EKS-CAE-00307
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00307
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/MLK260.13.3E-7753303251
StatusReviewed
Ensembl ProteinF52F12.3.1
UniProt AccessionQ9XTC6;
Protein NameMitogen-activated protein kinase kinase kinase mom-4
Protein Synonyms/Alias
Gene Namemom-4
Gene Synonyms/Alias mom-4; F52F12.3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
F52F12.3F52F12.3.2F52F12.3.2
F52F12.3F52F12.3.1F52F12.3.1
OrganismCaenorhabditis elegans
Functional DescriptionPart of the Wnt signaling pathway essential for thespecification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1.
Protein Length536
Protein Sequence
(FASTA)
MDNSSQSKPS SSSSSHSPSP AAITPTQRTT RDSGLCSTID IPEIQAQCID NLNSHYLGKG 60
TYGLVEKTRY RKTRQDDFRP AAIKYSSQLH MATLIREAKV MWDLRNHPNI IKIYGLYKSP 120
RNGQGVVMEY MDCGSMADLL YDRTHINYTI DHVASWMFQL SSAVDFFHSN SQVHRDLKLQ 180
NMLLSDRYRT MKLCDFGTFT SMHQSMTSNR GTPITMAPEV FRCEQYNMKS DIYSIGIIMW 240
QIIARNHPYR RDLSVPGLLY NVATANLRPQ ELECNPILSE FYKKCWNDNA DIRPTSSECV 300
EYFTLLKDEY PNGSVPLSDS STNGPAETPP PHAHRPTMLG TSSGSGIGSN NRTPTASKLL 360
NPQQPGQGHR RNRSETFVVQ PDLPYPTVPG EAGASRIPKS QSEAKNFRDR AKSEQRQPHR 420
DARPPPPFEH RRDSNDEEKH AVFMNICSNE ETRPIDPDTR DEKSLEIFHQ HCDNNKQYAD 480
AWVIKKEVMR AKHELIAQWP QHDHTVELLE RKYYLEQEIA RYRDIQDDNY FSTERM 536
Nucleotide Sequence
(FASTA)
ATGGACAATT CGTCACAGAG CAAACCGTCT AGTAGTTCGT CCAGTCATTC GCCAAGTCCT 60
GCCGCAATTA CACCAACACA ACGAACAACA CGAGATTCCG GATTGTGCTC AACAATTGAT 120
ATTCCCGAAA TTCAAGCACA ATGTATTGAT AATTTAAATA GTCATTATCT CGGAAAAGGC 180
ACTTATGGAT TGGTTGAGAA AACAAGATAT AGAAAAACTA GGCAGGATGA CTTTAGGCCA 240
GCAGCAATCA AATATTCTTC TCAACTTCAT ATGGCAACTC TTATAAGAGA AGCAAAAGTT 300
ATGTGGGATC TCAGAAATCA TCCTAATATT ATAAAAATTT ATGGACTGTA CAAAAGCCCT 360
CGGAATGGGC AAGGAGTCGT TATGGAATAT ATGGATTGTG GAAGCATGGC CGATTTACTC 420
TACGACAGAA CACACATTAA TTATACAATT GATCATGTGG CTTCATGGAT GTTTCAACTA 480
TCATCCGCCG TCGATTTTTT CCATTCCAAC AGCCAAGTTC ACAGAGATTT GAAACTTCAA 540
AACATGCTTC TCTCTGATCG ATATCGAACA ATGAAATTAT GTGATTTTGG AACATTTACC 600
TCAATGCATC AATCAATGAC TTCAAATCGT GGAACTCCAA TCACAATGGC TCCAGAAGTA 660
TTTCGATGTG AACAGTATAA TATGAAATCT GACATCTACA GTATTGGAAT TATAATGTGG 720
CAAATTATTG CTAGAAATCA TCCGTATCGA AGAGATCTCT CAGTTCCTGG ACTTTTATAT 780
AATGTTGCGA CAGCTAACTT ACGTCCACAA GAACTCGAAT GTAATCCTAT TTTGTCTGAA 840
TTTTATAAGA AATGTTGGAA TGATAATGCT GATATTCGAC CGACTTCTTC CGAATGTGTA 900
GAATATTTTA CTCTTCTAAA AGATGAATAT CCGAATGGGA GCGTACCTTT ATCGGATTCT 960
TCAACAAATG GACCAGCAGA AACTCCTCCA CCACATGCTC ATCGACCAAC AATGCTTGGA 1020
ACTTCTTCTG GAAGTGGAAT AGGATCAAAT AATCGAACAC CAACTGCTTC AAAACTTTTA 1080
AATCCTCAAC AACCTGGACA GGGTCATAGA AGAAATCGTA GTGAGACTTT TGTAGTGCAA 1140
CCGGATCTAC CGTATCCAAC GGTTCCGGGT GAAGCTGGTG CATCTAGAAT ACCAAAATCT 1200
CAAAGTGAAG CTAAAAATTT TCGGGATAGA GCCAAAAGCG AGCAAAGGCA ACCACATAGA 1260
GACGCACGTC CTCCTCCTCC TTTTGAGCAC CGAAGAGATA GCAACGATGA GGAAAAACAT 1320
