EKS-CAE-00316

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00316

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	349.7	1.9E-104	665	925	261

Status

Unreviewed

Ensembl Protein

F59A6.1

UniProt Accession

Q21029;

Protein Name

Protein Synonyms/Alias

Protein NSY-1;

Gene Name

nsy-1

Gene Synonyms/Alias

nsy-1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
F59A6.1	F59A6.1	F59A6.1

Organism

Caenorhabditis elegans

Functional Description

Protein Length

1498

Protein Sequence
(FASTA)

MSQNNKRQVQ HNHEMSNDVC PLPLPPRGAP PPTAYHASRM AATSSSTNGS FEKSAIPGNA 60

RKLHVVIVID QKVQKNLRVR EMALKDVQKV ADTLNVNLTR IDFDKLDFGE TETLDLFYNA 120

DVALVDVTVT HQQPSLCYHI GVRESMGQSY NMILTYWSPD PEYHIMDALK KTHAHLPMIV 180

YIHHQDSNQL QSYDKNNNDD DSKPPFARTN VPAKTITFQH RMKQVLKSVQ VEASAHSREK 240

FMSDLRKARE ITDGDQKNDY LDKMRTRLDN PDVLHPDTVS LMMLSYRDNQ NYGGMIRLVD 300

DLKRIPDCLK VVDTPVIRYQ YAFALNRRNK DGDRDLALNT VLSLVEGTTE NEEKNGPLSP 360

DVVCLAGRIY KDKFIASNYE DRESLNSAIE WYRRAFEMSP LEYSGINLTT LLRASGEHFE 420

NNLEMQQIAV VLNSLLGRKG ALQNLMEYWD VATYFEVSVL AENYQKACEA ALMMVKLKPP 480

VWYLKSTMEN IKLINRCAAT ISPIEKEKQQ FLFWSEFFME ATEADTDISC PRYPVLILEL 540

NKEFTPSYLT LNNEEGTVIL SHVLENSQQK KIHQSELRGI HRWHFARNNI KAVTESKRDD 600

RQLFLYVHEN SDDFNLLFPT KAHCKKAYDD MKSMADVADG NYQGRVLSNP DNEKIRFEYE 660

LSNSNERVVL GKGTYGTVYA ARDMDTQRQI VVKEIEVKYD EEVQPLMEEI SLHSTLCHAN 720

IVQYLGCDLV GKDGSNDHFL IFMEHVPGGS LSSLLRSKWG PMNENAMNYY GKQILEGLKY 780

LHELKIVHRD IKGDNVLVNT YSGVCKISDF GTCKRLAGLN PVTETFTGTL QYMAPEVIDH 840

GQRGYGAPAD IWSFGCTMVE MATGRPPFVE MQNPQAAMFR VGMFKTHPPI PTEITEKCRN 900

FIKSCFLPEA CDRPSAKDLL QDPFIYHNHH SISRTRSGSI NKKPATKIEL NHDKEKKEKS 960

KNQREMLRST SHIGGMGVVE RSPPTPEPMS ATLTAGFSHV HSQTVSNALS TAREEKKLHL 1020

KIDHARNRTF SSSSPVPDGQ SSAGTNMSHP GFQLSQPSSP IVDDTNHPHL IVSPISLNTM 1080

GSPLSSAALL NRTISDESSN SSSRFFMLQK DSERRRSLGQ FMQDYKDLII DSWSTLLIKQ 1140

SDTELVVTVY MLEMLLDGMR DFLLKKDNTK MQKMIDDIRG LLDYDTAKIG QINLALYHFS 1200

DSIQPVLRRL DIKPHWMFAL SNLITSAVQC AISILSPDLS LLLHAQDNLP STSSIVAIRN 1260

SSLSEGEALI ESRPPSREER VREDRKELRT LQEENEILIE RLLQVERELN AQLKSGITRA 1320

NRFRDFAMYR NTYPPFRTPP VAHAPPTPPF SASCGAQPSG TFTNQPPSFA SIKPIAQKII 1380

MPPGTENNYQ VTRVQEELVS WLRGLEIDER SIALIASEAY TKSDMMDFVT RDELLSIGVG 1440

GGSSCRIMRA IGEVRERQRR QPVFLSPMRS RDDSLDDYHS SSADDMYTGA AAETSSGN 1498

Nucleotide Sequence
(FASTA)

