| Tag | Content |
|---|
| EKPD ID | EPS-CAE-00087 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| PPP/PP1 | 412.7 | 3.2E-124 | 57 | 250 | 194 |
|
| Status | Reviewed |
| Ensembl Protein | F56C9.1.1 |
| UniProt Accession | P48727; |
| Protein Name | Serine/threonine-protein phosphatase PP1-beta |
| Protein Synonyms/Alias | CeGLC-7-beta; Glc seven-like phosphatase 2; |
| Gene Name | gsp-2 |
| Gene Synonyms/Alias | gsp-2; F56C9.1; |
| Ensembl Information | |
| Organism | Caenorhabditis elegans |
| Functional Description | Serine/threonine-protein phosphatase essential forchromosomal dynamics during meiosis and mitosis. Antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Essential for embryogenesis. |
| Protein Length | 333 |
Protein Sequence
(FASTA) | | MDVEKLNLDN IISRLLEVRG SKPGKNVQLT ESEIKGLCQK SREIFLSQPI LLELEAPLKI 60 | | CGDVHGQYYD LLRLFEYGGF PPESNYLFLG DYVDRGKQSL ETICLLLAYK IKYPENFFLL 120 | | RGNHECASIN RIYGFYDECK RRYNIKLWKT FTDCFNCLPV AAIIDEKIFC CHGGLSPDLQ 180 | | SMEQIRRIMR PTDVPDQGLL CDLLWSDPDK DVTGWGENDR GVSFTFGPEV VAKFLHKHDL 240 | | DLICRAHQVV EDGYEFFAKR QLVTLFSAPN YCGEFDNAGS MMTVDETLMC SFQILKPADK 300 | | KKYPYGAGGV GSNRPVTPPR NAPAAQPKKG AKK 333 |
|
Nucleotide Sequence
(FASTA) | | ATGGACGTAG AAAAGCTTAA TCTGGACAAT ATCATCTCCA GATTATTGGA AGTCAGAGGA 60 | | TCCAAACCAG GGAAAAATGT TCAACTCACA GAGAGCGAGA TCAAGGGGTT GTGCCAGAAG 120 | | TCTCGTGAAA TTTTTCTGAG CCAACCTATT CTTCTCGAGT TGGAAGCTCC GTTGAAAATT 180 | | TGCGGTGACG TGCACGGACA ATACTACGAT CTTTTGAGAC TGTTCGAGTA TGGTGGATTC 240 | | CCCCCAGAGT CGAACTACTT GTTCCTCGGC GATTATGTGG ACCGAGGGAA ACAATCGTTG 300 | | GAAACTATCT GTCTCCTACT TGCATATAAA ATCAAGTACC CGGAAAATTT CTTCCTGCTC 360 | | CGAGGAAACC ACGAGTGTGC CTCGATCAAC AGAATTTATG GCTTCTATGA CGAGTGCAAG 420 | | CGGCGATACA ACATCAAACT GTGGAAGACG TTCACCGATT GCTTTAACTG CCTGCCAGTT 480 | | GCCGCCATCA TCGACGAAAA GATCTTCTGC TGTCACGGAG GACTTTCTCC AGATCTTCAG 540 | | TCTATGGAGC AAATTCGTCG TATCATGAGG CCGACAGACG TACCAGATCA AGGATTGTTG 600 | | TGCGATCTGT TGTGGTCAGA TCCTGATAAA GATGTCACTG GCTGGGGAGA AAACGACCGA 660 | | GGCGTCTCTT TCACTTTCGG ACCAGAAGTT GTTGCCAAAT TCCTGCACAA GCACGATTTG 720 | | GATTTGATTT GCAGAGCTCA CCAGGTTGTG GAAGACGGTT ACGAATTCTT CGCTAAGCGG 780 | | CAGTTGGTTA CATTGTTCAG CGCTCCTAAT TATTGTGGAG AGTTTGATAA CGCGGGATCG 840 | | ATGATGACTG TCGATGAAAC ACTGATGTGC TCTTTCCAGA TCTTGAAACC AGCAGACAAG 900 | | AAGAAATATC CATATGGTGC TGGAGGAGTT GGTTCAAATA GACCAGTCAC CCCACCACGA 960 | | AACGCACCGG CTGCGCAACC AAAGAAGGGT GCCAAGAAGT AA 1002 |
|
| Domain Profile | S: 1 pvkicgdihgqykdllrlfeyggfppeanylflgdyvdrgkqsleticlllaykikypen 60 | p+kicgd+hgqy+dllrlfeyggfppe+nylflgdyvdrgkqsleticlllaykikypen | Q: 57 PLKICGDVHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPEN 116 | 89********************************************************** |
| S: 61 ffllrgnhesasinriygfydeckrrynvklwktftdcfnclpvaaiidekilcvhggls 120 | ffllrgnhe+asinriygfydeckrryn+klwktftdcfnclpvaaiideki+c+hggls | Q: 117 FFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPVAAIIDEKIFCCHGGLS 176 | ************************************************************ |
| S: 121 pdlksleqirrikrptdvpdegllcdllwsdpdkdvkgwgendrgvsftfgadvvakflk 180 | pdl+s+eqirri+rptdvpd+gllcdllwsdpdkdv+gwgendrgvsftfg +vvakfl+ | Q: 177 PDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVTGWGENDRGVSFTFGPEVVAKFLH 236 | ************************************************************ |
| S: 181 khdldlicrahqvv 194 | khdldlicrahqvv | Q: 237 KHDLDLICRAHQVV 250 | *************8 |
|
Domain Sequence
(FASTA) | | PLKICGDVHG QYYDLLRLFE YGGFPPESNY LFLGDYVDRG KQSLETICLL LAYKIKYPEN 60 | | FFLLRGNHEC ASINRIYGFY DECKRRYNIK LWKTFTDCFN CLPVAAIIDE KIFCCHGGLS 120 | | PDLQSMEQIR RIMRPTDVPD QGLLCDLLWS DPDKDVTGWG ENDRGVSFTF GPEVVAKFLH 180 | | KHDLDLICRA HQVV 194 |
|
| Keyword | Cell cycle; Cell division; Chromatin regulator; Complete proteome; Cytoplasm; Developmental protein; Hydrolase; Iron; Manganese; Meiosis; Metal-binding; Mitosis; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |