EKS-CAE-00114
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00114
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/Akt461.81.0E-138180437258
StatusReviewed
Ensembl ProteinF28H6.1b
UniProt AccessionQ9XTG7; O77145;
Protein NameSerine/threonine-protein kinase akt-2
Protein Synonyms/Alias Protein kinase B akt-2; PKB akt-2;
Gene Nameakt-2
Gene Synonyms/Alias akt-2; F28H6.1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
F28H6.1F28H6.1aF28H6.1a
F28H6.1F28H6.1bF28H6.1b
OrganismCaenorhabditis elegans
Functional DescriptionActs downstream of age-1 and pdk-1 in the daf-2/insulinreceptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead- related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance.
Protein Length483
Protein Sequence
(FASTA)
MSTENAHLQK EDIVIESWLH KKGEHIRNWR PRYFILFRDG TLLGFRSKPK EDQPLPEPLN 60
NFMIRDAATV CLDKPRPNMF IVRCLQWTTV IERTFYADSA DFRQMWIEAI QAVSSHNRLK 120
ENAGNTSMQE EDTNGNPSGE SDVNMDATST RSDNDFESTV MNIDEPEEVP RKNTVTMDDF 180
DFLKVLGQGT FGKVILCREK SSDKLYAIKI IRKEMVVDRS EVAHTLTENR VLYACVHPFL 240
TLLKYSFQAQ YHICFVMEFA NGGELFTHLQ RCKTFSEART RFYGSEIILA LGYLHHRNIV 300
YRDMKLENLL LDRDGHIKIT DFGLCKEEIK YGDKTSTFCG TPEYLAPEVI EDIDYDRSVD 360
WWGVGVVMYE MMCGRLPFSA KENGKLFELI TTCDLKFPNR LSPEAVTLLS GLLERVPAKR 420
LGAGPDDARE VSRAEFFKDV DWEATLRKEV EPPFKPNVMS ETDTSFFDRV RYVSILLKVS 480
EAI 483
Nucleotide Sequence
(FASTA)
ATGTCTACTG AAAACGCCCA TCTACAAAAA GAAGACATTG TTATTGAAAG TTGGCTTCAC 60
AAGAAAGGAG AGCACATTCG TAATTGGCGC CCCAGGTACT TCATCTTGTT TCGAGATGGA 120
ACGTTGCTTG GATTCCGGTC AAAGCCAAAG GAAGATCAGC CGTTACCAGA GCCACTGAAT 180
AATTTTATGA TTAGAGACGC AGCGACGGTT TGCCTTGACA AACCTCGACC AAATATGTTT 240
ATCGTGCGAT GTCTCCAATG GACCACTGTC ATTGAACGCA CATTTTATGC GGATAGCGCC 300
GACTTCCGTC AGATGTGGAT TGAAGCAATT CAAGCTGTAT CCAGTCACAA TCGTTTGAAA 360
GAAAATGCAG GAAATACCAG CATGCAGGAG GAAGATACTA ATGGAAATCC GTCTGGAGAA 420
AGTGATGTGA ACATGGACGC AACAAGCACC CGTTCGGATA ATGATTTTGA GTCAACTGTA 480
ATGAATATCG ACGAACCAGA GGAAGTTCCA AGAAAAAATA CAGTGACGAT GGACGATTTT 540
GACTTCCTCA AAGTTCTCGG TCAAGGAACC TTCGGAAAAG TTATTTTGTG CAGGGAGAAA 600
AGTTCTGATA AGCTCTACGC CATTAAGATT ATCAGAAAAG AAATGGTCGT TGATCGTTCT 660
GAGGTGGCCC ACACTTTGAC TGAAAATCGA GTTCTGTATG CTTGCGTTCA CCCTTTTCTC 720
ACGCTACTTA AATACAGTTT CCAAGCACAA TATCACATCT GTTTTGTGAT GGAGTTTGCA 780
AATGGTGGCG AGCTGTTCAC CCATCTTCAG AGGTGCAAAA CATTCAGCGA AGCACGAACA 840
AGATTTTATG GATCGGAAAT CATACTTGCT CTTGGATACC TTCATCACAG AAATATTGTG 900
TATCGTGATA TGAAACTCGA AAATTTGCTT CTCGACAGAG ATGGTCACAT CAAAATCACT 960
GACTTTGGGT TGTGCAAAGA GGAAATCAAA TATGGAGATA AAACAAGCAC CTTTTGCGGA 1020
ACACCAGAAT ACCTTGCACC AGAGGTTATC GAAGACATCG ACTATGACCG TAGTGTTGAC 1080
TGGTGGGGAG TCGGAGTGGT CATGTACGAA ATGATGTGTG GACGGCTTCC ATTTTCAGCA 1140
AAGGAGAACG GCAAACTCTT CGAACTAATT ACGACATGTG ATTTGAAGTT CCCGAATAGG 1200
