EKS-DRM-00213
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00213
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CK1/CK1468.75.8E-1419269261
StatusReviewed
Ensembl ProteinFBpp0085104
UniProt AccessionO76324; A4V3P5; Q0KHY4; Q9V462;
Protein NameDiscs overgrown protein kinase
Protein Synonyms/Alias Protein double-time;
Gene Namedco
Gene Synonyms/Alias dco; dbt; CG2048;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0002413FBpp0085106FBtr0085744
FBgn0002413FBpp0085105FBtr0085743
FBgn0002413FBpp0085104FBtr0085742
OrganismDrosophila melanogaster
Functional DescriptionInvolved in circadian rhythms, viability and molecularoscillations of the clock genes period (per) and timeless (tim). Dbt reduces the stability and thus the accumulation of monomeric per proteins, probably through phosphorylation. No evident circadian oscillation is detected in head.
Protein Length440
Protein Sequence
(FASTA)
MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ 60
GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH 120
SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA 180
SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL 240
CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN 300
PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG 360
GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG 420
GVGVGGMPSG GGGGGVGNAK 440
Nucleotide Sequence
(FASTA)
ATGGAGCTGC GCGTGGGTAA CAAATATCGC CTGGGCCGCA AGATAGGATC GGGATCGTTC 60
GGCGACATCT ACCTGGGCAC CACGATCAAC ACTGGCGAGG AGGTGGCCAT CAAGCTGGAG 120
TGCATCCGCA CCAAACACCC CCAGCTGCAC ATCGAGTCAA AGTTCTACAA GACGATGCAG 180
GGTGGCATAG GCATACCCCG CATAATCTGG TGCGGCAGCG AGGGCGACTA CAATGTGATG 240
GTGATGGAGC TACTCGGACC CTCGCTGGAG GACCTCTTCA ACTTTTGTTC ACGCCGCTTT 300
TCGTTGAAGA CGGTTCTGCT GCTGGCGGAC CAGATGATCT CCCGCATCGA TTACATACAC 360
TCGCGGGACT TCATCCATCG CGACATCAAG CCGGATAACT TCCTCATGGG TCTTGGCAAA 420
AAGGGCAACC TGGTGTACAT CATTGACTTT GGCCTGGCCA AGAAATTCCG CGATGCCCGG 480
TCGCTGAAGC ACATTCCCTA TCGGGAAAAC AAGAACCTCA CGGGCACTGC CCGCTATGCC 540
TCCATCAACA CACATTTGGG CATTGAGCAA TCGCGTCGTG ACGACCTGGA GTCCCTGGGC 600
TACGTCCTAA TGTACTTCAA TCTGGGCGCC TTGCCCTGGC AGGGCTTAAA GGCAGCCAAC 660
AAGAGGCAAA AGTACGAGAG GATCTCGGAG AAGAAGCTGT CCACCTCGAT TGTGGTGCTG 720
TGCAAGGGCT TCCCCAGCGA GTTCGTCAAC TATCTGAACT TCTGTCGCCA GATGCATTTC 780
GACCAGCGTC CCGATTACTG CCACCTGCGC AAACTCTTCC GCAACTTGTT CCACCGTTTG 840
GGCTTCACTT ACGACTATGT GTTTGACTGG AACCTGCTTA AGTTTGGCGG ACCTCGCAAT 900
CCCCAGGCGA TTCAGCAGGC GCAGGACGGA GCGGACGGCC AGGCGGGTCA TGATGCGGTG 960
GCCGCAGCAG CGGCGGTGGC AGCAGCGGCA GCCGCCTCCT CGCATCAACA ACAGCAGCAC 1020
AAGGTCAATG CGGCGCTGGG TGGCGGAGGA GGCAGTGCAG CGCAACAGCA ACTCCAGGGC 1080
GGCCAAACGC TGGCGATGCT GGGCGGCAAT GGAGGCGGTA ACGGCAGCCA ACTGATCGGC 1140
GGCAACGGAC TCAACATGGA CGACTCGATG GCGGCCACCA ACTCGTCGAG ACCGCCGTAC 1200
GACACGCCGG AGCGTCGGCC TTCGATACGG ATGCGGCAGG GAGGCGGTGG TGGCGGCGGT 1260
GGAGTGGGCG TAGGCGGTAT GCCGAGCGGC GGAGGGGGCG GTGGCGTGGG GAACGCCAAA 1320
TAA 1323
Domain Profile
S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60
         yr+++kiGsGsfGdiylg+++++geevaikle++++k+pql++es++yk++qgg giP++
Q: 9     YRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRI  68
         89**********************************************************
S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120
          ++g+e++ynv+v++llGpsledlf++c+r+fslktvllladq+isri+y+hs+++i+rd
Q: 69    IWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRD  128
         ************************************************************
S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180
         ikPdnfl+g+g+kg+ vy+idfGlakk+rda++ khipyre+k+ltGtaryasinthlg+
Q: 129   IKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGI  188
         ************************************************************
S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240
         eqsrrddleslgyvl+yf+ g lPWqglkaa+k+qkye+isekklstsi vlc+gfP+ef
Q: 189   EQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEF  248
         ************************************************************
S: 241   atylkyvrklkfeekPdyeyl  261
         ++yl+++r+++f+++Pdy +l
Q: 249   VNYLNFCRQMHFDQRPDYCHL  269
         ******************875
Domain Sequence
(FASTA)
YRLGRKIGSG SFGDIYLGTT INTGEEVAIK LECIRTKHPQ LHIESKFYKT MQGGIGIPRI 60
IWCGSEGDYN VMVMELLGPS LEDLFNFCSR RFSLKTVLLL ADQMISRIDY IHSRDFIHRD 120
IKPDNFLMGL GKKGNLVYII DFGLAKKFRD ARSLKHIPYR ENKNLTGTAR YASINTHLGI 180
EQSRRDDLES LGYVLMYFNL GALPWQGLKA ANKRQKYERI SEKKLSTSIV VLCKGFPSEF 240
VNYLNFCRQM HFDQRPDYCH L 261
KeywordATP-binding; Biological rhythms; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00422
EKS-ANC-00439
EKS-BOT-00452
EKS-CAE-00380
EKS-CAJ-00458
EKS-CAF-00452
EKS-CAP-00486
EKS-CII-00257
EKS-CIS-00212
EKS-DAR-00857
EKS-DAN-00027
EKS-DIO-00094
EKS-EQC-00442
EKS-ERE-00046
EKS-FEC-00431
EKS-GAM-00265
EKS-GAG-00380
EKS-GAA-00550
EKS-GOG-00444
EKS-HOS-00460
EKS-ICT-00433
EKS-LAC-00465
EKS-LOA-00460
EKS-MAM-00451
EKS-MAE-00069
EKS-MEG-00370
EKS-MIM-00080
EKS-MOD-00443
EKS-MUM-00485
EKS-MUP-00445
EKS-MYL-00445
EKS-NOL-00411
EKS-OCP-00113
EKS-ORN-00571
EKS-ORA-00393
EKS-ORC-00426
EKS-ORL-00522
EKS-OTG-00454
EKS-PAT-00428
EKS-PES-00398
EKS-PEM-00248
EKS-POA-00441
EKS-PRC-00057
EKS-PTV-00160
EKS-RAN-00465
EKS-SAH-00423
EKS-SOA-00043
EKS-SUS-00400
EKS-TAG-00516
EKS-TAR-00565
EKS-TAS-00063
EKS-TEN-00565
EKS-TUT-00162
EKS-XET-00603
EKS-XIM-00563
EKS-SAC-00093
EKS-SCP-00094
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0048148; P:behavioral response to cocaine
GO:0008062; P:eclosion rhythm
GO:0001737; P:establishment of imaginal disc-derived wing hair orientation
GO:0042067; P:establishment of ommatidial planar polarity
GO:0007446; P:imaginal disc growth
GO:0045475; P:locomotor rhythm
GO:0043066; P:negative regulation of apoptotic process
GO:0051781; P:positive regulation of cell division
GO:0030307; P:positive regulation of cell growth
GO:0042306; P:regulation of protein import into nucleus
GO:0030431; P:sleep
GO:0016055; P:Wnt receptor signaling pathway
KEGG
dme:Dmel_CG2048;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013