EKS-CAE-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	360.4	9.9E-108	293	586	294

Status

Reviewed

Ensembl Protein

F29C4.1a

UniProt Accession

P20792;

Protein Name

Cell surface receptor daf-1

Protein Synonyms/Alias

Abnormal dauer formation protein 1;

Gene Name

daf-1

Gene Synonyms/Alias

daf-1; F29C4.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F29C4.1	F29C4.1b	F29C4.1b
F29C4.1	F29C4.1a	F29C4.1a

Organism

Caenorhabditis elegans

Functional Description

Controls the dauer/nondauer developmental decision in arange of environmental conditions.

Protein Length

669

Protein Sequence
(FASTA)

MRIRHVVFCL LALVYGAETS DDDLDERTNI FIRDKLIPAL KLAEVTKVNF TRLHLCHCSR 60

EVGCNARTTG WVPGIEFLNE TDRSFYENTC YTDGSCYQSA RPSPEISHFG CMDEKSVTDE 120

TEFHDTAAKV CTNNTKDPHA TVWICCDKGN FCANETIIHL APGPQQSSTW LILTILALLT 180

FIVLLGIAIF LTRKSWEAKF DWYIRFKPKP GDPLRETENN VPMVTMGDGA GSSVPEVAPI 240

EQQGSTMSTS AGNSFPPGIM PNNMKDMLDV LEETSGSGMG PTTLHKLTIG GQIRLTGRVG 300

SGRFGNVSRG DYRGEAVAVK VFNALDEPAF HKETEIFETR MLRHPNVLRY IGSDRVDTGF 360

VTELWLVTEY HPSGSLHDFL LENTVNIETY YNLMRSTASG LAFLHNQIGG SKESNKPAMA 420

HRDIKSKNIM VKNDLTCAIG DLGLSLSKPE DAASDIIANE NYKCGTVRYL APEILNSTMQ 480

FTVFESYQCA DVYSFSLVMW ETLCRCEDGD VLPREAATVI PYIEWTDRDP QDAQMFDVVC 540

TRRLRPTENP LWKDHPEMKH IMEIIKTCWN GNPSARFTSY ICRKRMDERQ QLLLDKKAKA 600

VAQTAGVTVQ DRKILGPQKP KDESPANGAP RIVQKEIDRE DEQENWRETA KTPNGHISSN 660

DDSSRPLLG 669

Nucleotide Sequence
(FASTA)

ATGAGGATAC GGCACGTGGT GTTCTGCCTG CTCGCACTGG TTTATGGCGC CGAAACTTCC 60

GACGATGATC TCGACGAACG GACAAATATC TTCATCCGTG ATAAACTGAT TCCGGCGTTG 120

AAGCTTGCAG AAGTGACCAA GGTGAATTTC ACACGATTAC ACTTATGCCA TTGCTCAAGG 180

GAAGTTGGAT GCAACGCGAG GACTACCGGA TGGGTGCCTG GAATCGAGTT CCTTAATGAG 240

ACGGATCGCA GTTTTTATGA GAACACGTGC TACACGGACG GAAGCTGCTA CCAGAGCGCT 300

CGGCCGTCAC CCGAAATCTC ACATTTCGGA TGCATGGACG AGAAATCTGT GACCGACGAG 360

ACCGAGTTTC ACGATACGGC AGCGAAAGTG TGCACGAACA ACACGAAAGA CCCGCACGCT 420

ACCGTCTGGA TTTGCTGTGA TAAGGGAAAT TTTTGTGCGA ACGAGACGAT CATCCACTTG 480

GCGCCAGGCC CGCAGCAGTC ATCCACGTGG CTGATTCTTA CTATCCTCGC CCTGCTCACG 540

TTCATCGTGC TCCTGGGCAT TGCAATTTTC CTCACCAGAA AATCATGGGA GGCGAAATTC 600

GACTGGTATA TAAGATTCAA GCCAAAACCT GGAGATCCTC TACGCGAGAC GGAGAACAAT 660

GTACCGATGG TTACAATGGG CGACGGTGCT GGAAGTTCTG TGCCAGAAGT TGCTCCAATC 720

GAGCAGCAGG GAAGCACAAT GAGCACATCT GCAGGGAACT CGTTCCCTCC TGGAATCATG 780

CCTAATAACA TGAAGGATAT GCTTGATGTA CTCGAGGAGA CAAGTGGATC TGGTATGGGT 840

CCAACTACAC TTCACAAACT CACGATTGGT GGACAGATCA GGTTAACTGG TAGAGTTGGA 900

TCCGGAAGAT TTGGTAACGT GTCACGTGGA GACTACCGAG GTGAAGCGGT CGCTGTGAAG 960

GTTTTCAATG CGCTCGACGA GCCGGCGTTC CACAAGGAGA CGGAGATCTT TGAGACGCGG 1020

ATGTTGAGGC ATCCGAATGT GCTGAGATAT ATTGGAAGTG ATCGGGTTGA TACTGGATTT 1080

GTAACAGAAC TTTGGCTGGT GACAGAGTAT CATCCCAGCG GGTCCTTGCA CGATTTTCTG 1140

CTCGAGAATA CGGTTAACAT TGAGACGTAT TATAATTTGA TGAGGTCGAC GGCAAGTGGA 1200

CTTGCGTTCC TGCACAATCA GATTGGAGGG AGCAAAGAGT CCAACAAGCC AGCGATGGCT 1260

CACCGGGATA TCAAGAGCAA GAACATCATG GTCAAGAACG ATCTGACGTG TGCCATCGGA 1320

GATCTCGGTC TCTCGTTATC CAAGCCAGAA GACGCGGCAT CAGATATTAT TGCCAATGAG 1380

AACTACAAGT GCGGTACTGT TAGATACCTT GCACCGGAAA TCCTGAACAG TACGATGCAG 1440

TTCACCGTCT TCGAGAGCTA CCAATGTGCC GATGTCTACT CATTTTCTCT AGTCATGTGG 1500

GAAACCCTAT GCAGATGTGA AGATGGAGAT GTTCTGCCGA GAGAAGCGGC CACAGTGATC 1560

CCATATATTG AGTGGACCGA TCGGGATCCA CAAGACGCTC AGATGTTTGA TGTGGTTTGC 1620

ACGCGGAGGC TCAGACCTAC AGAGAATCCT CTGTGGAAGG ATCATCCGGA AATGAAACAC 1680

ATTATGGAGA TTATCAAAAC GTGCTGGAAT GGCAATCCGA GCGCCCGTTT CACCTCCTAT 1740

ATTTGCCGCA AACGAATGGA TGAACGGCAG CAACTGTTGC TGGACAAGAA GGCAAAAGCT 1800

GTGGCCCAGA CGGCAGGGGT GACAGTTCAG GATCGGAAGA TTTTGGGTCC CCAGAAACCG 1860

AAAGACGAGT CACCGGCAAA TGGTGCTCCG CGGATAGTTC AGAAGGAGAT TGATCGAGAA 1920

GATGAGCAGG AAAATTGGCG GGAAACTGCA AAAACTCCCA ATGGACACAT TTCCAGTAAT 1980

GACGACTCGT CACGCCCACT TCTTGGTTAG 2010

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         ++l+  +g+Gr+g+V ++++rge+vAvK+f++ de ++++E+ei++t +lrh+n+l++i+

Q: 293   IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIG  352

         678899******************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         +d+ +++ +tel+lvteyh++gsL+d+L ++t+++e++++l++s+asGla+LH++i g+k

Q: 353   SDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQIGGSK  412

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLal.kleeekeeldlaansqvGtkRYmaP  179

         +++Kpa+aHRD+kskNi+vk+dltc+i+DlGL+l k e++++++ +++n ++Gt RY+aP

Q: 413   ESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLsKPEDAASDIIANENYKCGTVRYLAP  472

         **********************************7788888889999*************

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyk...lpfeevvgsdPs  236

         E+l+++++++ fe++++aDvYs++Lv+WE ++Rce+ +++ ++ +   +p+ e+ ++dP+

Q: 473   EILNSTMQFTVFESYQCADVYSFSLVMWETLCRCED-GDVLPREAatvIPYIEWTDRDPQ  531

         ************************************.666666655679***********

S: 237   leemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

           +m +vv++++lrP+ +  wk+++++k+++++++ cW+ +p+aR+t+   +kr+

Q: 532   DAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM  586

         ************************************************9988886

Domain Sequence
(FASTA)

IRLTGRVGSG RFGNVSRGDY RGEAVAVKVF NALDEPAFHK ETEIFETRML RHPNVLRYIG 60

SDRVDTGFVT ELWLVTEYHP SGSLHDFLLE NTVNIETYYN LMRSTASGLA FLHNQIGGSK 120

ESNKPAMAHR DIKSKNIMVK NDLTCAIGDL GLSLSKPEDA ASDIIANENY KCGTVRYLAP 180

EILNSTMQFT VFESYQCADV YSFSLVMWET LCRCEDGDVL PREAATVIPY IEWTDRDPQD 240

AQMFDVVCTR RLRPTENPLW KDHPEMKHIM EIIKTCWNGN PSARFTSYIC RKRM 294

Keyword

Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0040024	; P:dauer larval development
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043051	; P:regulation of pharyngeal pumping
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

cel:CELE_F29C4.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013