EKS-DRM-00152

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00152

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	444.4	1.5E-133	889	1145	257

Status

Reviewed

Ensembl Protein

FBpp0071570

UniProt Accession

P04412; O18370; O61601; P81868; Q9W2G0;

Protein Name

Epidermal growth factor receptor

Protein Synonyms/Alias

Egfr; Drosophila relative of ERBB; Gurken receptor; Protein torpedo;

Gene Name

Egfr

Gene Synonyms/Alias

Egfr; c-erbB, DER, top; CG10079;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0003731	FBpp0071570	FBtr0071653
FBgn0003731	FBpp0071571	FBtr0071654

Organism

Drosophila melanogaster

Functional Description

Binds to four ligands: Spitz, Gurken, Vein and Argos,which is an antagonist. Transduces the signal through the ras-raf- MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle.

Protein Length

1377

Protein Sequence
(FASTA)

MMIISMWMSI SRGLWDSSSI WSVLLILACM ASITTSSSVS NAGYVDNGNM KVCIGTKSRL 60

SVPSNKEHHY RNLRDRYTNC TYVDGNLELT WLPNENLDLS FLDNIREVTG YILISHVDVK 120

KVVFPKLQII RGRTLFSLSV EEEKYALFVT YSKMYTLEIP DLRDVLNGQV GFHNNYNLCH 180

MRTIQWSEIV SNGTDAYYNY DFTAPERECP KCHESCTHGC WGEGPKNCQK FSKLTCSPQC 240

AGGRCYGPKP RECCHLFCAG GCTGPTQKDC IACKNFFDEG VCKEECPPMR KYNPTTYVLE 300

TNPEGKYAYG ATCVKECPGH LLRDNGACVR SCPQDKMDKG GECVPCNGPC PKTCPGVTVL 360

HAGNIDSFRN CTVIDGNIRI LDQTFSGFQD VYANYTMGPR YIPLDPERLE VFSTVKEITG 420

YLNIEGTHPQ FRNLSYFRNL ETIHGRQLME SMFAALAIVK SSLYSLEMRN LKQISSGSVV 480

IQHNRDLCYV SNIRWPAIQK EPEQKVWVNE NLRADLCEKN GTICSDQCNE DGCWGAGTDQ 540

CLTCKNFNFN GTCIADCGYI SNAYKFDNRT CKICHPECRT CNGAGADHCQ ECVHVRDGQH 600

CVSECPKNKY NDRGVCRECH ATCDGCTGPK DTIGIGACTT CNLAIINNDA TVKRCLLKDD 660

KCPDGYFWEY VHPQEQGSLK PLAGRAVCRK CHPLCELCTN YGYHEQVCSK CTHYKRREQC 720

ETECPADHYT DEEQRECFQC HPECNGCTGP GADDCKSCRN FKLFDANETG PYVNSTMFNC 780

TSKCPLEMRH VNYQYTAIGP YCAASPPRSS KITANLDVNM IFIITGAVLV PTICILCVVT 840

YICRQKQKAK KETVKMTMAL SGCEDSEPLR PSNIGANLCK LRIVKDAELR KGGVLGMGAF 900

GRVYKGVWVP EGENVKIPVA IKELLKSTGA ESSEEFLREA YIMASVEHVN LLKLLAVCMS 960

SQMMLITQLM PLGCLLDYVR NNRDKIGSKA LLNWSTQIAK GMSYLEEKRL VHRDLAARNV 1020

LVQTPSLVKI TDFGLAKLLS SDSNEYKAAG GKMPIKWLAL ECIRNRVFTS KSDVWAFGVT 1080

IWELLTFGQR PHENIPAKDI PDLIEVGLKL EQPEICSLDI YCTLLSCWHL DAAMRPTFKQ 1140

LTTVFAEFAR DPGRYLAIPG DKFTRLPAYT SQDEKDLIRK LAPTTDGSEA IAEPDDYLQP 1200

KAAPGPSHRT DCTDEIPKLN RYCKDPSNKN SSTGDDETDS SAREVGVGNL RLDLPVDEDD 1260

YLMPTCQPGP NNNNNINNPN QNNMAAVGVA AGYMDLIGVP VSVDNPEYLL NAQTLGVGES 1320

PIPTQTIGIP VMGVPGTMEV KVPMPGSEPT SSDHEYYNDT QRELQPLHRN RNTETRV 1377

Nucleotide Sequence
(FASTA)

