EKS-CAE-00120

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00120

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/FGFR	466.3	3.8E-140	588	876	289

Status

Reviewed

Ensembl Protein

F58A3.2b.1

UniProt Accession

Q10656; Q7JL68; Q7YZM7; Q7YZM8; Q7YZN0; Q7YZN1; Q7Z025; Q8MQ14; Q93804; Q95QE0; Q95QE1;

Protein Name

Myoblast growth factor receptor egl-15

Protein Synonyms/Alias

Egg-laying defective protein 15;

Gene Name

egl-15

Gene Synonyms/Alias

egl-15; F58A3.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F58A3.2	F58A3.2e	F58A3.2e
F58A3.2	F58A3.2d	F58A3.2d
F58A3.2	F58A3.2c	F58A3.2c
F58A3.2	F58A3.2a.3	F58A3.2a.3
F58A3.2	F58A3.2a.2	F58A3.2a.2
F58A3.2	F58A3.2b.4	F58A3.2b.4
F58A3.2	F58A3.2a.1	F58A3.2a.1
F58A3.2	F58A3.2b.3	F58A3.2b.3
F58A3.2	F58A3.2b.2	F58A3.2b.2
F58A3.2	F58A3.2b.1	F58A3.2b.1
F58A3.2	F58A3.2a.4	F58A3.2a.4

Organism

Caenorhabditis elegans

Functional Description

Activation leads to the phosphorylation of SOC-1 on Tyr-408 triggering PTP-2 recruitment and/or activation. Activates the SEM-5/SOS-1/RAS/MAPK pathway. Acts in the hypodermis to regulate axon growth. Isoform 2 has no effect on axon growth but affects the maintenance of axon position. Isoform b acts as a receptor for an extracellular signal required for the guidance of sex myoblast migration during gonad development. Isoforms 1, 3, 4 and 5 appear to play a role in maintaining body morphology at higher temperatures.

Protein Length

988

Protein Sequence
(FASTA)

MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE IKFDCQTAAS 60

KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID VSDQGLWSCR VHNAYGQISR 120

NFTVEVIDPL KLFDWLTEHR VFDISHLLPK LLPPAEMRRV KSQLGGWEKM NNEQKIVRAR 180

HILRLRQINH ALGTEFINAD EKENKEDEEE DYSVSQPVAP DAGLTELNIT AEEPPYFKSN 240

DNIVLFNETH ALPAGRTLKL NCRAKGYPEP QIIWYKNGKM LKKSSARSGG YEFKFNRWSL 300

EVEDAVVADS GEFHCEALNK VGSAKKYFHV IIVNRMRRPP IIVPNILANQ SVNINDTATF 360

HCKVVSDLLP HIIWVRINKI NGSYSYYNNS AEEYMFNYTE MDTFDKAHVH HVGDESTLTI 420

FNVSLDDQGI YACLSGNSLG MSMANATLTV NEFMAIHLLT GDEPKIDRWT TSDYIFTTIL 480

LFLLLAATLF GILFMVCKQT LHKKGFMDDT VGLVARKKRV VVSKRPMNED NENSDDEPSP 540

YQIQIIETPI TKKEAARKQR KRMNSENTVL SEYEVDSDPV WEVERSKLSL VHMLGEGAFG 600

EVWKATYKET ENNEIAVAVK KLKMSAHEKE LIDLVSEMET FKVIGEHENV LRLIGCCTGA 660

GPLYVVVELC KHGNLRDFLR AHRPKEEKAK KSSQELTDYL EPRKASDKDD IELIPNLTQR 720

HLVQFAWQVA QGMNFLASKK IIHRDLAARN VLVGDGHVLK ISDFGLSRDV HCNDYYRKRG 780

NGRLPIKWMA LEALDSNVYT VESDVWSYGV LLWEIMTLGG TPYPTIAMPE LYANLKEGYR 840

MEPPHLCPQE VYHLMCSCWR EKLEERPSFK TIVDYLDWML TMTNETIEGS QEFNDQFFSE 900

RSTASGPVSP MESFQKKRKH RPLSAPVNLP SEPQHTICDD YESNFSVEPP NDPNHLYCND 960

NMLKNHIITP ETSQRIPSNN NSMSKPEF 988

Nucleotide Sequence
(FASTA)