ATGTCGCAGA ACAACAAGAG GCAAGTGCAG CATAATCACG AGATGTCTAA TGATGTGTGT 60

CCTTTGCCAC TACCGCCACG TGGCGCTCCG CCTCCAACCG CATACCACGC AAGTCGAATG 120

GCTGCAACTT CATCCTCAAC CAACGGATCT TTCGAAAAGT CAGCGATTCC AGGAAATGCA 180

CGAAAACTTC ACGTGGTGAT TGTGATTGAT CAGAAAGTGC AAAAGAATTT ACGCGTTCGA 240

GAAATGGCTC TGAAAGATGT ACAGAAAGTG GCAGACACAT TGAATGTTAA TTTAACGCGC 300

ATCGATTTTG ACAAATTGGA CTTTGGCGAA ACAGAAACTC TGGATCTATT CTACAATGCT 360

GACGTGGCAC TTGTTGATGT TACGGTAACC CATCAACAAC CAAGTCTTTG TTATCATATT 420

GGAGTTCGTG AGAGCATGGG ACAGTCATAC AATATGATAC TCACTTATTG GTCTCCTGAT 480

CCAGAATATC ATATTATGGA TGCTTTGAAG AAAACTCATG CACATCTTCC AATGATTGTA 540

TATATTCATC ATCAAGATTC AAATCAATTG CAGAGTTATG ATAAGAATAA TAACGATGAT 600

GATTCAAAAC CTCCATTTGC TAGAACAAAT GTTCCAGCAA AAACAATAAC TTTTCAACAT 660

CGAATGAAAC AAGTTTTGAA AAGTGTTCAA GTGGAAGCAT CAGCACATTC TCGCGAGAAG 720

TTCATGTCGG ATTTGCGAAA AGCTCGTGAA ATCACAGATG GAGATCAGAA GAATGATTAT 780

CTTGATAAAA TGAGAACAAG ACTTGATAAT CCGGATGTAT TACATCCAGA TACCGTATCC 840

CTTATGATGC TCTCTTATCG TGATAATCAG AATTATGGAG GAATGATTCG TCTTGTTGAT 900

GATTTGAAAA GAATTCCGGA TTGTTTGAAA GTTGTAGACA CGCCGGTTAT TCGATATCAG 960

TATGCGTTTG CTCTGAACCG AAGAAACAAG GATGGGGACC GTGATTTGGC ATTAAATACC 1020

GTACTCAGTT TGGTGGAGGG AACAACTGAA AACGAAGAGA AGAATGGCCC ATTGAGTCCA 1080

GACGTTGTTT GTCTTGCTGG CCGTATCTAC AAAGATAAAT TCATTGCATC CAACTACGAA 1140

GACCGTGAAA GCCTGAACAG TGCAATTGAA TGGTATCGCC GTGCATTCGA AATGTCACCT 1200

CTGGAATATT CAGGAATAAA TCTGACAACT CTTCTTCGAG CAAGTGGAGA ACACTTTGAG 1260

AATAATCTCG AAATGCAGCA AATCGCTGTT GTCCTCAACT CGTTGCTCGG ACGGAAAGGG 1320

GCACTTCAGA ACCTAATGGA ATATTGGGAT GTGGCAACTT ATTTCGAAGT TTCTGTTCTA 1380

GCAGAGAATT ACCAGAAAGC ATGTGAAGCA GCTTTGATGA TGGTCAAGTT GAAACCTCCA 1440

GTTTGGTATT TAAAGTCTAC GATGGAAAAT ATCAAATTAA TAAATCGATG TGCAGCAACA 1500

ATCAGTCCAA TCGAGAAGGA GAAGCAACAA TTCCTTTTCT GGAGTGAATT CTTCATGGAG 1560

GCAACTGAGG CAGACACTGA TATTAGTTGC CCAAGATACC CAGTACTTAT TCTGGAACTC 1620

AATAAGGAAT TCACACCTTC TTATCTGACT CTGAATAATG AAGAGGGAAC AGTAATTCTG 1680

AGTCATGTTC TGGAAAACAG CCAACAGAAA AAGATTCATC AATCCGAGTT GAGAGGTATA 1740

CATCGATGGC ATTTTGCAAG GAATAATATC AAAGCAGTGA CTGAATCGAA ACGAGATGAT 1800

CGTCAATTAT TCCTTTATGT TCATGAAAAT TCAGATGATT TCAACCTTCT GTTCCCGACA 1860

AAGGCTCATT GCAAAAAAGC CTACGATGAC ATGAAATCAA TGGCCGATGT TGCTGATGGA 1920

AACTACCAAG GAAGAGTACT AAGCAATCCG GATAATGAGA AGATCAGATT CGAGTATGAA 1980

TTGAGTAATT CAAATGAGCG TGTCGTTCTT GGAAAAGGAA CCTATGGAAC TGTGTACGCT 2040

GCACGAGATA TGGATACTCA GCGACAAATT GTTGTAAAAG AAATTGAAGT GAAGTATGAT 2100

