EKS-DRM-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	307.6	1.0E-91	4	254	251

Status

Reviewed

Ensembl Protein

FBpp0074373

UniProt Accession

P23647; Q26346; Q26347; Q27412; Q9VWR7;

Protein Name

Serine/threonine-protein kinase fused

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

fu; CG6551;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0001079	FBpp0074373	FBtr0074602

Organism

Drosophila melanogaster

Functional Description

Probable serine/threonine-protein kinase; maternallyrequired for correct patterning in the posterior part of each embryonic metamere. May be involved in control of cell division during metamorphosis and ovarian development. May interact with costal-2.

Protein Length

805

Protein Sequence
(FASTA)

MNRYAVSSMV GQGSFGCVYK ATRKDDSKVV AIKVISKRGR ATKELKNLRR ECDIQARLKH 60

PHVIEMIESF ESKTDLFVVT EFALMDLHRY LSYNGAMGEE PARRVTGHLV SALYYLHSNR 120

ILHRDLKPQN VLLDKNMHAK LCDFGLARNM TLGTHVLTSI KGTPLYMAPE LLAEQPYDHH 180

ADMWSLGCIA YESMAGQPPF CASSILHLVK MIKHEDVKWP STLTSECRSF LQGLLEKDPG 240

LRISWTQLLC HPFVEGRIFI AETQAEAAKE SPFTNPEAKV KSSKQSDPEV GDLDEALAAL 300

DFGESRQENL TTSRDSINAI APSDVEHLET DVEDNMQRVV VPFADLSYRD LSGVRAMPMV 360

HQPVINSHTC FVSGNSNMIL NHMNDNFDFQ ASLRGGGVAA KPIVAPTVRQ SRSKDLEKRK 420

LSQNLDNFSV RLGHSVDHEA QRKATEIATQ EKHNQENKPP AEAISYANSQ PPQQQPQQLK 480

HSMHSTNEEK LSSDNTPPCL LPGWDSCDES QSPPIENDEW LAFLNRSVQE LLDGELDSLK 540

QHNLVSIIVA PLRNSKAIPR VLKSVAQLLS LPFVLVDPVL IVDLELIRNV YVDVKLVPNL 600

MYACKLLLSH KQLSDSAASA PLTTGSLSRT LRSIPELTVE ELETACSLYE LVCHLVHLQQ 660

QFLTQFCDAV AILAASDLFL NFLTHDFRQS DSDAASVRLA GCMLALMGCV LRELPENAEL 720

VERIVFNPRL NFVSLLQSRH HLLRQRSCQL LRLLARFSLR GVQRIWNGEL RFALQQLSEH 780

HSYPALRGEA AQTLDEISHF TFFVT 805

Nucleotide Sequence
(FASTA)

