EKS-CAE-00177
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00177
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CASK489.24.1E-14718281264
StatusReviewed
Ensembl ProteinF17E5.1a
UniProt AccessionP54936;
Protein NameProtein lin-2
Protein Synonyms/Alias Abnormal cell lineage protein 2;
Gene Namelin-2
Gene Synonyms/Alias lin-2; F17E5.1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
F17E5.1F17E5.1bF17E5.1b
F17E5.1F17E5.1aF17E5.1a
OrganismCaenorhabditis elegans
Functional DescriptionMay play a structural role in the induction of thevulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.
Protein Length961
Protein Sequence
(FASTA)
MRELDPDESN LLLDEQLSIR DVIEQGPFSN VYRILHGPSN RKFLLRSINL NLFRQHTGLG 60
FEEIDEEIRI CQNLQHPYIC RLEKTINSVH YRHIIFENME GNDICFEIVQ RASNGFVFSE 120
YVVSHYTRQL LDALDYCHTR KIVHRDVRPH NLVLASKDTS APLKLCGFGV AKDLSEIGGS 180
MACGRVGVPQ FMAPEIVRKD RVSCSSDIWS SGVVLFLLLA GRLPFSGSTS DIYERIMQTD 240
VDVDGYMPNI SESARNLVRR MLNADPSKRI SAKEALNHEW IRDKEHMASR KHMNDVIDQM 300
RRYNESRKLK SNVLSAVNSG RFDETTPRQD TPQTAFVDGS SPGGDCCHRG ESSSNDAAEP 360
PADKDLSGAY KVLGSLDAIN SLLDPNSYKP GSTTFQKIHD DGSVRNLLRL YDKIKALPCE 420
PVVTEVDTST LRKETLNQID GLLGPSPEAL ELRQLLNSPH LASCVQALDV VVCEIRDPKN 480
EASGSGDKEG NCVSSDPAPA YLNGGVLPLG AQRAGTSFEH FNQSAVHTSY DEEEEELYDC 540
MSRLRLVQFQ KDTQEPMGIT LKVNEDGRCF VARIMHGGMI HRQATLHVGD EIREINGMSV 600
ANRSVESLQE MLRDARGQVT FKIIPSYRSA PPACEIFVRA QFDYEPSQDD LIPCPQAGIP 660
FKTGDILQVI SKDDHNWWQA RFVSSFPSIG NSSNAQRSNQ QQVAGLIPSP ELQEWRTACL 720
AMERSKNTCN THCMWFNKKK KYYTTKYLQK HSALFDQLDL VTYEEVMRLS QYRRKTLVLL 780
GAHGVGRRHI KNTLIHRHPN RFAYPIPHTT RPPRKDEVDG KHYYFVTNEQ MMADIQNNEY 840
LEYGTHEESM YGTKLETIRN IHKSGKIAIL DVEPQALKVL RTAEYSPFVV FIAAPNLQGM 900
QDPDGSLEKL LNESDVLRQA FGHLFDFIIT NSDIDDTIAQ LERLVEKLPA YPQWLPVTWV 960
Y 961
Nucleotide Sequence
(FASTA)
ATGAGGGAGC TTGACCCGGA CGAGTCGAAC CTTCTCCTCG ATGAACAACT GTCGATCCGG 60
GATGTGATAG AACAAGGTCC ATTTTCAAAT GTATACCGAA TACTTCATGG ACCATCAAAT 120
CGAAAATTTT TACTGAGATC AATCAATTTG AATTTGTTCA GACAGCACAC CGGGTTAGGA 180
TTTGAAGAAA TCGACGAGGA AATTAGAATA TGCCAAAATC TACAGCACCC TTACATATGC 240
CGACTGGAAA AAACTATCAA CAGCGTTCAT TATCGACATA TCATTTTTGA GAACATGGAG 300
GGAAATGATA TTTGTTTTGA AATAGTTCAA AGAGCAAGTA ATGGATTCGT ATTTTCTGAA 360
TATGTAGTAA GTCACTATAC ACGGCAGCTC CTAGATGCTC TAGATTACTG TCACACTAGG 420
AAAATTGTTC ATAGAGATGT ACGGCCTCAC AATTTAGTAT TAGCGTCAAA AGATACTTCA 480
GCTCCACTGA AACTGTGTGG ATTTGGAGTT GCAAAAGATT TGTCTGAAAT TGGTGGTTCA 540
ATGGCTTGTG GTCGAGTAGG TGTACCGCAA TTCATGGCTC CAGAGATAGT GCGAAAAGAT 600
CGAGTGTCAT GCTCGTCGGA TATCTGGTCT TCCGGTGTCG TCCTTTTTCT CTTGCTAGCT 660
GGACGATTAC CTTTCTCCGG GTCTACTTCC GATATCTATG AAAGGATCAT GCAAACAGAT 720
GTAGATGTTG ACGGATATAT GCCAAATATT TCTGAAAGTG CACGGAACCT TGTGAGAAGA 780
ATGCTCAACG CGGACCCTTC AAAACGAATC AGTGCAAAAG AAGCTCTGAA CCATGAATGG 840
ATCAGAGATA AAGAACACAT GGCGAGCAGA AAACACATGA ATGACGTCAT TGATCAGATG 900
