EKS-DRM-00134
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00134
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK421.12.1E-12625277253
StatusReviewed
Ensembl ProteinFBpp0074608
UniProt AccessionP52304; A4V258; Q9VWB2;
Protein NameSerine/threonine-protein kinase polo
Protein Synonyms/Alias
Gene Namepolo
Gene Synonyms/Alias polo; CG12306;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0003124FBpp0099722FBtr0100318
FBgn0003124FBpp0074608FBtr0074839
OrganismDrosophila melanogaster
Functional DescriptionMay play a role in regulating both nuclear andcytoplasmic aspects of the mitotic cycle.
Protein Length576
Protein Sequence
(FASTA)
MAAKPEDKST DIPDRLVDIN QRKTYKRMRF FGKGGFAKCY EIIDVETDDV FAGKIVSKKL 60
MIKHNQKEKT AQEITIHRSL NHPNIVKFHN YFEDSQNIYI VLELCKKRSM MELHKRRKSI 120
TEFECRYYIY QIIQGVKYLH DNRIIHRDLK LGNLFLNDLL HVKIGDFGLA TRIEYEGERK 180
KTLCGTPNYI APEILTKKGH SFEVDIWSIG CVMYTLLVGQ PPFETKTLKD TYSKIKKCEY 240
RVPSYLRKPA ADMVIAMLQP NPESRPAIGQ LLNFEFLKGS KVPMFLPSSC LTMAPRIGSN 300
DTIEDSMHRK PLMEMNGIRP DDTRLESTFL KANLHDAITA SAQVCRHSED YRSDIESLYQ 360
QLTNLINGKP RILQGNLGDE NTDPAAQPLF WISKWVDYSD KYGFGYQLCD EGIGVMFNDT 420
TKLILLPNQI NVHFIDKDGK ETYMTTTDYC KSLDKKMKLL SYFKRYMIEH LVKAGANNVN 480
IESDQISRMP HLHSWFRTTC AVVMHLTNGS VQLNFSDHMK LILCPRMSAI TYMDQEKNFR 540
TYRFSTIVEN GVSKDLYQKI RYAQEKLRKM LEKMFT 576
Nucleotide Sequence
(FASTA)
ATGGCCGCGA AGCCCGAGGA TAAGAGCACG GATATTCCGG ATCGCCTCGT CGACATCAAC 60
CAGCGGAAAA CCTACAAGCG CATGCGGTTC TTCGGCAAGG GCGGGTTTGC AAAATGTTAC 120
GAGATCATCG ATGTGGAAAC CGACGACGTC TTCGCCGGCA AGATCGTATC CAAGAAGCTG 180
ATGATCAAAC ACAATCAGAA GGAGAAGACC GCCCAGGAGA TAACTATTCA CCGCAGCCTT 240
AACCATCCGA ACATTGTCAA GTTTCACAAC TACTTTGAAG ATTCGCAGAA TATCTACATT 300
GTGCTGGAGC TGTGCAAGAA AAGATCCATG ATGGAGCTGC ACAAACGTAG GAAAAGCATT 360
ACGGAGTTCG AATGCCGCTA CTACATTTAC CAGATAATCC AGGGCGTTAA GTACTTGCAC 420
GATAACCGCA TTATCCATCG AGATCTGAAG CTGGGCAATC TCTTCCTCAA CGATTTGTTG 480
CACGTGAAGA TCGGGGATTT CGGGTTGGCC ACGCGCATTG AGTATGAGGG CGAGCGAAAA 540
AAGACCTTAT GCGGAACGCC CAACTATATA GCCCCGGAGA TCCTCACCAA GAAGGGCCAC 600
TCCTTCGAGG TGGACATCTG GTCGATTGGC TGCGTCATGT ACACACTGCT TGTGGGCCAG 660
CCGCCGTTCG AAACCAAGAC TCTGAAGGAT ACGTACTCGA AAATCAAGAA GTGCGAGTAC 720
CGCGTGCCCA GCTACTTAAG GAAACCGGCG GCGGATATGG TCATCGCCAT GCTGCAGCCA 780
AATCCGGAGA GCCGCCCGGC AATTGGTCAG CTGCTGAACT TTGAGTTCCT CAAGGGCTCA 840
AAGGTGCCCA TGTTCTTGCC CAGCTCTTGT CTGACAATGG CGCCGCGTAT CGGCAGCAAC 900
GACACCATCG AGGATTCGAT GCACCGCAAG CCACTGATGG AGATGAACGG CATCAGGCCC 960
GACGACACTC GTCTGGAGTC GACCTTCCTC AAGGCCAATC TGCACGACGC CATTACCGCG 1020
TCAGCGCAGG TGTGCCGCCA CAGCGAGGAC TATCGCAGCG ATATCGAGAG CCTGTACCAG 1080
CAGCTCACTA ATCTTATCAA CGGAAAGCCG CGAATTCTGC AAGGCAATCT GGGCGACGAG 1140
AACACAGATC CTGCAGCGCA GCCGCTCTTC TGGATATCCA AGTGGGTTGA CTACAGCGAC 1200
AAGTACGGAT TTGGTTACCA GCTGTGCGAT GAGGGCATCG GCGTGATGTT CAACGACACC 1260
ACAAAGCTGA TCCTGCTGCC GAATCAGATC AACGTACACT TCATCGACAA GGATGGCAAG 1320
GAGACGTACA TGACCACCAC GGATTACTGC AAGTCGCTTG ACAAGAAGAT GAAGCTGCTG 1380
TCGTACTTTA AGCGCTACAT GATCGAGCAC CTGGTGAAGG CAGGTGCCAA CAATGTGAAC 1440
ATTGAGAGCG ATCAAATCTC GCGTATGCCC CATTTACACT CCTGGTTCCG TACAACATGT 1500
GCCGTAGTTA TGCATTTGAC CAACGGTTCT GTGCAGCTAA ACTTCTCAGA TCACATGAAG 1560
CTCATCCTCT GCCCGCGCAT GAGTGCTATA ACCTATATGG ACCAGGAGAA GAACTTCCGC 1620
ACCTACCGAT TTTCGACCAT TGTGGAGAAC GGCGTGTCTA AAGACTTGTA CCAGAAGATC 1680