GAGGAAGTAC AACCGTTGAT GGAAGAAATA AGTCTTCATT CCACGTTGTG CCATGCTAAT 2160

ATTGTACAAT ATCTTGGATG TGATTTGGTT GGAAAAGATG GCTCAAATGA TCACTTTTTG 2220

ATTTTTATGG AGCATGTTCC TGGAGGATCA CTCAGTTCAT TGCTTCGTTC CAAGTGGGGT 2280

CCAATGAATG AAAATGCGAT GAACTACTAC GGGAAGCAAA TTCTGGAGGG TCTTAAGTAT 2340

CTTCACGAGC TAAAAATTGT GCATCGAGAC ATCAAAGGAG ACAATGTTCT TGTGAACACT 2400

TACTCGGGAG TCTGCAAAAT TTCCGATTTT GGAACATGCA AACGTCTTGC TGGGCTGAAT 2460

CCAGTAACCG AAACTTTCAC TGGAACTCTT CAGTATATGG CTCCAGAAGT TATCGATCAT 2520

GGACAACGTG GATATGGTGC ACCTGCAGAT ATTTGGTCAT TTGGGTGTAC AATGGTTGAA 2580

ATGGCAACTG GGCGGCCTCC GTTTGTTGAG ATGCAGAATC CGCAGGCGGC AATGTTCAGA 2640

GTTGGAATGT TCAAAACTCA TCCTCCAATT CCAACGGAAA TTACTGAAAA GTGTAGAAAC 2700

TTTATCAAAA GTTGTTTCTT GCCAGAAGCA TGTGATCGTC CATCAGCAAA AGATCTTCTC 2760

CAAGATCCAT TTATTTATCA CAACCATCAT TCTATTTCAA GAACGCGTAG CGGCTCGATC 2820

AACAAGAAAC CTGCCACCAA AATCGAGTTG AATCATGACA AGGAAAAGAA GGAAAAATCG 2880

AAAAATCAAC GAGAAATGCT CCGTTCAACA TCGCATATCG GTGGAATGGG AGTTGTTGAA 2940

AGATCTCCAC CAACACCTGA ACCAATGTCA GCCACTCTTA CTGCTGGATT CTCTCATGTT 3000

CACAGTCAAA CTGTATCGAA TGCATTGTCA ACTGCACGAG AAGAAAAGAA GCTTCATCTC 3060

AAGATTGATC ATGCAAGGAA TCGAACATTC AGTTCAAGTA GTCCAGTACC AGATGGTCAA 3120

TCATCTGCTG GAACTAATAT GTCTCATCCT GGATTCCAAT TGAGTCAGCC ATCAAGTCCT 3180

ATTGTCGATG ATACAAATCA CCCTCATTTG ATTGTCTCTC CAATTTCTCT GAATACAATG 3240

GGATCTCCAC TTTCATCAGC TGCACTTCTC AATCGAACAA TTTCCGATGA AAGTTCCAAT 3300

AGTTCAAGTC GATTCTTCAT GCTTCAAAAG GATTCAGAAC GTAGAAGATC CTTGGGACAA 3360

TTCATGCAAG ATTACAAAGA CTTGATCATT GACTCTTGGA GCACATTGCT CATTAAACAA 3420

AGTGACACGG AACTCGTAGT GACTGTCTAT ATGTTGGAAA TGTTACTTGA TGGAATGAGA 3480

GATTTCTTGT TGAAAAAGGA TAATACAAAG ATGCAAAAAA TGATTGATGA TATTCGAGGT 3540

CTTTTGGATT ATGATACTGC TAAAATTGGC CAGATAAACC TTGCTCTCTA CCACTTCTCC 3600

GATTCAATTC AACCTGTTCT CCGTCGCCTT GATATAAAGC CTCATTGGAT GTTTGCACTT 3660

TCAAATCTAA TCACTTCAGC CGTTCAATGT GCCATTTCAA TTCTAAGTCC AGATCTTTCT 3720

CTCCTACTTC ATGCTCAAGA TAATCTTCCA TCCACATCAT CAATTGTTGC AATCAGAAAT 3780

TCCTCACTTT CTGAAGGTGA AGCTCTCATT GAATCTCGAC CTCCAAGTCG TGAAGAACGA 3840

GTTCGTGAGG ATCGAAAAGA ATTGAGAACT TTACAAGAAG AAAATGAAAT TCTAATTGAA 3900

CGATTGCTTC AAGTGGAAAG AGAATTAAAT GCTCAACTCA AATCCGGAAT CACCAGAGCC 3960

AATCGTTTCC GAGATTTTGC CATGTACCGT AACACATATC CACCATTCCG TACTCCACCA 4020

GTCGCTCATG CTCCCCCAAC TCCTCCATTC AGTGCTTCAT GTGGTGCTCA ACCGTCAGGA 4080

ACATTTACAA ATCAACCTCC GAGCTTCGCC TCAATAAAAC CAATTGCTCA GAAAATCATA 4140

ATGCCACCCG GAACCGAGAA TAATTATCAA GTGACACGTG TTCAGGAGGA GCTTGTCAGT 4200