TTAAGCCCAG AAGCCGTAAC ATTACTATCT GGACTACTCG AAAGGGTCCC AGCTAAGCGG 1260
CTTGGTGCCG GTCCTGATGA TGCACGTGAA GTTTCGAGAG CTGAATTTTT CAAAGATGTG 1320
GATTGGGAAG CAACATTAAG AAAAGAAGTC GAACCTCCAT TTAAGCCAAA TGTGATGTCT 1380
GAAACGGACA CGAGTTTCTT TGACAGAGTA CGTTACGTTT CAATTCTTTT GAAAGTTTCA 1440
GAAGCAATAT GA 1452
Domain Profile
S: 1     fdllkllGkGtfGkvilvrekatqklyalkilkkevivakdevahtlterrvlkrtkhpf  60
         fd+lk+lG+GtfGkvil+rek+++klya+ki++ke++v+++evahtlte+rvl+++ hpf
Q: 180   FDFLKVLGQGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPF  239
         9***********************************************************
S: 61    lvalkysfqtkeklclvleyvnGGelffhlskervfsedrarfygaeivsaldylhskdv  120
         l+ lkysfq++ ++c+v+e++nGGelf+hl+++++fse+r+rfyg+ei++al+ylh++++
Q: 240   LTLLKYSFQAQYHICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNI  299
         ************************************************************
S: 121   vyrdlklenllldkdGhikitdfGlckeeikdgdktktfcGtpeylapevlededygkav  180
         vyrd+klenllld+dGhikitdfGlckeeik+gdkt+tfcGtpeylapev+ed dy+++v
Q: 300   VYRDMKLENLLLDRDGHIKITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSV  359
         ************************************************************
S: 181   dwwglGvvlyemlcGrlpfynkdheklfelilleelkfprklseeaksllsGllkkdpkk  240
         dwwg+Gvv+yem+cGrlpf +k++ klfeli++++lkfp++ls+ea +llsGll++ p+k
Q: 360   DWWGVGVVMYEMMCGRLPFSAKENGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAK  419
         ************************************************************
S: 241   rlGggkddakeireheff  258
         rlG+g+dda+e++++eff
Q: 420   RLGAGPDDAREVSRAEFF  437
         *****************9
Domain Sequence
(FASTA)
FDFLKVLGQG TFGKVILCRE KSSDKLYAIK IIRKEMVVDR SEVAHTLTEN RVLYACVHPF 60
LTLLKYSFQA QYHICFVMEF ANGGELFTHL QRCKTFSEAR TRFYGSEIIL ALGYLHHRNI 120
VYRDMKLENL LLDRDGHIKI TDFGLCKEEI KYGDKTSTFC GTPEYLAPEV IEDIDYDRSV 180
DWWGVGVVMY EMMCGRLPFS AKENGKLFEL ITTCDLKFPN RLSPEAVTLL SGLLERVPAK 240
RLGAGPDDAR EVSRAEFF 258
KeywordAlternative splicing; ATP-binding; Complete proteome; Developmental protein; Immunity; Innate immunity; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Dasypus novemcinctus"; ?>Takifugu rubripes"; ?>
EKS-DAN-00010
EKS-TAR-00183
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0005543; F:phospholipid binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043053; P:dauer entry
GO:0008340; P:determination of adult lifespan
GO:0045087; P:innate immune response
GO:0008286; P:insulin receptor signaling pathway
KEGG
cel:CELE_F28H6.1;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR017892; Pkinase_C.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00169; PH; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00233; PH; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013