EKS-CAE-00383
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00383
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK461.21.9E-13849333285
StatusReviewed
Ensembl ProteinF42G8.3b.1
UniProt AccessionQ8MXI4; Q8MXI3;
Protein NameMitogen-activated protein kinase pmk-2
Protein Synonyms/Alias Stress-activated protein kinase pmk-2; p38 MAP kinase 2;
Gene Namepmk-2
Gene Synonyms/Alias pmk-2; F42G8.3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
F42G8.3F42G8.3b.1F42G8.3b.1
F42G8.3F42G8.3a.1F42G8.3a.1
F42G8.3F42G8.3a.2F42G8.3a.2
F42G8.3F42G8.3b.2F42G8.3b.2
OrganismCaenorhabditis elegans
Functional DescriptionResponds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets.
Protein Length397
Protein Sequence
(FASTA)
MGMSATMGDS ASIPGVFFAD FGPAPPEITP EGYHEVELNK TKWVLPQWYN SLKPLGEGAY 60
GVVCTAEYEP TGDRVAIKKF FRPFQSTIHA KRTYRELKLL RTLQHDNVLE MIDVFTPDPD 120
ASSLNNVYFV SVLMGSDLQN IMKIQRLTDE QIQLLIYQVL RGLKYIHSAG IIHRDLKPSN 180
IAVNERCEVK ILDFGLARAQ DAEMTGYVAT RWYRAPEIML NWMHYTQTVD VWSVGCILAE 240
LVSGRPLFPG DDHIDQLTKI MSVVGTPKEE FWSKIQSEEA RNYIKNRSPI IRQDFVTLFP 300
MASPYALELL EMMLILDPDR RISVSSALRH DYLREYSVPN DEPVAMDTVT IDPAEERATT 360
LSDWRELIWN EIRLFQNSAR RLSFVSCTDT EEEPMKI 397
Nucleotide Sequence
(FASTA)
ATGGGGATGT CGGCGACCAT GGGCGATTCA GCCAGCATTC CCGGTGTCTT TTTTGCCGAT 60
TTTGGTCCTG CCCCGCCTGA GATTACTCCA GAAGGATATC ATGAGGTCGA ACTAAACAAA 120
ACGAAATGGG TCTTACCTCA ATGGTACAAC AGTTTGAAGC CTCTAGGAGA AGGAGCGTAT 180
GGAGTTGTAT GCACAGCAGA ATATGAGCCA ACTGGAGATC GAGTTGCAAT TAAAAAGTTC 240
TTTCGCCCAT TTCAAAGTAC AATTCACGCA AAACGAACCT ATCGGGAACT GAAACTTCTA 300
AGAACTCTAC AACATGATAA TGTATTGGAA ATGATTGATG TATTCACACC AGATCCAGAT 360
GCATCTTCTT TGAATAATGT ATATTTCGTA TCCGTTCTGA TGGGCTCCGA TTTACAAAAT 420
ATTATGAAAA TCCAACGACT GACCGATGAA CAAATCCAAC TGCTTATCTA TCAAGTGTTA 480
CGTGGGCTCA AGTATATCCA TTCGGCAGGG ATTATCCATC GCGATTTAAA ACCATCGAAT 540
ATTGCTGTCA ATGAGAGATG CGAAGTCAAG ATTCTCGATT TTGGATTGGC TCGTGCTCAA 600
GACGCCGAAA TGACTGGATA CGTGGCAACA AGATGGTACA GAGCTCCAGA GATTATGCTC 660
AATTGGATGC ATTATACACA GACTGTTGAT GTTTGGTCAG TTGGATGTAT TCTTGCGGAA 720
CTGGTATCCG GGAGACCATT GTTTCCAGGC GATGATCATA TTGATCAGCT AACAAAGATA 780
ATGTCAGTTG TGGGTACCCC AAAAGAAGAA TTCTGGTCCA AAATTCAATC AGAAGAAGCT 840
CGAAATTATA TTAAAAATCG TTCTCCAATT ATCCGTCAGG ACTTCGTTAC ATTGTTTCCA 900
ATGGCTTCTC CATATGCTCT CGAACTTCTC GAAATGATGC TAATTTTGGA TCCGGACAGA 960
AGAATTTCTG TATCAAGTGC TCTTCGTCAT GACTATCTTC GTGAATACTC TGTGCCAAAT 1020
GATGAACCAG TTGCAATGGA TACGGTCACA ATTGATCCAG CTGAAGAACG AGCAACAACG 1080
TTATCCGACT GGCGAGAGTT AATTTGGAAT GAGATTCGAT TATTCCAAAA CTCGGCACGA 1140
AGACTAAGTT TTGTAAGCTG TACGGATACG GAAGAAGAGC CAATGAAAAT ATGA 1194
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y+slkplgeGaygvv++a+++ t++rvaikk++rpfq++++akrt+RElkll++l+h+N+
Q: 49    YNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQHDNV  108
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         ++++dvftp+ ++++l++vY+v+ lm++dL++++k q+l+de+i+ll+yq+lrglky+Hs
Q: 109   LEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMKIQRLTDEQIQLLIYQVLRGLKYIHS  168
         ************************************************************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++vne+ce+kildFGlar++d+e    +t+yvatrwYraPei+l++++
Q: 169   AGIIHRDLKPSNIAVNERCEVKILDFGLARAQDAE----MTGYVATRWYRAPEIMLNWMH  224
         ***********************************....*********************
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         yt++vD+WsvGCIlaEl++g+plfpg+d+idql+ki++v+gtp+eef++ki+seearnyi
Q: 225   YTQTVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYI  284
         ************************************************************
S: 241   kslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         k+++++ ++df +lfp+as++al+Lle++L+ldpd+Risv++aL+h+Yl
Q: 285   KNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYL  333
         ************************************************7
Domain Sequence
(FASTA)
YNSLKPLGEG AYGVVCTAEY EPTGDRVAIK KFFRPFQSTI HAKRTYRELK LLRTLQHDNV 60
LEMIDVFTPD PDASSLNNVY FVSVLMGSDL QNIMKIQRLT DEQIQLLIYQ VLRGLKYIHS 120
AGIIHRDLKP SNIAVNERCE VKILDFGLAR AQDAEMTGYV ATRWYRAPEI MLNWMHYTQT 180
VDVWSVGCIL AELVSGRPLF PGDDHIDQLT KIMSVVGTPK EEFWSKIQSE EARNYIKNRS 240
PIIRQDFVTL FPMASPYALE LLEMMLILDP DRRISVSSAL RHDYL 285
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0009792; P:embryo development ending in birth or egg hatching
GO:0040007; P:growth
GO:0040035; P:hermaphrodite genitalia development
GO:0002119; P:nematode larval development
GO:0006950; P:response to stress
KEGG
cel:CELE_F42G8.3;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008352; MAPK_p38.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
PR01773; P38MAPKINASE.
Created Date20-Feb-2013