EKS-DRM-00079

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00079

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	496.9	1.3E-149	431	690	260

Status

Reviewed

Ensembl Protein

FBpp0088351

UniProt Accession

P32023; A4V044; A4V046; Q0E8U1; Q24302; Q24303; Q9I7Q0; Q9I7Q2;

Protein Name

cGMP-dependent protein kinase, isozyme 2 forms cD5/T2

Protein Synonyms/Alias

cGK; Foraging protein;

Gene Name

for

Gene Synonyms/Alias

for; DG2, PGK2, Pkg24A; CG10033;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0000721	FBpp0088921	FBtr0089311
FBgn0000721	FBpp0088922	FBtr0089310
FBgn0000721	FBpp0290613	FBtr0301399
FBgn0000721	FBpp0088351	FBtr0089305
FBgn0000721	FBpp0088923	FBtr0089312
FBgn0000721	FBpp0088924	FBtr0089309
FBgn0000721	FBpp0088350	FBtr0089304
FBgn0000721	FBpp0088353	FBtr0089307
FBgn0000721	FBpp0088352	FBtr0089306
FBgn0000721	FBpp0088354	FBtr0089308
FBgn0000721	FBpp0099769	FBtr0100363

Organism

Drosophila melanogaster

Functional Description

Protein Length

742

Protein Sequence
(FASTA)

MQSLRISGCT PSGTGGSATP SPVGLVDPNF IVSNYVAASP QEERFIQIIQ AKELKIQEMQ 60

RALQFKDNEI AELKSHLDKF QSVFPFSRGS AAGCAGTGGA SGSGAGGSGG SGPGTATGAT 120

RKSGQNFQRQ RALGISAEPQ SESSLLLEHV SFPKYDKDER SRELIKAAIL DNDFMKNLDL 180

TQIREIVDCM YPVKYPAKNL IIKEGDVGSI VYVMEDGRVE VSREGKYLST LSGAKVLGEL 240

AILYNCQRTA TITAITECNL WAIERQCFQT IMMRTGLIRQ AEYSDFLKSV PIFKDLAEDT 300

LIKISDVLEE THYQRGDYIV RQGARGDTFF IISKGKVRVT IKQQDTQEEK FIRMLGKGDF 360

FGEKALQGDD LRTANIICES ADGVSCLVID RETFNQLISN LDEIKHRYDD EGAMERRKIN 420

EEFRDINLTD LRVIATLGVG GFGRVELVQT NGDSSRSFAL KQMKKSQIVE TRQQQHIMSE 480

KEIMGEANCQ FIVKLFKTFK DKKYLYMLME SCLGGELWTI LRDKGNFDDS TTRFYTACVV 540

EAFDYLHSRN IIYRDLKPEN LLLNERGYVK LVDFGFAKKL QTGRKTWTFC GTPEYVAPEV 600

ILNRGHDISA DYWSLGVLMF ELLTGTPPFT GSDPMRTYNI ILKGIDAIEF PRNITRNASN 660

LIKKLCRDNP AERLGYQRGG ISEIQKHKWF DGFYWWGLQN CTLEPPIKPA VKSVVDTTNF 720

DDYPPDPEGP PPDDVTGWDK DF 742

Nucleotide Sequence
(FASTA)

ATGCAGAGTC TGCGGATCTC GGGATGCACG CCCAGCGGTA CGGGTGGCTC GGCCACGCCC 60

TCGCCGGTGG GCCTGGTGGA TCCGAATTTC ATAGTCAGCA ACTATGTGGC CGCCTCGCCG 120

CAGGAGGAGC GCTTCATTCA GATCATTCAG GCCAAGGAGC TCAAGATACA GGAAATGCAA 180

AGGGCCCTCC AGTTCAAGGA CAACGAAATA GCCGAGCTAA AGTCGCACTT GGACAAATTC 240

CAGAGTGTCT TTCCCTTCAG CCGTGGCAGT GCGGCCGGTT GTGCGGGCAC GGGCGGAGCG 300

TCGGGATCTG GAGCTGGCGG AAGTGGTGGC AGTGGTCCCG GCACCGCCAC AGGTGCCACA 360

CGCAAGTCGG GTCAGAATTT CCAGAGGCAG AGGGCATTGG GTATCTCCGC CGAGCCACAG 420

AGCGAGTCCT CGCTGCTCCT CGAGCACGTC AGCTTTCCCA AATACGACAA GGATGAGCGC 480

TCCCGTGAAC TTATCAAGGC TGCCATATTG GATAATGATT TCATGAAGAA TCTGGATCTG 540

ACGCAGATCC GCGAGATCGT TGACTGCATG TATCCGGTTA AGTATCCAGC CAAGAATCTG 600

ATCATCAAGG AGGGAGATGT CGGAAGCATC GTTTATGTCA TGGAAGATGG ACGCGTGGAG 660

GTTTCCCGCG AGGGCAAGTA CCTCTCCACA TTGTCGGGAG CGAAGGTCCT TGGCGAATTG 720

GCGATCCTGT ACAACTGCCA GCGGACGGCG ACCATCACCG CGATCACCGA GTGCAACCTG 780

TGGGCCATCG AGCGCCAGTG CTTTCAGACC ATCATGATGC GAACGGGCCT GATCCGGCAG 840

GCGGAGTACA GCGATTTCCT CAAGAGTGTG CCCATCTTCA AAGACCTGGC GGAAGACACG 900

CTCATCAAAA TCTCCGATGT TTTGGAGGAG ACGCACTACC AGCGTGGCGA CTACATAGTG 960

CGCCAAGGCG CCCGAGGCGA TACCTTCTTC ATCATATCCA AGGGAAAAGT GCGAGTGACG 1020

ATCAAGCAGC AGGACACGCA GGAGGAGAAG TTCATTCGCA TGCTGGGCAA AGGGGATTTC 1080

TTTGGAGAGA AGGCTCTCCA GGGCGATGAT CTGCGCACGG CGAATATTAT TTGCGAGTCC 1140

GCCGATGGCG TCAGTTGTCT GGTCATCGAT CGCGAGACCT TCAATCAGCT AATTTCCAAT 1200

CTAGACGAGA TCAAGCATCG CTACGACGAC GAGGGCGCCA TGGAACGCAG AAAGATCAAC 1260

GAGGAATTCC GGGACATTAA CCTCACAGAT CTGCGCGTCA TCGCAACCCT TGGAGTTGGA 1320

GGCTTCGGTC GCGTAGAGCT GGTCCAAACT AATGGAGATA GCTCCAGGTC CTTCGCGCTC 1380

AAGCAGATGA AAAAGTCACA GATTGTGGAG ACGCGTCAGC AGCAACACAT CATGTCCGAG 1440

AAGGAGATCA TGGGCGAGGC CAATTGCCAG TTCATCGTGA AGCTGTTCAA GACCTTCAAG 1500

GACAAGAAGT ACCTGTACAT GCTGATGGAG AGTTGCCTGG GCGGAGAGCT CTGGACGATT 1560

CTACGGGACA AGGGCAACTT CGACGACAGC ACCACCCGCT TCTACACGGC ATGTGTGGTG 1620

GAGGCCTTTG ATTACTTGCA CTCGCGTAAC ATCATCTACC GCGATCTTAA GCCGGAGAAC 1680

CTGCTGCTCA ATGAACGAGG ATATGTGAAG CTGGTGGACT TTGGCTTTGC CAAGAAGCTG 1740

CAGACGGGCA GGAAGACCTG GACTTTCTGC GGCACTCCAG AGTACGTGGC TCCCGAGGTG 1800

ATTCTCAACC GGGGCCACGA CATCAGTGCG GATTACTGGT CGCTGGGAGT GCTCATGTTC 1860

GAGTTACTTA CTGGTACCCC TCCATTCACG GGCTCGGATC CCATGCGCAC CTACAACATT 1920

ATACTTAAGG GCATCGACGC CATCGAATTC CCAAGGAATA TCACCCGCAA TGCCAGCAAC 1980

CTGATCAAGA AGCTCTGTCG CGACAATCCA GCCGAGCGTT TGGGCTACCA GCGTGGGGGA 2040

ATCAGCGAGA TCCAAAAGCA CAAATGGTTC GATGGCTTCT ATTGGTGGGG CCTGCAGAAC 2100

TGCACACTGG AACCGCCCAT TAAGCCCGCC GTGAAAAGCG TTGTGGATAC AACAAACTTT 2160

GATGACTATC CTCCCGATCC TGAGGGTCCG CCGCCAGATG ATGTCACTGG ATGGGACAAG 2220

GACTTCTGA 2229

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+viatlgvggfgrvelv+++ d+s++falk++kk++iv+t+qq+h++sek+i+ ea+++

Q: 431   LRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMGEANCQ  490

         689*********************************************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivkl++tfkd+ky+y+l+e+clggelwtilrd+g+fdd+t++f++acvvea++ylhs+n

Q: 491   FIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRN  550

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenlll+e+gy+klvdfgfakkl++g+ktwtfcgtpeyvape+iln+ghd+s+

Q: 551   IIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILNRGHDISA  610

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         dyw+lg+l++elltg+ppf+g+dp++tyn+ilkgid++e+pr+it++a++likklcrdnp

Q: 611   DYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNP  670

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         aerlgy++ggi++i+khkwf

Q: 671   AERLGYQRGGISEIQKHKWF  690

         *******************9

Domain Sequence
(FASTA)

LRVIATLGVG GFGRVELVQT NGDSSRSFAL KQMKKSQIVE TRQQQHIMSE KEIMGEANCQ 60

FIVKLFKTFK DKKYLYMLME SCLGGELWTI LRDKGNFDDS TTRFYTACVV EAFDYLHSRN 120

IIYRDLKPEN LLLNERGYVK LVDFGFAKKL QTGRKTWTFC GTPEYVAPEV ILNRGHDISA 180

DYWSLGVLMF ELLTGTPPFT GSDPMRTYNI ILKGIDAIEF PRNITRNASN LIKKLCRDNP 240

AERLGYQRGG ISEIQKHKWF 260

Keyword

Alternative splicing; ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity
GO:0046959	; P:habituation
GO:0030536	; P:larval feeding behavior
GO:0008345	; P:larval locomotory behavior
GO:0007616	; P:long-term memory
GO:0008016	; P:regulation of heart contraction
GO:0032095	; P:regulation of response to food
GO:0009744	; P:response to sucrose stimulus
GO:0007614	; P:short-term memory

KEGG

dme:Dmel_CG10033

;

InterPros

IPR000961	; AGC-kinase_C.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 1.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013