EKS-DRM-00121

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00121

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	528.1	4.7E-159	389	639	251

Status

Reviewed

Ensembl Protein

FBpp0303167

UniProt Accession

P00522; Q95TV1; Q9VV86;

Protein Name

Tyrosine-protein kinase Abl

Protein Synonyms/Alias

D-ash; Protein abelson;

Gene Name

Abl

Gene Synonyms/Alias

Abl; ABL-1, Dash; CG4032;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0000017	FBpp0303167	FBtr0330134
FBgn0000017	FBpp0303168	FBtr0330135
FBgn0000017	FBpp0303169	FBtr0330136
FBgn0000017	FBpp0075116	FBtr0075357
FBgn0000017	FBpp0303164	FBtr0330131
FBgn0000017	FBpp0303163	FBtr0330130
FBgn0000017	FBpp0303166	FBtr0330133
FBgn0000017	FBpp0303165	FBtr0330132
FBgn0000017	FBpp0111702	FBtr0112790

Organism

Drosophila melanogaster

Functional Description

Arm and Abl proteins function cooperatively at adherensjunctions in both the CNS and epidermis; critical for embryonic epithelial morphogenesis regulating cell shape changes and cell migration. Plays a critical role in transducing embryonic midline repulsive cues; may regulate cytoskeletal dynamics underlying a growth cone's response to midline cues. The ability of pCC/MP2 axons to correctly interpret midline repulsive cues and stay on the ipsilateral side is dependent on the strength of both Slit/robo and Abl-dependent signaling pathways.

Protein Length

1522

Protein Sequence
(FASTA)

MGAQQGKDRG AHSGGGGSGA PVSCIGLSSS PVASVSPHCI SSSSGVSSAP LGGGSTLRGS 60

RIKSSSSGVA SGSGSGGGGG GSGSGLSQRS GGHKDARCNP TVGLNIFTEH NGTKHSSFRG 120

HPGKYHMNLE ALLQSRPLPH IPAGSTAASL LADAAELQQH QQDSGGLGLQ GSSLGGGHSS 180

TTSVFESAHR WTSKENLLAP GPEEDDPQLF VALYDFQAGG ENQLSLKKGE QVRILSYNKS 240

GEWCEAHSDS GNVGWVPSNY VTPLNSLEKH SWYHGPISRN AAEYLLSSGI NGSFLVRESE 300

SSPGQRSISL RYEGRVYHYR ISEDPDGKVF VTQEAKFNTL AELVHHHSVP HEGHGLITPL 360

LYPAPKQNKP TVFPLSPEPD EWEICRTDIM MKHKLGGGQY GEVYEAVWKR YGNTVAVKTL 420

KEDTMALKDF LEEAAIMKEM KHPNLVQLIG VCTREPPFYI ITEFMSHGNL LDFLRSAGRE 480

TLDAVALLYM ATQIASGMSY LESRNYIHRD LAARNCLVGD NKLVKVADFG LARLMRDDTY 540

TAHAGAKFPI KWTAPEGLAY NKFSTKSDVW AFGVLLWEIA TYGMSPYPAI DLTDVYHKLD 600

KGYRMERPPG CPPEVYDLMR QCWQWDATDR PTFKSIHHAL EHMFQESSIT EAVEKQLNAN 660

ATSASSSAPS TSGVATGGGA TTTTAASGCA SSSSATASLS LTPQMVKKGL PGGQALTPNA 720

HHNDPHQQQA STPMSETGST STKLSTFSSQ GKGNVQMRRT TNKQGKQAPA PPKRTSLLSS 780

SRDSTYREED PANARCNFID DLSTNGLARD INSLTQRYDS ETDPAADPDT DATGDSLEQS 840

LSQVIAAPVT NKMQHSLHSG GGGGGIGPRS SQQHSSFKRP TGTPVMGNRG LETRQSKRSQ 900

LHSQAPGPGP PSTQPHHGNN GVVTSAHPIT VGALDVMNVK QVVNRYGTLP KGARIGAYLD 960

SLEDSSEAAP ALPATAPSLP PANGHATPPA ARLNPKASPI PPQQMIRSNS SGGVTMQNNA 1020

AASLNKLQRH RTTTEGTMMT FSSFRAGGSS SSPKRSASGV ASGVQPALAN LEFPPPPLDL 1080

PPPPEEFEGG PPPPPPAPES AVQAIQQHLH AQLPNNGNIS NGNGTNNNDS SHNDVSNIAP 1140

SVEEASSRFG VSLRKREPST DSCSSLGSPP EDLKEKLITE IKAAGKDTAP ASHLANGSGI 1200

AVVDPVSLLV TELAESMNLP KPPPQQQQKL TNGNSTGSGF KAQLKKVEPK KMSAPMPKAE 1260

PANTIIDFKA HLRRVDKEKE PATPAPAPAT VAVANNANCN TTGTLNRKED GSKKFSQAMQ 1320

KTEIKIDVTN SNVEADAGAA GEGDLGKRRS TDDEEQSHTE GLGSGGQGSA DMTQSLYEQK 1380

PQIQQKPAVP HKPTKLTIYA TPIAKLTEPA SSASSTQISR ESILELVGLL EGSLKHPVNA 1440

IAGSQWLQLS DKLNILHNSC VIFAENGAMP PHSKFQFREL VTRVEAQSQH LRSAGSKNVQ 1500

DNERLVAEVG QSLRQISNAL NR 1522

Nucleotide Sequence
(FASTA)

ATGGGGGCTC AGCAGGGCAA GGACAGGGGC GCCCACTCGG GAGGAGGCGG CTCGGGGGCC 60

CCCGTCAGCT GCATCGGCCT CTCCAGCAGC CCAGTGGCCT CCGTTTCCCC CCACTGCATC 120

TCCAGTTCCA GCGGCGTCAG CAGCGCCCCC CTCGGCGGGG GCTCCACGCT CCGTGGCTCC 180

CGCATCAAGT CCTCGTCCTC CGGCGTGGCC AGTGGCAGCG GATCGGGCGG AGGCGGTGGC 240

GGATCCGGAT CGGGGCTGAG CCAGCGTAGT GGCGGACACA AGGATGCACG CTGCAATCCC 300

ACCGTGGGTC TCAACATATT CACCGAGCAT AACGGTACCA AGCACAGCTC TTTTCGCGGC 360

CATCCAGGCA AATATCACAT GAACTTAGAA GCCCTGCTGC AGTCGCGTCC ATTACCTCAC 420

ATTCCGGCCG GCAGCACGGC GGCCTCTCTT CTGGCGGATG CCGCTGAGCT GCAGCAGCAT 480

CAGCAGGATT CCGGTGGACT GGGACTGCAG GGCTCCTCCC TGGGCGGTGG TCACAGTTCG 540

ACTACATCCG TGTTTGAATC CGCCCATCGG TGGACCTCGA AGGAGAACCT ACTGGCCCCC 600

GGACCCGAGG AGGATGATCC GCAACTTTTT GTGGCGCTAT ACGATTTCCA AGCCGGCGGA 660

GAGAATCAAT TGAGTCTGAA GAAAGGCGAG CAGGTGCGCA TACTTAGCTA CAACAAATCG 720

GGGGAGTGGT GCGAGGCGCA CTCGGACTCC GGAAACGTTG GATGGGTGCC CTCCAACTAT 780

GTCACGCCGC TCAATTCGCT GGAGAAGCAC TCCTGGTACC ACGGGCCTAT CTCACGCAAC 840

GCCGCCGAGT ATCTTCTCAG CTCCGGAATC AATGGCAGTT TCCTGGTCCG TGAAAGTGAA 900

AGTTCACCGG GTCAAAGGAG CATCAGTTTG AGATACGAGG GTCGCGTCTA TCACTACCGC 960

ATCTCAGAGG ATCCCGATGG GAAAGTCTTC GTTACCCAGG AGGCCAAGTT TAACACTCTG 1020

GCCGAGCTGG TGCATCATCA CAGCGTGCCC CATGAGGGTC ACGGCCTGAT CACACCGCTC 1080

CTATATCCGG CGCCCAAGCA GAACAAGCCC ACCGTCTTTC CGCTGAGTCC CGAGCCGGAT 1140

GAGTGGGAGA TCTGCCGGAC GGACATCATG ATGAAGCACA AGCTAGGCGG CGGTCAGTAC 1200

GGAGAGGTCT ACGAGGCCGT TTGGAAGCGG TATGGCAATA CGGTGGCTGT TAAAACGCTC 1260

AAGGAGGACA CCATGGCACT GAAGGACTTC CTCGAAGAGG CGGCCATCAT GAAGGAAATG 1320

AAGCACCCTA ATCTGGTGCA GCTCATTGGT GTTTGCACCA GAGAACCACC GTTCTATATC 1380

ATCACCGAGT TTATGTCGCA CGGCAATCTG TTGGACTTCC TGCGCTCCGC CGGACGCGAA 1440

ACGCTCGATG CAGTAGCGTT GCTGTACATG GCCACTCAGA TAGCGTCGGG AATGAGCTAC 1500

CTGGAGTCGC GCAACTACAT TCATCGCGAT CTCGCTGCCC GCAATTGCCT GGTGGGTGAC 1560

AACAAGCTGG TCAAGGTGGC GGATTTCGGC CTGGCACGTT TGATGCGGGA CGACACGTAT 1620

ACAGCACATG CCGGAGCCAA GTTCCCGATC AAATGGACCG CACCGGAGGG TCTGGCCTAC 1680

AACAAGTTTA GCACCAAATC AGACGTTTGG GCCTTCGGAG TCTTGCTGTG GGAAATCGCC 1740

ACGTATGGAA TGTCACCGTA TCCGGCCATC GATCTGACCG ATGTGTACCA CAAGCTAGAC 1800

AAGGGCTATC GCATGGAGCG ACCGCCAGGC TGCCCGCCGG AGGTGTACGA CTTGATGCGC 1860

CAGTGCTGGC AGTGGGATGC CACCGACAGG CCCACGTTCA AGAGCATACA CCATGCGCTG 1920

GAGCACATGT TTCAGGAATC GTCCATCACC GAAGCGGTGG AAAAGCAGCT GAACGCCAAC 1980

GCCACCAGCG CGAGCAGCTC CGCTCCGAGC ACATCGGGCG TGGCCACCGG CGGAGGAGCC 2040

ACAACCACGA CGGCGGCCAG CGGCTGCGCT TCCTCATCCT CGGCCACCGC CTCGCTAAGT 2100

CTCACACCGC AGATGGTGAA GAAGGGTTTA CCCGGCGGTC AGGCCCTCAC GCCGAACGCC 2160

