EKS-CAE-00203

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00203

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	353.6	1.1E-105	66	330	265

Status

Reviewed

Ensembl Protein

F42G10.2

UniProt Accession

Q20347; O01707;

Protein Name

MAP kinase kinase mkk-4

Protein Synonyms/Alias

Gene Name

mkk-4

Gene Synonyms/Alias

mkk-4; F42G10.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F42G10.2	F42G10.2	F42G10.2

Organism

Caenorhabditis elegans

Functional Description

Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology.

Protein Length

363

Protein Sequence
(FASTA)

MVQEDDENLR NSMSLRPTSL STRPTSLSVN GNEKTLPEES VLRSLSTGTL KYPDDEHLYT 60

FSSANLQDLG AIGNGNFGTV YKMRHKETGK LIAVKRIRCN NIGHREQIRL LREHDTIVKS 120

EKGPNIVKFY GAIFSEGDCW ICMELMDISM DLLYKRVYMV KNSRLNENVV GHITVCTVDA 180

LDYLKKELKI IHRDVKPSNI LVDGTGAVKL CDFGICGQLE ESFAKTHDAG CQPYLAPERI 240

TSSDKYDVRS DVWSLGITLY EIATGKFPYQ EWNSLFDQIA TVVSGDPPIL HPDSDDFHYS 300

LPLVKFINTC LTKDRRHRPK YDTLKSFDFY RIYAVAGPEI EEAKRILGVE AIDTRNHPVD 360

HRG 363

Nucleotide Sequence
(FASTA)

ATGGTTCAAG AAGATGACGA GAATTTACGC AATTCAATGT CCCTTCGGCC GACTTCGTTG 60

TCAACACGTC CCACATCACT TTCGGTAAAC GGAAATGAGA AGACGCTTCC AGAAGAAAGT 120

GTGTTACGTT CTCTTTCGAC AGGCACATTA AAATACCCTG ATGACGAACA TTTATACACA 180

TTCAGCTCCG CTAATTTACA AGATCTTGGA GCAATTGGAA ACGGCAATTT TGGAACAGTT 240

TACAAAATGC GTCACAAAGA AACTGGAAAA CTGATAGCTG TGAAGAGGAT ACGATGCAAC 300

AACATTGGAC ATAGAGAACA AATCCGCTTA CTTCGAGAGC ACGACACAAT TGTGAAATCC 360

GAGAAAGGAC CAAATATCGT GAAGTTTTAC GGAGCGATTT TCAGCGAGGG TGATTGCTGG 420

ATTTGCATGG AACTGATGGA CATTTCGATG GACCTTCTTT ATAAACGAGT ATATATGGTG 480

AAAAATAGTC GGCTGAATGA AAATGTCGTC GGACATATCA CAGTTTGCAC TGTAGATGCA 540

TTGGATTATT TGAAGAAAGA ATTAAAAATT ATTCATCGAG ACGTGAAACC CTCCAATATT 600

CTTGTAGACG GAACTGGAGC AGTGAAACTT TGCGATTTTG GTATTTGTGG GCAGTTAGAA 660

GAATCATTTG CGAAAACTCA TGACGCCGGT TGTCAGCCGT ATCTTGCACC CGAAAGGATT 720

ACAAGTTCAG ACAAATATGA TGTGAGATCG GATGTGTGGT CATTGGGAAT AACTTTGTAC 780

GAAATAGCAA CAGGAAAATT TCCCTACCAA GAATGGAATT CACTTTTTGA TCAGATTGCT 840

ACAGTAGTAA GCGGTGATCC TCCAATTCTA CATCCAGACA GCGACGATTT CCATTACAGT 900

TTGCCGCTTG TCAAGTTTAT CAATACTTGC TTAACTAAAG ACAGACGCCA TCGGCCCAAA 960

TATGATACTC TGAAGAGTTT TGACTTTTAT AGAATATACG CAGTTGCCGG ACCCGAAATT 1020

GAAGAGGCTA AGCGAATTCT TGGAGTTGAA GCAATTGACA CAAGAAATCA TCCTGTCGAC 1080

CACAGAGGAT AG 1092

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtir.leikkeeqkqilrelevlkkssnspy  59

         l++l+ +G+Gn+g+V+k++hk++gk++avK+ir ++i ++eq ++lre++++ ks++ p+

Q: 66    LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRcNNIGHREQIRLLREHDTIVKSEKGPN  125

         68999****************************99*************************

S: 60    ivkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleyl  118

         ivkfyGa++segd++icmelmd +s+d ++k+v+++ ++r++e+v+g+i+v++v+al+yl

Q: 126   IVKFYGAIFSEGDCWICMELMD-ISMDLLYKRVYMVkNSRLNENVVGHITVCTVDALDYL  184

         **********************.**********99989**********************

S: 119   keklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPEriegkk  177

         k++lkiiHRDvKPsNiLv+ +G vKlCDFG++gql++s+Ak++ +G+++Y+aPEri++++

Q: 185   KKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTHdAGCQPYLAPERITSSD  244

         ************************************************************

S: 178   kYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee....efseefq  233

         kY+v+sdvWslG+tl+e+atg++py+++++ ++++ ++v+++pp+l+ +    ++s  ++

Q: 245   KYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVSGDPPILHPDsddfHYSLPLV  304

         **********************************************98888999******

S: 234   efvskClkkdekeRpklkellkhafi  259

         +f+++Cl+kd+++Rpk+++l++ +f+

Q: 305   KFINTCLTKDRRHRPKYDTLKSFDFY  330

         *********************99985

Domain Sequence
(FASTA)

LQDLGAIGNG NFGTVYKMRH KETGKLIAVK RIRCNNIGHR EQIRLLREHD TIVKSEKGPN 60

IVKFYGAIFS EGDCWICMEL MDISMDLLYK RVYMVKNSRL NENVVGHITV CTVDALDYLK 120

KELKIIHRDV KPSNILVDGT GAVKLCDFGI CGQLEESFAK THDAGCQPYL APERITSSDK 180

YDVRSDVWSL GITLYEIATG KFPYQEWNSL FDQIATVVSG DPPILHPDSD DFHYSLPLVK 240

FINTCLTKDR RHRPKYDTLK SFDFY 265

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0050807	; P:regulation of synapse organization

KEGG

cel:CELE_F42G10.2

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013