ATGATGATTA TCAGCATGTG GATGAGCATA TCGCGAGGAT TGTGGGACAG CAGCTCCATC 60

TGGTCGGTGC TGCTGATCCT CGCCTGCATG GCATCCATCA CCACAAGCTC ATCGGTCAGC 120

AATGCCGGCT ATGTGGATAA TGGCAATATG AAAGTCTGCA TCGGCACTAA ATCTCGGCTC 180

TCCGTGCCCT CCAACAAGGA ACATCATTAC CGGAACCTCA GAGATCGGTA CACGAACTGT 240

ACGTATGTGG ATGGCAACCT GGAGCTGACC TGGCTGCCCA ACGAGAATTT GGACCTCAGC 300

TTCCTGGACA ACATACGGGA GGTCACCGGC TATATTCTGA TCAGTCATGT GGACGTTAAG 360

AAAGTGGTAT TTCCCAAACT ACAAATCATT CGCGGACGCA CGCTGTTCAG CTTATCCGTG 420

GAGGAGGAGA AGTATGCCTT GTTCGTCACT TATTCCAAAA TGTACACGCT GGAGATTCCC 480

GATCTACGCG ATGTCTTAAA TGGCCAAGTG GGCTTCCACA ACAACTACAA TCTCTGCCAC 540

ATGCGAACGA TCCAGTGGTC GGAGATTGTA TCCAACGGCA CGGATGCATA CTACAACTAC 600

GACTTTACTG CTCCGGAGCG CGAGTGTCCC AAGTGCCACG AGAGCTGCAC GCACGGATGT 660

TGGGGCGAGG GTCCCAAGAA TTGCCAGAAG TTCAGCAAGC TCACCTGCTC GCCACAGTGT 720

GCCGGAGGTC GTTGCTATGG ACCAAAGCCG CGGGAGTGTT GTCACCTCTT CTGCGCCGGA 780

GGATGCACTG GTCCCACGCA AAAGGATTGC ATCGCCTGCA AGAACTTCTT CGACGAGGGC 840

GTATGCAAGG AGGAATGCCC GCCCATGCGC AAGTACAATC CCACCACCTA TGTTCTTGAA 900

ACGAATCCTG AGGGAAAGTA TGCCTATGGT GCCACCTGCG TCAAGGAGTG TCCCGGTCAT 960

CTGTTGCGTG ATAATGGCGC CTGCGTGCGC AGCTGTCCCC AGGACAAGAT GGACAAGGGG 1020

GGCGAGTGTG TGCCCTGCAA TGGACCGTGC CCCAAAACCT GCCCGGGCGT TACTGTCCTG 1080

CATGCCGGCA ACATTGACTC GTTCCGGAAT TGTACGGTGA TCGATGGCAA CATTCGCATT 1140

TTGGATCAGA CCTTCTCGGG CTTCCAGGAT GTCTATGCCA ACTACACGAT GGGACCACGA 1200

TACATACCGC TGGATCCCGA GCGACTGGAG GTGTTCTCCA CGGTGAAGGA GATCACCGGG 1260

TATCTGAATA TCGAGGGAAC CCACCCGCAG TTCCGGAATC TGTCGTACTT CCGCAATCTG 1320

GAAACAATTC ATGGCCGCCA GCTGATGGAG AGCATGTTTG CCGCTTTGGC GATCGTTAAG 1380

TCATCCCTGT ACAGCCTGGA GATGCGCAAT CTGAAGCAGA TTAGTTCCGG CAGTGTGGTC 1440

ATCCAGCATA ATAGAGACCT CTGCTACGTA AGCAATATCC GTTGGCCGGC CATTCAGAAG 1500

GAGCCCGAAC AGAAGGTGTG GGTCAACGAG AATCTCAGGG CGGATCTATG CGAGAAAAAT 1560

GGAACCATTT GCTCGGATCA GTGCAACGAG GACGGCTGCT GGGGAGCTGG CACGGATCAG 1620

TGCCTTACCT GCAAGAACTT CAATTTCAAT GGCACCTGCA TCGCCGACTG TGGTTATATA 1680

