| Tag | Content |
|---|
| EKPD ID | EPS-CAE-00095 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Asp-Based PTP/FCP | 159.7 | 8.8E-47 | 58 | 227 | 170 |
|
| Status | Reviewed |
| Ensembl Protein | F45E12.1a |
| UniProt Accession | Q20432; |
| Protein Name | CTD nuclear envelope phosphatase 1 homolog |
| Protein Synonyms/Alias | Serine/threonine-protein phosphatase dullard homolog; Small C-terminal domain phosphatase-like phosphatase 2; |
| Gene Name | scpl-2 |
| Gene Synonyms/Alias | scpl-2; F45E12.1; |
| Ensembl Information | |
| Organism | Caenorhabditis elegans |
| Functional Description | Serine/threonine protein phosphatase that maydephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. |
| Protein Length | 246 |
Protein Sequence
(FASTA) | | MTTIAQSVFC FLAGFFNFFL LYFRKTSRAY CKYQVVKYHS NIPMSPLTTH RLLTVKRKIL 60 | | VLDLDETLIH SHHDGVLRQT VKPGTPSDFT IRVVIDRHPV KFSVHERPHV DYFLSVVSQW 120 | | YELVVFTASM EVYGTSVADR LDRGRGILKR RYFRQHCTME VGGYTKDLSA IHPDLSSICI 180 | | LDNSPGAYRK FPHNAIPIPS WFSDPNDTCL LNLLPFLDAL RFTSDVRSVL SRNMQALPET 240 | | QSVQYY 246 |
|
Nucleotide Sequence
(FASTA) | | ATGACAACAA TCGCACAGTC TGTTTTTTGT TTTCTTGCCG GATTCTTCAA CTTTTTTCTC 60 | | CTATATTTCC GCAAAACGAG CAGAGCGTAC TGCAAATATC AAGTTGTCAA GTATCACAGC 120 | | AACATTCCAA TGTCTCCTCT TACAACACAT AGACTATTGA CTGTGAAACG GAAAATCCTG 180 | | GTTTTGGATC TTGACGAAAC ACTCATTCAT TCACATCATG ACGGTGTTCT TCGACAAACA 240 | | GTCAAACCTG GAACTCCGTC TGATTTTACG ATACGGGTGG TTATCGATCG ACATCCTGTG 300 | | AAATTCTCGG TTCACGAACG TCCACATGTC GACTATTTTT TGTCAGTTGT CAGTCAATGG 360 | | TATGAATTGG TGGTTTTCAC AGCGAGTATG GAAGTTTATG GAACATCAGT AGCTGATCGG 420 | | TTAGATCGTG GACGAGGAAT TCTCAAGAGG CGTTATTTCC GTCAACATTG CACAATGGAA 480 | | GTCGGAGGCT ATACGAAGGA TTTGTCTGCA ATTCATCCCG ATCTTTCAAG CATCTGTATT 540 | | CTTGACAACT CTCCTGGAGC CTATCGAAAA TTCCCACACA ATGCCATTCC AATTCCATCA 600 | | TGGTTTTCTG ATCCAAACGA CACGTGTCTT CTCAATCTTC TTCCATTCCT CGACGCACTT 660 | | CGATTTACGT CAGATGTTCG AAGTGTGCTC TCACGGAACA TGCAAGCTCT TCCTGAAACA 720 | | CAATCAGTAC AGTACTACTA A 741 |
|
| Domain Profile | S: 1 ktLVLDLDetLvhsksekde.e...............e..ektkasvkkRPgldeFLkel 42 | k+LVLDLDetL+hs ++ + + k+sv+ RP++d+FL + | Q: 58 KILVLDLDETLIHSHHDGVLrQtvkpgtpsdftirvvIdrHPVKFSVHERPHVDYFLSVV 117 | 78*************5444442556677777777765157999***************** |
| S: 43 skayevviftasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlsk 102 | s++ye+v+ftas++ y +v d+ld+ + ++k+r++r++ct+e g y+KdLs ++ dls+ | Q: 118 SQWYELVVFTASMEVYGTSVADRLDRGRGILKRRYFRQHCTMEVGGYTKDLSAIHPDLSS 177 | **************************99999***************************** |
| S: 103 vvivDdsprsfelqpdnlipiepfygdsdkdtellkllpflealeksddvr 153 | + i+D+sp ++++ p+n+ipi+++++d ++dt+ll+llpfl+al++ +dvr | Q: 178 ICILDNSPGAYRKFPHNAIPIPSWFSD-PNDTCLLNLLPFLDALRFTSDVR 227 | ***************************.*****************999998 |
|
Domain Sequence
(FASTA) | | KILVLDLDET LIHSHHDGVL RQTVKPGTPS DFTIRVVIDR HPVKFSVHER PHVDYFLSVV 60 | | SQWYELVVFT ASMEVYGTSV ADRLDRGRGI LKRRYFRQHC TMEVGGYTKD LSAIHPDLSS 120 | | ICILDNSPGA YRKFPHNAIP IPSWFSDPND TCLLNLLPFL DALRFTSDVR 170 |
|
| Keyword | Complete proteome; Hydrolase; Membrane; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |