EKS-DRM-00164

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00164

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	272.8	4.0E-81	16	282	267

Status

Reviewed

Ensembl Protein

FBpp0079065

UniProt Accession

P10676; P10677; Q8MRP1; Q9VM23; Q9VM24;

Protein Name

Neither inactivation nor afterpotential protein C

Protein Synonyms/Alias

Gene Name

ninaC

Gene Synonyms/Alias

ninaC; CG5125;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0002938	FBpp0079065	FBtr0079437
FBgn0002938	FBpp0079064	FBtr0079436

Organism

Drosophila melanogaster

Functional Description

Required for photoreceptor cell function. The ninaCproteins combines putative serine/threonine-protein kinase and myosin activities.

Protein Length

1135

Protein Sequence
(FASTA)

MMYLPYAQLP DPTDKFEIYE EIAQGVNAKV FRAKELDNDR IVALKIQHYD EEHQVSIEEE 60

YRTLRDYCDH PNLPEFYGVY KLSKPNGPDE IWFVMEYCAG GTAVDMVNKL LKLDRRMREE 120

HIAYIIRETC RAAIELNRNH VLHRDIRGDN ILLTKNGRVK LCDFGLSRQV DSTLGKRGTC 180

IGSPCWMAPE VVSAMESREP DITVRADVWA LGITTIELAD GKPPFADMHP TRAMFQIIRN 240

PPPTLMRPTN WSQQINDFIS ESLEKNAENR PMMVEMVEHP FLTELIENED EMRSDIAEML 300

ELSRDVKTLY KEPELFVDRG YVKRFDEKPE KMYPEDLAAL ENPVDENIIE SLRHRILMGE 360

SYSFIGDILL SLNSNEIKQE FPQEFHAKYR FKSRSENQPH IFSVADIAYQ DMLHHKEPQH 420

IVLSGESYSG KSTNARLLIK HLCYLGDGNR GATGRVESSI KAILMLVNAG TPVNNDSTRC 480

VLQYCLTFGK TGKMSGAVFN MYMLEKLRVA TTDGTQHNFH IFYYFYDFIN QQNQLKEYNL 540

KADRNYRYLR VPPEVPPSKL KYRRDDPEGN VERYREFENI LRDIDFNHKQ LETVRKVLAA 600

ILNIGNIRFR QNGKYAEVEN TDIVSRIAEL LRVDEKKFMW SLTNFIMVKG GIAERRQYTT 660

EEARDARDAV ASTLYSRLVD FIINRINMNM SFPRAVFGDT NAIIIHDMFG FECFNRNGLE 720

QLMINTLNEQ MQYHYNQRIF ISEMLEMEAE DIDTINLNFY DNKTALDNLL TKPDGLFYII 780

DDASRSCQDQ DLIMDRVSEK HSQFVKKHTA TEISVAHYTG RIIYDTRAFT DINRDFVPPE 840

MIETFRSSLD ESIMLMFTNQ LTKAGNLTMP FEAVQHKDES ERKSYALNTL SAGCISQVNN 900

LRTLAANFRF TCLTLLKMLS QNANLGVHFV RCIRADLEYK PRSFHSDVVQ QQMKALGVLD 960

TVIARQKGFS SRLPFDEFLR RYQFLAFDFD EPVEMTKDNC RLLFLRLKME GWALGKTKVF 1020

LRYYNDEFLA RLYELQVKKV IKVQSMMRAL LARKRVKGGK VFKLGKKGPE HHDVAASKIQ 1080

KGKKTQVDRL REYDEEHIDI SETPSEAEEM FLEARMDEAL AAVRIAKIEQ ASAEE 1135

Nucleotide Sequence
(FASTA)

ATGATGTATT TACCGTACGC GCAATTGCCG GATCCTACGG ATAAATTCGA GATCTACGAG 60

GAGATAGCCC AAGGCGTCAA TGCCAAGGTT TTTCGGGCCA AGGAGCTCGA CAATGATCGG 120

ATCGTTGCCC TGAAGATTCA GCACTACGAT GAGGAGCACC AGGTTTCCAT CGAGGAGGAG 180

TATCGCACTC TGCGGGACTA CTGCGACCAT CCCAATCTTC CCGAGTTCTA TGGCGTCTAC 240

AAGCTGTCGA AGCCAAACGG ACCTGATGAG ATCTGGTTTG TCATGGAGTA CTGCGCTGGG 300

GGAACAGCAG TGGACATGGT TAACAAGCTT TTGAAACTGG ATCGTCGAAT GCGAGAGGAG 360

CACATCGCCT ACATTATCCG GGAGACTTGC CGTGCTGCCA TCGAGCTGAA CCGTAATCAT 420

GTCCTGCATC GGGACATTCG GGGAGATAAC ATATTGTTGA CCAAAAATGG ACGGGTCAAG 480

CTGTGCGATT TCGGTTTATC CCGTCAGGTG GATTCCACTC TGGGCAAGAG GGGCACCTGC 540

ATTGGATCTC CCTGCTGGAT GGCTCCCGAA GTGGTGTCCG CCATGGAATC CCGCGAACCG 600

GACATCACCG TTCGTGCCGA TGTCTGGGCC TTGGGAATCA CTACCATTGA GTTGGCCGAT 660

GGAAAGCCAC CGTTCGCTGA CATGCATCCC ACTAGGGCCA TGTTCCAGAT CATTCGCAAT 720

CCACCGCCGA CCTTAATGCG ACCCACTAAT TGGTCGCAGC AGATCAATGA TTTTATATCC 780

GAGAGTTTGG AGAAAAATGC CGAAAATCGG CCCATGATGG TTGAGATGGT GGAGCATCCA 840

TTCCTCACGG AGCTCATCGA AAACGAGGAC GAGATGCGAT CGGACATCGC AGAAATGTTG 900

GAACTCTCTA GGGATGTAAA GACTTTGTAC AAGGAGCCGG AATTGTTCGT GGACCGCGGC 960

TATGTGAAGA GGTTCGATGA GAAGCCGGAA AAGATGTATC CGGAGGACTT GGCTGCCTTG 1020

GAAAATCCCG TGGATGAAAA CATAATCGAG TCACTGCGTC ATCGCATTTT GATGGGGGAA 1080

TCGTACAGTT TCATTGGCGA TATCCTTTTA TCCTTGAATT CCAATGAAAT CAAGCAGGAA 1140

TTTCCGCAGG AGTTCCATGC CAAGTATCGC TTCAAGTCGC GTTCGGAAAA CCAGCCGCAT 1200

ATTTTCTCGG TGGCCGATAT CGCCTACCAG GATATGCTGC ATCATAAGGA GCCGCAACAC 1260

ATCGTGCTCT CCGGAGAGAG CTACTCGGGC AAGTCCACAA ATGCCCGGCT GCTAATCAAG 1320

CATCTGTGCT ACTTGGGTGA TGGAAATCGT GGGGCCACCG GGCGCGTGGA GAGCTCCATC 1380

AAGGCCATCC TGATGTTGGT GAATGCAGGA ACTCCGGTAA ACAACGACTC CACAAGATGT 1440

GTCCTACAAT ATTGCTTGAC CTTTGGAAAA ACCGGCAAAA TGAGTGGGGC CGTTTTTAAT 1500

ATGTATATGC TGGAGAAACT ACGAGTGGCC ACTACGGACG GAACCCAGCA CAACTTCCAC 1560

ATCTTCTACT ACTTCTACGA CTTTATTAAT CAGCAAAATC AGCTTAAGGA GTACAATCTG 1620

AAGGCTGATC GCAATTATCG TTATCTGCGA GTTCCGCCAG AGGTTCCGCC ATCGAAACTC 1680

AAGTATCGTC GTGATGATCC CGAGGGCAAT GTGGAGAGGT ACAGGGAGTT CGAGAACATC 1740

CTGCGGGACA TTGATTTCAA TCACAAGCAA TTGGAGACCG TTCGCAAAGT TTTGGCTGCC 1800

ATTTTGAACA TTGGCAACAT CCGTTTCCGG CAGAACGGAA AGTATGCGGA AGTGGAGAAC 1860

ACGGACATTG TGTCCCGGAT CGCCGAGCTC CTCCGTGTGG ATGAGAAAAA GTTCATGTGG 1920

TCTCTGACCA ACTTCATTAT GGTCAAGGGC GGGATCGCCG AGAGGCGACA GTACACCACT 1980

GAAGAAGCTA GGGATGCACG CGATGCGGTG GCCAGCACGC TCTACTCTCG ATTGGTGGAC 2040

TTTATCATCA ACAGGATTAA CATGAACATG TCCTTCCCAC GGGCTGTGTT CGGAGACACA 2100

AATGCCATCA TTATTCACGA CATGTTTGGA TTTGAGTGCT TTAATCGAAA TGGTCTGGAG 2160

CAACTAATGA TCAATACTCT AAACGAGCAA ATGCAATATC ACTACAATCA ACGTATTTTT 2220

ATCAGCGAAA TGCTGGAAAT GGAAGCTGAA GACATTGACA CCATCAACTT GAATTTCTAT 2280

GACAACAAGA CAGCTCTGGA TAATCTGCTA ACCAAACCGG ATGGCCTGTT CTACATCATT 2340

GACGATGCCT CACGCTCCTG TCAAGATCAG GATTTGATTA TGGATCGCGT TTCGGAGAAG 2400

CACAGCCAGT TTGTGAAGAA GCACACTGCC ACTGAAATAT CCGTGGCTCA TTACACGGGC 2460

CGCATCATCT ATGATACGCG CGCCTTCACC GACATCAACC GGGACTTTGT GCCGCCGGAA 2520

ATGATCGAGA CCTTCCGCTC CTCGCTGGAT GAGAGCATCA TGCTCATGTT CACCAATCAA 2580

CTGACCAAGG CTGGCAATCT CACCATGCCA TTCGAGGCAG TGCAGCATAA GGATGAATCT 2640

GAACGGAAGT CATATGCCTT GAATACCCTA AGTGCCGGAT GCATCTCCCA AGTGAACAAT 2700

CTACGTACCC TGGCGGCCAA CTTCCGCTTC ACCTGCCTGA CCCTGCTCAA AATGCTAAGC 2760

CAGAATGCAA ATCTCGGCGT GCACTTCGTT CGCTGCATTC GCGCTGATCT GGAGTACAAG 2820

CCCAGATCCT TCCACTCGGA TGTCGTCCAG CAACAGATGA AGGCCTTGGG AGTTCTGGAC 2880

ACTGTTATTG CTCGCCAGAA GGGATTCAGC TCGCGTCTGC CATTCGACGA GTTCCTAAGG 2940

CGATACCAAT TCCTTGCCTT TGACTTTGAT GAGCCCGTGG AAATGACCAA GGATAACTGT 3000

CGTCTATTAT TCTTGCGCCT CAAGATGGAA GGCTGGGCCT TGGGCAAGAC CAAGGTGTTT 3060

TTGCGCTACT ATAACGATGA GTTCTTAGCC AGATTGTATG AGCTGCAGGT GAAGAAGGTC 3120

ATCAAAGTGC AGTCCATGAT GCGAGCTTTG CTAGCACGGA AACGAGTTAA GGGCGGCAAA 3180

GTTTTCAAAT TGGGCAAAAA GGGACCGGAG CATCATGATG TGGCCGCGTC CAAAATACAA 3240

AAAGGTAAAA AAACGCAGGT GGATAGGCTA AGAGAGTACG ACGAGGAGCA CATCGACATA 3300

AGCGAGACGC CCTCGGAGGC GGAGGAGATG TTCCTCGAGG CCAGAATGGA TGAGGCTCTG 3360

GCAGCGGTGC GAATAGCCAA AATCGAGCAG GCCTCCGCCG AGGAATAG 3408

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkk.lkhpniv  59

         +e++eei +G  +kv+ a+e +++++va+k+ ++++ e++ ++++e+++l++ ++hpn+

Q: 16    FEIYEEIAQGVNAKVFRAKELDNDRIVALKIQHYDE-EHQVSIEEEYRTLRDyCDHPNLP  74

         899*******************************98.88999********983577****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         e+++++        +e+w+vmey+agG++ d+v+   +l+++++Ee+iayi+re+++a

Q: 75    EFYGVYKLskpngPDEIWFVMEYCAGGTAVDMVNklLKLDRRMREEHIAYIIRETCRAAI  134

         ******998999999******************96667899*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

          l +++v+Hrdi+++niLlt++g+VkL+dfg++ q+++t  kr t++g+p+wmAPEv+++

Q: 135   ELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRGTCIGSPCWMAPEVVSA  194

         ***********************************************************9

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         +   e + + +aD+w+lGIt+iela+g+pPf+d++p++a+++i +n+pp+l++++++s++

Q: 195   MesrEPDITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQ  254

         98777789****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         +++f+++ l+kn e+Rp++ e+++h+Fl

Q: 255   INDFISESLEKNAENRPMMVEMVEHPFL  282

         ***************************7

Domain Sequence
(FASTA)

FEIYEEIAQG VNAKVFRAKE LDNDRIVALK IQHYDEEHQV SIEEEYRTLR DYCDHPNLPE 60

FYGVYKLSKP NGPDEIWFVM EYCAGGTAVD MVNKLLKLDR RMREEHIAYI IRETCRAAIE 120

LNRNHVLHRD IRGDNILLTK NGRVKLCDFG LSRQVDSTLG KRGTCIGSPC WMAPEVVSAM 180

ESREPDITVR ADVWALGITT IELADGKPPF ADMHPTRAMF QIIRNPPPTL MRPTNWSQQI 240

NDFISESLEK NAENRPMMVE MVEHPFL 267

Keyword

Actin-binding; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Motor protein; Myosin; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Sensory transduction; Serine/threonine-protein kinase; Transferase; Vision.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016027	; C:inaD signaling complex
GO:0005875	; C:microtubule associated complex
GO:0042385	; C:myosin III complex
GO:0005524	; F:ATP binding
GO:0042623	; F:ATPase activity, coupled
GO:0005516	; F:calmodulin binding
GO:0003774	; F:motor activity
GO:0035091	; F:phosphatidylinositol binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0016062	; P:adaptation of rhodopsin mediated signaling
GO:0007010	; P:cytoskeleton organization
GO:0016059	; P:deactivation of rhodopsin mediated signaling
GO:0033227	; P:dsRNA transport
GO:0006886	; P:intracellular protein transport
GO:0007601	; P:visual perception

KEGG

dme:Dmel_CG5125

;

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00015	; IQ; 2.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 2.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013