EKS-DRM-00142

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00142

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	432.4	9.8E-130	200	493	294

Status

Unreviewed

Ensembl Protein

FBpp0078723

UniProt Accession

C7LA64;

Protein Name

Protein Synonyms/Alias

AT26493p;

Gene Name

tkv-RC

Gene Synonyms/Alias

tkv-RC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0003716	FBpp0078723	FBtr0079089
FBgn0003716	FBpp0078722	FBtr0079088
FBgn0003716	FBpp0078721	FBtr0079087
FBgn0003716	FBpp0078720	FBtr0079086

Organism

Drosophila melanogaster

Functional Description

Protein Length

509

Protein Sequence
(FASTA)

MAPKSRKKKA HARSLTCYCD GSCPDNVSNG TCETRPGGSC FSAVQQLYDE TTGMYEEERT 60

YGCMPPEDNG GFLMCKVAAV PHLHGKNIVC CDKEDFCNRD LYPTYTPKLT TPAPDLPVSS 120

ESLHTLAVFG SIIISLSVFM LIVASLCFTY KRREKLRKQP RLINSMCNSQ LSPLSQLVEQ 180

SSGSGSGLPL LVQRTIAKQI QMVRLVGKGR YGEVWLAKWR DERVAVKTFF TTEEASWFRE 240

TEIYQTVLMR HDNILGFIAA DIKGNGSWTQ MLLITDYHEM GSLHDYLSMS VINPQKLQLL 300

AFSLASGLAH LHDEIFGTPG KPAIAHRDIK SKNILVKRNG QCAIADFGLA VKYNSELDVI 360

HIAQNPRVGT RRYMAPEVLS QQLDPKQFEE FKRADMYSVG LVLWEMTRRC YTPVSGTKTT 420

TCEDYALPYH DVVPSDPTFE DMHAVVCVKG FRPPIPSRWQ EDDVLATVSK IMQECWHPNP 480

TVRLTALRVK KTLGRLETDC LIDVPIKIV 509

Nucleotide Sequence
(FASTA)

ATGGCGCCGA AATCCAGAAA GAAGAAGGCT CATGCCCGCT CCCTAACCTG CTACTGCGAT 60

GGCAGTTGTC CGGACAATGT AAGCAATGGA ACCTGCGAGA CCAGACCCGG TGGCAGTTGC 120

TTCAGCGCAG TCCAACAGCT TTACGATGAG ACGACCGGGA TGTACGAGGA GGAGCGTACA 180

TATGGATGCA TGCCTCCCGA AGACAACGGT GGTTTTCTCA TGTGCAAGGT AGCCGCTGTA 240

CCCCACCTGC ATGGCAAGAA CATTGTCTGC TGCGACAAGG AGGACTTCTG CAACCGTGAC 300

CTGTACCCCA CCTACACACC CAAGCTGACC ACACCAGCGC CGGATTTGCC CGTGAGCAGC 360

GAGTCCCTAC ACACGCTGGC CGTCTTTGGC TCCATCATCA TCTCCCTGTC CGTGTTTATG 420

CTGATCGTGG CTAGCTTATG TTTCACCTAC AAGCGACGCG AGAAGCTGCG CAAGCAGCCA 480

CGTCTCATCA ACTCAATGTG CAACTCACAG CTGTCGCCTT TGTCACAACT GGTGGAACAG 540

AGTTCGGGCT CCGGATCGGG ATTACCATTG CTGGTGCAAA GAACCATTGC CAAGCAGATT 600

CAGATGGTGC GACTGGTGGG CAAAGGACGA TATGGCGAGG TCTGGCTGGC CAAATGGCGC 660

GATGAGCGGG TGGCCGTCAA GACCTTCTTT ACGACCGAAG AGGCTTCTTG GTTCCGCGAG 720

ACTGAAATCT ATCAGACAGT GCTGATGCGA CACGACAATA TCTTGGGCTT CATTGCCGCC 780

GATATCAAGG GTAATGGTAG CTGGACACAG ATGTTGCTGA TCACCGACTA CCACGAGATG 840

GGCAGCCTAC ACGATTACCT CTCAATGTCG GTGATCAATC CGCAGAAGCT GCAATTGCTG 900

GCGTTTTCGC TGGCCTCCGG ATTGGCCCAC CTGCACGACG AGATTTTCGG AACCCCTGGC 960

AAACCAGCTA TCGCTCATCG CGATATCAAG AGCAAGAACA TTTTGGTCAA GCGGAATGGG 1020

CAGTGCGCTA TTGCTGACTT CGGGCTGGCA GTGAAGTACA ACTCGGAACT GGATGTCATT 1080

CACATTGCAC AGAATCCACG TGTCGGCACT CGACGCTACA TGGCTCCAGA AGTATTGAGT 1140

CAGCAGCTGG ATCCCAAGCA GTTTGAAGAG TTCAAACGGG CTGATATGTA TTCAGTGGGT 1200

CTCGTTCTGT GGGAGATGAC CCGTCGCTGC TACACACCCG TATCGGGCAC CAAGACGACC 1260

ACCTGCGAGG ACTACGCCCT GCCCTATCAC GATGTGGTGC CCTCGGATCC CACGTTCGAG 1320

GACATGCACG CTGTTGTGTG CGTAAAGGGT TTCCGGCCGC CGATACCATC ACGCTGGCAG 1380

GAGGATGATG TACTCGCCAC CGTATCCAAG ATCATGCAGG AGTGCTGGCA CCCGAATCCC 1440

ACCGTTCGGC TGACTGCCCT GCGCGTAAAG AAGACGCTGG GGCGACTGGA AACAGACTGT 1500

CTAATCGATG TGCCCATTAA GATTGTCTAA 1530

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         +++++l+gkGrygeVw ak+r+e+vAvK+f+t++easw+rE+eiyqtvl+rh+nil+fia

Q: 200   IQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIA  259

         799*********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k ++s+t++ll+t+yhe+gsL+dyL++++++ ++l  la slasGlahLH+ei+gt

Q: 260   ADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTP  319

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  KpaiaHRD+kskNilvk++++c+iaD+GLa+k+++e +++++a+n +vGt+RYmaPE

Q: 320   G--KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPE  377

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRcee.....vdeeveeyklpfeevvgsdP  235

         vl+++l+ k+fe+fkraD+Ys+gLvlWE+++Rc +     ++ ++e+y+lp+++vv+sdP

Q: 378   VLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTpvsgtKTTTCEDYALPYHDVVPSDP  437

         *********************************998777667799***************

S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++e+m++vv++k  rP ip++w+++++l+++sk+++ecW+ +p++Rltalrvkk+l

Q: 438   TFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTL  493

         ******************************************************97

Domain Sequence
(FASTA)

IQMVRLVGKG RYGEVWLAKW RDERVAVKTF FTTEEASWFR ETEIYQTVLM RHDNILGFIA 60

ADIKGNGSWT QMLLITDYHE MGSLHDYLSM SVINPQKLQL LAFSLASGLA HLHDEIFGTP 120

GKPAIAHRDI KSKNILVKRN GQCAIADFGL AVKYNSELDV IHIAQNPRVG TRRYMAPEVL 180

SQQLDPKQFE EFKRADMYSV GLVLWEMTRR CYTPVSGTKT TTCEDYALPY HDVVPSDPTF 240

EDMHAVVCVK GFRPPIPSRW QEDDVLATVS KIMQECWHPN PTVRLTALRV KKTL 294

Keyword

ATP-binding; Kinase; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0007178	; P:transmembrane receptor protein serine/threonine kinase signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013