EKS-DRM-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	454.3	1.2E-136	204	455	252

Status

Reviewed

Ensembl Protein

FBpp0303536

UniProt Accession

P08630; A4V0F3; A4V0F4; O45032; O76132; O76133; P11361; Q6NNV0; Q8T0A0; Q9VLQ2; Q9VLQ3;

Protein Name

Tyrosine-protein kinase Btk29A

Protein Synonyms/Alias

Dsrc28C; Dsrc29a;

Gene Name

Btk29A

Gene Synonyms/Alias

Btk29A; Src2, Src29A, Tec29; CG8049;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0003502	FBpp0303536	FBtr0330693
FBgn0003502	FBpp0303535	FBtr0330692
FBgn0003502	FBpp0111748	FBtr0112835
FBgn0003502	FBpp0111749	FBtr0112836
FBgn0003502	FBpp0079236	FBtr0079616
FBgn0003502	FBpp0079235	FBtr0079615
FBgn0003502	FBpp0079238	FBtr0079618
FBgn0003502	FBpp0079237	FBtr0079617

Organism

Drosophila melanogaster

Functional Description

Required for proper ring canal development. Alsorequired for the development of male genitalia and for adult survival.

Protein Length

464

Protein Sequence
(FASTA)

MPGGIPTPGT PNSKAKDNSH FVKLVVALYP FKAIEGGDLS LEKNAEYEVI DDSQEHWWKV 60

KDALGNVGYI PSNYVKPKAL LGLERYEWYV GDMSRQRAES LLKQGDKEGC FVVRKSSTKG 120

LYTLSLHTKV PQSHVKHYHI KQNARCEYYL SEKHCCETIP DLINYHRHNS GGLACRLKSS 180

PCDRPVPPTA GLSHDKWEIH PMELMLMEEL GSGQFGVVRR GKWRGSIDTA VKMMKEGTMS 240

EDDFIEEAKV MTKLQHPNLV QLYGVCSKHR PIYIVTEYMK HGSLLNYLRR HEKTLIGNMG 300

LLLDMCIQVS KGMTYLERHN YIHRDLAARN CLVGSENVVK VADFGLARYV LDDQYTSSGG 360

TKFPIKWAPP EVLNYTRFSS KSDVWAYGVL MWEIFTCGKM PYGRLKNTEV VERVQRGIIL 420

EKPKSCAKEI YDVMKLCWSH GPEERPAFRV LMDQLALVAQ TLTD 464

Nucleotide Sequence
(FASTA)