ATGAGTTATT TCCTTGCATC CTGCCTCGGT GTGGGCTTAC TTTCTACAGT TTCTTGTTCT 60

CTTCAAGGAT TGACCAGTCA TTACAGAGAA AATATTCCCC GTTTCAAGCA TGTAGCAAAC 120

GAAAGATACG AAGTATTTCT TGGAGATGAG ATAAAATTTG ACTGTCAAAC CGCGGCGTCA 180

AAGATTTCTG CCTTTGTCGA ATGGTATCGT AATGACAAGT TACTCAAAAA TGATCAAATA 240

GATAAAGACA AAATTCGGAA AGATAATAAC AGGATGATGC TTCACTTGAA GAATATTGAT 300

GTTTCAGATC AGGGTCTTTG GTCTTGCCGC GTACACAACG CATATGGACA AATATCACGA 360

AATTTTACAG TTGAAGTTAT TGATCCACTT AAACTGTTCG ATTGGCTCAC TGAGCATCGA 420

GTATTCGATA TTAGTCATTT ATTGCCAAAA TTGCTACCTC CTGCGGAAAT GAGGAGAGTG 480

AAAAGCCAAT TGGGCGGATG GGAGAAGATG AATAATGAAC AGAAAATTGT TCGAGCCAGG 540

CACATTCTGA GATTAAGACA GATCAATCAT GCTTTGGGAA CCGAATTTAT CAATGCTGAT 600

GAAAAAGAAA ACAAAGAAGA CGAAGAAGAA GACTATAGTG TTTCACAACC GGTTGCTCCA 660

GATGCGGGGC TCACTGAGCT GAATATTACT GCGGAAGAGC CACCATATTT CAAGTCAAAC 720

GACAACATTG TATTGTTTAA TGAAACGCAT GCTCTACCAG CAGGACGAAC ATTGAAACTT 780

AATTGTCGCG CAAAAGGATA CCCTGAGCCA CAGATTATCT GGTACAAAAA CGGCAAAATG 840

TTGAAGAAAA GTAGTGCTCG GTCCGGCGGA TACGAATTCA AGTTCAATAG ATGGTCTTTA 900

GAAGTGGAAG ATGCTGTCGT AGCAGATTCT GGGGAGTTTC ATTGTGAAGC ATTGAACAAA 960

GTTGGAAGTG CAAAAAAGTA TTTCCATGTG ATCATAGTCA ACAGAATGAG AAGACCGCCC 1020

ATTATCGTTC CGAATATTTT GGCTAATCAA TCAGTAAATA TTAATGACAC TGCCACATTC 1080

CACTGCAAAG TTGTCTCTGA CTTATTGCCT CATATTATTT GGGTACGCAT CAACAAAATC 1140

AATGGGTCGT ATAGCTACTA CAACAATTCA GCTGAAGAGT ATATGTTCAA TTACACAGAG 1200

ATGGACACTT TTGATAAAGC GCACGTCCAT CACGTTGGTG ATGAATCGAC GCTTACTATT 1260

TTCAATGTGT CGCTGGATGA TCAGGGAATA TATGCTTGTC TCAGTGGAAA CTCACTGGGG 1320

ATGTCGATGG CGAATGCCAC TTTAACGGTG AATGAGTTTA TGGCCATACA TTTGCTCACT 1380

GGTGACGAAC CGAAGATAGA TAGATGGACA ACATCCGATT ATATATTTAC AACAATTCTG 1440

CTTTTCTTAC TGCTTGCTGC AACATTATTT GGAATTTTGT TTATGGTGTG CAAACAAACA 1500

CTACACAAAA AAGGATTCAT GGATGATACT GTTGGATTAG TGGCAAGAAA AAAAAGAGTC 1560

GTAGTTAGCA AAAGGCCAAT GAATGAAGAT AATGAGAATT CGGATGATGA GCCATCACCT 1620

TATCAAATTC AAATAATAGA GACTCCAATT ACAAAGAAAG AAGCAGCGAG AAAACAAAGA 1680

AAACGTATGA ATTCAGAAAA CACTGTTCTT TCGGAATACG AGGTTGATTC GGATCCAGTT 1740

TGGGAAGTTG AAAGATCAAA ATTGAGTTTG GTTCACATGC TTGGCGAGGG AGCATTTGGA 1800

GAAGTTTGGA AAGCAACATA CAAAGAAACA GAAAACAATG AAATCGCAGT TGCTGTCAAA 1860

AAATTGAAAA TGTCAGCTCA CGAAAAAGAG CTCATTGACT TGGTCAGTGA AATGGAAACA 1920

TTCAAAGTTA TAGGAGAACA TGAGAACGTG TTGCGATTGA TTGGATGCTG TACAGGCGCT 1980

GGTCCGCTTT ATGTCGTTGT TGAGCTGTGC AAGCATGGGA ATTTGCGCGA TTTCTTGAGA 2040

GCACATAGAC CTAAGGAAGA GAAGGCAAAA AAGTCCAGCC AAGAATTGAC GGATTATTTG 2100

GAACCACGAA AAGCATCTGA TAAGGATGAC ATTGAGCTCA TACCAAATTT GACACAACGC 2160

CATCTTGTAC AATTTGCTTG GCAAGTGGCT CAAGGAATGA ACTTCTTGGC ATCAAAGAAG 2220

ATCATACATC GTGATTTGGC AGCAAGAAAT GTTCTCGTCG GTGATGGACA CGTTCTGAAA 2280

ATATCGGATT TTGGACTATC GAGAGATGTG CACTGTAACG ATTATTATAG AAAACGTGGA 2340

AACGGCAGAC TTCCCATTAA ATGGATGGCT TTAGAAGCGT TGGACTCAAA TGTATACACC 2400

GTGGAAAGTG ATGTATGGTC ATATGGAGTT CTCCTTTGGG AAATCATGAC ACTTGGTGGA 2460

ACTCCCTATC CAACGATTGC CATGCCTGAA CTCTATGCTA ACCTCAAAGA AGGATACAGA 2520

ATGGAGCCAC CACATTTATG TCCCCAAGAA GTCTACCATT TGATGTGCAG CTGCTGGAGA 2580

GAAAAATTGG AAGAACGACC ATCTTTTAAA ACAATCGTAG ATTATTTGGA TTGGATGTTA 2640

ACAATGACAA ATGAGACTAT TGAGGGATCA CAAGAATTTA ATGATCAATT TTTCTCCGAA 2700