ATGAACCGCT ACGCGGTAAG CTCGATGGTG GGGCAAGGAT CCTTCGGGTG CGTATACAAG 60

GCGACACGCA AGGACGACAG CAAGGTGGTG GCCATCAAAG TGATCTCCAA GCGCGGAAGA 120

GCCACGAAAG AGCTGAAGAA TTTGCGCAGG GAGTGCGACA TTCAGGCCCG GCTGAAGCAT 180

CCGCACGTCA TCGAGATGAT CGAGTCCTTC GAGTCGAAGA CGGACCTTTT CGTGGTCACT 240

GAGTTCGCGC TGATGGACCT GCACCGCTAC CTGTCCTACA ATGGAGCCAT GGGCGAGGAG 300

CCGGCACGTC GGGTGACCGG GCATCTGGTG TCCGCTCTGT ACTACCTGCA TTCAAACCGC 360

ATCCTCCACC GGGATCTCAA ACCGCAAAAC GTGCTGCTCG ACAAGAACAT GCACGCGAAA 420

CTCTGCGACT TTGGACTGGC CCGCAACATG ACCCTGGGTA CCCACGTGCT CACCTCGATC 480

AAGGGAACGC CCCTCTACAT GGCCCCGGAG CTGCTGGCGG AGCAGCCGTA CGACCATCAT 540

GCGGACATGT GGTCACTGGG CTGCATAGCC TACGAAAGCA TGGCCGGTCA GCCGCCCTTC 600

TGTGCCAGCT CCATCCTGCA TCTGGTGAAG ATGATCAAGC ACGAGGACGT CAAGTGGCCG 660

AGCACGCTGA CTAGCGAGTG CCGCTCCTTC CTACAGGGCC TGCTTGAGAA GGACCCCGGT 720

CTGCGCATAT CCTGGACGCA GCTGTTGTGT CACCCCTTCG TTGAGGGACG CATCTTTATC 780

GCAGAAACGC AGGCGGAGGC GGCCAAGGAA TCGCCTTTCA CAAATCCCGA AGCCAAGGTT 840

AAGTCGTCAA AACAGTCCGA TCCGGAGGTA GGCGATCTGG ACGAGGCCCT GGCCGCTTTG 900

GACTTTGGCG AGTCGCGACA GGAAAACTTG ACCACCTCCC GCGACAGCAT AAACGCCATT 960

GCTCCCAGCG ATGTTGAGCA TCTTGAGACC GATGTGGAGG ACAATATGCA ACGTGTGGTC 1020

GTTCCCTTCG CGGACTTGTC CTACAGGGAT CTGTCTGGTG TTCGGGCAAT GCCGATGGTA 1080

CACCAGCCGG TGATCAACTC GCACACTTGC TTCGTCAGTG GCAACTCCAA TATGATCCTC 1140

AATCATATGA ACGACAACTT CGACTTTCAG GCTTCCTTGC GGGGCGGAGG CGTGGCCGCT 1200

AAGCCAATAG TCGCTCCAAC CGTACGCCAG TCGCGCAGCA AGGATCTAGA GAAGCGTAAG 1260

CTTAGTCAGA ATCTGGATAA CTTCTCTGTT CGCTTGGGTC ACAGCGTCGA CCATGAGGCG 1320

CAACGCAAGG CCACGGAGAT TGCTACACAG GAAAAGCATA ACCAGGAAAA CAAGCCTCCC 1380

GCTGAAGCAA TTTCCTACGC AAATTCTCAG CCCCCGCAGC AACAGCCACA ACAACTTAAA 1440

CACTCAATGC ATTCCACCAA TGAGGAAAAG CTGAGCAGCG ACAACACTCC GCCGTGCCTG 1500

CTCCCGGGGT GGGATAGCTG CGATGAATCC CAAAGTCCGC CCATCGAGAA CGATGAGTGG 1560

CTAGCCTTCT TGAACAGATC GGTGCAGGAG CTGCTTGACG GCGAACTGGA CTCATTGAAA 1620

CAGCACAACC TGGTGAGCAT TATTGTGGCA CCGCTGCGCA ACTCCAAGGC CATTCCACGG 1680

GTACTCAAGA GTGTGGCCCA GTTGCTGTCG TTGCCCTTTG TGCTGGTGGA TCCTGTTTTG 1740

ATTGTTGACC TCGAGCTCAT CCGCAACGTG TACGTGGACG TAAAACTGGT GCCCAATCTC 1800

ATGTACGCCT GCAAGCTGCT CCTGTCGCAC AAACAACTCT CGGACTCGGC TGCCTCCGCC 1860

CCACTCACCA CGGGTTCGCT CAGTCGAACG TTGCGTAGCA TTCCGGAGCT AACTGTCGAG 1920

GAGCTGGAGA CGGCTTGCAG TCTGTACGAA CTGGTCTGCC ACTTGGTACA CCTGCAGCAG 1980

CAGTTCCTAA CGCAGTTCTG CGATGCGGTT GCCATTCTGG CAGCAAGCGA TCTGTTCCTC 2040

AACTTCCTCA CGCACGACTT CAGGCAATCG GATTCAGACG CCGCCTCTGT TCGCCTGGCT 2100

GGGTGCATGT TGGCCCTGAT GGGCTGTGTG CTGCGCGAGC TGCCCGAAAA CGCGGAGCTT 2160

GTAGAACGGA TTGTCTTTAA TCCGCGGCTA AACTTCGTCT CGCTCCTGCA GAGCCGACAC 2220

CACCTGTTGC GGCAACGTTC CTGTCAGCTG CTGCGCCTGC TGGCCCGCTT CAGCCTGCGC 2280

GGCGTGCAGC GCATATGGAA TGGAGAGCTG CGATTTGCGC TGCAACAACT CTCTGAGCAC 2340

CACTCGTACC CGGCACTCCG TGGGGAGGCC GCCCAGACCC TCGACGAGAT CAGTCACTTC 2400

ACTTTTTTCG TCACCTAG 2418

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkkl.kkslenlekeikilkelkhen  59

         y++++++G+Gsf++vyk++ rk++s+vvAikv++k+++ +k+l+nl++e++i+ +lkh++

Q: 4     YAVSSMVGQGSFGCVYKAT-RKDDSKVVAIKVISKRGRaTKELKNLRRECDIQARLKHPH  62

         78999**************.9*****************9*********************

S: 60    ivalldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskki  119

         ++++++++e+++++++v+e++  +dL+++l+ ++++ e+ +r+++ +l+sal++Lhs++i

Q: 63    VIEMIESFESKTDLFVVTEFAL-MDLHRYLSYNGAMGEEPARRVTGHLVSALYYLHSNRI  121

         *********************9.*************************************

S: 120   vhrDlkPqniLlsyadakkelkkvtlkladFglarvlkeesma.atlkGsplYmaPEvvk  178

         +hrDlkPqn+Ll+        k++++kl+dFglar+++ +++  +++kG+plYmaPE+++

Q: 122   LHRDLKPQNVLLD--------KNMHAKLCDFGLARNMTLGTHVlTSIKGTPLYMAPELLA  173

         *************........99******************999****************

S: 179   eqqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdl  238

         eq yd++aD+WS+G+i ye ++G+pPf+a+si++Lv++i+++dv   ++p++++se++++

Q: 174   EQPYDHHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHEDV---KWPSTLTSECRSF  230

         ********************************************...*************

S: 239   lqsLLqrdpkkRisfeelfahpfl  262

         lq+LL++dp  Ris+++l++hpf+

Q: 231   LQGLLEKDPGLRISWTQLLCHPFV  254

         **********************96

Domain Sequence
(FASTA)

YAVSSMVGQG SFGCVYKATR KDDSKVVAIK VISKRGRATK ELKNLRRECD IQARLKHPHV 60

IEMIESFESK TDLFVVTEFA LMDLHRYLSY NGAMGEEPAR RVTGHLVSAL YYLHSNRILH 120

RDLKPQNVLL DKNMHAKLCD FGLARNMTLG THVLTSIKGT PLYMAPELLA EQPYDHHADM 180

WSLGCIAYES MAGQPPFCAS SILHLVKMIK HEDVKWPSTL TSECRSFLQG LLEKDPGLRI 240

SWTQLLCHPF V 251

Keyword

ATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Segmentation polarity protein; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0035301	; C:Hedgehog signaling complex
GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007293	; P:germarium-derived egg chamber formation
GO:0007228	; P:positive regulation of hh target transcription factor activity
GO:0042993	; P:positive regulation of transcription factor import into nucleus
GO:0031647	; P:regulation of protein stability
GO:0030162	; P:regulation of proteolysis
GO:0007367	; P:segment polarity determination

KEGG

dme:Dmel_CG6551

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013