GCCGTTTTTA TGAATATTTG TTCGAATGAG GAGACTAGAC CTATTGATCC TGATACTCGT 1380
GACGAAAAAT CTTTGGAAAT CTTTCATCAA CACTGTGATA ATAATAAACA ATATGCAGAT 1440
GCTTGGGTCA TTAAAAAAGA AGTTATGAGA GCTAAACATG AGCTAATTGC CCAATGGCCT 1500
CAACACGATC ACACGGTAGA ACTTCTTGAA CGGAAATATT ATCTGGAACA AGAAATTGCA 1560
AGATATCGGG ACATCCAAGA TGATAATTAC TTTTCAACTG AAAGAATGTG A 1611
Domain Profile
S: 3     leeligsgafgkvykakwrkke......vavKklreeaeekekleklereakllskls.h  55
         +++++g+g++g v k+++rk++      +a+K  ++ +++     +l reak++++l+ h
Q: 53    NSHYLGKGTYGLVEKTRYRKTRqddfrpAAIKYSSQLHMA-----TLIREAKVMWDLRnH  107
         6789****************9999************9999.....9***********88*
S: 56    pniiellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYL  114
         pnii+++G++++++n +++vmey+++gs++++l++++++++++++++sw++q++++++++
Q: 108   PNIIKIYGLYKSPRNgQGVVMEYMDCGSMADLLYDRTHINYTIDHVASWMFQLSSAVDFF  167
         ***************9********************************************
S: 115   hseapkkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlke  174
         hs+   +++hrdLk +n+Lls++ +t+k+cdFGt+++++ ++++s++gt+++maPEv+++
Q: 168   HSN---SQVHRDLKLQNMLLSDRYRTMKLCDFGTFTSMH-QSMTSNRGTPITMAPEVFRC  223
         ***...789******************************.********************
S: 175   ekvseksDvwSygvvLWelltrevPyk.dlselaiaykvalkglrlpipsscpeklkkLm  233
         e++++ksD++S+g+++W++++r++Py+ dls   ++y+va+ +lr++   +c++ l++++
Q: 224   EQYNMKSDIYSIGIIMWQIIARNHPYRrDLSVPGLLYNVATANLRPQEL-ECNPILSEFY  282
         **************************99*******************99.9*********
S: 234   kecwnedpekRpsfseivksl  254
         k+cwn++++ Rp++se+v+++
Q: 283   KKCWNDNADIRPTSSECVEYF  303
         *****************9976
Domain Sequence
(FASTA)
NSHYLGKGTY GLVEKTRYRK TRQDDFRPAA IKYSSQLHMA TLIREAKVMW DLRNHPNIIK 60
IYGLYKSPRN GQGVVMEYMD CGSMADLLYD RTHINYTIDH VASWMFQLSS AVDFFHSNSQ 120
VHRDLKLQNM LLSDRYRTMK LCDFGTFTSM HQSMTSNRGT PITMAPEVFR CEQYNMKSDI 180
YSIGIIMWQI IARNHPYRRD LSVPGLLYNV ATANLRPQEL ECNPILSEFY KKCWNDNADI 240
RPTSSECVEY F 251
KeywordATP-binding; Complete proteome; Developmental protein; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.
Sequence SourceEnsembl
Orthology
Ortholog group
Ciona intestinalis"; ?>Myotis lucifugus"; ?>Taeniopygia guttata"; ?>
EKS-CII-00215
EKS-MYL-00379
EKS-TAG-00451
Gene Ontology
GO:0005524; F:ATP binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0046872; F:metal ion binding
GO:0008356; P:asymmetric cell division
GO:0045167; P:asymmetric protein localization involved in cell fate determination
GO:0009792; P:embryo development ending in birth or egg hatching
GO:0001714; P:endodermal cell fate specification
GO:0042694; P:muscle cell fate specification
GO:0046777; P:protein autophosphorylation
GO:0016055; P:Wnt receptor signaling pathway
KEGG
cel:CELE_F52F12.3;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; FALSE_NEG.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013