EPS-DRM-00079
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-DRM-00079
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CDC25/CDC25118.51.9E-34270370101
StatusReviewed
Ensembl ProteinFBpp0080412
UniProt AccessionQ03019; Q9V454;
Protein NameCdc25-like protein phosphatase twine
Protein Synonyms/Alias
Gene Nametwe
Gene Synonyms/Alias twe; CG4965;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0002673FBpp0080412FBtr0080855
FBgn0002673FBpp0303863FBtr0331446
FBgn0002673FBpp0303862FBtr0331445
FBgn0002673FBpp0303861FBtr0331444
OrganismDrosophila melanogaster
Functional DescriptionRequired during meiosis. Regulates the transition fromthe extended G2 phase to the onset of the first meiotic division.
Protein Length426
Protein Sequence
(FASTA)
MASKRLMLDV EEEDDESGAC GQENFDPHDA DMEYQAKRRK SAVQETPLQW MLKRHIPAST 60
TVLSPITELS QNMNGARLDG TPKSTQRIPA NRTLNNFNSL SSRTLGSFSS SCSSYESGNS 120
LDDEYMDMFE MESAENHNLE LPDDLEVLLS GQLKSESNLE EMSNKKGSLR RCLSMYPSEQ 180
PEEAVQEPDQ ETNMPMKKMQ RKTLSMNDAE IMRALGDEPE LIGDLSKPCT LPCLATGIRH 240
RDLKTISSDT LARLIQGEFD EQLGSQGGYE IIDCRYPYEF LGGHIRGAKN LYTRGQIQEA 300
FPTLTSNQEN RRIYVFHCEF SSERGPKLLR YLRSNDRSQH THNYPALDYP ELYILHNGYK 360
EFFGLYSQLC QPSQYVPMLA PAHNDEFRYF RAKTKSWQCG EGGDSGIGGG GSRGLRKSRS 420
RLLYAE 426
Nucleotide Sequence
(FASTA)
ATGGCGAGCA AGCGGCTAAT GCTCGATGTG GAGGAAGAAG ATGATGAAAG TGGAGCGTGT 60
GGTCAGGAGA ATTTCGATCC CCATGATGCC GATATGGAAT ACCAGGCCAA AAGGCGAAAA 120
TCAGCCGTGC AGGAGACTCC GCTGCAATGG ATGCTGAAGC GGCATATTCC TGCCAGCACC 180
ACCGTTCTGT CGCCCATCAC CGAATTGTCG CAGAATATGA ATGGAGCCCG CCTGGATGGC 240
ACTCCCAAGT CCACCCAGAG AATCCCAGCC AACAGGACCC TGAATAACTT TAATAGCCTG 300
TCCTCGCGAA CACTCGGCAG TTTCAGTAGC TCCTGCTCGA GTTACGAGTC GGGCAACTCG 360
CTGGATGATG AGTACATGGA CATGTTCGAA ATGGAATCAG CCGAGAATCA CAATCTTGAG 420
TTGCCCGATG ACTTGGAAGT GCTCCTCAGC GGACAGCTGA AATCGGAAAG CAATTTAGAG 480
GAGATGTCCA ACAAAAAAGG CTCCCTGCGT CGCTGCCTTA GCATGTATCC CAGTGAACAG 540
CCAGAGGAAG CGGTTCAAGA ACCAGATCAG GAGACCAACA TGCCCATGAA GAAGATGCAA 600
CGGAAAACTC TATCAATGAA CGACGCCGAG ATCATGAGAG CACTGGGAGA TGAACCAGAG 660
TTAATCGGAG ATCTCAGCAA GCCATGTACC CTGCCCTGTT TGGCGACAGG CATTAGACAT 720
CGTGATCTAA AGACCATCTC CAGTGACACA TTGGCCAGAC TGATTCAGGG CGAGTTTGAT 780
GAACAATTGG GAAGCCAGGG CGGATACGAG ATCATAGACT GCCGTTACCC ATACGAGTTC 840
CTTGGCGGAC ACATACGGGG AGCGAAGAAT TTGTACACAC GTGGGCAGAT ACAGGAGGCG 900
TTTCCCACGC TGACCTCCAA TCAGGAAAAT CGACGCATCT ACGTCTTCCA CTGTGAGTTC 960
TCCTCGGAAC GGGGTCCCAA GCTATTGCGC TACCTGCGGA GCAACGACAG AAGTCAGCAT 1020
ACCCACAACT ATCCGGCACT GGACTATCCT GAACTTTATA TCCTGCACAA TGGGTACAAG 1080
GAGTTCTTCG GTCTATACTC GCAGCTATGC CAGCCCAGCC AATATGTACC AATGCTGGCA 1140
CCGGCGCACA ATGATGAGTT TCGATATTTT CGGGCCAAGA CCAAGTCCTG GCAATGTGGC 1200
GAGGGCGGAG ACAGTGGAAT CGGCGGTGGA GGCTCTCGCG GCCTCCGGAA ATCACGTTCA 1260
CGACTGCTCT ACGCCGAGTG A 1281
Domain Profile
S: 6     viidcrypyeyegghiktavnlkleeevedfllkkpivpldldkrvilvfhcefssergp  65
          iidcrypye++gghi++a nl+++ ++++++   p +  + ++r i vfhcefssergp
Q: 270   EIIDCRYPYEFLGGHIRGAKNLYTRGQIQEAF---PTLTSNQENRRIYVFHCEFSSERGP  326
         59****************************99...77888999999**************
S: 66    rlarflrerdralne..ypslyypelyilkggykeffeklkelc  107
         +l r+lr +dr+     yp+l ypelyil+ gykeff  +++lc
Q: 327   KLLRYLRSNDRSQHThnYPALDYPELYILHNGYKEFFGLYSQLC  370
         ***********876445*********************999999
Domain Sequence
(FASTA)
EIIDCRYPYE FLGGHIRGAK NLYTRGQIQE AFPTLTSNQE NRRIYVFHCE FSSERGPKLL 60
RYLRSNDRSQ HTHNYPALDY PELYILHNGY KEFFGLYSQL C 101
KeywordCell cycle; Cell division; Complete proteome; Hydrolase; Meiosis; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Caenorhabditis elegans"; ?>Schizosaccharomyces pombe"; ?>
EPS-CAE-00099
EPS-SCP-00019
Gene Ontology
GO:0005622; C:intracellular
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0051301; P:cell division
GO:0009790; P:embryo development
GO:0000087; P:M phase of mitotic cell cycle
GO:0007140; P:male meiosis
GO:0008315; P:meiotic G2/MI transition
GO:0051078; P:meiotic nuclear envelope disassembly
GO:0007279; P:pole cell formation
GO:0051445; P:regulation of meiotic cell cycle
GO:0007348; P:regulation of syncytial blastoderm mitotic cell cycle
GO:0007283; P:spermatogenesis
KEGG
dme:Dmel_CG4965;
InterPros
IPR000751; MPI_Phosphatase.
IPR001763; Rhodanese-like_dom.
Pfam
PF00581; Rhodanese; 1.
SMARTs
SM00450; RHOD; 1.
Prosites
PS50206; RHODANESE_3; 1.
Prints
PR00716; MPIPHPHTASE.
Created Date20-Feb-2013