EKS-CAE-00257

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00257

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/Alpha	203.7	4.4E-60	109	301	193

Status

Reviewed

Ensembl Protein

F42A10.4a.1

UniProt Accession

O01991; O01992; Q20309; Q8MYP9;

Protein Name

Eukaryotic elongation factor 2 kinase

Protein Synonyms/Alias

eEF-2 kinase; eEF-2K; Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase;

Gene Name

efk-1

Gene Synonyms/Alias

efk-1; F42A10.4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F42A10.4	F42A10.4b.1	F42A10.4b.1
F42A10.4	F42A10.4a.2	F42A10.4a.2
F42A10.4	F42A10.4a.1	F42A10.4a.1
F42A10.4	F42A10.4b.2	F42A10.4b.2

Organism

Caenorhabditis elegans

Functional Description

Phosphorylates 2 adjacent threonine residues, 'Thr-57'and 'Thr-59', in the N-terminus of eukaryotic elongation factor-2. Binds calmodulin (By similarity).

Protein Length

768

Protein Sequence
(FASTA)

MTIDTTNESD NSPTNSPGLE ASARTFSLNA SKMVRITDDY ADEVFIEQND VVIEKPRMDP 60

LHVRKLMETW RKAARRARTN YIDPWDEFNI HEYPVQRAKR YRYSAIRKQW TEDIVDVRLH 120

PDSFARGAMR ECYRLKKCSK HGTSQDWSSN YVAKRYICQV DRRVLFDDVR LQMDAKLWAE 180

EYNRYNPPKK IDIVQMCVIE MIDVKGSPLY HLEHFIEGKY IKYNSNSGFV SNAARLTPQA 240

FSHFTFERSG HQMMVVDIQG VGDLYTDPQI HTVVGTDYGD GNLGTRGMAL FFHSHRCNDI 300

CETMDLSNFE LSPPEIEATE VAMEVAAKQK KSCIVPPTVF EARRNRISSE CVHVEHGISM 360

DQLRKRKTLN QSSTDLSAKS HNEDCVCPEC IPVVEQLCEP CSEDEEDEEE DYPRSEKSGN 420

SQKSRRSRMS ISTRSSGDES ASRPRKCGFV DLNSLRQRHD SFRSSVGTYS MNSSRQTRDT 480

EKDEFWKVLR KQSVPANILS LQLQQMAANL ENDEDVPQVT GHQFSVLGQI HIDLSRYHEL 540

GRFVEVDSEH KEMLEGSEND ARVPIKYDKQ SAIFHLDIAR KCGILEAVLT SAHIVLGLPH 600

ELLKEVTVDD LFPNGFGEQE NGIRADKGQK PCDLEEFGSD LMEIAAEMGD KGAMLYMAHA 660

YETGQHLGPN RRTDYKKSID WYQRVVGFQE EEELDSDCGK TTFSSFAPLT RHEILAKMAE 720

MYKEGGYGLN QDFERAYGLF NEAAEAAMEA MNGKLANKYY EKAEMCGE 768

Nucleotide Sequence
(FASTA)