CGATATGCCC AGGAGAAACT TAGGAAAATG CTGGAGAAGA TGTTCACATA A 1731
Domain Profile
S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60
         y+r++++GkGgfakcye+ d+et++vfa k+v+k+l++k++q+ek ++ei+ihrsl+h+n
Q: 25    YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPN  84
         99**********************************************************
S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120
         ivk++++fed++n+y+vlelc++rs++el+krrk++te e+ryy++qi++g+kylh++ri
Q: 85    IVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRI  144
         ************************************************************
S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180
         +hrdlklgnlfln+ l+vkigdfGlatr+e+e+erkktlcGtPnyiaPe+l+kkghs+ev
Q: 145   IHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEV  204
         ************************************************************
S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240
         diWs+Gc++ytllvG+PPfetk+lk+ty+kikk+ey++Ps l+k+a++++ ++l+++Pe+
Q: 205   DIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPES  264
         ************************************************************
S: 241   rpsleevlkdefl  253
         rp++ ++l+ efl
Q: 265   RPAIGQLLNFEFL  277
         **********996
Domain Sequence
(FASTA)
YKRMRFFGKG GFAKCYEIID VETDDVFAGK IVSKKLMIKH NQKEKTAQEI TIHRSLNHPN 60
IVKFHNYFED SQNIYIVLEL CKKRSMMELH KRRKSITEFE CRYYIYQIIQ GVKYLHDNRI 120
IHRDLKLGNL FLNDLLHVKI GDFGLATRIE YEGERKKTLC GTPNYIAPEI LTKKGHSFEV 180
DIWSIGCVMY TLLVGQPPFE TKTLKDTYSK IKKCEYRVPS YLRKPAADMV IAMLQPNPES 240
RPAIGQLLNF EFL 253
KeywordATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00244
EKS-ANC-00253
EKS-BOT-00261
EKS-CAE-00234
EKS-CAJ-00267
EKS-CAF-00268
EKS-CAP-00296
EKS-CHH-00011
EKS-CII-00158
EKS-CIS-00035
EKS-DAR-00596
EKS-DAN-00009
EKS-ECT-00012
EKS-EQC-00256
EKS-FEC-00247
EKS-GAM-00161
EKS-GAG-00220
EKS-GAA-00322
EKS-GOG-00259
EKS-HOS-00268
EKS-ICT-00246
EKS-LAC-00273
EKS-LOA-00271
EKS-MAM-00263
EKS-MAE-00014
EKS-MEG-00209
EKS-MIM-00017
EKS-MOD-00258
EKS-MUM-00291
EKS-MUP-00258
EKS-MYL-00262
EKS-NOL-00241
EKS-ORN-00340
EKS-ORA-00231
EKS-ORC-00247
EKS-ORL-00317
EKS-OTG-00267
EKS-PAT-00248
EKS-PES-00234
EKS-PEM-00136
EKS-POA-00254
EKS-PRC-00018
EKS-PTV-00033
EKS-RAN-00276
EKS-SAH-00247
EKS-SUS-00226
EKS-TAG-00279
EKS-TAR-00335
EKS-TEN-00331
EKS-TUB-00014
EKS-TUT-00029
EKS-VIP-00009
EKS-XET-00336
EKS-XIM-00332
EKS-SAC-00030
EKS-SCP-00027
Gene Ontology
GO:0005814; C:centriole
GO:0000940; C:condensed chromosome outer kinetochore
GO:0005874; C:microtubule
GO:0030496; C:midbody
GO:0005635; C:nuclear envelope
GO:0000922; C:spindle pole
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0030954; P:astral microtubule nucleation
GO:0051297; P:centrosome organization
GO:0000910; P:cytokinesis
GO:0007060; P:male meiosis chromosome segregation
GO:0007067; P:mitosis
GO:0007052; P:mitotic spindle organization
GO:0007406; P:negative regulation of neuroblast proliferation
GO:0006911; P:phagocytosis, engulfment
GO:0007344; P:pronuclear fusion
GO:0035046; P:pronuclear migration
GO:0008104; P:protein localization
GO:0035044; P:sperm aster formation
GO:0007058; P:spindle assembly involved in female meiosis II
KEGG
dme:Dmel_CG12306;
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013