TCCAATGCCT ACAAGTTTGA CAATAGAACG TGCAAGATAT GCCATCCAGA GTGCCGGACT 1740

TGCAATGGAG CTGGAGCAGA TCACTGCCAG GAGTGCGTCC ATGTGAGGGA CGGTCAGCAC 1800

TGTGTGTCCG AGTGCCCGAA GAACAAGTAC AACGATCGTG GTGTCTGCCG AGAGTGCCAC 1860

GCCACCTGCG ATGGATGCAC TGGGCCCAAG GACACCATCG GCATTGGAGC GTGTACAACG 1920

TGCAATTTGG CCATTATCAA CAATGACGCC ACAGTAAAAC GCTGCCTGCT GAAGGACGAC 1980

AAGTGCCCCG ATGGGTACTT CTGGGAGTAT GTGCATCCAC AAGAGCAGGG ATCGCTAAAG 2040

CCATTGGCCG GCAGAGCAGT TTGCCGAAAG TGCCATCCCC TTTGCGAGCT GTGCACCAAC 2100

TACGGATACC ATGAACAGGT GTGCTCCAAG TGCACCCACT ACAAGCGACG AGAGCAGTGC 2160

GAGACCGAGT GTCCGGCCGA TCACTACACG GATGAGGAGC AGCGCGAGTG CTTCCAGTGC 2220

CACCCAGAAT GCAACGGTTG CACTGGTCCG GGTGCCGACG ATTGCAAGTC TTGTCGCAAC 2280

TTCAAGTTGT TCGACGCGAA TGAGACGGGT CCCTATGTGA ACTCCACGAT GTTCAATTGC 2340

ACCTCGAAGT GTCCCTTGGA GATGCGACAT GTGAACTATC AGTACACGGC CATTGGACCC 2400

TACTGTGCAG CTAGTCCGCC GAGGAGCAGC AAGATAACTG CCAATCTGGA TGTGAACATG 2460

ATCTTCATTA TCACTGGTGC TGTTCTGGTG CCGACGATCT GCATCCTCTG CGTGGTCACA 2520

TACATTTGTC GGCAAAAGCA AAAGGCCAAG AAAGAAACAG TGAAGATGAC CATGGCTCTG 2580

TCCGGCTGTG AGGATTCCGA GCCGCTGCGT CCCTCGAACA TTGGAGCCAA TCTATGCAAG 2640

TTGCGCATTG TCAAGGACGC CGAGTTGCGC AAGGGCGGAG TCCTCGGAAT GGGAGCCTTT 2700

GGACGAGTGT ACAAGGGCGT TTGGGTGCCG GAGGGTGAGA ACGTCAAGAT TCCAGTGGCC 2760

ATTAAGGAGC TGCTCAAGTC CACAGGCGCC GAGTCAAGCG AAGAGTTCCT CCGCGAAGCC 2820

TACATCATGG CCTCTGTGGA GCACGTTAAT CTGCTGAAGC TCCTGGCCGT CTGCATGTCC 2880

TCACAAATGA TGCTAATCAC GCAACTGATG CCGCTTGGCT GCCTGTTGGA CTATGTGCGA 2940

AATAACCGGG ACAAGATCGG CTCTAAGGCT CTGCTCAACT GGAGCACGCA AATCGCCAAG 3000

GGCATGTCGT ATCTGGAGGA GAAGCGACTG GTCCACAGAG ACTTGGCTGC CCGCAATGTC 3060

CTGGTGCAGA CTCCCTCGCT GGTGAAGATC ACCGACTTTG GGCTGGCCAA GTTGCTGAGC 3120

AGCGATTCCA ATGAGTACAA GGCTGCTGGC GGCAAGATGC CCATCAAGTG GTTGGCACTG 3180

GAGTGCATTC GCAATCGTGT ATTCACCAGC AAGTCCGATG TCTGGGCCTT TGGTGTGACA 3240

ATTTGGGAAC TGCTGACCTT TGGCCAGCGT CCACACGAGA ACATCCCCGC TAAGGATATT 3300

CCCGATCTTA TTGAAGTCGG TCTGAAGCTG GAGCAGCCGG AGATTTGTTC GCTGGACATT 3360

TACTGCACAC TTCTCTCGTG CTGGCACTTG GATGCCGCCA TGCGTCCAAC CTTCAAGCAG 3420

CTGACTACGG TCTTTGCTGA GTTCGCCAGA GATCCGGGTC GCTATCTGGC CATTCCCGGG 3480

GATAAGTTCA CCCGGCTGCC GGCCTACACG AGTCAGGATG AGAAGGATCT CATCCGAAAA 3540

TTGGCTCCCA CCACCGATGG GTCCGAAGCC ATTGCGGAAC CCGATGACTA CCTGCAACCC 3600

AAGGCAGCAC CTGGTCCTAG TCACAGAACC GACTGCACGG ATGAGATACC CAAGCTGAAC 3660

CGCTACTGCA AGGATCCTAG CAACAAGAAT TCGAGTACCG GAGACGATGA GACGGATTCG 3720

AGTGCCCGGG AAGTGGGCGT GGGTAATCTG CGCCTCGATC TACCAGTCGA TGAGGATGAT 3780

TACCTGATGC CCACATGCCA ACCGGGGCCC AACAACAACA ACAACATAAA TAATCCCAAT 3840

CAAAACAATA TGGCAGCTGT GGGCGTGGCT GCCGGCTACA TGGATCTCAT CGGAGTGCCC 3900

GTTAGTGTGG ACAATCCGGA GTATCTGCTA AACGCGCAGA CACTGGGTGT TGGGGAGTCG 3960

CCGATACCCA CCCAGACCAT CGGGATACCG GTGATGGGAG TCCCGGGCAC CATGGAGGTC 4020

AAGGTGCCAA TGCCAGGCAG TGAGCCAACG AGCTCCGATC ACGAGTACTA CAATGATACC 4080

CAACGGGAGT TGCAGCCACT GCATCGAAAC CGCAACACGG AGACGAGGGT GTAG 4134

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+k  vlG+GafG+vykG+w+pegenvkipvaik+l ++tg+++++e+l+ea+++as++h

Q: 889   LRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEH  948

         6899********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

          nl++ll++c+ss+++l+tql+plGclldyvr+++dk+Gs++llnw++qiakGmsyleek

Q: 949   VNLLKLLAVCMSSQMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEK  1008

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

         rlvhrdlaarnvlv++p+ vkitdfGlakll++d++e+ka+ggk+pikwlale+i++r++

Q: 1009  RLVHRDLAARNVLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVF  1068

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         t++sdvw++Gvt+welltfG++p+++ipak+ipdl+e G +l+qp+ic++d+y++l++cw

Q: 1069  TSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCW  1128

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         ++da++rp+fk+l++ f

Q: 1129  HLDAAMRPTFKQLTTVF  1145

         **************998

Domain Sequence
(FASTA)