ATGCCTGGCG GTATACCCAC TCCCGGAACA CCAAATTCCA AAGCCAAGGA CAACTCCCAC 60

TTTGTCAAGC TGGTGGTGGC TCTCTATCCA TTCAAGGCCA TCGAAGGCGG CGATTTATCG 120

CTGGAAAAGA ATGCCGAATA CGAAGTGATA GATGACTCAC AAGAGCACTG GTGGAAGGTC 180

AAAGATGCCT TGGGGAATGT CGGCTATATA CCCAGCAACT ATGTCAAGCC GAAGGCTCTT 240

CTGGGCCTGG AGCGCTATGA ATGGTATGTG GGCGACATGT CACGACAGAG AGCCGAATCG 300

CTGCTGAAGC AAGGTGATAA GGAGGGCTGC TTTGTGGTCA GGAAGTCATC GACCAAGGGT 360

CTCTACACAC TATCGCTGCA TACCAAAGTT CCACAGTCGC ATGTGAAGCA CTACCACATC 420

AAGCAAAATG CTCGCTGCGA GTATTATTTG AGTGAGAAGC ACTGCTGTGA AACAATTCCG 480

GATCTGATTA ACTACCATCG CCACAACTCT GGGGGTTTGG CTTGCCGACT CAAATCCTCG 540

CCCTGCGATC GCCCAGTTCC ACCGACGGCG GGATTGTCCC ACGACAAATG GGAGATCCAT 600

CCGATGGAAC TGATGCTGAT GGAGGAGCTT GGATCGGGAC AGTTTGGTGT TGTGCGGCGC 660

GGCAAGTGGC GTGGGTCTAT CGACACAGCG GTCAAGATGA TGAAGGAAGG AACCATGTCC 720

GAGGACGATT TCATTGAGGA GGCCAAGGTG ATGACCAAGC TGCAGCATCC AAATCTTGTG 780

CAGCTATATG GCGTCTGCTC CAAGCACCGG CCCATCTACA TTGTGACCGA GTACATGAAG 840

CACGGATCCT TGTTGAATTA CTTGCGACGG CATGAGAAGA CCCTGATTGG TAATATGGGT 900

CTACTCCTTG ACATGTGCAT ACAGGTTAGC AAGGGAATGA CCTACCTGGA GCGCCATAAC 960

TACATTCACC GGGATCTGGC TGCCCGCAAC TGTCTCGTGG GTTCCGAGAA TGTCGTTAAA 1020

GTGGCCGACT TTGGATTGGC CCGATACGTT CTCGACGATC AGTATACCAG CTCTGGCGGA 1080

ACCAAGTTCC CCATCAAGTG GGCCCCGCCC GAAGTGCTCA ACTACACGCG CTTCTCCTCT 1140

AAGAGCGATG TGTGGGCATA CGGTGTGCTG ATGTGGGAGA TCTTCACTTG CGGCAAGATG 1200

CCATACGGTC GCCTAAAGAA TACCGAGGTT GTGGAGCGTG TGCAGCGCGG AATTATCCTA 1260

GAAAAACCAA AGTCGTGTGC CAAGGAGATT TATGATGTCA TGAAGTTGTG CTGGTCACAT 1320

GGACCCGAGG AGCGTCCCGC TTTCCGTGTG CTCATGGATC AGCTGGCTCT TGTGGCCCAA 1380

ACGCTAACCG ACTAA 1395

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         l+l++elgsgqfgvv++gkwr++id+a+k++keg+mse+dfieeakvm+kl+hp+lvqly

Q: 204   LMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLY  263

         789*********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekel..llemckdvcegmeylerksfih  118

         gvc+k++piyivtey+++g+llnylr+++k+l  ++  ll+mc++v++gm+yler+++ih

Q: 264   GVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMglLLDMCIQVSKGMTYLERHNYIH  323

         ********************************9998879*********************

S: 119   rdlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksd  178

         rdlaarnclv++e+vvkv+dfglaryvlddqy+ss g+kfp+kw+ppevl+y+++ssksd

Q: 324   RDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSD  383

         ************************************************************

S: 179   vwafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpe  238

         vwa+gvlmwe+f++gk+py + +n+evve+v+rg++l++pk+++k++y+vmk cw++ pe

Q: 384   VWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPE  443

         ************************************************************

S: 239   erptfkellsal  250

         erp+f+ l+++l

Q: 444   ERPAFRVLMDQL  455

         *********998

Domain Sequence
(FASTA)

LMLMEELGSG QFGVVRRGKW RGSIDTAVKM MKEGTMSEDD FIEEAKVMTK LQHPNLVQLY 60

GVCSKHRPIY IVTEYMKHGS LLNYLRRHEK TLIGNMGLLL DMCIQVSKGM TYLERHNYIH 120

RDLAARNCLV GSENVVKVAD FGLARYVLDD QYTSSGGTKF PIKWAPPEVL NYTRFSSKSD 180

VWAYGVLMWE IFTCGKMPYG RLKNTEVVER VQRGIILEKP KSCAKEIYDV MKLCWSHGPE 240

ERPAFRVLMD QL 252

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0045172	; C:germline ring canal
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0030036	; P:actin cytoskeleton organization
GO:0007349	; P:cellularization
GO:0007619	; P:courtship behavior
GO:0008340	; P:determination of adult lifespan
GO:0042023	; P:DNA endoreduplication
GO:0007391	; P:dorsal closure
GO:0007301	; P:female germline ring canal formation
GO:0008258	; P:head involution
GO:0007485	; P:imaginal disc-derived male genitalia development
GO:0007476	; P:imaginal disc-derived wing morphogenesis
GO:0007254	; P:JNK cascade
GO:0030717	; P:karyosome formation
GO:0007424	; P:open tracheal system development
GO:0030723	; P:ovarian fusome organization
GO:0030833	; P:regulation of actin filament polymerization
GO:0007435	; P:salivary gland morphogenesis
GO:0046960	; P:sensitization

KEGG

dme:Dmel_CG8049

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013