CGAAGGTACA ATGAATCAAG AAAATTGAAG AGCAATGTGT TGTCGGCCGT CAATAGTGGC 960
AGGTTTGACG AGACGACTCC CCGGCAAGAC ACACCTCAAA CCGCATTCGT TGACGGATCA 1020
TCGCCAGGTG GAGATTGCTG TCATCGTGGA GAGTCATCGT CAAATGATGC AGCCGAACCA 1080
CCCGCCGACA AGGATCTGTC AGGAGCTTAT AAGGTTCTTG GAAGTTTGGA CGCCATCAAC 1140
AGTCTTTTGG ACCCCAACAG CTACAAGCCC GGCAGCACCA CTTTCCAGAA AATTCATGAC 1200
GACGGGAGTG TTCGGAATCT GTTAAGGTTG TATGACAAGA TCAAAGCGTT GCCGTGTGAG 1260
CCGGTGGTAA CGGAGGTCGA CACGTCAACT CTTCGAAAAG AGACACTTAA CCAAATAGAC 1320
GGCCTTCTTG GACCAAGCCC CGAAGCATTG GAACTCCGAC AACTACTGAA TTCACCACAT 1380
TTAGCTAGTT GTGTCCAAGC GCTTGACGTA GTGGTTTGTG AAATTCGTGA TCCGAAAAAT 1440
GAAGCAAGTG GTTCAGGAGA CAAGGAGGGC AATTGTGTAT CAAGTGATCC AGCACCGGCA 1500
TATCTAAACG GAGGCGTCTT GCCATTGGGC GCCCAGAGGG CCGGAACATC CTTCGAGCAT 1560
TTCAATCAAT CGGCTGTCCA CACATCATAC GACGAAGAAG AAGAAGAATT ATACGACTGC 1620
ATGTCGCGAT TAAGGCTTGT GCAATTTCAA AAAGACACGC AAGAACCAAT GGGAATTACG 1680
TTGAAGGTCA ACGAAGATGG AAGGTGTTTT GTGGCAAGAA TTATGCATGG AGGCATGATT 1740
CATAGACAAG CAACCCTTCA TGTTGGAGAT GAAATCCGTG AAATAAATGG AATGAGCGTA 1800
GCGAATCGGA GTGTAGAATC GCTTCAAGAA ATGCTCAGAG ATGCTCGAGG TCAAGTCACC 1860
TTTAAAATCA TCCCATCTTA CCGATCCGCA CCACCAGCGT GCGAGATTTT TGTACGTGCT 1920
CAATTCGACT ACGAACCAAG TCAAGACGAT CTGATTCCGT GTCCACAGGC TGGAATTCCT 1980
TTTAAAACTG GCGATATTCT TCAGGTAATC TCCAAGGATG ACCATAACTG GTGGCAAGCA 2040
CGATTTGTAT CTTCGTTCCC GTCAATTGGA AATTCTTCAA ATGCACAACG AAGCAATCAA 2100
CAGCAAGTGG CAGGCCTCAT TCCGTCGCCG GAGCTTCAAG AATGGAGGAC AGCATGTTTG 2160
GCGATGGAAA GATCCAAAAA CACTTGTAAT ACTCACTGCA TGTGGTTCAA CAAGAAGAAA 2220
AAGTATTACA CAACTAAATA TCTTCAGAAG CATTCTGCAC TGTTTGATCA ACTTGATCTG 2280
GTGACTTATG AAGAAGTAAT GAGGCTGTCA CAATATCGGA GAAAAACCTT AGTACTTCTT 2340
GGAGCTCATG GCGTTGGCAG AAGACATATC AAGAACACTT TGATACACAG ACACCCGAAT 2400
AGATTTGCAT ATCCAATTCC CCATACAACT CGACCGCCAC GAAAAGATGA AGTTGATGGT 2460
AAACATTACT ATTTTGTTAC AAATGAGCAA ATGATGGCGG ACATTCAAAA TAATGAATAT 2520
CTAGAGTATG GAACGCACGA AGAAAGTATG TATGGAACAA AGCTAGAAAC CATTCGCAAT 2580
ATTCATAAGA GTGGAAAAAT TGCAATTTTG GATGTGGAAC CACAAGCATT AAAGGTTCTG 2640
AGGACTGCAG AATATTCACC ATTTGTTGTG TTTATTGCAG CACCAAACTT GCAAGGAATG 2700
CAGGATCCGG ATGGTTCTTT GGAAAAGCTC TTGAATGAAT CGGATGTTCT TCGGCAAGCT 2760
TTTGGTCACC TTTTCGACTT TATCATCACA AACAGCGATA TTGATGACAC GATTGCTCAA 2820
TTAGAACGTT TAGTCGAAAA ATTACCCGCT TACCCGCAAT GGCTTCCAGT CACTTGGGTC 2880
TACTGA 2886
Domain Profile
S: 2     elcevigkGpfsvvrriihresnqkfavkivdvakftsspGlstedlkreasichmlkhp  61
         ++++vi++Gpfs+v+ri+h++sn+kf+++++++++f++++Gl++e++++e++ic++l+hp
Q: 18    SIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLGFEEIDEEIRICQNLQHP  77
         89**********************************************************
S: 62    yivelletyssegmlylvfefmeGadlcfeivkrasaGfvyseavashymrqilealryc  121
         yi++l++t++s+++++++fe+meG+d+cfeiv+ras+Gfv+se+v+shy+rq+l+al+yc
Q: 78    YICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSEYVVSHYTRQLLDALDYC  137
         ************************************************************
S: 122   hdnkivhrdvrphcvllaskdnsapvklgGfGvaiqlseisglvagGrvGvphfmapevv  181
         h++kivhrdvrph+++laskd+sap+kl+GfGva++lsei+g++a+GrvGvp+fmape+v
Q: 138   HTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIGGSMACGRVGVPQFMAPEIV  197
         ************************************************************
S: 182   krerygksvdvwgaGvvlfillsGrlpflGskerlfesiikgklkldarewssisesakd  241
         +++r+++s+d+w++Gvvlf+ll+Grlpf+Gs+++++e+i+++++++d+++ ++isesa++
Q: 198   RKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQTDVDVDGYM-PNISESARN  256
         **************************************************.*********
S: 242   lvrrmlaadpakrisvkealnhewl  266
         lvrrml+adp+kris+kealnhew+
Q: 257   LVRRMLNADPSKRISAKEALNHEWI  281
         ************************8
Domain Sequence
(FASTA)
SIRDVIEQGP FSNVYRILHG PSNRKFLLRS INLNLFRQHT GLGFEEIDEE IRICQNLQHP 60
YICRLEKTIN SVHYRHIIFE NMEGNDICFE IVQRASNGFV FSEYVVSHYT RQLLDALDYC 120
HTRKIVHRDV RPHNLVLASK DTSAPLKLCG FGVAKDLSEI GGSMACGRVG VPQFMAPEIV 180
RKDRVSCSSD IWSSGVVLFL LLAGRLPFSG STSDIYERIM QTDVDVDGYM PNISESARNL 240
VRRMLNADPS KRISAKEALN HEWI 264
KeywordAlternative splicing; Calmodulin-binding; Complete proteome; Reference proteome; Repeat; SH3 domain.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00177
EKS-ANC-00182
EKS-BOT-00189
EKS-CAJ-00196
EKS-CAF-00195
EKS-CAP-00214
EKS-CII-00122
EKS-CIS-00227
EKS-DAR-00489
EKS-DRM-00100
EKS-EQC-00184
EKS-FEC-00177
EKS-GAM-00106
EKS-GAG-00161
EKS-GAA-00233
EKS-GOG-00185
EKS-HOS-00194
EKS-LAC-00199
EKS-LOA-00185
EKS-MAM-00189
EKS-MEG-00146
EKS-MOD-00187
EKS-MUM-00191
EKS-MUP-00191
EKS-MYL-00194
EKS-NOL-00178
EKS-ORN-00240
EKS-ORA-00167
EKS-ORC-00172
EKS-ORL-00225
EKS-OTG-00195
EKS-PAT-00179
EKS-PES-00164
EKS-POA-00183
EKS-SAH-00181
EKS-SUS-00162
EKS-TAG-00214
EKS-TAR-00246
EKS-TEN-00240
EKS-XET-00219
EKS-XIM-00236
Gene Ontology
GO:0030054; C:cell junction
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0018991; P:oviposition
GO:0040026; P:positive regulation of vulval development
GO:0009791; P:post-embryonic development
KEGG
cel:CELE_F17E5.1;
InterPros
IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR020590; Guanylate_kinase_CS.
IPR011009; Kinase-like_dom.
IPR004172; L27.
IPR014775; L27_C.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR011511; SH3_2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
Pfam
PF00625; Guanylate_kin; 1.
PF02828; L27; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
PF07653; SH3_2; 1.
SMARTs
SM00072; GuKc; 1.
SM00569; L27; 2.
SM00228; PDZ; 1.
SM00220; S_TKc; 1.
SM00326; SH3; 1.
Prosites
PS00856; GUANYLATE_KINASE_1; 1.
PS50052; GUANYLATE_KINASE_2; 1.
PS51022; L27; 2.
PS50106; PDZ; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50002; SH3; 1.
Prints
Created Date20-Feb-2013