CACCACAACG ATCCGCACCA GCAGCAGGCC AGCACGCCCA TGTCAGAAAC CGGATCCACT 2220

TCCACCAAGC TAAGCACTTT CTCCAGCCAG GGCAAGGGCA ATGTCCAGAT GCGTCGCACC 2280

ACCAACAAGC AGGGCAAACA GGCGCCCGCC CCACCAAAGC GAACCAGCCT GCTCTCGAGC 2340

AGTCGGGACT CCACTTATCG CGAGGAGGAT CCAGCCAACG CCAGATGCAA TTTCATCGAC 2400

GACCTCAGCA CGAATGGACT AGCCCGGGAC ATCAACAGTT TGACGCAGCG GTACGATTCC 2460

GAAACAGATC CGGCAGCCGA CCCGGACACA GATGCCACGG GCGATAGTCT GGAGCAGAGT 2520

CTGAGCCAAG TGATAGCCGC TCCGGTCACC AACAAGATGC AGCATTCTCT TCACAGCGGA 2580

GGAGGAGGAG GAGGAATAGG TCCTCGATCC TCGCAGCAAC ACAGCTCCTT CAAGCGACCG 2640

ACTGGAACAC CCGTGATGGG TAACCGAGGA CTAGAGACCC GGCAGAGCAA GCGGTCCCAG 2700

CTCCATTCAC AGGCTCCGGG TCCAGGACCG CCATCAACTC AACCGCATCA TGGCAACAAC 2760

GGCGTGGTGA CCAGTGCTCA TCCCATCACT GTGGGTGCGC TCGATGTGAT GAATGTCAAG 2820

CAGGTGGTGA ACCGCTACGG AACACTACCA AAGGGTGCCA GAATCGGTGC CTATCTGGAC 2880

AGTCTTGAGG ATAGCAGTGA GGCTGCTCCT GCTCTTCCGG CAACTGCTCC TTCTCTGCCA 2940

CCAGCCAATG GACACGCCAC GCCTCCGGCT GCCAGACTAA ATCCGAAGGC CAGCCCCATT 3000

CCGCCACAGC AAATGATCAG GAGCAACTCG TCGGGCGGAG TGACCATGCA AAACAATGCG 3060

GCTGCCAGCT TAAACAAGCT TCAGCGTCAT CGCACCACTA CCGAAGGCAC CATGATGACG 3120

TTCTCCTCCT TCCGGGCGGG CGGTTCCAGT AGCTCACCCA AGCGGAGTGC CTCGGGAGTG 3180

GCTTCAGGAG TCCAGCCAGC TCTGGCCAAC CTTGAGTTTC CACCGCCTCC GTTGGACTTG 3240

CCTCCGCCGC CCGAGGAATT CGAAGGCGGA CCACCACCTC CTCCACCGGC GCCGGAGAGC 3300

GCTGTGCAGG CCATCCAGCA GCACTTGCAT GCCCAGCTGC CAAACAATGG CAACATTAGC 3360

AATGGAAACG GAACAAACAA CAACGACAGC AGCCACAACG ATGTTAGCAA CATAGCTCCC 3420

AGTGTGGAGG AGGCCAGCTC CAGATTCGGT GTGTCTCTGA GAAAACGCGA GCCCTCCACC 3480

GACTCCTGCA GCTCGCTGGG CAGTCCACCC GAGGATCTCA AGGAAAAGCT AATCACCGAA 3540

ATCAAGGCGG CCGGCAAGGA TACTGCTCCG GCCTCACATC TGGCCAACGG CTCGGGCATC 3600

GCTGTCGTGG ACCCCGTCTC CCTGCTTGTC ACCGAACTAG CCGAGAGCAT GAACCTGCCA 3660

AAGCCGCCGC CGCAGCAGCA GCAAAAGCTG ACCAACGGCA ATAGTACTGG GTCCGGATTC 3720

AAGGCTCAGC TGAAGAAAGT CGAGCCCAAA AAGATGAGCG CGCCAATGCC CAAGGCGGAG 3780

CCGGCAAATA CCATCATCGA CTTCAAGGCT CATCTGCGCC GGGTGGACAA GGAAAAGGAG 3840

CCAGCAACTC CAGCTCCAGC TCCAGCTACT GTAGCCGTAG CCAACAATGC CAACTGCAAT 3900

ACAACGGGCA CTTTGAACCG GAAGGAGGAC GGCAGCAAGA AGTTCTCGCA GGCCATGCAA 3960

AAGACTGAAA TCAAAATCGA CGTAACAAAC TCGAATGTGG AGGCGGATGC GGGAGCAGCG 4020

GGCGAGGGCG ATCTCGGCAA GCGGCGAAGC ACAGATGACG AGGAGCAGTC GCACACGGAG 4080

GGCCTGGGAT CGGGAGGCCA AGGATCAGCA GACATGACCC AGTCGCTGTA CGAGCAGAAG 4140

CCACAGATCC AGCAAAAGCC AGCGGTGCCG CACAAGCCAA CAAAGCTAAC CATCTACGCC 4200

ACGCCTATTG CCAAACTGAC CGAACCAGCC AGCTCCGCCA GCTCCACACA GATATCACGG 4260

GAGAGCATTC TGGAGCTGGT TGGCCTGCTA GAGGGCTCGC TCAAGCACCC GGTGAATGCC 4320