LRKGGVLGMG AFGRVYKGVW VPEGENVKIP VAIKELLKST GAESSEEFLR EAYIMASVEH 60

VNLLKLLAVC MSSQMMLITQ LMPLGCLLDY VRNNRDKIGS KALLNWSTQI AKGMSYLEEK 120

RLVHRDLAAR NVLVQTPSLV KITDFGLAKL LSSDSNEYKA AGGKMPIKWL ALECIRNRVF 180

TSKSDVWAFG VTIWELLTFG QRPHENIPAK DIPDLIEVGL KLEQPEICSL DIYCTLLSCW 240

HLDAAMRPTF KQLTTVF 257

Keyword

3D-structure; Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005006	; F:epidermal growth factor-activated receptor activity
GO:0007469	; P:antennal development
GO:0048149	; P:behavioral response to ethanol
GO:0007298	; P:border follicle cell migration
GO:0007420	; P:brain development
GO:0046845	; P:branched duct epithelial cell fate determination, open tracheal system
GO:0030031	; P:cell projection assembly
GO:0016337	; P:cell-cell adhesion
GO:0030381	; P:chorion-containing eggshell pattern formation
GO:0042676	; P:compound eye cone cell fate commitment
GO:0001752	; P:compound eye photoreceptor fate commitment
GO:0035225	; P:determination of genital disc primordium
GO:0046843	; P:dorsal appendage formation
GO:0007391	; P:dorsal closure
GO:0061331	; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis
GO:0035088	; P:establishment or maintenance of apical/basal cell polarity
GO:0007455	; P:eye-antennal disc morphogenesis
GO:0048139	; P:female germ-line cyst encapsulation
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0007369	; P:gastrulation
GO:0007390	; P:germ-band shortening
GO:0030718	; P:germ-line stem cell maintenance
GO:0008406	; P:gonad development
GO:0007482	; P:haltere development
GO:0003015	; P:heart process
GO:0008586	; P:imaginal disc-derived wing vein morphogenesis
GO:0007474	; P:imaginal disc-derived wing vein specification
GO:0007479	; P:leg disc proximal/distal pattern formation
GO:0035160	; P:maintenance of epithelial integrity, open tracheal system
GO:0048140	; P:male germ-line cyst encapsulation
GO:0008071	; P:maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded
GO:0016203	; P:muscle attachment
GO:0042694	; P:muscle cell fate specification
GO:0043066	; P:negative regulation of apoptotic process
GO:0046673	; P:negative regulation of compound eye retinal cell programmed cell death
GO:0045749	; P:negative regulation of S phase of mitotic cell cycle
GO:0035310	; P:notum cell fate specification
GO:0007477	; P:notum development
GO:0001742	; P:oenocyte differentiation
GO:0016318	; P:ommatidial rotation
GO:0007314	; P:oocyte anterior/posterior axis specification
GO:0007310	; P:oocyte dorsal/ventral axis specification
GO:0007422	; P:peripheral nervous system development
GO:0008284	; P:positive regulation of cell proliferation
GO:0090303	; P:positive regulation of wound healing
GO:0007458	; P:progression of morphogenetic furrow involved in compound eye morphogenesis
GO:0045466	; P:R7 cell differentiation
GO:0045610	; P:regulation of hemocyte differentiation
GO:0045468	; P:regulation of R8 cell spacing in compound eye
GO:0007431	; P:salivary gland development
GO:0016330	; P:second mitotic wave involved in compound eye morphogenesis
GO:0007367	; P:segment polarity determination
GO:0035277	; P:spiracle morphogenesis, open tracheal system
GO:0048865	; P:stem cell fate commitment
GO:0007421	; P:stomatogastric nervous system development
GO:0035202	; P:tracheal pit formation in open tracheal system
GO:0007473	; P:wing disc proximal/distal pattern formation

KEGG

dme:Dmel_CG10079

;

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 7.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013