TGGCTACGTG GATTGGAAAT TGACGAACGA TCGATTGCTC TGATCGCCTC CGAAGCTTAT 4260

ACAAAGAGCG ATATGATGGA TTTTGTGACA AGAGACGAGC TGCTCAGTAT TGGTGTTGGC 4320

GGAGGTTCAT CTTGTCGTAT AATGCGTGCA ATTGGTGAAG TTCGTGAACG TCAACGCCGT 4380

CAGCCAGTCT TCCTGTCTCC AATGCGAAGT CGAGATGATT CTTTGGATGA TTATCATTCA 4440

AGCAGTGCCG ATGATATGTA CACTGGCGCT GCTGCTGAAA CTTCATCTGG AAACTGA 4497

Domain Profile

S: 2     qkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHe  61

         ++r v+gkG++g+vyaa+d+dt+++++vKe+e+k+++     ev++l+eEi+l+++l H

Q: 665   NERVVLGKGTYGTVYAARDMDTQRQIVVKEIEVKYDE-----EVQPLMEEISLHSTLCHA  719

         57899**************************997774.....799***************

S: 62    nivkyyGv.....eveeeelkiflEyvegGslsslle.kygkleesvikkytkqilegla  115

         niv+y+G+     + +++++ if+E+v+gGslssll+ k+g+++e+ ++ y kqilegl+

Q: 720   NIVQYLGCdlvgkDGSNDHFLIFMEHVPGGSLSSLLRsKWGPMNENAMNYYGKQILEGLK  779

         ********77766678999******************9**********************

S: 116   yLHekkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPE  174

         yLHe kivHRDiKg+N+l+++ sgv+k+sDFG++krla ln++   +e++tGtl+ymaPE

Q: 780   YLHELKIVHRDIKGDNVLVNTySGVCKISDFGTCKRLAGLNPV---TETFTGTLQYMAPE  836

         ******************************************9...8*************

S: 175   vikkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklse  234

         vi+++++gyg+ aDiWs+gc+++em+tg++Pf e+++++a+mf+vg+ kt+P+ip++++e

Q: 837   VIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPIPTEITE  896

         ************************************************************

S: 235   egkdflekcleldpkkrpsaeeLLkhefl  263

         ++++f+++c+  ++ +rpsa++LL+++f+

Q: 897   KCRNFIKSCFLPEACDRPSAKDLLQDPFI  925

         ***************************96

Domain Sequence
(FASTA)

NERVVLGKGT YGTVYAARDM DTQRQIVVKE IEVKYDEEVQ PLMEEISLHS TLCHANIVQY 60

LGCDLVGKDG SNDHFLIFME HVPGGSLSSL LRSKWGPMNE NAMNYYGKQI LEGLKYLHEL 120

KIVHRDIKGD NVLVNTYSGV CKISDFGTCK RLAGLNPVTE TFTGTLQYMA PEVIDHGQRG 180

YGAPADIWSF GCTMVEMATG RPPFVEMQNP QAAMFRVGMF KTHPPIPTEI TEKCRNFIKS 240

CFLPEACDRP SAKDLLQDPF I 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0043025	; C:neuronal cell body
GO:0014069	; C:postsynaptic density
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045165	; P:cell fate commitment
GO:0006935	; P:chemotaxis
GO:0045087	; P:innate immune response
GO:0002119	; P:nematode larval development
GO:0018991	; P:oviposition
GO:0040010	; P:positive regulation of growth rate

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013