGC TAGACGAACT GATTCGAAGG 1380

AAAGAAAGTT TGGATTCGGA GATGGAAGAA GAAATACGAG AGTTGCAGAG AAGATACAAA 1440

ACAAAAAGGC AACCAATACT GGATGTTATA GAAATCAAAA AACGACTTCA ATGA 1494

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         ++++ ++g+G++g+v++a ++++g+++aikk+ +++  +l+e++keis+++++k++++v+

Q: 35    FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDT--DLQEIIKEISIMQQCKSKYVVK  92

         78999*****************************96..9*********************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         y++s++k+++lw+vmey+ +Gs+sd+++ +++++l+E++i+++lr++lk+L+ylH+ k+i

Q: 93    YYGSYFKHSDLWIVMEYCGAGSISDIMR-ARRKPLSEQEISAVLRDTLKGLQYLHDLKKI  151

         ****************************.99*****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdika+niLl+++g  kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gYd+k

Q: 152   HRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE--EIGYDTK  209

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         aDiwslGItaie+aeg+pP++d++p++a+++i++++pp++k+++++s+ef++f+++cl k

Q: 210   ADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEWSSEFNDFIRSCLIK  269

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         +pe+R++a +l++h+F+

Q: 270   KPEERKTALRLCEHTFI  286

         ****************7

Domain Sequence
(FASTA)

FDIVGKLGEG SYGSVHKAIH RESGHVLAIK KVPVDTDLQE IIKEISIMQQ CKSKYVVKYY 60

GSYFKHSDLW IVMEYCGAGS ISDIMRARRK PLSEQEISAV LRDTLKGLQY LHDLKKIHRD 120

IKAGNILLNT DGIAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIEEI GYDTKADIWS 180

LGITAIEMAE GRPPYSDIHP MRAIFMIPTK PPPTFKKPEE WSSEFNDFIR SCLIKKPEER 240

KTALRLCEHT FI 252

Keyword

Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008340	; P:determination of adult lifespan
GO:0040011	; P:locomotion
GO:0048747	; P:muscle fiber development
GO:0040017	; P:positive regulation of locomotion
GO:0007165	; P:signal transduction

KEGG

cel:CELE_F14H12.4

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR011524	; SARAH.
IPR024205	; SARAH_domain.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF11629	; Mst1_SARAH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.
PS50951	; SARAH; 1.

Prints

Created Date

20-Feb-2013