AGATCCACGG CATCAGGTCC AGTTTCTCCT ATGGAGTCAT TCCAGAAAAA GAGAAAACAT 2760

CGCCCTCTTT CAGCTCCAGT GAATCTTCCA TCAGAGCCAC AACACACAAT TTGCGACGAC 2820

TATGAGTCCA ATTTTTCTGT AGAACCACCC AATGATCCGA ATCATCTCTA CTGCAATGAC 2880

AATATGCTGA AAAATCACAT TATTACACCG GAAACCTCTC AACGTATTCC ATCAAACAAC 2940

AATAGCATGA GCAAACCCGA ATTTTGA 2967

Domain Profile

S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60

         l+l+++lGeGafG+v+ka++    k++e++e++vavk+lk++a++k+l+dlvseme++k+

Q: 588   LSLVHMLGEGAFGEVWKATY----KETENNEIAVAVKKLKMSAHEKELIDLVSEMETFKV  643

         79******************....************************************

S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask.........dks  111

         iG+h+n+++l+G+ct++Gplyv+ve++++Gnlr+flra+rpk+e+a+k         +++

Q: 644   IGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKssqeltdylEPR  703

         ********************************************9999899999999888

S: 112   kasee.......qltekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiad  164

         kas++       +lt+++lv+fa+qva+Gm++laskk+ihrdlaarnvlv++++vlki+d

Q: 704   KASDKddielipNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLKISD  763

         888889999999************************************************

S: 165   fGlardvheidyykkttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspy  224

         fGl+rdvh++dyy+k++nGrlp+kwma+eal+++vyt++sdvws+Gvllwei+tlGg+py

Q: 764   FGLSRDVHCNDYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPY  823

         ************************************************************

S: 225   pgiaveelfkllkeGhrmekpakctkelyvlmrecwhakaserptfkqlvedl  277

         p+ia++el+++lkeG+rme p+ c++e+y+lm++cw++k +erp+fk++v++l

Q: 824   PTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYL  876

         **************************************************987

Domain Sequence
(FASTA)

LSLVHMLGEG AFGEVWKATY KETENNEIAV AVKKLKMSAH EKELIDLVSE METFKVIGEH 60

ENVLRLIGCC TGAGPLYVVV ELCKHGNLRD FLRAHRPKEE KAKKSSQELT DYLEPRKASD 120

KDDIELIPNL TQRHLVQFAW QVAQGMNFLA SKKIIHRDLA ARNVLVGDGH VLKISDFGLS 180

RDVHCNDYYR KRGNGRLPIK WMALEALDSN VYTVESDVWS YGVLLWEIMT LGGTPYPTIA 240

MPELYANLKE GYRMEPPHLC PQEVYHLMCS CWREKLEERP SFKTIVDYL 289

Keyword

Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Kinase; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005623	; C:cell
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005003	; F:ephrin receptor activity
GO:0046872	; F:metal ion binding
GO:0004672	; F:protein kinase activity
GO:0007411	; P:axon guidance
GO:0016477	; P:cell migration
GO:0048546	; P:digestive tract morphogenesis
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0043652	; P:engulfment of apoptotic cell
GO:0048013	; P:ephrin receptor signaling pathway
GO:0008543	; P:fibroblast growth factor receptor signaling pathway
GO:0040035	; P:hermaphrodite genitalia development
GO:0007517	; P:muscle organ development
GO:0002119	; P:nematode larval development
GO:0018991	; P:oviposition
GO:0006898	; P:receptor-mediated endocytosis
GO:0031344	; P:regulation of cell projection organization
GO:0032940	; P:secretion by cell

KEGG

cel:CELE_F58A3.2

;

InterPros

IPR020766	; Fibroblast_GF_rcpt-like.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 2.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013