| Tag | Content |
|---|
| EKPD ID | EKS-DRM-00222 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/MAPK | 425.7 | 1.0E-127 | 38 | 326 | 289 |
|
| Status | Reviewed |
| Ensembl Protein | FBpp0112423 |
| UniProt Accession | P40417; A8Y4W1; A8Y4W2; Q7PL59; Q9W5M2; Q9W5M3; |
| Protein Name | Mitogen-activated protein kinase ERK-A |
| Protein Synonyms/Alias | Extracellular-regulated kinase A; Protein rolled; |
| Gene Name | rl |
| Gene Synonyms/Alias | rl; ERKa; CG12559; |
| Ensembl Information | |
| Organism | Drosophila melanogaster |
| Functional Description | Required downstream of Raf in the sevenless (sev), torso(tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. |
| Protein Length | 376 |
Protein Sequence
(FASTA) | | MEEFNSSGSV VNGTGSTEVP QSNAEVIRGQ IFEVGPRYIK LAYIGEGAYG MVVSADDTLT 60 | | NQRVAIKKIS PFEHQTYCQR TLREITILTR FKHENIIDIR DILRVDSIDQ MRDVYIVQCL 120 | | METDLYKLLK TQRLSNDHIC YFLYQILRGL KYIHSANVLH RDLKPSNLLL NKTCDLKICD 180 | | FGLARIADPE HDHTGFLTEY VATRWYRAPE IMLNSKGYTK SIDIWSVGCI LAEMLSNRPI 240 | | FPGKHYLDQL NHILGVLGSP SRDDLECIIN EKARNYLESL PFKPNVPWAK LFPNADALAL 300 | | DLLGKMLTFN PHKRIPVEEA LAHPYLEQYY DPGDEPVAEV PFRINMENDD ISRDALKSLI 360 | | FEETLKFKER QPDNAP 376 |
|
Nucleotide Sequence
(FASTA) | | ATGGAGGAAT TTAATTCGAG CGGATCAGTA GTTAATGGTA CAGGATCTAC GGAAGTTCCT 60 | | CAATCTAATG CTGAAGTTAT AAGGGGACAA ATATTTGAAG TTGGTCCTAG GTATATTAAA 120 | | CTCGCCTATA TAGGTGAAGG AGCTTATGGC ATGGTTGTGT CTGCGGATGA CACGCTAACA 180 | | AACCAAAGAG TTGCAATAAA AAAAATATCG CCCTTTGAAC ACCAAACTTA TTGTCAAAGG 240 | | ACTCTCAGAG AAATAACCAT ATTGACCAGA TTTAAACATG AAAACATTAT TGATATTCGA 300 | | GATATTCTTC GAGTTGATAG CATAGACCAA ATGAGAGATG TTTATATTGT ACAGTGTTTG 360 | | ATGGAGACTG ATTTGTATAA ACTACTTAAA ACACAGAGGC TAAGTAATGA TCACATCTGT 420 | | TACTTCTTAT ATCAGATATT GCGTGGACTC AAGTACATTC ATTCCGCAAA CGTCTTGCAT 480 | | CGGGACCTTA AGCCAAGTAA TTTACTGTTG AACAAGACGT GCGACTTAAA AATTTGCGAC 540 | | TTTGGATTGG CTCGTATTGC AGATCCCGAG CACGATCATA CTGGCTTTCT CACAGAATAC 600 | | GTTGCTACCC GATGGTATAG AGCACCTGAA ATAATGCTTA ACTCAAAAGG ATACACCAAA 660 | | TCTATAGACA TATGGTCCGT TGGCTGCATT TTGGCTGAAA TGTTAAGTAA TCGGCCAATA 720 | | TTTCCTGGAA AACATTACCT GGATCAACTT AATCATATTC TTGGAGTATT GGGTTCACCG 780 | | TCCCGGGACG ATTTAGAGTG TATTATTAAT GAAAAGGCAC GGAACTATTT GGAATCTTTA 840 | | CCATTTAAGC CAAATGTACC CTGGGCGAAA CTATTTCCAA ATGCTGATGC GTTGGCTTTA 900 | | GATCTCCTTG GAAAAATGTT AACATTTAAC CCGCATAAAC GGATTCCTGT CGAGGAAGCT 960 | | CTTGCACATC CCTATTTAGA GCAATATTAT GATCCTGGAG ATGAGCCTGT CGCTGAAGTG 1020 | | CCATTTCGGA TTAATATGGA AAATGATGAC ATTTCTCGAG ATGCCCTGAA GTCGTTGATT 1080 | | TTTGAAGAAA CCTTAAAATT TAAGGAACGA CAACCAGACA ATGCGCCTTA A 1131 |
|
| Domain Profile | S: 1 yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi 60 | y +l ++geGayg+vvsa d+ t++rvaikk+s pf+++t ++rtlRE+++l+++kheNi | Q: 38 YIKLAYIGEGAYGMVVSADDTLTNQRVAIKKIS-PFEHQTYCQRTLREITILTRFKHENI 96 | 567899**************************9.************************** |
| S: 61 iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs 120 | i++ d+++ ++ +++++dvY+v+ lmetdL+k++k+q+ls++hi ++lyqilrglky+Hs | Q: 97 IDIRDILRVDS-IDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKYIHS 155 | **********9.************************************************ |
| S: 121 anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl 178 | anv+HrDlKPsNll+n++c+lki+dFGlar+ad+e++++ lteyvatrwYraPei+l++ | Q: 156 ANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTgfLTEYVATRWYRAPEIMLNS 215 | ***********************************99999******************** |
| S: 179 keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn 238 | k ytk++DiWsvGCIlaE+l+++p+fpgk+++dql++il vlg+ps+++l++i +e+arn | Q: 216 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECIINEKARN 275 | ************************************************************ |
| S: 239 yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl 289 | y++slp k++ ++++lfp+a+ aldLl k+L+++p+kRi veeaL+hpYl | Q: 276 YLESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYL 326 | **************************************************7 |
|
Domain Sequence
(FASTA) | | YIKLAYIGEG AYGMVVSADD TLTNQRVAIK KISPFEHQTY CQRTLREITI LTRFKHENII 60 | | DIRDILRVDS IDQMRDVYIV QCLMETDLYK LLKTQRLSND HICYFLYQIL RGLKYIHSAN 120 | | VLHRDLKPSN LLLNKTCDLK ICDFGLARIA DPEHDHTGFL TEYVATRWYR APEIMLNSKG 180 | | YTKSIDIWSV GCILAEMLSN RPIFPGKHYL DQLNHILGVL GSPSRDDLEC IINEKARNYL 240 | | ESLPFKPNVP WAKLFPNADA LALDLLGKML TFNPHKRIPV EEALAHPYL 289 |
|
| Keyword | Alternative splicing; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |