EKS-DRM-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	439.5	7.0E-132	36	320	285

Status

Reviewed

Ensembl Protein

FBpp0089160

UniProt Accession

P18431; O76881; P23646; Q27603; Q27604; Q27605; Q8MRF7; Q9NF42; Q9U094; Q9W4X3;

Protein Name

Protein kinase shaggy

Protein Synonyms/Alias

Protein zeste-white 3;

Gene Name

sgg

Gene Synonyms/Alias

sgg; gsk3, zw3; CG2621;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0003371	FBpp0304140	FBtr0331752
FBgn0003371	FBpp0304141	FBtr0331753
FBgn0003371	FBpp0291395	FBtr0302185
FBgn0003371	FBpp0070449	FBtr0070466
FBgn0003371	FBpp0089162	FBtr0070472
FBgn0003371	FBpp0089158	FBtr0070473
FBgn0003371	FBpp0089159	FBtr0070474
FBgn0003371	FBpp0111741	FBtr0112828
FBgn0003371	FBpp0304139	FBtr0331751
FBgn0003371	FBpp0089161	FBtr0070476
FBgn0003371	FBpp0070451	FBtr0070468
FBgn0003371	FBpp0291178	FBtr0301966
FBgn0003371	FBpp0070450	FBtr0070467
FBgn0003371	FBpp0089160	FBtr0070475
FBgn0003371	FBpp0070454	FBtr0070471
FBgn0003371	FBpp0070453	FBtr0070470
FBgn0003371	FBpp0070452	FBtr0070469

Organism

Drosophila melanogaster

Functional Description

Required for several developmental events such assyncytial blastoderm formation and embryonic segmentation. Is involved in transcriptional regulation. Required for arm phosphorylation. Wg signaling operates by inactivating the sgg repression of en autoactivation. Negatively controls the neuromuscular junction (NMJ) growth in presynaptic motoneurons. Plays a role in the regulation of microtubule dynamics and actin cytoskeleton during embryogenesis. Required for phosphorylation of sra in activated eggs. Essential for completion of meiosis, possibly by triggering calcineurin activation via sra phosphorylation. Phosphorylates microtubule-associated protein futsch in axons.

Protein Length

496

Protein Sequence
(FASTA)

MLINRGSLLE GRDGSKITTV VATPGQGTDR VQEVSYTDTK VIGNGSFGVV FQAKLCDTGE 60

LVAIKKVLQD RRFKNRELQI MRKLEHCNIV KLLYFFYSSG EKRDEVFLNL VLEYIPETVY 120

KVARQYAKTK QTIPINFIRL YMYQLFRSLA YIHSLGICHR DIKPQNLLLD PETAVLKLCD 180

FGSAKQLLHG EPNVSYICSR YYRAPELIFG AINYTTKIDV WSAGCVLAEL LLGQPIFPGD 240

SGVDQLVEVI KVLGTPTREQ IREMNPNYTE FKFPQIKSHP WQKVFRIRTP TEAINLVSLL 300

LEYTPSARIT PLKACAHPFF DELRMEGNHT LPNGRDMPPL FNFTEHELSI QPSLVPQLLP 360

KHLQNASGPG GNRPSAGGAA SIAASGSTSV SSTGSGASVE GSAQPQSQGT AAAAGSGSGG 420

ATAGTGGASA GGPGSGNNSS SGGASGAPSA VAAGGANAAV AGGAGGGGGA GAATAAATAT 480

GAIGATNAGG ANVTDS 496

Nucleotide Sequence
(FASTA)

ATGTTGATCA ACCGCGGCTC CCTACTCGAA GGTCGCGATG GTTCTAAAAT CACAACAGTT 60

GTTGCAACAC CCGGCCAAGG CACCGATCGC GTACAAGAGG TCTCCTATAC AGACACAAAG 120

GTCATCGGCA ATGGCAGCTT CGGCGTCGTG TTCCAGGCAA AGCTCTGCGA TACCGGCGAA 180

CTGGTGGCAA TCAAAAAAGT TTTACAAGAC AGACGATTTA AGAATCGCGA ATTGCAAATA 240

ATGCGCAAAT TGGAGCATTG TAATATTGTG AAGCTTTTGT ACTTTTTCTA TTCGAGTGGT 300

GAAAAGCGTG ATGAAGTATT TTTGAATTTA GTCCTCGAAT ATATACCAGA AACCGTATAC 360

AAAGTGGCTC GCCAATATGC CAAAACCAAG CAAACGATAC CAATCAACTT TATTCGGCTC 420

TACATGTATC AACTGTTCAG AAGTTTGGCC TACATCCACT CGCTGGGCAT TTGCCATCGT 480

GATATCAAGC CGCAGAATCT TCTGCTCGAT CCGGAGACGG CTGTGCTGAA GCTCTGTGAC 540

TTTGGCAGCG CCAAACAGCT GCTGCACGGC GAGCCGAATG TATCGTATAT CTGCTCCCGG 600

TATTACCGCG CCCCCGAGCT CATCTTTGGC GCCATCAATT ATACAACAAA GATCGATGTC 660

TGGAGTGCCG GTTGCGTTTT GGCCGAACTG CTGCTGGGCC AGCCCATCTT CCCTGGCGAT 720

TCCGGTGTGG ATCAGCTCGT CGAGGTCATC AAGGTCCTGG GCACACCGAC AAGAGAACAG 780

ATACGCGAAA TGAATCCAAA CTACACGGAA TTCAAGTTCC CTCAGATTAA GAGTCATCCA 840

TGGCAGAAAG TTTTCCGTAT ACGCACTCCT ACAGAAGCTA TCAACTTGGT GTCCCTGCTG 900

CTCGAGTATA CGCCCAGTGC CAGGATCACA CCGCTCAAGG CCTGCGCACA TCCGTTCTTC 960

GATGAGCTAC GCATGGAGGG TAATCACACC TTGCCCAACG GTCGCGATAT GCCGCCGCTG 1020

TTCAACTTCA CAGAGCATGA GCTCTCAATA CAGCCCAGCC TAGTGCCGCA GTTGTTGCCC 1080

AAGCATCTGC AGAACGCATC CGGACCTGGC GGCAATCGAC CCTCGGCCGG CGGAGCAGCC 1140

TCCATTGCGG CCAGCGGCTC CACCAGCGTC TCGTCAACGG GCAGTGGTGC CTCGGTGGAA 1200

GGATCCGCCC AGCCACAGTC GCAGGGTACA GCAGCAGCTG CGGGATCCGG ATCGGGCGGA 1260

GCAACAGCAG GAACCGGCGG AGCGAGTGCC GGTGGACCCG GATCTGGTAA CAACAGTAGC 1320

AGCGGCGGAG CATCGGGAGC GCCGTCCGCT GTGGCTGCCG GAGGAGCCAA TGCCGCCGTC 1380

GCTGGCGGTG CTGGTGGTGG TGGCGGAGCC GGTGCGGCGA CCGCAGCTGC AACAGCAACT 1440

GGCGCTATAG GCGCGACTAA TGCCGGCGGC GCCAATGTAA CAGATTCATA G 1491

Domain Profile

S: 1     leelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLly  60

         ++++k+ig+GsFg+V+qa+l+++ e  vaiKkvlqd+++kn+El+i+rkl+H+niv+Lly

Q: 36    YTDTKVIGNGSFGVVFQAKLCDTGEL-VAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLY  94

         5789**********************.*********************************

S: 61    ffsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhs  120

         ff++s ek+d+v+lnlvley+Pet++kv+r+++++k+++++  ++ly+yQlfr+lay+hs

Q: 95    FFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHS  154

         ************************************************************

S: 121   leivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakey  180

         l+i+HrDiKPqNll+d+et+vlKlcDfGsak+l ++epnvsYi+sRyYRaPEL++ga +y

Q: 155   LGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINY  214

         ************************************************************

S: 181   ttkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfk  240

         ttkiDvWsagcvlaEll+g+++f+g+s++dql++++kvlGtpt+e+i+emn++y+e+kf+

Q: 215   TTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFP  274

         ************************************************************

S: 241   kikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         +ik+++++kv++ ++++ea++l++ +l+y+p++R+++l+++ahpff

Q: 275   QIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFF  320

         *********************************************9

Domain Sequence
(FASTA)

YTDTKVIGNG SFGVVFQAKL CDTGELVAIK KVLQDRRFKN RELQIMRKLE HCNIVKLLYF 60

FYSSGEKRDE VFLNLVLEYI PETVYKVARQ YAKTKQTIPI NFIRLYMYQL FRSLAYIHSL 120

GICHRDIKPQ NLLLDPETAV LKLCDFGSAK QLLHGEPNVS YICSRYYRAP ELIFGAINYT 180

TKIDVWSAGC VLAELLLGQP IFPGDSGVDQ LVEVIKVLGT PTREQIREMN PNYTEFKFPQ 240

IKSHPWQKVF RIRTPTEAIN LVSLLLEYTP SARITPLKAC AHPFF 285

Keyword

Alternative splicing; ATP-binding; Cell junction; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Kinase; Meiosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Segmentation polarity protein; Serine/threonine-protein kinase; Synapse; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005938	; C:cell cortex
GO:0030054	; C:cell junction
GO:0005813	; C:centrosome
GO:0035324	; C:female germline ring canal
GO:0045169	; C:fusome
GO:0072686	; C:mitotic spindle
GO:0031594	; C:neuromuscular junction
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008407	; P:chaeta morphogenesis
GO:0035293	; P:chitin-based larval cuticle pattern formation
GO:0009649	; P:entrainment of circadian clock
GO:0003382	; P:epithelial cell morphogenesis
GO:0090163	; P:establishment of epithelial cell planar polarity
GO:0007143	; P:female meiosis
GO:0046959	; P:habituation
GO:0007507	; P:heart development
GO:0045475	; P:locomotor rhythm
GO:0043508	; P:negative regulation of JUN kinase activity
GO:0045879	; P:negative regulation of smoothened signaling pathway
GO:0045886	; P:negative regulation of synaptic growth at neuromuscular junction
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0007219	; P:Notch signaling pathway
GO:0008355	; P:olfactory learning
GO:0030707	; P:ovarian follicle cell development
GO:0030589	; P:pseudocleavage involved in syncytial blastoderm formation
GO:0045610	; P:regulation of hemocyte differentiation
GO:0070507	; P:regulation of microtubule cytoskeleton organization
GO:0042306	; P:regulation of protein import into nucleus
GO:0030162	; P:regulation of proteolysis
GO:0072347	; P:response to anesthetic
GO:0007367	; P:segment polarity determination
GO:0035019	; P:somatic stem cell maintenance
GO:0051124	; P:synaptic growth at neuromuscular junction
GO:0035309	; P:wing and notum subfield formation
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

dme:Dmel_CG2621

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013