ATCGCTGGAT CTCAGTGGCT GCAGCTGAGT GACAAGCTCA ACATCCTGCA CAATTCGTGC 4380

GTGATCTTCG CGGAGAACGG AGCGATGCCG CCGCACTCCA AGTTCCAGTT CCGGGAGCTG 4440

GTCACGCGCG TGGAAGCACA GTCGCAGCAC TTGCGCTCCG CCGGCAGCAA GAACGTCCAG 4500

GACAACGAGC GCCTGGTGGC CGAAGTCGGT CAGTCGCTGC GTCAGATCTC CAATGCGCTT 4560

AACAGGTAA 4569

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevye+vwk+y++tvavktlkedtm++++fl+eaa+mke+khpnlvql

Q: 389   IMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQL  448

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         +gvctreppfyiitefms+gnlld+lr+a re+++av+llymatqi+s+m+yle++n+ih

Q: 449   IGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIH  508

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvg+nklvkvadfgl+rlm++dtytahagakfpikwtape+laynkfs+ksd

Q: 509   RDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSD  568

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspyp+idl++vy++l+kgyrmerp gcpp+vy+lmr+cw+w+++

Q: 569   VWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDAT  628

         ************************************************************

S: 241   drpsfaeihqa  251

         drp+f++ih+a

Q: 629   DRPTFKSIHHA  639

         *********97

Domain Sequence
(FASTA)

IMMKHKLGGG QYGEVYEAVW KRYGNTVAVK TLKEDTMALK DFLEEAAIMK EMKHPNLVQL 60

IGVCTREPPF YIITEFMSHG NLLDFLRSAG RETLDAVALL YMATQIASGM SYLESRNYIH 120

RDLAARNCLV GDNKLVKVAD FGLARLMRDD TYTAHAGAKF PIKWTAPEGL AYNKFSTKSD 180

VWAFGVLLWE IATYGMSPYP AIDLTDVYHK LDKGYRMERP PGCPPEVYDL MRQCWQWDAT 240

DRPTFKSIHH A 251

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045179	; C:apical cortex
GO:0030424	; C:axon
GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0019897	; C:extrinsic to plasma membrane
GO:0005927	; C:muscle tendon junction
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0007417	; P:central nervous system development
GO:0007303	; P:cytoplasmic transport, nurse cell to oocyte
GO:0007391	; P:dorsal closure
GO:0003382	; P:epithelial cell morphogenesis
GO:0008045	; P:motor neuron axon guidance
GO:0045886	; P:negative regulation of synaptic growth at neuromuscular junction
GO:0001764	; P:neuron migration
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0003402	; P:planar cell polarity pathway involved in axis elongation
GO:0008064	; P:regulation of actin polymerization or depolymerization
GO:0008360	; P:regulation of cell shape
GO:0032880	; P:regulation of protein localization
GO:0031647	; P:regulation of protein stability
GO:0007370	; P:ventral furrow formation

KEGG

dme:Dmel_CG4032

;

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013