ATGACGATCG ACACAACAAA TGAGAGCGAC AATAGTCCAA CTAACTCACC AGGATTGGAG 60

GCCTCGGCTC GGACATTCTC GCTCAATGCG TCAAAAATGG TTCGGATAAC CGACGACTAC 120

GCAGATGAAG TGTTCATTGA ACAGAATGAT GTCGTTATCG AGAAGCCTCG TATGGATCCT 180

CTCCACGTTA GAAAACTTAT GGAGACATGG CGCAAGGCTG CTCGCCGAGC AAGAACAAAC 240

TATATAGATC CATGGGATGA GTTCAACATC CACGAGTATC CAGTACAACG AGCTAAACGA 300

TATAGGTATT CTGCAATCAG AAAGCAATGG ACAGAGGATA TAGTCGATGT GAGACTTCAT 360

CCGGACAGTT TTGCACGTGG AGCCATGCGA GAATGCTACC GACTCAAAAA GTGCTCCAAG 420

CACGGAACAA GTCAAGATTG GAGCAGCAAC TATGTCGCAA AAAGATACAT TTGTCAAGTC 480

GATCGTAGAG TTCTTTTCGA TGATGTCAGA CTTCAGATGG ATGCCAAATT ATGGGCTGAA 540

GAATATAATC GGTATAATCC ACCGAAGAAA ATTGATATTG TTCAAATGTG TGTCATTGAG 600

ATGATTGATG TAAAAGGTTC TCCACTCTAT CATTTGGAGC ATTTCATCGA GGGAAAATAT 660

ATAAAATACA ATTCAAACTC AGGATTTGTA TCAAATGCAG CTCGTCTTAC ACCACAAGCA 720

TTTTCTCACT TCACCTTCGA ACGTTCTGGT CATCAAATGA TGGTTGTCGA TATTCAAGGA 780

GTTGGTGATC TTTACACAGA TCCTCAGATT CATACAGTTG TGGGAACTGA TTATGGAGAT 840

GGAAACCTCG GAACTCGTGG AATGGCTCTT TTCTTCCATT CACACAGATG TAACGATATT 900

TGTGAGACAA TGGATCTATC AAATTTCGAA CTTTCGCCAC CTGAAATCGA GGCTACCGAA 960

GTTGCGATGG AAGTAGCTGC AAAGCAGAAA AAGTCATGCA TAGTTCCTCC AACTGTGTTC 1020

GAAGCAAGAA GAAATCGAAT TTCAAGTGAA TGTGTACATG TCGAGCATGG TATTTCGATG 1080

GATCAATTGA GAAAAAGGAA GACGTTGAAT CAATCGTCAA CCGATTTGTC AGCAAAGAGT 1140

CACAACGAAG ACTGTGTATG TCCTGAGTGT ATTCCAGTTG TTGAGCAACT CTGTGAGCCT 1200

TGCTCCGAAG ATGAAGAGGA CGAAGAAGAA GACTATCCAA GAAGTGAAAA AAGTGGAAAT 1260

AGTCAGAAAA GTCGACGTAG TAGAATGAGC ATTTCAACGA GATCTTCTGG CGATGAATCA 1320

GCATCTCGTC CTAGAAAATG CGGATTTGTA GATTTAAACT CACTTCGTCA GAGACATGAT 1380

AGCTTCAGAA GTTCTGTTGG GACATATTCT ATGAATAGTT CTAGACAAAC CAGAGACACT 1440

GAAAAGGATG AATTCTGGAA GGTTCTTCGA AAACAATCAG TTCCAGCAAA CATTCTATCA 1500

CTTCAACTTC AACAAATGGC TGCTAACCTG GAAAATGATG AAGACGTACC ACAAGTCACC 1560

GGGCATCAGT TCTCTGTCCT CGGTCAGATT CATATTGATC TCTCACGATA TCATGAGCTC 1620

GGGCGGTTCG TAGAAGTTGA TTCAGAACAT AAGGAAATGC TTGAGGGAAG TGAAAATGAC 1680

GCTCGTGTAC CAATCAAATA CGACAAGCAG TCTGCAATTT TCCATTTGGA TATCGCTCGG 1740

AAGTGTGGAA TCCTTGAGGC TGTGCTAACA TCGGCTCATA TTGTTCTCGG ATTACCACAT 1800

GAATTGTTGA AAGAAGTCAC CGTTGATGAT CTGTTTCCTA ATGGGTTTGG AGAACAGGAA 1860

AATGGAATTC GAGCTGATAA AGGACAAAAA CCTTGTGACC TAGAAGAGTT CGGCTCCGAT 1920

CTGATGGAAA TTGCTGCAGA GATGGGTGAT AAGGGTGCAA TGCTGTACAT GGCACACGCT 1980

TATGAAACTG GTCAGCATCT CGGACCGAAT CGAAGAACGG ATTATAAGAA ATCGATTGAT 2040

TGGTATCAAC GCGTCGTTGG ATTCCAAGAA GAAGAAGAAC TTGACTCTGA TTGTGGAAAA 2100

ACGACATTCT CCTCATTTGC TCCACTGACT CGTCACGAGA TTCTAGCCAA AATGGCTGAA 2160

ATGTACAAAG AGGGAGGTTA TGGCCTGAAT CAAGACTTCG AACGAGCATA TGGTCTATTC 2220

AATGAAGCTG CTGAAGCAGC AATGGAAGCA ATGAATGGAA AGCTCGCAAA TAAATACTAT 2280

GAAAAAGCGG AAATGTGTGG AGAATGA 2307

Domain Profile

S: 4     sWsqqetivlikvlskeekkGalRkalrvkkgslflvkeelkevvryvakiykeqkvlhl  63

         +W++   iv ++     + +Ga+R++ r kk s++   + +    +yvak+y+ q+++ +

Q: 109   QWTE--DIVDVRLHPDSFARGAMRECYRLKKCSKHGTSQDWSS--NYVAKRYICQVDRRV  164

         5654..46999999999************************98..***************

S: 64    ylrdverqraaqklvtefnqvkPkkivyiprlievfLkdrtsknqlltvEeyllGefvKy  123

          + dv+ q++a+ + +e+n+  P+k ++i +++ ++++d ++  +l ++E+ ++G+++Ky

Q: 165   LFDDVRLQMDAKLWAEEYNRYNPPKKIDIVQMCVIEMIDVKGS-PLYHLEHFIEGKYIKY  223

         ******************************************9.****************

S: 124   nnnngdeikrenkleelmlafsHftyeytngellVvDlqGvgeklTDpqiatksrgtkfg  183

         n+n+g      n ++ +++afsHft+e+++++++VvD+qGvg+ +TDpqi+t  +gt+ g

Q: 224   NSNSG---FVSNAARLTPQAFSHFTFERSGHQMMVVDIQGVGDLYTDPQIHT-VVGTDYG  279

         *****...667899**************************************.*******

S: 184   kanlgeraiknFfakhhCNeiC  205

         ++nlg+r+++ Ff +h+CN iC

Q: 280   DGNLGTRGMALFFHSHRCNDIC  301

         **********************

Domain Sequence
(FASTA)

QWTEDIVDVR LHPDSFARGA MRECYRLKKC SKHGTSQDWS SNYVAKRYIC QVDRRVLFDD 60

VRLQMDAKLW AEEYNRYNPP KKIDIVQMCV IEMIDVKGSP LYHLEHFIEG KYIKYNSNSG 120

FVSNAARLTP QAFSHFTFER SGHQMMVVDI QGVGDLYTDP QIHTVVGTDY GDGNLGTRGM 180

ALFFHSHRCN DIC 193

Keyword

Alternative splicing; ATP-binding; Calcium; Calmodulin-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>