EKS-CAE-00300

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00300

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	405.6	1.1E-121	240	489	250

Status

Unreviewed

Ensembl Protein

F49B2.5

UniProt Accession

O45539;

Protein Name

Protein Synonyms/Alias

Protein SRC-2;

Gene Name

src-2

Gene Synonyms/Alias

src-2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F49B2.5	F49B2.5	F49B2.5

Organism

Caenorhabditis elegans

Functional Description

Protein Length

507

Protein Sequence
(FASTA)

MGSCIGKEDP PPGATSPVHT SSTLGRESLP SHPRIPSIGP IAASSSGNTI DKNQNISQSA 60

NFVALFQYDA RTDDDLSFKK DDILEILNDT QGDWWFARHK ATGRTGYIPS NYVAREKSIE 120

SQPWYFGKMR RIDAEKCLLH TLNEHGAFLV RDSESRQHDL SLSVRENDSV KHYRIRQLDH 180

GGYFIARRRP FATLHDLIAH YQREADGLCV NLGAPCAKSE APQTTTFTYD DQWEVDRRSV 240

RLIRQIGAGQ FGEVWEGRWN VNVPVAVKKL KAGTADPTDF LAEAQIMKKL RHPKLLSLYA 300

VCTRDEPILI VTELMQENLL TFLQRRGRQC QMPQLVEISA QVAAGMAYLE EMNFIHRDLA 360

ARNILINNSL SVKIADFGLA RILMKENEYE ARTGARFPIK WTAPEAANYN RFTTKSDVWS 420

FGILLTEIVT FGRLPYPGMT NAEVLQQVDA GYRMPCPAGC PVTLYDIMQQ CWRSDPDKRP 480

TFETLQWKLE DLFNLDSSEY KEASINF 507

Nucleotide Sequence
(FASTA)

ATGGGATCCT GTATTGGAAA AGAGGATCCA CCGCCTGGTG CAACGTCACC AGTCCACACG 60

TCATCCACGT TGGGAAGGGA GTCACTGCCA AGTCATCCAC GAATTCCGTC CATCGGTCCG 120

ATTGCGGCGT CTTCCAGTGG AAATACGATT GATAAAAATC AGAATATCTC GCAATCTGCG 180

AATTTTGTCG CTTTATTCCA ATATGATGCA CGGACAGATG ATGATTTGAG TTTTAAGAAG 240

GATGATATCC TTGAAATTCT AAATGATACC CAAGGAGACT GGTGGTTCGC CAGGCACAAG 300

GCAACTGGAC GGACTGGGTA TATCCCGTCG AATTATGTTG CCAGGGAGAA AAGTATCGAG 360

TCACAGCCGT GGTACTTTGG AAAAATGCGG CGAATCGATG CGGAAAAATG TCTATTGCAC 420

ACTTTAAATG AGCACGGAGC ATTTTTAGTG AGAGATTCCG AAAGTCGACA GCATGATTTA 480

TCATTATCAG TCCGAGAGAA CGACAGCGTA AAGCACTACC GTATCCGTCA ACTGGACCAC 540

GGCGGGTATT TTATCGCCCG GAGGCGCCCG TTTGCCACGT TACACGACCT GATTGCACAT 600

TACCAACGAG AAGCCGATGG TCTTTGTGTG AATCTGGGAG CTCCTTGTGC CAAGTCAGAA 660

GCCCCACAGA CAACGACATT CACATATGAT GACCAATGGG AAGTGGACCG CCGTTCGGTT 720

CGTCTCATTC GACAAATTGG AGCCGGGCAG TTTGGAGAGG TATGGGAAGG CCGATGGAAT 780

GTGAACGTCC CCGTCGCTGT GAAAAAGCTA AAGGCCGGAA CCGCAGATCC TACGGATTTC 840

CTAGCCGAGG CACAGATTAT GAAGAAGCTC CGGCATCCGA AGCTTCTGTC CCTGTATGCA 900

GTCTGCACAC GTGATGAGCC GATTCTTATA GTCACCGAGC TAATGCAGGA GAATCTGCTC 960

ACATTCTTAC AGCGACGAGG TCGGCAGTGT CAGATGCCTC AGCTGGTGGA GATCTCGGCG 1020

CAGGTTGCCG CTGGAATGGC CTACCTAGAG GAGATGAATT TCATCCATCG AGACCTAGCA 1080

GCACGAAACA TCCTTATCAA CAACTCCCTA TCTGTAAAAA TCGCAGATTT CGGGTTAGCC 1140

AGGATATTGA TGAAGGAGAA CGAGTACGAA GCAAGAACCG GAGCACGGTT TCCGATAAAA 1200

TGGACGGCGC CCGAGGCGGC GAACTATAAT CGATTCACAA CCAAGTCGGA TGTCTGGAGT 1260

TTTGGAATCC TGCTCACCGA GATTGTCACG TTCGGACGGT TACCCTATCC AGGTATGACA 1320

AACGCCGAAG TCCTACAACA AGTCGACGCC GGGTACCGTA TGCCGTGCCC AGCCGGGTGC 1380

CCAGTCACCC TTTACGACAT AATGCAACAG TGCTGGAGAA GCGACCCGGA CAAACGGCCA 1440

ACCTTTGAGA CCCTCCAATG GAAGTTGGAG GATCTGTTCA ATCTGGACTC TTCCGAGTAT 1500

AAGGAGGCCA GCATAAATTT CTGA 1524

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l++++G+GqfGevw+g+w+ +v+vavk+lk gt +p++fl+eaqi+kklrh+kl++ly

Q: 240   VRLIRQIGAGQFGEVWEGRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLY  299

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++++ePi+ivtelm++ +ll+fl+ ++g+++++p+lv+++aqva+Gmaylee+n+ihr

Q: 300   AVCTRDEPILIVTELMQE-NLLTFLQ-RRGRQCQMPQLVEISAQVAAGMAYLEEMNFIHR  357

         ****************98.9*****9.889******************************

S: 121   dlaarnvlvgeslvvkvadfGlar.lieddeytakegaklPikWtaPeaiklgkftiksd  179

         dlaarn+l+++sl vk+adfGlar l++++ey+a++ga++PikWtaPea+++++ft+ksd

Q: 358   DLAARNILINNSLSVKIADFGLARiLMKENEYEARTGARFPIKWTAPEAANYNRFTTKSD  417

         ************************7789********************************

S: 180   vWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpe  239

         vWsfGillteivt G++PypGmtn+evl+qv++gyr+p+p+ cp +ly+++++cw++dp+

Q: 418   VWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPD  477

         ************************************************************

S: 240   erPtfetlqevl  251

         +rPtfetlq++l

Q: 478   KRPTFETLQWKL  489

         *********986

Domain Sequence
(FASTA)

VRLIRQIGAG QFGEVWEGRW NVNVPVAVKK LKAGTADPTD FLAEAQIMKK LRHPKLLSLY 60

AVCTRDEPIL IVTELMQENL LTFLQRRGRQ CQMPQLVEIS AQVAAGMAYL EEMNFIHRDL 120

AARNILINNS LSVKIADFGL ARILMKENEY EARTGARFPI KWTAPEAANY NRFTTKSDVW 180

SFGILLTEIV TFGRLPYPGM TNAEVLQQVD AGYRMPCPAG CPVTLYDIMQ QCWRSDPDKR 240

PTFETLQWKL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0040007	; P:growth
GO:0040035	; P:hermaphrodite genitalia development
GO:0002119	; P:nematode larval development

KEGG

cel:CELE_F49B2.5

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013