| Tag | Content |
|---|
| EKPD ID | EPS-CAE-00088 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP1 | 408.9 | 4.5E-123 | 58 | 251 | 194 |
|
| Status | Reviewed |
| Ensembl Protein | F29F11.6a |
| UniProt Accession | Q27497; |
| Protein Name | Serine/threonine-protein phosphatase PP1-alpha |
| Protein Synonyms/Alias | CeGLC-7-alpha; Glc seven-like phosphatase 1; |
| Gene Name | gsp-1 |
| Gene Synonyms/Alias | gsp-1; F29F11.6; |
| Ensembl Information | |
| Organism | Caenorhabditis elegans |
| Functional Description | Serine/threonine-protein phosphatase which antagonizesthe function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. |
| Protein Length | 329 |
Protein Sequence
(FASTA) | | MSNDGDLNID NLITRLLEVR GCRPGKPVTM SEAEIRALCH KSREIFLSQP ILLELEAPLK 60 | | ICGDIHGQYN DLLRLFEYGG FPPEANYLFL GDYVDRGKQS LETICLLLAY KVKYPENFFL 120 | | LRGNHECASI NRIYGFYDEC KRRFSIKLWK TFTDCFNCLP IAALIDEKIF CCHGGLSPDL 180 | | QNMEQIRRVM RPTDVPDTGL LCDLLWSDPD KDVTGWGEND RGVSFTFGPD VVAKFLNRHD 240 | | LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG GMMSVDETLM CSFQILKPSE 300 | | KKAKYQYQGM NSGRPAVGGG RPGTTAGKK 329 |
|
Nucleotide Sequence
(FASTA) | | ATGTCGAACG ATGGAGATTT AAACATTGAC AATCTGATCA CCAGACTTCT TGAAGTTCGC 60 | | GGATGTCGTC CAGGAAAGCC AGTTACCATG TCGGAGGCGG AGATCCGTGC TCTTTGTCAT 120 | | AAATCTCGTG AGATCTTCCT ATCACAGCCA ATTCTTCTGG AACTCGAAGC ACCTCTCAAG 180 | | ATTTGTGGAG ACATACATGG ACAATATAAC GACTTGCTCC GTTTATTCGA ATACGGAGGA 240 | | TTCCCACCAG AGGCCAATTA CTTGTTCCTC GGAGATTATG TCGATCGTGG AAAGCAGAGC 300 | | TTGGAAACAA TTTGCTTGTT GCTCGCATAC AAAGTCAAAT ATCCAGAAAA CTTTTTCCTT 360 | | CTTCGTGGAA ACCACGAATG TGCTTCAATT AACCGTATTT ATGGATTCTA CGATGAATGT 420 | | AAGAGACGTT TTTCGATCAA ATTGTGGAAA ACTTTCACCG ATTGCTTCAA CTGTCTTCCA 480 | | ATTGCTGCAC TCATTGATGA GAAGATCTTC TGCTGTCACG GAGGACTCTC CCCAGATCTC 540 | | CAAAATATGG AACAAATTCG CCGTGTGATG CGACCAACCG ATGTTCCTGA TACTGGATTG 600 | | TTGTGCGATT TGCTCTGGTC TGATCCAGAC AAGGATGTTA CCGGATGGGG AGAAAATGAT 660 | | AGAGGAGTCT CGTTCACATT TGGACCTGAT GTCGTTGCAA AGTTTTTGAA CAGACATGAT 720 | | TTGGATCTGA TATGCAGAGC TCATCAGGTC GTCGAAGATG GATATGAGTT CTTTGCTAAG 780 | | CGACAACTTG TCACACTATT CTCTGCTCCA AATTATTGTG GAGAATTCGA TAACGCTGGT 840 | | GGAATGATGA GCGTTGATGA GACATTAATG TGCAGTTTCC AGATTCTGAA ACCATCGGAG 900 | | AAAAAAGCGA AATATCAGTA TCAAGGAATG AACAGTGGAC GACCAGCAGT GGGCGGAGGA 960 | | CGGCCTGGAA CGACTGCTGG TAAGAAGTAA 990 |
|
| Domain Profile | S: 1 pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen 60 | p+kicgdihgqy+dllrlfeyggfppeanylflgdyvdrgkqsleticlllayk+kypen | Q: 58 PLKICGDIHGQYNDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKVKYPEN 117 | 89********************************************************** |
| S: 61 ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls 120 | ffllrgnhe+asinriygfydeckrr+++klwktftdcfnclp+aa+ideki+c+hggls | Q: 118 FFLLRGNHECASINRIYGFYDECKRRFSIKLWKTFTDCFNCLPIAALIDEKIFCCHGGLS 177 | ************************************************************ |
| S: 121 pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk 180 | pdl+++eqirr++rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfg dvvakfl+ | Q: 178 PDLQNMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPDVVAKFLN 237 | ************************************************************ |
| S: 181 khdldlicrahqvv 194 | +hdldlicrahqvv | Q: 238 RHDLDLICRAHQVV 251 | *************8 |
|
Domain Sequence
(FASTA) | | PLKICGDIHG QYNDLLRLFE YGGFPPEANY LFLGDYVDRG KQSLETICLL LAYKVKYPEN 60 | | FFLLRGNHEC ASINRIYGFY DECKRRFSIK LWKTFTDCFN CLPIAALIDE KIFCCHGGLS 120 | | PDLQNMEQIR RVMRPTDVPD TGLLCDLLWS DPDKDVTGWG ENDRGVSFTF GPDVVAKFLN 180 | | RHDLDLICRA HQVV 194 |
|
| Keyword | Cell cycle; Cell division; Chromatin regulator; Complete proteome; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Mitosis; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |